LOCUS       NM_028198               5052 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus exportin 5 (Xpo5), mRNA.
ACCESSION   NM_028198
VERSION     NM_028198.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5052)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5052)
  AUTHORS   Wang,J., Lee,J.E., Riemondy,K., Yu,Y., Marquez,S.M., Lai,E.C. and
            Yi,R.
  TITLE     XPO5 promotes primary miRNA processing independently of RanGTP
  JOURNAL   Nat Commun 11 (1), 1845 (2020)
   PUBMED   32296071
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5052)
  AUTHORS   Nuovo,G., Tran,H., Gutierrez,A., Fadda,P., Pichiorri,F.,
            Caserta,E., Hofmeister,C.C., Chesi,M., Leif Bergsagel,P.,
            Morris,D., Shi,Q., Coffey,M. and Thirukkumaran,C.
  TITLE     Importin-beta and exportin-5 are strong biomarkers of productive
            reoviral infection of cancer cells
  JOURNAL   Ann Diagn Pathol 32, 28-34 (2018)
   PUBMED   29414394
  REMARK    GeneRIF: productive reoviral infection is strongly correlated with
            elevated importin-beta and exportin-5 levels which may serve as
            biomarkers of the disease in clinical specimens
REFERENCE   4  (bases 1 to 5052)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   5  (bases 1 to 5052)
  AUTHORS   Nothnick,W.B., Healy,C. and Hong,X.
  TITLE     Steroidal regulation of uterine miRNAs is associated with
            modulation of the miRNA biogenesis components Exportin-5 and Dicer1
  JOURNAL   Endocrine 37 (2), 265-273 (2010)
   PUBMED   20852728
  REMARK    GeneRIF: miRNA biogenesis components Drosha, Dgcr8, Exportin-5 and
            Dicer1 are expressed in the mouse uterus and that Exportin-5 and
            Dicer1 appear to be the major steroid regulated components in the
            miRNA biogenesis pathway
REFERENCE   6  (bases 1 to 5052)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5052)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   8  (bases 1 to 5052)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 5052)
  AUTHORS   Bohnsack,M.T., Regener,K., Schwappach,B., Saffrich,R.,
            Paraskeva,E., Hartmann,E. and Gorlich,D.
  TITLE     Exp5 exports eEF1A via tRNA from nuclei and synergizes with other
            transport pathways to confine translation to the cytoplasm
  JOURNAL   EMBO J 21 (22), 6205-6215 (2002)
   PUBMED   12426392
  REMARK    GeneRIF: Exp5 exports eEF1A via tRNA from nuclei and synergizes
            with other transport pathways to confine translation to the
            cytoplasm.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116739.13.
            
            On Feb 12, 2019 this sequence version replaced NM_028198.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092371.1, AF343581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC116739.13        90676-90890         c
            216-337             AC116739.13        88925-89046         c
            338-410             AC116739.13        87142-87214         c
            411-548             AC116739.13        85785-85922         c
            549-731             AC116739.13        85444-85626         c
            732-758             AC116739.13        79485-79511         c
            759-944             AC116739.13        78939-79124         c
            945-1021            AC116739.13        77893-77969         c
            1022-1121           AC116739.13        76020-76119         c
            1122-1205           AC116739.13        75073-75156         c
            1206-1331           AC116739.13        74185-74310         c
            1332-1422           AC116739.13        72850-72940         c
            1423-1551           AC116739.13        72220-72348         c
            1552-1682           AC116739.13        70910-71040         c
            1683-1838           AC116739.13        68530-68685         c
            1839-1880           AC116739.13        67247-67288         c
            1881-1970           AC116739.13        66693-66782         c
            1971-2170           AC116739.13        65772-65971         c
