LOCUS       NM_001311143            4549 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus exportin 6 (Xpo6), transcript variant 1, mRNA.
ACCESSION   NM_001311143 XM_006508247
VERSION     NM_001311143.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4549)
  AUTHORS   Wu,Y., Gou,Y., Wang,T., Li,P., Li,Y., Lu,X., Li,W. and Liu,Z.
  TITLE     Exportin XPO6 upregulation activates the TLR2/MyD88/NF-kappaB
            signaling by facilitating TLR2 mRNA nuclear export in COPD
            pulmonary monocytes
  JOURNAL   Int Immunopharmacol 135, 112310 (2024)
   PUBMED   38788453
  REMARK    GeneRIF: Exportin XPO6 upregulation activates the
            TLR2/MyD88/NF-kappaB signaling by facilitating TLR2 mRNA nuclear
            export in COPD pulmonary monocytes.
REFERENCE   2  (bases 1 to 4549)
  AUTHORS   Fu,B., Wang,L., Li,S. and Dorf,M.E.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   3  (bases 1 to 4549)
  AUTHORS   Dopie,J., Skarp,K.P., Rajakyla,E.K., Tanhuanpaa,K. and
            Vartiainen,M.K.
  TITLE     Active maintenance of nuclear actin by importin 9 supports
            transcription
  JOURNAL   Proc Natl Acad Sci U S A 109 (9), E544-E552 (2012)
   PUBMED   22323606
  REMARK    GeneRIF: Measurements of nuclear export rates and depletion studies
            clarified that nuclear export of actin is mediated by exportin 6.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135809.4 and AC012297.12.
            
            On Feb 16, 2018 this sequence version replaced NM_001311143.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154709.1, SRR9219379.5919.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-603               AC135809.4         53491-54093         c
            604-694             AC135809.4         27750-27840         c
            695-807             AC135809.4         24622-24734         c
            808-1005            AC135809.4         22721-22918         c
            1006-1165           AC012297.12        175944-176103       c
            1166-1243           AC012297.12        171807-171884       c
            1244-1697           AC012297.12        167909-168362       c
            1698-1824           AC012297.12        164317-164443       c
            1825-1934           AC012297.12        155648-155757       c
            1935-2043           AC012297.12        146109-146217       c
            2044-2136           AC012297.12        144631-144723       c
            2137-2206           AC012297.12        143310-143379       c
            2207-2366           AC012297.12        139455-139614       c
            2367-2459           AC012297.12        135440-135532       c
            2460-2604           AC012297.12        130891-131035       c
            2605-2751           AC012297.12        128740-128886       c
            2752-2941           AC012297.12        127835-128024       c
            2942-3097           AC012297.12        124997-125152       c
            3098-3212           AC012297.12        123869-123983       c
            3213-3384           AC012297.12        123535-123706       c
            3385-3546           AC012297.12        122154-122315       c
            3547-3645           AC012297.12        120184-120282       c
            3646-3876           AC012297.12        119787-120017       c
            3877-4549           AC012297.12        116801-117473       c
FEATURES             Location/Qualifiers
     source          1..4549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.01 cM"
     gene            1..4549
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /note="exportin 6"
                     /db_xref="GeneID:74204"
                     /db_xref="MGI:MGI:2429950"
     exon            1..603
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     CDS             601..3978
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /note="isoform 1 is encoded by transcript variant 1; RAN
                     binding protein 20"
                     /codon_start=1
                     /product="exportin-6 isoform 1"
                     /protein_id="NP_001298072.1"
                     /db_xref="CCDS:CCDS80800.1"
                     /db_xref="GeneID:74204"
                     /db_xref="MGI:MGI:2429950"
                     /translation="MASEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQVGA
                     WRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTL
