LOCUS       NM_009532               2449 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus X-ray repair complementing defective repair in Chinese
            hamster cells 1 (Xrcc1), transcript variant 1, mRNA.
ACCESSION   NM_009532 XM_017322131 XM_359249
VERSION     NM_009532.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2449)
  AUTHORS   Koczor,C.A., Thompson,M.K., Sharma,N., Prakash,A. and Sobol,R.W.
  TITLE     Polbeta/XRCC1 heterodimerization dictates DNA damage recognition
            and basal Polbeta protein levels without interfering with mouse
            viability or fertility
  JOURNAL   DNA Repair (Amst) 123, 103452 (2023)
   PUBMED   36702010
  REMARK    GeneRIF: Polbeta/XRCC1 heterodimerization dictates DNA damage
            recognition and basal Polbeta protein levels without interfering
            with mouse viability or fertility.
REFERENCE   2  (bases 1 to 2449)
  AUTHORS   Uyeda,A., Onishi,K., Hirayama,T., Hattori,S., Miyakawa,T., Yagi,T.,
            Yamamoto,N. and Sugo,N.
  TITLE     Suppression of DNA Double-Strand Break Formation by DNA Polymerase
            beta in Active DNA Demethylation Is Required for Development of
            Hippocampal Pyramidal Neurons
  JOURNAL   J Neurosci 40 (47), 9012-9027 (2020)
   PUBMED   33087478
REFERENCE   3  (bases 1 to 2449)
  AUTHORS   Kim,J., Kim,K., Mo,J.S. and Lee,Y.
  TITLE     Atm deficiency in the DNA polymerase beta null cerebellum results
            in cerebellar ataxia and Itpr1 reduction associated with alteration
            of cytosine methylation
  JOURNAL   Nucleic Acids Res 48 (7), 3678-3691 (2020)
   PUBMED   32123907
REFERENCE   4  (bases 1 to 2449)
  AUTHORS   Xu,C., Xu,J., Ji,G., Liu,Q., Shao,W., Chen,Y., Gu,J., Weng,Z.,
            Zhang,X., Wang,Y. and Gu,A.
  TITLE     Deficiency of X-ray repair cross-complementing group 1 in
            primordial germ cells contributes to male infertility
  JOURNAL   FASEB J 33 (6), 7427-7436 (2019)
   PUBMED   30998386
  REMARK    GeneRIF: demonstrated that Xrcc1 deficiency in primordial germ
            cells induced elevated levels of reactive oxygen species,
            mitochondria dysfunction, apoptosis, and loss of stemness of
            spermatogonial stem cells (SSCs) in testes. In Xrcc1-deficienct
            SSCs, elevated oxidative stress and mitochondrial dysfunction could
            be partially reversed by treatment with the antioxidant
            N-acetylcysteine
REFERENCE   5  (bases 1 to 2449)
  AUTHORS   Yousafzai,N.A., Zhou,Q., Xu,W., Shi,Q., Xu,J., Feng,L., Chen,H.,
            Shin,V.Y., Jin,H. and Wang,X.
  TITLE     SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance
            in lung cancer
  JOURNAL   Cell Death Dis 10 (5), 363 (2019)
   PUBMED   31043584
  REMARK    GeneRIF: SIRT1 confers chemoresistance to lung cancer cells by
            deacetylating and stabilizing XRCC1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2449)
  AUTHORS   Rudert,F., Saunders,A.M., Rebstock,S., Thompson,J.A. and
            Zimmermann,W.
  TITLE     Characterization of murine carcinoembryonic antigen gene family
            members
  JOURNAL   Mamm Genome 3 (5), 262-273 (1992)
   PUBMED   1638085
REFERENCE   7  (bases 1 to 2449)
  AUTHORS   Levy,H.P., Schultz,R.A. and Cohen,M.M.
  TITLE     Comparative gene mapping in the species Muntiacus muntjac
  JOURNAL   Cytogenet Cell Genet 61 (4), 276-281 (1992)
   PUBMED   1486805
REFERENCE   8  (bases 1 to 2449)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     A molecular genetic linkage map of mouse chromosome 7
  JOURNAL   Genomics 8 (3), 525-535 (1990)
   PUBMED   1981054
REFERENCE   9  (bases 1 to 2449)
  AUTHORS   Mohrenweiser,H.W., Carrano,A.V., Fertitta,A., Perry,B.,
            Thompson,L.H., Tucker,J.D. and Weber,C.A.