            2171-2270           AC116739.13        64290-64389         c
            2271-2452           AC116739.13        63321-63502         c
            2453-2553           AC116739.13        59883-59983         c
            2554-2650           AC116739.13        59152-59248         c
            2651-2787           AC116739.13        57700-57836         c
            2788-2885           AC116739.13        56691-56788         c
            2886-2932           AC116739.13        55282-55328         c
            2933-3030           AC116739.13        54714-54811         c
            3031-3093           AC116739.13        54125-54187         c
            3094-3176           AC116739.13        53461-53543         c
            3177-3284           AC116739.13        52779-52886         c
            3285-3422           AC116739.13        52147-52284         c
            3423-3587           AC116739.13        51811-51975         c
            3588-5052           AC116739.13        50103-51567         c
FEATURES             Location/Qualifiers
     source          1..5052
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..5052
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /note="exportin 5"
                     /db_xref="GeneID:72322"
                     /db_xref="MGI:MGI:1913789"
     exon            1..215
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..3725
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /note="ran-binding protein 21"
                     /codon_start=1
                     /product="exportin-5"
                     /protein_id="NP_082474.1"
                     /db_xref="CCDS:CCDS37631.1"
                     /db_xref="GeneID:72322"
                     /db_xref="MGI:MGI:1913789"
                     /translation="MEMEQVNALCEELVKAVTVMMDPSSTQRYRLEALKFCEEFKEKC
                     PICVPCGLKLAEKTQIAIVRHFGLQILEHVVKFRWNSMSRLEKVYLKNSVMELIANGT
                     LRILEEENHIKDVLSRIVVEMIKREWPQHWPDMLMELDTLFRQGETQRELVMFILLRL
                     AEDVVTFQTLPTQRRRDIQQTLTQNMERILNFLLNTLQENVNKYQQMKTDSSQEAEAQ
                     ANCRVSVAALNTLAGYIDWVSLNHITAENCKLVETLCLLLNEQELQLGAAECLLIAVS
                     RKGKLEDRKRLMILFGDVAMHYILSAAQTADGGGLVEKHYLFLKRLCQVLCALGNLLC
                     ALLALDANIQTPINFGMYLESFLAFTTHPSQFLRSSTHMTWGALFRHEVLSRDPALLA
                     VIPKYLRASMTNLVKMGFPSKTDSPSCEYSRFDFDSDEDFNAFFNSSRAQHGEVVRCV
                     CRLDPKTSFQMAAEWLKYQLSASIDTGPVNSCSTAGTGEGGFCSIFSPSYVQWEAMTF
                     FLESVINQMFRTLDKEELPVSDGIELLQLVLNFEIKDPLVLSCVLTNVSALFPFVTYK
                     PAFLPQVFSKLFSFVTFESVGESKAPRTRAVRNVRRHACSSINKMCRDYPDLVLPNFD
                     MLYSHVKQLLSNELLLTQMEKCALMEALVLVSNQFKDYERQKLFLEELMAPVVNIWLS
                     EEMCRALSDIDSFIAYVGADLKSCDPAVEDPCGLNRARMSFCVYSILGVMRRTSWPSD
                     LEEAKAGGFVVGYTPSGNPIFRNPCTEQILRLLDNLLALVRTHNTLYTPEMLTKMAEP
                     FTKALDIVESEKTAILGLPQPLLEFNDHPVYRTTLERMQRFFGILYENCYHILGKAGP
                     SMQQDFYTVEDLASQLLGSAFVNLNNIPDFRLRSMLRVFVKPLVLFCPSEHYETLISP
                     ILGPLFTYLHMRLSQKWHVINQRSILCGEDEIAEDNPESQEMLEEQLVRMLTREAMDL
                     IMACCVSKKTADHTAAPTADGDDEEMMATEVAPSSVVELTDLGKCLMKHEDVCTALLI
                     TAFNSLTWKDTLSCQRATTQLCWPLLKQVMSGTLLADAVTWLFTSVLKGLQMHGQHDG
                     CMASLVHLAFQIYEALRPRYLEIRAVMEQIPEINKESLDQFDCKLLNPSLQKAADKRR
                     KDHFKRLIAGCIGKPLGEQFRKEVHIKNLPWLFKKPKPMLETEVLDSEEGGLATIFEP
                     "
     exon            216..337
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            338..410
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            411..548
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            549..731
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            732..758
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            759..944
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1021
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1121
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1205