                     PYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACP
                     REDLSVARKEELRKLLLDQVQTVLGLLTGILETVWDKHSVTAATPPPSPTSGESGDLL
                     SNLLQSPSSAKLLHQPIPILDVESEYVCSLALECLAHLFSWIPLSASITPSLLTTIFH
                     FARFGCDTRARKMASVNGSSQNCVLGQERGRLGVLAMSCINELMSKNCVPMEFEEYLL
                     RMFQQTFYLLQKITKDNNAHTVKSRLEELDESYIEKFTDFLRLFVSVHLRRIESYSQF
                     PVVEFLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYLTSKIKSRLGDKEAVLNRYEDAL
                     VLLLTEVLNRIQFRYNQAQLEELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHA
                     FSTLFPVLQDNLEVYLGLQQFVVTSGSGHRLNITAENDCRRLHCSLRDLSSLLQAVGR
                     LAEYFIGDVFAARFNDALTVVERLVKVTLYGSQIKLYNIETAVPSVLKPDLIDVHAQS
                     LAALQAYSHWLAQYCGEAHRQNTQQFVTLISTTMDAITPLISTKVQDKLLLSACHLLV
                     SLATTVRPVFLISIPAVQKVFNSIIDASAQRLTDKAQVLVCRALSNTLLLPWPNLPES
                     EQQWPLRSINHASLISALSRDYHSLKPSATAPQRKVPLGDTKVIIHQTLSVLEDIVEN
                     ISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTLFRGLRVQMGVP
                     FTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSI
                     IALCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTVLASVQRGIAEEQME
                     NEPQFSAIMQAFGQSFLQPDIHLFKQNLFYLETLNTKQKLYHKKIFRTTMLFQFVNVL
                     LQVLVHKSHDLLQEEIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDANQKNVLGRNF
                     KMDRDLPSFTQNVHRLVNDLRYYRLCNDSLPPGTVKL"
     exon            604..694
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            695..807
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1005
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1165
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1243
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1697
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1824
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1934
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2043
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2136
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2206
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2366
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2459
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2604
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2751
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2941
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3097
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3212
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3384
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3546
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3645
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..3876
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..4549
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4520..4525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /note="hexamer: AATAAA"
     polyA_site      4549
                     /gene="Xpo6"
                     /gene_synonym="2610005L19Rik; C230091E20Rik; exp6;
                     mKIAA0370; Ranbp20"
                     /note="major polyA site"
ORIGIN      
        1 cggttccagc gccgcagcag gccgcgggct gaggggccgc ctggtgctcg ccacttccgg
       61 cgcgttgggc tgttggcaga gggtggccgc gaggggcgag ccgcggctac tggtggcgcg
      121 cagggatgcg gagggagccc gccgcgagga cagaggtggc gaggacagca agggcccgcg
      181 ggcctctctc ctgagccggc cgcgccgccc aggcccaggc agcctctgcc ccttcagtct
      241 cggctgaggc ccgtcgccgc ctcgggccgc ggaggccggg gagtccctgc ctgggcccgc
      301 agcctccctc tcgggggtcg ggcccaggcg gggggcctcg tgtagccgcc tctgaacccc
      361 attttctgct tttgcgtttc cccggggtgg gccgaggtct ggatgaatcg cttcgggggg
      421 tccccgaagg ggcccgtgtg ctccttttaa aggtgccggc ggggcccggg tagggaaccg
      481 gttgtctttg catgggcggg ggactccccg agcctgccgg gaccatgacc tgaactgtgc
      541 gagcgggaca cgacggatcc caagagctag ctcacctgag ccatcccctt cccggccagc
      601 atggcatcag aagaagcctc cctcagggcg ttggaaagcc tgatgacgga atttttccat
      661 gactgcacaa ccaatgaaag gaagcgggag atagaggagc ttcttaataa ctttgcccag
      721 caagtaggag cttggagatt ctgcttatat tttctgtcca gcacaaggaa tgactatgta
      781 atgatgtaca gcttaacggt ttttgagaat ctaatcaata aaatgtggct tggggtccca
      841 tctcaggata agatggaaat ccgtagctgc ttgcccaaac ttctcttggc tcaccataaa
      901 accttacctt actttattcg gaataaactc tgcaaagtta tcgttgatat tggacgccaa
      961 gattggccca tgttctacca tgactttttc actaacattt tacagttgat ccagtcccct