  TITLE     Refined mapping of the three DNA repair genes, ERCC1, ERCC2, and
            XRCC1, on human chromosome 19
  JOURNAL   Cytogenet Cell Genet 52 (1-2), 11-14 (1989)
   PUBMED   2558854
REFERENCE   10 (bases 1 to 2449)
  AUTHORS   Siciliano,M.J., Carrano,A.V. and Thompson,L.H.
  TITLE     Assignment of a human DNA-repair gene associated with
            sister-chromatid exchange to chromosome 19
  JOURNAL   Mutat Res 174 (4), 303-308 (1986)
   PUBMED   3736579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161166.7.
            
            On or before Jan 27, 2018 this sequence version replaced
            XM_017322131.1, NM_009532.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AC161166.7         124723-124859       c
            138-504             AC161166.7         124199-124565       c
            505-597             AC161166.7         123676-123768       c
            598-714             AC161166.7         111706-111822       c
            715-873             AC161166.7         105864-106022       c
            874-948             AC161166.7         105265-105339       c
            949-1060            AC161166.7         105058-105169       c
            1061-1170           AC161166.7         104591-104700       c
            1171-1276           AC161166.7         104414-104519       c
            1277-1535           AC161166.7         103986-104244       c
            1536-1652           AC161166.7         103632-103748       c
            1653-1746           AC161166.7         101249-101342       c
            1747-1876           AC161166.7         100980-101109       c
            1877-1931           AC161166.7         100632-100686       c
            1932-2068           AC161166.7         100407-100543       c
            2069-2159           AC161166.7         99259-99349         c
            2160-2235           AC161166.7         98429-98504         c
            2236-2449           AC161166.7         98120-98333         c
FEATURES             Location/Qualifiers
     source          1..2449
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 11.42 cM"
     gene            1..2449
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /note="X-ray repair complementing defective repair in
                     Chinese hamster cells 1"
                     /db_xref="GeneID:22594"
                     /db_xref="MGI:MGI:99137"
     exon            1..137
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..504
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..2349
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     repair protein XRCC1; X-ray repair cross-complementing
                     protein 1"
                     /codon_start=1
                     /product="DNA repair protein XRCC1 isoform 1"
                     /protein_id="NP_033558.3"
                     /db_xref="CCDS:CCDS20955.1"
                     /db_xref="GeneID:22594"
                     /db_xref="MGI:MGI:99137"
                     /translation="MPEISLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTIS
                     VVLQLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGATAGEQDYEVLLVTSSFMSPSESR
                     SGSNPNRVRIFGPDKLVRAAAEKRWDRVKIVCSQPYSKDSPYGLSFVKFHSPPDKDEA
                     EATSQKVTVTKLGQFRVKEEDDSANSLKPGALFFSRINKTSSASTSDPAGPSYAAATL
                     QASSAASSASPVPKVVGSSSKPQEPPKGKRKLDLSLEDRKPPSKPSAGPSTLKRPKLS
                     VPSRTPAAAPASTPAQRAVPGKPRGEGTEPRGARTGPQELGKILQGVVVVLSGFQNPF
                     RSELRDKALELGAKYRPDWTPDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCHHM
                     RRRLPSRRYLMAGLGSSSEDEGDSHSESGEDEAPKLPQKRPQPKAKTQAAGPSSPPRP
                     PTPKETKAPSPGPQDNSDTEGEESEGRDNGAEDSGDTEDELRRVAKQREQRQPPAPEE
                     NGEDPYAGSTDENTDSETPSEADLPIPELPDFFEGKHFFLYGEFPGDERRRLIRYVTA
                     FNGELEDYMNERVQFVITAQEWDPNFEEALMENPSLAFVRPRWIYSCNEKQKLLPHQL
                     YGVVPQA"
     exon            505..597
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..714
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..873