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1331
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1422
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1551
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1682
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1838
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1880
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1970
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2170
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2270
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2452
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2553
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2650
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2787
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2885
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2932
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..3030
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3093
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3176
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3284
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3422
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3587
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     exon            3588..5052
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3746
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /note="major polyA site"
     regulatory      5032..5037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /note="hexamer: AGTAAA"
     polyA_site      5052
                     /gene="Xpo5"
                     /gene_synonym="2410004H11Rik; 2700038C24Rik; Exp5;
                     mKIAA1291; RanBp21"
                     /note="major polyA site"
ORIGIN      
        1 gtttccccac ccccagcccg ccgcggcccg gtatcaacgt gtggtcccgc caggggaact
       61 gtgcgtaacc tcgtgctccc gggacgccgg tggggttccc ggctctagcc atggagatgg
      121 agcaagtgaa cgcgctgtgc gaggagctag tgaaagcggt gacggtcatg atggacccca
      181 gctctaccca gcgctaccgg ctggaagccc tcaagttttg tgaagagttt aaagaaaaat
      241 gccctatctg tgttccatgt ggcttgaagt tggctgaaaa aacacaaatt gccatcgtca
      301 gacattttgg ccttcagatc ctggagcatg ttgtcaagtt tcgatggaac agcatgtccc
      361 gattggagaa ggtctatctg aagaacagtg tcatggagct gatcgcaaat ggaacactga
      421 ggattttgga ggaggagaac cacattaaag atgttctgtc tagaattgtg gtagagatga
      481 tcaaacgaga gtggccacag cactggcctg acatgctcat ggagttggat actctcttca
      541 ggcaagggga aacgcagagg gagttggtga tgttcatcct tctccgactg gccgaggatg
      601 tagtgacctt tcagacgctc cccactcaaa gaagaaggga tattcagcaa acattgacgc
      661 agaacatgga aagaatcttg aattttctac tcaatacgct tcaggaaaat gtaaacaagt
      721 accaacaaat gaagacagat tcatctcagg aggcagaggc tcaagccaac tgtcgagtaa
      781 gcgtggcggc cctgaacact ctagccggct acattgactg ggtatctttg aaccatatca
      841 ctgccgagaa ctgtaaactc gtggagactc tgtgcctgct tctcaatgag caggagctgc
      901 agttgggagc cgccgagtgt ctgctcattg cagtcagcag aaaaggcaag ctggaggacc
      961 ggaagcgctt gatgatcctg tttggagatg tcgccatgca ttatattctc tcggccgcac
     1021 agactgcaga tggaggaggc ttggtcgaaa aacactacct cttcctgaag agactttgtc
     1081 aggtgttatg tgcactggga aatctgctat gtgcactgct ggccttagat gctaacatac
     1141 aaacacctat aaactttgga atgtacctgg aatcttttct tgctttcaca acccatccaa
     1201 gtcagttttt acgctcttca acccatatga cgtggggagc cctcttcagg catgaagttc
     1261 tgtcccgtga tccggcactg ttagcagtaa taccaaaata tcttcgtgct tctatgacaa
     1321 acttggtcaa gatgggcttt ccttctaaaa cagatagccc cagctgtgaa tattcccgat
     1381 ttgatttcga tagtgatgag gacttcaatg ctttcttcaa ctcctcccga gcccagcatg
     1441 gagaggtggt gaggtgtgtg tgtcgactgg atcctaagac tagcttccag atggcggcag
     1501 aatggctcaa gtatcagctg tcagcttcta ttgacactgg acctgtgaac tcatgttcta
     1561 cagctggaac tggagaggga ggcttctgct ccatcttctc accttcatat gtgcagtggg
     1621 aagctatgac tttttttttg gaaagtgtga tcaaccagat gtttcgaaca ctagacaaag
     1681 aagagctccc ggttagtgat gggatagagc tgctgcagct ggtgttgaac tttgaaatca
     1741 aggatcccct cgtcctgtcc tgcgtcctca ctaatgtctc agcgctcttc ccatttgtca
     1801 catacaagcc tgcgttcttg ccccaggtct tctctaagct cttttcattt gttacttttg
