LOCUS       NM_001360170            1545 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus X-ray repair complementing defective repair in Chinese
            hamster cells 1 (Xrcc1), transcript variant 4, mRNA.
ACCESSION   NM_001360170
VERSION     NM_001360170.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1545)
  AUTHORS   Koczor,C.A., Thompson,M.K., Sharma,N., Prakash,A. and Sobol,R.W.
  TITLE     Polbeta/XRCC1 heterodimerization dictates DNA damage recognition
            and basal Polbeta protein levels without interfering with mouse
            viability or fertility
  JOURNAL   DNA Repair (Amst) 123, 103452 (2023)
   PUBMED   36702010
  REMARK    GeneRIF: Polbeta/XRCC1 heterodimerization dictates DNA damage
            recognition and basal Polbeta protein levels without interfering
            with mouse viability or fertility.
REFERENCE   2  (bases 1 to 1545)
  AUTHORS   Uyeda,A., Onishi,K., Hirayama,T., Hattori,S., Miyakawa,T., Yagi,T.,
            Yamamoto,N. and Sugo,N.
  TITLE     Suppression of DNA Double-Strand Break Formation by DNA Polymerase
            beta in Active DNA Demethylation Is Required for Development of
            Hippocampal Pyramidal Neurons
  JOURNAL   J Neurosci 40 (47), 9012-9027 (2020)
   PUBMED   33087478
REFERENCE   3  (bases 1 to 1545)
  AUTHORS   Kim,J., Kim,K., Mo,J.S. and Lee,Y.
  TITLE     Atm deficiency in the DNA polymerase beta null cerebellum results
            in cerebellar ataxia and Itpr1 reduction associated with alteration
            of cytosine methylation
  JOURNAL   Nucleic Acids Res 48 (7), 3678-3691 (2020)
   PUBMED   32123907
REFERENCE   4  (bases 1 to 1545)
  AUTHORS   Xu,C., Xu,J., Ji,G., Liu,Q., Shao,W., Chen,Y., Gu,J., Weng,Z.,
            Zhang,X., Wang,Y. and Gu,A.
  TITLE     Deficiency of X-ray repair cross-complementing group 1 in
            primordial germ cells contributes to male infertility
  JOURNAL   FASEB J 33 (6), 7427-7436 (2019)
   PUBMED   30998386
  REMARK    GeneRIF: demonstrated that Xrcc1 deficiency in primordial germ
            cells induced elevated levels of reactive oxygen species,
            mitochondria dysfunction, apoptosis, and loss of stemness of
            spermatogonial stem cells (SSCs) in testes. In Xrcc1-deficienct
            SSCs, elevated oxidative stress and mitochondrial dysfunction could
            be partially reversed by treatment with the antioxidant
            N-acetylcysteine
REFERENCE   5  (bases 1 to 1545)
  AUTHORS   Yousafzai,N.A., Zhou,Q., Xu,W., Shi,Q., Xu,J., Feng,L., Chen,H.,
            Shin,V.Y., Jin,H. and Wang,X.
  TITLE     SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance
            in lung cancer
  JOURNAL   Cell Death Dis 10 (5), 363 (2019)
   PUBMED   31043584
  REMARK    GeneRIF: SIRT1 confers chemoresistance to lung cancer cells by
            deacetylating and stabilizing XRCC1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1545)
  AUTHORS   Rudert,F., Saunders,A.M., Rebstock,S., Thompson,J.A. and
            Zimmermann,W.
  TITLE     Characterization of murine carcinoembryonic antigen gene family
            members
  JOURNAL   Mamm Genome 3 (5), 262-273 (1992)
   PUBMED   1638085
REFERENCE   7  (bases 1 to 1545)
  AUTHORS   Levy,H.P., Schultz,R.A. and Cohen,M.M.
  TITLE     Comparative gene mapping in the species Muntiacus muntjac
  JOURNAL   Cytogenet Cell Genet 61 (4), 276-281 (1992)
   PUBMED   1486805
REFERENCE   8  (bases 1 to 1545)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     A molecular genetic linkage map of mouse chromosome 7
  JOURNAL   Genomics 8 (3), 525-535 (1990)
   PUBMED   1981054
REFERENCE   9  (bases 1 to 1545)
  AUTHORS   Mohrenweiser,H.W., Carrano,A.V., Fertitta,A., Perry,B.,
            Thompson,L.H., Tucker,J.D. and Weber,C.A.
  TITLE     Refined mapping of the three DNA repair genes, ERCC1, ERCC2, and
            XRCC1, on human chromosome 19
  JOURNAL   Cytogenet Cell Genet 52 (1-2), 11-14 (1989)
   PUBMED   2558854
REFERENCE   10 (bases 1 to 1545)
  AUTHORS   Siciliano,M.J., Carrano,A.V. and Thompson,L.H.
