LOCUS       NM_001412407            6143 bp    mRNA    linear   ROD 14-OCT-2024
DEFINITION  Mus musculus exportin 1 (Xpo1), transcript variant 3, mRNA.
ACCESSION   NM_001412407 XM_006514430
VERSION     NM_001412407.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6143)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6143)
  AUTHORS   Paloczi,K., Buzas,E.I. and Falus,A.
  TITLE     Differential impact of exportin-1-mediated nuclear export of RNAs
            on the RNA content of extracellular vesicle subpopulations
  JOURNAL   Biol Futur 74 (1-2), 91-99 (2023)
   PUBMED   37097386
  REMARK    GeneRIF: Differential impact of exportin-1-mediated nuclear export
            of RNAs on the RNA content of extracellular vesicle subpopulations.
REFERENCE   3  (bases 1 to 6143)
  AUTHORS   Jin,L., Liao,W., Zhou,X., Wang,Y. and Qian,J.
  TITLE     Hydrocortisone alleviates sepsis-induced acute kidney injury
            through HSF-1-mediated transcriptional suppression of XPO1
  JOURNAL   Tissue Cell 79, 101915 (2022)
   PUBMED   36087493
  REMARK    GeneRIF: Hydrocortisone alleviates sepsis-induced acute kidney
            injury through HSF-1-mediated transcriptional suppression of XPO1.
REFERENCE   4  (bases 1 to 6143)
  AUTHORS   Pianigiani,G., Gagliardi,A., Mezzasoma,F., Rocchio,F., Tini,V.,
            Bigerna,B., Sportoletti,P., Caruso,S., Marra,A., Peruzzi,S.,
            Petito,E., Spinozzi,G., Shacham,S., Landesman,Y., Quintarelli,C.,
            Gresele,P., Locatelli,F., Martelli,M.P., Falini,B. and Brunetti,L.
  TITLE     Prolonged XPO1 inhibition is essential for optimal antileukemic
            activity in NPM1-mutated AML
  JOURNAL   Blood Adv 6 (22), 5938-5949 (2022)
   PUBMED   36037515
  REMARK    GeneRIF: Prolonged XPO1 inhibition is essential for optimal
            antileukemic activity in NPM1-mutated AML.
REFERENCE   5  (bases 1 to 6143)
  AUTHORS   Gorostieta-Salas,E., Moreno-Blas,D., Geronimo-Olvera,C.,
            Cisneros,B., Court,F.A. and Castro-Obregon,S.
  TITLE     Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to
            Autophagy Dysfunction and Senescent Features in Old Mouse Brain
  JOURNAL   Oxid Med Cell Longev 2021, 6682336 (2021)
   PUBMED   34434486
  REMARK    GeneRIF: Enhanced Activity of Exportin-1/CRM1 in Neurons
            Contributes to Autophagy Dysfunction and Senescent Features in Old
            Mouse Brain.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6143)
  AUTHORS   Phillips,R.S., Ramos,S.B. and Blackshear,P.J.
  TITLE     Members of the tristetraprolin family of tandem CCCH zinc finger
            proteins exhibit CRM1-dependent nucleocytoplasmic shuttling
  JOURNAL   J Biol Chem 277 (13), 11606-11613 (2002)
   PUBMED   11796723
REFERENCE   7  (bases 1 to 6143)
  AUTHORS   Hilditch-Maguire,P., Trettel,F., Passani,L.A., Auerbach,A.,
            Persichetti,F. and MacDonald,M.E.
  TITLE     Huntingtin: an iron-regulated protein essential for normal nuclear
            and perinuclear organelles
  JOURNAL   Hum Mol Genet 9 (19), 2789-2797 (2000)
   PUBMED   11092755
REFERENCE   8  (bases 1 to 6143)
  AUTHORS   Ohno,M., Segref,A., Bachi,A., Wilm,M. and Mattaj,I.W.
  TITLE     PHAX, a mediator of U snRNA nuclear export whose activity is
            regulated by phosphorylation
  JOURNAL   Cell 101 (2), 187-198 (2000)
   PUBMED   10786834
REFERENCE   9  (bases 1 to 6143)
  AUTHORS   Bodendorf,U., Cziepluch,C., Jauniaux,J.C., Rommelaere,J. and
            Salome,N.