     1861 aatctgttgg ggaaagtaag gcccccagga ctcgggcagt caggaatgta aggagacatg
     1921 cttgttcctc catcaacaag atgtgtcggg actacccaga ccttgttctg cccaattttg
     1981 acatgcttta tagccacgtg aagcaactcc tctccaatga gctcctcctg acccagatgg
     2041 agaagtgcgc cctcatggaa gctctggttc tcgttagcaa ccaattcaag gattatgagc
     2101 ggcagaagtt attcctagag gagctgatgg caccggtggt caacatctgg ctttctgaag
     2161 aaatgtgcag agcgctgtca gatattgact ccttcattgc ctatgtgggt gctgatctga
     2221 aaagctgtga cccagctgtg gaggatccat gtggcttgaa ccgtgcacga atgagctttt
     2281 gtgtgtacag catcctgggg gttatgagac gcactagctg gccttccgac ctagaagaag
     2341 ccaaagctgg gggctttgtg gtgggctaca cacccagtgg aaatcccatc ttccgtaacc
     2401 cctgcacaga gcagatcctc agacttctcg acaatttgct tgcccttgta agaactcaca
     2461 atactttata tacaccggaa atgctaacga aaatggcaga acctttcacc aaggctctgg
     2521 atatagttga atctgaaaaa acggcaatat taggattacc tcagcctctc ttggaattca
     2581 acgaccaccc tgtctataga accactctgg agaggatgca gcggttcttt ggcattctct
     2641 atgaaaactg ttaccatatc ctagggaagg caggcccttc catgcagcaa gatttctaca
     2701 ctgtggagga ccttgcttcc cagctccttg gatcagcttt cgtcaacttg aacaatattc
     2761 ctgacttccg gcttagatct atgcttcgtg tcttcgtgaa gcccctcgtg ctcttctgcc
     2821 cctcagaaca ctatgaaacc ctgatatctc ccatccttgg acctctcttc acctacctcc
     2881 acatgaggct ctctcagaag tggcatgtca tcaaccagag gagcatcctg tgtggagaag
     2941 atgagattgc agaggacaac cccgagtctc aggaaatgct cgaggaacag ctggtgagga
     3001 tgctcacccg agaagccatg gacctaatca tggcttgctg tgtgtcgaag aagactgccg
     3061 accacacagc cgctcccact gcagatggag atgatgaaga gatgatggcc actgaagtag
     3121 ccccctcgtc tgtggtggag ctcacagacc tgggcaaatg cctcatgaag cacgaggatg
     3181 tctgcacagc actgctaatc acagcattta attctctgac ctggaaggac acactgtctt
     3241 gccagagggc taccacacag ctctgctggc ccctcctcaa acaggtgatg tctgggaccc
     3301 tgctcgcaga cgctgtcact tggcttttca ccagtgtgct gaaaggactg cagatgcacg
     3361 ggcagcacga tgggtgcatg gcttccctgg tccacttggc cttccagata tacgaggcgc
     3421 tgcgccccag gtacctagag ataagagcag taatggagca gatccctgaa ataaacaagg
     3481 agtctctgga ccaatttgac tgcaagcttt taaacccctc ccttcaaaaa gcagctgata
     3541 aacgacggaa ggaccacttc aaacgtctaa tcgctggctg cattgggaaa cccttgggag
     3601 aacagttccg aaaagaagtt cacattaaga accttccctg gcttttcaaa aaacccaaac
     3661 caatgttgga gacagaagtg ctggacagtg aggagggtgg actggccacc atctttgaac
     3721 cctgaatcaa gcttttgggc atccttctcc ggcctcggtt gtcatctctt cttcccccgt
     3781 gtagctaatc tctaggccct cctcgcactg ccgcctcact ttccaccgag tcagcctgga
     3841 gcagctcaga tctgggtcaa gctggagtag agtgggtcct gcgcgaggac ccaggtcatc
     3901 ctactagagt gcagggtgtt gggacctacg ccattccaga gaggtggcgg gagctggtag
     3961 ccagccggca gtctgggctt ttccaggaaa agctagagca caagggcctc tctccagagc
     4021 agctgcagca gtgcagacag acagacagaa ggactggggt gctgtgccca acccactgac
     4081 cgtgtgtgca aggtctcagc cgctttcttt tggactacaa gggtcccact tgagcccctt
     4141 gctgctgggc taacagggat ccttttccac tcccaggggc atgtctggcc taggtgctac
     4201 atgctgaccc gtatatggcc agttttctca gtctaaagca agaatctggc cacttgggaa
     4261 cccatggtac agagctattg ctaaagtctg agcgcactgt ccagggaaca agagctaaac
     4321 agaattcagt ctaacactct gttccttaaa gtggacatct tgcctttctc tgattgaccc
     4381 tcgagggttt ccccagtgtc tgatgacacc aaccatacag aagtaatcca gaccaggtag
     4441 gcttctgaca agttagccaa gcagccactg tccctcctgg gacagctgag tccaggtgcc
     4501 ttggaaatct cagtggtctc ttaagcttct gaagactctc ttctcaaggg tcatttctaa
     4561 aagtgttcca gtcagagcca acacttttaa gtccttaagg tccctgggaa gggcacaaag
     4621 caaacagagc aagatgggcg agacctagtc ctgcctattt ctctggatgt tggcacgccc
     4681 actgtccacc cagccccaac tttgacctag tgtgggacac agtcatgcat agtaaagttg
     4741 caaagtcaga gctgggaaat agcaactaga atcgaggtca ctgtccaccc tacagctgca
     4801 caaggccgtc ctcctcctgc ctggtgcttg gggtctgcag gttgtaaagg tgagctcagt
     4861 gttgccctcc acactcgata gctgcctgct cctgtctgct tagggctgtg gaggatgtag
     4921 ttgtatttat tatgttgtaa tatttttaac atcctatgac ttcatgctag aaattttcta
     4981 ttgtttatag aaccttttgt agaaatgcta actaaagtac atctgcatgt cagtaaaaat
     5041 ctgtttcata ca
//