  TITLE     Assignment of a human DNA-repair gene associated with
            sister-chromatid exchange to chromosome 19
  JOURNAL   Mutat Res 174 (4), 303-308 (1986)
   PUBMED   3736579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161166.7 and AK046611.1.
            
            Transcript Variant: This variant (4) differs in the 3' UTR and
            coding sequence compared to variant 1. The resulting isoform (4)
            has a shorter and distinct C-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK046611.1, BB645465.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849376 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AC161166.7         124723-124859       c
            138-342             AC161166.7         124361-124565       c
            343-1545            AK046611.1         1-1203
FEATURES             Location/Qualifiers
     source          1..1545
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 11.42 cM"
     gene            1..1545
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /note="X-ray repair complementing defective repair in
                     Chinese hamster cells 1"
                     /db_xref="GeneID:22594"
                     /db_xref="MGI:MGI:99137"
     exon            1..137
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..504
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..759
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /note="isoform 4 is encoded by transcript variant 4; DNA
                     repair protein XRCC1; X-ray repair cross-complementing
                     protein 1"
                     /codon_start=1
                     /product="DNA repair protein XRCC1 isoform 4"
                     /protein_id="NP_001347099.1"
                     /db_xref="GeneID:22594"
                     /db_xref="MGI:MGI:99137"
                     /translation="MPEISLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTIS
                     VVLQLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGATAGEQDYEVSRVGEADTPCLYH"
     exon            505..597
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..1545
                     /gene="Xrcc1"
                     /gene_synonym="Xrcc-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcatgagct aagagaggtc tgagatcttt gtcggccatc tgtctgtcga tgttcgtctc
       61 tgtgtgtcca tccgtccgtc cgtctgtttg tctgcatttg gagagagaag gggaacagag
      121 cgtgtccgca acaacaggtt cccaggaagc cgagtctcca cgttatcagg cggctaggcc
      181 ggagagtggt ggaacctgag agaggcgggg ccggaggggg aatgcctgtt gctaagggaa
      241 cccggcgcct cgctcgcgga gaggcccaac cgagcatgcg cagtgttgac gtgtgcgccg
      301 gcgcgccgcg gtttgaaagg cccgagcctt gcgcgcttgc gcactgagtc ccgtgcaggg
      361 cgcgcgcgct cccccaacct tctccggggg ccccccggag ctgcaaccct tcttcttcat
      421 tccctggacg gtcgggcgtc cacgggcgtg gacatgccgg agatcagcct ccgccacgtc
      481 gtgtcctgca gcagccagga ctcgacccat tgtgccgaaa atcttctcaa ggcggacact
      541 taccggaagt ggcgggcagc caaggcagga gagaagacca tctctgtggt cctacagttg
      601 gagaaggagg agcagatcca cagtgtggac attggcaatg atggctcggc ctttgtggag
      661 gtgctagtgg gcagctcggc tggaggggcc acagctggtg aacaggacta tgaggtaagc
      721 agggttggag aggccgacac cccgtgtctc tatcactaac acccccccac ctcaccaccc
      781 ccatctccat cacaacaccc ccccacacct cacccctatg tctccatcac tagccccccc
      841 aacacacaca ccagccgcca catgtgatta cattagtgtg gagagccacc caccctgcct
      901 gtctcctgga gggtcctggg tatgccgagg agacagagca ggcatggggg aaagctgggc
      961 tgcctggatt gtggtcaaat aaggaacaag aggccctcac ttgtaaaatt caattgcagc
     1021 ttaggtagtg gcctgggaac tggggttcca cagtgtcatg actctggtaa cctacaaaat
     1081 acaggccctt tatgattgat acttaatttt ttccttgaga tgggtctttc cttttgccca
     1141 ggctggcatt gactcctaga ctcaagcagt tctgcctcag cctcccagga agctgggact
     1201 actatagtgt gctctgtcaa gcctgcctca taggactggc agaggccact gtagctcaga
     1261 gtattagcct actgtttttc cagtaaagtg atggcggtga aaactgcact caccatgagg
     1321 cagttgacaa gtctgagcct aagccagtga agaacgaagg gtgtgtgcgc gcgtgcgtgc
     1381 gtgcgtgcgt gcgtgcgtgc gtgcgtgcgt gcgtgcatgt atgtgcgtgt atgtgtatgt
     1441 gagagagagg gcagagccag gtccagcctt ctgatgttag actaccccag cgttggtctt
     1501 tgttgcacag ctgtgcctgt tgaaaataaa gatgttttga atgtt
//