  TITLE     Nuclear export factor CRM1 interacts with nonstructural proteins
            NS2 from parvovirus minute virus of mice
  JOURNAL   J Virol 73 (9), 7769-7779 (1999)
   PUBMED   10438867
REFERENCE   10 (bases 1 to 6143)
  AUTHORS   Taagepera,S., McDonald,D., Loeb,J.E., Whitaker,L.L., McElroy,A.K.,
            Wang,J.Y. and Hope,T.J.
  TITLE     Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7457-7462 (1998)
   PUBMED   9636171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772359.8.
            
            On Sep 29, 2022 this sequence version replaced XM_006514430.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034710.1, SRR1660815.106867.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-778               AL772359.8         43172-43949
            779-910             AL772359.8         49067-49198
            911-1012            AL772359.8         54894-54995
            1013-1085           AL772359.8         58365-58437
            1086-1147           AL772359.8         63659-63720
            1148-1192           AL772359.8         64268-64312
            1193-1374           AL772359.8         65375-65556
            1375-1423           AL772359.8         65908-65956
            1424-1543           AL772359.8         66038-66157
            1544-1672           AL772359.8         67606-67734
            1673-1831           AL772359.8         68538-68696
            1832-2029           AL772359.8         69761-69958
            2030-2168           AL772359.8         71474-71612
            2169-2350           AL772359.8         71780-71961
            2351-2507           AL772359.8         72044-72200
            2508-2671           AL772359.8         72288-72451
            2672-2806           AL772359.8         73033-73167
            2807-2990           AL772359.8         73977-74160
            2991-3097           AL772359.8         74577-74683
            3098-3292           AL772359.8         76990-77184
            3293-3461           AL772359.8         78695-78863
            3462-3596           AL772359.8         81004-81138
            3597-3756           AL772359.8         81221-81380
            3757-3853           AL772359.8         81828-81924
            3854-6143           AL772359.8         83193-85482
FEATURES             Location/Qualifiers
     source          1..6143
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 14.28 cM"
     gene            1..6143
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /note="exportin 1"
                     /db_xref="GeneID:103573"
                     /db_xref="MGI:MGI:2144013"
     exon            1..778
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..910
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             785..4000
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /note="chromosome region maintenance 1 protein homolog;
                     exportin 1, CRM1 homolog"
                     /codon_start=1
                     /product="exportin-1"
                     /protein_id="NP_001399336.1"
                     /db_xref="CCDS:CCDS24475.1"
                     /db_xref="GeneID:103573"
                     /db_xref="MGI:MGI:2144013"
                     /translation="MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQR
                     MAQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGI
                     KKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTS
                     ESLCQNNMVILKLLSEEVFDFSSGQITQVKAKHLKDSMCNEFSQIFQLCQFVMENSQN
                     APLVHATLETLLRFLNWIPLGYIFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSV
                     SQYEEQFETLFTLTMMQLKQMLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHG
                     QLLEKRLNLREALMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASP
                     LLSGSQHFDIPPRRQLYLTVLSKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDS
                     INLYKNMRETLVYLTHLDYVDTEIIMTKKLQNQVNGTEWSWKNLNTLCWAIGSISGAM
                     HEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVV
                     NKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICD
                     LQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDP