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..948
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1060
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1170
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1276
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1535
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1652
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1746
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1876
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1931
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2068
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2159
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2235
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2449
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2426..2431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /note="hexamer: AATAAA"
     polyA_site      2447
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /note="major polyA site"
ORIGIN      
        1 gtcatgagct aagagaggtc tgagatcttt gtcggccatc tgtctgtcga tgttcgtctc
       61 tgtgtgtcca tccgtccgtc cgtctgtttg tctgcatttg gagagagaag gggaacagag
      121 cgtgtccgca acaacaggtt cccaggaagc cgagtctcca cgttatcagg cggctaggcc
      181 ggagagtggt ggaacctgag agaggcgggg ccggaggggg aatgcctgtt gctaagggaa
      241 cccggcgcct cgctcgcgga gaggcccaac cgagcatgcg cagtgttgac gtgtgcgccg
      301 gcgcgccgcg gtttgaaagg cccgagcctt gcgcgcttgc gcactgagtc ccgtgcaggg
      361 cgcgcgcgct cccccaacct tctccggggg ccccccggag ctgcaaccct tcttcttcat
      421 tccctggacg gtcgggcgtc cacgggcgtg gacatgccgg agatcagcct ccgccacgtc
      481 gtgtcctgca gcagccagga ctcgacccat tgtgccgaaa atcttctcaa ggcggacact
      541 taccggaagt ggcgggcagc caaggcagga gagaagacca tctctgtggt cctacagttg
      601 gagaaggagg agcagatcca cagtgtggac attggcaatg atggctcggc ctttgtggag
      661 gtgctagtgg gcagctcggc tggaggggcc acagctggtg aacaggacta tgaggtcctt
      721 ctggtcacct cctctttcat gtccccctct gagagccgaa gtggctcaaa tcccaaccgt
      781 gttcgcattt ttggacctga caagttagtc cgggcagcag cggagaagcg ctgggaccgt
      841 gttaaaattg tgtgcagcca gccatacagc aaggactcgc catacggcct gagttttgtg
      901 aagtttcaca gccctcctga caaagatgag gcagaggcta catctcagaa ggtgacagtg
      961 accaagctcg gccagtttcg tgtgaaagag gaggatgaca gtgccaactc cctgaagcca
     1021 ggggctctct tcttcagtcg tatcaacaag acgtcatcag cctctacgag tgacccagca
     1081 ggacccagct atgcagcagc tacactgcag gcctctagtg cagcctcctc agcctctcca
     1141 gtccccaagg ttgtgggcag ctcttccaag cctcaggagc ctcccaaagg gaagagaaaa
     1201 ctggacttga gtctagaaga caggaaacct cccagcaaac cctcggcagg gccatccacc
     1261 ctcaagagac ccaaattgtc tgtccctagt cgtactccag ctgcagctcc agcctctacc
     1321 ccagcacaga gagccgtccc agggaagccc cggggagaag gcacagagcc taggggggct
     1381 cgcactggac cccaagagct tggcaagatc ctgcaagggg tggtggtggt gctcagtggc
     1441 ttccagaacc ccttccgctc agagctccgg gacaaggccc tggaactggg ggccaagtat
     1501 cggccagact ggaccccaga cagcacacat ctcatctgtg cctttgccaa cactcccaaa
     1561 tacagccagg tcctgggcct tggaggccgg attgtgcgta aagagtgggt gctggactgt
     1621 caccacatgc ggcgccggct gccctcccgg aggtacctca tggcaggcct tggatccagc
     1681 agtgaggacg aaggggactc tcacagtgag agcggcgaag acgaagctcc caagcttccc
     1741 caaaagcggc cccagcccaa agccaagacc caggcagcag gacccagctc acccccgagg
     1801 ccaccaaccc caaaagagac caaagcaccg tcaccaggac cccaggacaa tagtgacact
     1861 gagggggaag agtcagaagg acgggacaac ggggcagaag attctgggga caccgaggat
     1921 gaactgagga gggtggccaa acagagggaa caaaggcagc ccccagcccc agaggagaat
     1981 ggcgaggacc cgtatgcagg ctccacagat gagaacacag acagtgagac cccctcagag
     2041 gctgacctgc caatcccaga gctcccagac ttcttcgagg gcaaacactt cttcctgtat
     2101 ggcgagttcc ctggggatga gaggaggagg ctcatccgct acgtgaccgc tttcaatggc
     2161 gagctcgagg actatatgaa tgagcgggtc cagttcgtca tcacggccca ggagtgggac
     2221 cccaactttg aggaggccct gatggaaaac ccttccctgg ccttcgtgcg gccccggtgg
     2281 atctacagtt gtaatgagaa gcagaagtta ctcccccatc agctctatgg ggtggtgccc
     2341 caggcctgag tgtacacctg tgtacgtgca gatgtgcaca tgtatgcaca ggcctgagtg
     2401 cacacgtgtg tacacacaag agtttaataa aggagacttt gtttgaagc
//