     1021 gtgacaaccc cccttggact gatcatgctg aagacaactt cggaagagct agcttgtcca
     1081 cgtgaggacc tcagcgtggc tcggaaggag gagttgcgga agctgctgct ggaccaggtg
     1141 cagacagtgc ttgggctctt gacaggtatc ttggaaactg tctgggacaa acacagtgtt
     1201 actgctgcca ccccaccacc atccccgacg tcaggagaaa gtggtgattt actgagtaac
     1261 ctgttgcaga gtcctagttc agccaaactg ctgcaccagc ccatccccat cctggatgtg
     1321 gagagtgagt atgtctgttc cctggccttg gagtgcctgg cccacctctt cagttggatt
     1381 cctctgtctg ccagcatcac cccatccctc ctcaccacta tcttccactt tgctcgattt
     1441 ggctgcgata cccgggccag aaagatggca tcagtgaatg gcagcagcca gaactgtgtt
     1501 ttgggtcagg agcgtggccg acttggggtc ttggccatgt cctgcatcaa tgaactcatg
     1561 tccaagaact gtgtgcctat ggaatttgag gaatacttat tgcgaatgtt tcaacaaacc
     1621 ttctacctcc tgcaaaaaat caccaaggat aacaatgccc acacggtgaa gagcaggcta
     1681 gaggaactcg atgagagtta cattgagaag tttactgact tcctgcggct ctttgtgagt
     1741 gttcacctaa gaagaatcga gtcctattcc cagttcccgg tggtggagtt cttgaccctt
     1801 ctgttcaagt acacgtttca tcagcctact catgaaggtt acttctcttg tttggatatc
     1861 tggacactgt ttttggacta tctgacaagt aaaattaaaa gtcgtctcgg agacaaggaa
     1921 gcagttctca acaggtacga agatgctctg gtcctcttgc ttacagaggt gttgaatcga
     1981 atccagttca gatacaacca ggcccaactc gaggagctgg atgatgagac cctggacgac
     2041 gatcagcaga cagagtggca gcggtactta cgccagagct tggaggtcgt ggccaaagtg
     2101 atggagctcc ttcccacaca cgccttctca accctgttcc cagttcttca ggacaattta
     2161 gaagtttatt tgggattaca gcaatttgta gttacttcgg ggtcaggaca caggctgaac
     2221 atcacagcgg agaacgactg ccggcgtttg cactgttccc tgcgagactt gagctccctg
     2281 ctgcaggctg tgggccgatt agctgaatac ttcattgggg atgtgtttgc tgcaaggttc
     2341 aatgatgctc tcacagttgt ggagaggttg gtcaaagtta ctctgtatgg atctcagata
     2401 aaactgtaca acattgaaac agctgtgcca tcagtgttga aacccgacct cattgatgtg
     2461 cacgctcagt cacttgcggc tctccaggcc tactcccact ggctggcgca gtactgcggt
     2521 gaagcccatc gacagaacac acagcagttt gtgacactca tctctaccac aatggacgcc
     2581 atcacacctc tcatcagcac caaggtccaa gacaagttgc tgctgtctgc gtgccaccta
     2641 ctggtctcac tagccaccac cgtgcggcct gtctttctga tcagtatccc tgcagtgcag
     2701 aaggtgttca acagcatcat tgatgcctct gcccagcgtc taacagataa ggcgcaggtg
     2761 ttggtttgcc gtgcactttc taataccttg ctccttccat ggccaaatct tcctgagagt
     2821 gagcagcagt ggcctctgcg ctcgatcaac catgccagcc tcatctctgc actctcccgg
     2881 gactaccaca gcctgaagcc cagtgctact gccccccaga gaaaggtgcc acttggtgac
     2941 accaaagtga ttattcacca gacacttagt gtcttggaag atatcgtgga gaatatttct
     3001 ggggaatcca ccaagtctcg acagatctgc taccagtcac tgcaggaatc tgttcaggtc
     3061 tccctggccc tctttccagc ttttatccat cagtcagatg tgactgacga gatgctgagc
     3121 ttcttcctca ccttgttccg aggccttcga gtacagatgg gcgtgccgtt cacagagcag
     3181 atcatacaga ctttcctcaa catgtttacc agagaacagt tggctgagag catcctccat
     3241 gaaggcagca ctggctgccg ggtggtggag aagttcctga agatcctaca agtggtggtt
     3301 caggagcctg gccaggtgtt caagcccttc ctccccagca ttatcgcgct gtgcatggag
     3361 caagtgtacc ccatcattgc tgagcgcccg tcccctgatg tcaaggctga gctgtttgag
     3421 ctcctctttc gaacgctcca tcacaactgg cggtacttct tcaagtccac tgtcctcgct
     3481 agcgtgcaga ggggcatcgc tgaggagcag atggagaatg agccccagtt cagtgccatc
     3541 atgcaggctt ttggacagtc ctttcttcag cctgacatcc acctgttcaa acaaaatctc
     3601 ttctacttgg agactctgaa cacgaagcag aaactatacc acaaaaagat cttccggacc
     3661 accatgctgt tccagttcgt gaacgtgctg ctccaggtcc tggttcataa gtctcatgac
     3721 cttctgcagg aggagatcgg cattgccatt tacaacatgg cttctgtcga ctttgatggc
     3781 ttctttgcag cctttcttcc agagttcctg actagctgtg atggtgtgga tgccaatcag
     3841 aaaaacgttc tggggcggaa tttcaagatg gatcgggacc taccatcgtt cacccagaat
     3901 gtgcacaggc tggtaaatga tctccgttac taccgactct gcaatgacag cctgccccct
     3961 ggcaccgtga agctctagga gtgcctgctt gccttcctgg ctgctcactg ccccagggat
     4021 gtgcctgctg ccaccaccac ctacaccacc tgcacctgtg ccacggaagt ctgtgacaag
     4081 ccttgaccac tctctggatt ggtgtgccct gagcaagtgg cctgcctctg ccctctcctg
     4141 ctgcctccag cacagcaggt tttggagttc atttgacact ggtagagttt ctacacattt
     4201 ggagcaggca gagggaccta tggccagatg ccagggaggt acccagagac cccacagcgt
     4261 ggttcatgca gatcgtgtgt atcagtcctg agtcaaaatg gccaaggacc tctgacaaca
     4321 gtgccacctt ctcaccattc cacctcccct ccgctcctgg cccagccagc ccaggagaaa
     4381 ttcgacattg gaactgtttc tgtcgatcct cctgcccctc caatggcctt gaagtctctg
     4441 ctctttgtca gagattcacg aagacttttt ttgttgtttt ctcatcattc cattgtgata
     4501 ctaaggagct taatgactaa ataaaatgct taagttgttg ttatataaa
//