                     ETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVT
                     KQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAAREP
                     EVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVN
                     SHCFPAFLAIPPAQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVAQEEAAAQSF
                     YQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKISTPLNPGNPVNNQM
                     FIQDYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDT
                     SDLFLEERETALRQAQEEKHKLQMSVPGILNPHEIPEEMCD"
     exon            911..1012
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1085
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1147
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1192
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1374
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1423
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1543
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1672
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1831
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..2029
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2168
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2350
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2507
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2671
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2806
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2990
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3097
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3292
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3461
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3596
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..3756
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..3853
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3854..6143
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4101..4106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /note="hexamer: ATTAAA"
     polyA_site      4119
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /note="major polyA site"
     regulatory      4886..4891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /note="hexamer: AATAAA"
     polyA_site      4906
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /note="major polyA site"
     regulatory      6119..6124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
                     /note="hexamer: AATAAA"
     polyA_site      6143
                     /gene="Xpo1"
                     /gene_synonym="Crm1; Exp1"
ORIGIN      
        1 aaacgctccg cggcgccatg ggctgaaaac tcaaccgaga tggaatctcc cagtctgaac
       61 cggtttcaac cggttccgag tttgaggcac taggaggagg gggagaagcg gctgcagcgg
      121 ccgcggcagg agcagcggga gcttcagcat cagcaagagc aacagtagct acagccccgg
      181 cggccgtgcc tgttccagcc tttgctgcag cagtcgtgca accatcccga gggggagggg
      241 ggaggcacca gtcgctgagg agcacgcgaa ggggggaaag tttaggctag ctcgggtggg
      301 ggggcccggc gccggagcgg cgtgagcgag ggagccctgt gtggtagggg gagccggact
      361 gcaactggcg gcagagcggc cccggccgta cggactcgcg ctgctgctcc cgccgccgcc
      421 tgtggctgga gggtcctggg ctctgtctca cggactggcc cgctcccctc ccccttcctt
      481 ccctccccag ccgggcggga gcatttattt ctcggattaa ttcccctttt tggtggggcg
      541 cgtgtgtgtg cgtgcgcgcg tgtgtgtgcg tgagtgtgtg ttgggtggag ttgtccctag
      601 aatagtaaat actgagcttt tttttttttt tttgcccttc tctgcttttt aatttctttt
      661 ttgtttaagg tgggaaaact gtgaaaccca ccttgatttc ctcccctctc cctcctcccc
      721 accttccctc gccccaagcc cggacaagga aggaagaagc agttggttga atttctggta
      781 atctatgcca gcaattatga caatgttagc agaccatgca gctcgtcagc tgcttgattt
      841 cagccaaaaa ctggatatca accttttaga caacgtggtg aattgcttat accatggaga
      901 aggagcccag caaagaatgg ctcaagaagt actgacacat ttaaaggagc atcctgatgc
      961 ttggacacgg gtcgacacaa tattggagtt ttcgcagaac atgaacacga aatactatgg
     1021 actacagatt ttggaaaatg tgatcaaaac aaggtggaag atccttccaa ggaaccagtg
     1081 tgaaggaata aaaaaatatg ttgttggtct cattatcaag acatcctctg acccaacttg
     1141 tgtagagaaa gaaaaggtgt atattgggaa attgaatatg attcttgttc agatacttaa
     1201 gcaagagtgg cctaagcatt ggccaacttt tatcagtgac attgttggag cgagtaggac
     1261 cagtgaaagt ctatgtcaaa ataatatggt gattcttaaa ctcttgagtg aagaagtgtt
