LOCUS       NP_001346817            1088 aa            linear   ROD 28-APR-2025
DEFINITION  exportin-7 isoform 1 [Mus musculus].
ACCESSION   NP_001346817 XP_006519424
VERSION     NP_001346817.1
DBSOURCE    REFSEQ: accession NM_001359888.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1088)
  AUTHORS   Hu,X., Wang,J., Yang,K., Fan,H., Wu,J., Ren,J., Han,G., Li,J.,
            Xue,Z., Liu,X. and Lv,X.
  TITLE     The GWAS SNP rs80207740 modulates erythrocyte traits via
            allele-specific binding of IKZF1 and targeting XPO7 gene
  JOURNAL   FASEB J 38 (10), e23666 (2024)
   PUBMED   38780091
  REMARK    GeneRIF: The GWAS SNP rs80207740 modulates erythrocyte traits via
            allele-specific binding of IKZF1 and targeting XPO7 gene.
REFERENCE   2  (residues 1 to 1088)
  AUTHORS   Lin,Y., Zhan,M. and Xu,B.
  TITLE     Exportin XPO7 acts as an oncogenic factor in prostate cancer via
            upregulation of TCF3
  JOURNAL   J Cancer Res Clin Oncol 149 (10), 7663-7677 (2023)
   PUBMED   37000263
  REMARK    GeneRIF: Exportin XPO7 acts as an oncogenic factor in prostate
            cancer via upregulation of TCF3.
REFERENCE   3  (residues 1 to 1088)
  AUTHORS   Modepalli,S., Martinez-Morilla,S., Venkatesan,S., Fasano,J.,
            Paulsen,K., Gorlich,D., Hattangadi,S. and Kupfer,G.M.
  TITLE     An In Vivo Model for Elucidating the Role of an Erythroid-Specific
            Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine
            Erythropoiesis
  JOURNAL   Exp Hematol 114, 22-32 (2022)
   PUBMED   35973480
  REMARK    GeneRIF: An In Vivo Model for Elucidating the Role of an
            Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7
            (Xpo7) in Murine Erythropoiesis.
REFERENCE   4  (residues 1 to 1088)
  AUTHORS   Markiewicz,L., Uspienski,T., Baran,B., Niedziolka,S.M. and
            Niewiadomski,P.
  TITLE     Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from
            the nucleus
  JOURNAL   Cell Signal 80, 109907 (2021)
   PUBMED   33383157
  REMARK    GeneRIF: Xpo7 negatively regulates Hedgehog signaling by exporting
            Gli2 from the nucleus.
REFERENCE   5  (residues 1 to 1088)
  AUTHORS   Cantu,I., van de Werken,H.J.G., Gillemans,N., Stadhouders,R.,
            Heshusius,S., Maas,A., Esteghamat,F., Ozgur,Z., van IJcken,W.F.J.,
            Grosveld,F., von Lindern,M., Philipsen,S. and van Dijk,T.B.
  TITLE     The mouse KLF1 Nan variant impairs nuclear condensation and
            erythroid maturation
  JOURNAL   PLoS One 14 (3), e0208659 (2019)
   PUBMED   30921348
  REMARK    GeneRIF: Results found that XPO7 expression was significantly
            downregulated in the presence of the KLF1 Nan variant erythroid
            progenitors, potentially contributing to increased nuclear size.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1088)
  AUTHORS   Kalsotra,A., Xiao,X., Ward,A.J., Castle,J.C., Johnson,J.M.,
            Burge,C.B. and Cooper,T.A.
  TITLE     A postnatal switch of CELF and MBNL proteins reprograms alternative
            splicing in the developing heart
  JOURNAL   Proc Natl Acad Sci U S A 105 (51), 20333-20338 (2008)
   PUBMED   19075228
REFERENCE   7  (residues 1 to 1088)
  AUTHORS   Koury,S., Yarlagadda,S., Moskalik-Liermo,K., Popli,N., Kim,N.,
            Apolito,C., Peterson,A., Zhang,X., Zu,P., Tamburlin,J. and
            Bofinger,D.
  TITLE     Differential gene expression during terminal erythroid
            differentiation
  JOURNAL   Genomics 90 (5), 574-582 (2007)
   PUBMED   17764892
REFERENCE   8  (residues 1 to 1088)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (residues 1 to 1088)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 1088)
  AUTHORS   Koch,P., Bohlmann,I., Schafer,M., Hansen-Hagge,T.E., Kiyoi,H.,
            Wilda,M., Hameister,H., Bartram,C.R. and Janssen,J.W.
  TITLE     Identification of a novel putative Ran-binding protein and its
            close homologue
  JOURNAL   Biochem Biophys Res Commun 278 (1), 241-249 (2000)
   PUBMED   11071879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143729.1, AK036837.1, AK039776.1, AA051428.1 and AI431041.1.
            
            On Jan 18, 2018 this sequence version replaced XP_006519424.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1088
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.44 cM"
     Protein         1..1088
                     /product="exportin-7 isoform 1"
                     /note="ran-binding protein 16; RAN binding protein 16"
                     /calculated_mol_wt=123829
     Region          30..>306
                     /region_name="CRM1"
                     /note="Importin beta-related nuclear transport receptor
                     [Nuclear structure / Intracellular trafficking and
                     secretion]; COG5101"
                     /db_xref="CDD:227432"
     Region          31..97
                     /region_name="IBN_N"
                     /note="Importin-beta N-terminal domain; smart00913"
                     /db_xref="CDD:197981"
     CDS             1..1088
                     /gene="Xpo7"
                     /gene_synonym="4930506C02Rik; exp7; Ranbp16"
                     /coded_by="NM_001359888.1:65..3331"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS88710.1"
                     /db_xref="GeneID:65246"
                     /db_xref="MGI:MGI:1929705"
ORIGIN      
        1 mrdsgrksla qlenlckqly ettdtttrlq aekalveftn spdclskcql llergsssys
       61 qllaatcltk lvsrtnnplp leqridirny vlnylatrpk latfvtqali qlyaritklg
      121 wfdcqkddyv frnaitdvtr flqdsveyci igvtilsqlt neinqadtth pltkhrkias
      181 sfrdsslfdi ftlscnllkq asgknlnlnd esqhgllmql lklthnclnf dfigtstdes
      241 sddlctvqip tswrsaflds stlqlffdly hsippsfspl vlsclvqias vrrslfnnae
      301 rakflshlvd gvkrilenpq slsdpnnyhe fcrllarlks nyqlgelvkv enypdvirli
      361 anftvtslqh wefapnsvhy llslwqrlaa svpyvkatep hmletytpev tkayitsrle
      421 svhiilrdgl edpledtglv qqqldqlsti grceyektca llvqlfdqsa qsyqellqsa
      481 saspmdiavq egrltwlvyi igaviggrvs fastdeqdam dgelvcrvlq lmnltdsrla
      541 qagneklela mlsffeqfrk iyigdqvqks sklyrrlsev lglndetmvl svfigkvitn
      601 lkywgrcepi tsktlqllnd lsigyssvrk lvklsavqfm lnnhtsehfs flginnqsnl
      661 tdmrcrttfy talgrllmvd lgededqyeq fmlpltaafe avaqmfstns fneqeakrtl
      721 vglvrdlrgi afafnaktsf mmlfewiyps ympilqraie lwyhdpactt pvlklmaelv
      781 hnrsqrlqfd vsspngillf retskmitmy gnriltlgev pkdqvyalkl kgisicfsml
      841 kaalsgsyvn fgvfrlygdd alenalqtfi klllsiphsd lldypklsqs yysllevltq
      901 dhmnfiasle phvimyilss isegltaldt mvctgccscl dhivtylfkq lsrstkkrtt
      961 plnresdcfl himqqhpami qqmlstvlni iifedcrnqw smsrpllgli llnekyfsdl
     1021 rnsivnsqpp ekqqamhlcf enlmegiern lltknrdrft qnlsafrrev ndsmknstyg
     1081 vnsndmms
//