     1321 tgatttctct agtggacaga taacccaagt taaagcaaag catttaaaag acagcatgtg
     1381 caatgagttt tcacaaatat ttcagctttg tcagtttgtg atggaaaatt cccaaaatgc
     1441 tccccttgtt catgctacat tagaaacact gctgagattt ctgaactgga ttccactggg
     1501 atacatcttt gagaccaagt taatcagcac attaatttac aagttcctga atgttccaat
     1561 gttccgaaat gtgtctctaa agtgcctcac tgagattgct ggtgtgagtg taagccaata
     1621 tgaggaacaa tttgaaactc tgtttacact tacaatgatg cagctaaaac agatgcttcc
     1681 tttaaacact aatatccgac ttgcatactc gaatgggaaa gatgatgaac agaactttat
     1741 tcaaaatctc agcctgtttc tctgtacctt tctaaaagag cacggtcaac ttctagaaaa
     1801 acgactgaat ctcagggaag cactcatgga ggctcttcat tatatgttgt tggtgtctga
     1861 agtggaagaa actgaaattt ttaaaatctg ccttgagtac tggaatcatt tggcagctga
     1921 gctctacaga gagagtccat tttctacatc tgcttctccc ttgttatctg gaagtcaaca
     1981 ctttgatatt cctcctagga gacagctgta cttgaccgtg ttatcaaagg tccgtttatt
     2041 gatggttagt cgcatggcta aaccagagga ggtactggtt gtagaaaatg atcagggaga
     2101 agttgtaaga gagttcatga aggatactga ttccataaat ttatataaga atatgagaga
     2161 aacattagtt tatcttactc atctggatta tgtagatacg gaaataataa tgactaagaa
     2221 acttcaaaat caagtgaatg gtacagaatg gtcatggaag aatttgaata cgttgtgttg
     2281 ggcaataggc tccatcagtg gcgcaatgca tgaagaggat gagaagcggt ttcttgttac
     2341 tgttataaag gatcttttag gattatgtga gcagaaaaga ggcaaagata ataaagctat
     2401 tattgcatcg aatatcatgt acatagtagg tcaataccca agatttttga gagcacactg
     2461 gaaatttttg aagacagtag taaacaagct attcgaattc atgcatgaga cccatgatgg
     2521 agtccaggat atggcttgtg acacatttat taaaatagct caaaaatgcc gtaggcattt
     2581 tgttcaggtt caagttggag aagtaatgcc gttcattgat gagattttaa acaacataaa
     2641 tactataatt tgtgatcttc agcctcagca ggttcataca ttttatgaag ctgtggggta
     2701 catgattggt gcacagacag accagacagt tcaagagcat ttgatagaaa aatacatgct
     2761 actccctaat caagtgtggg acagtataat tcagcaggct accaaaaatg tggatatcct
     2821 gaaagatcct gaaacagtca agcagctggg tagcatatta aaaacaaatg tgagagcctg
     2881 caaagctgtt ggtcatccct ttgtaattca gcttggcaga atttatttag acatgcttaa
     2941 tgtatataag tgcctcagtg aaaatatttc tgcagctatt caagctaatg gtgagatggt
     3001 tacaaagcaa ccattgatta gaagtatgcg gacagtaaaa agggaaactt taaagttaat
     3061 atctggttgg gtgagccgtt ccaatgatcc tcagatggta gctgaaaact ttgttcctcc
     3121 tttgttggat gcagttctta ttgattacca gagaaatgta ccagctgcta gagaaccaga
     3181 agtgcttagt actatggcca ttattgtcaa caaattaggt ggacatataa cagctgaaat
     3241 acctcaaata ttcgatgcag tttttgagtg cacattgaat atgataaata aggattttga
     3301 agagtatcca gaacacagaa caaacttttt cttattactt caagctgtca attctcactg
     3361 tttcccagca ttcctagcta ttccacctgc acagttcaag ctggttttgg attctattat
     3421 ttgggctttt aaacatacta tgaggaatgt tgcagataca ggcttacaga tactttttac
     3481 acttttacaa aatgttgcac aagaggaagc tgccgcacag agtttttatc aaacttattt
     3541 ttgtgatatt cttcagcata ttttctctgt tgtaacagac acttcacata ctgcaggtct
     3601 aacaatgcat gcatcaattc ttgcatatat gtttaatttg gttgaagaag gaaaaataag
     3661 tacaccacta aatcctggaa atccagttaa caaccaaatg tttattcaag actatgtggc
     3721 taatctcctt aaatctgcat tccctcatct acaagatgct caagtaaagc tctttgtaac
     3781 aggacttttc agcttaaatc aggatattcc tgctttcaaa gaacacctaa gggatttctt
     3841 agttcaaata aaggagtttg caggtgaaga tacatcggat ctatttttgg aagaaagaga
     3901 aacagccctt cgacaggctc aggaggagaa acataaactt caaatgtctg tacctgggat
     3961 tcttaatcca cacgaaattc cagaagaaat gtgtgattaa aatctgaagt catgctaggc
     4021 ttttttctct ctgcaacatt tgttcctgga agaaaagagc agatggatta tttgtcgacc
     4081 aaaatgatgc caatttgtaa attaaaatgt cacctagtgg ccctttttct tatgtgtttt
     4141 ttgtataaga aattttctgt gaaatattct ttcattgttt aagcttttgt tttggtcatc
     4201 tttattcagt ttgcatgaag ttgaaaatta cggcattttt aagataactt ttacttcatg
     4261 cccattttga ggcaatgctg tgggaggcag taaatttgat ttgaaaatag acttgtaaat
     4321 tctaatacaa aattataaat tttttcttgt aaacaataca aattttaatt agggagcatt
     4381 tttttctagc ctgtatcttg gcctagaaga aacgtaatga gtaaagcaat tgcgtcaagg
     4441 gggttctaga gctgcattgt ccggagttgg cacctcctga gctgaattgt ctgtctctag
     4501 actacgtgta ttaaagtctg tgtgtcaagt ttgcagcaag atcatgtgca tatcatccca
     4561 ttgtaaagca acttcaaaaa tatgggaaca gttagttatt tttacacagt tctttttgtt
     4621 tgtgtgtgtg tgtgtgtgct gtcgcttgtc gacaacagct ttttgttttc ctcaatgagg
     4681 agtgttgctc atttgtgagc cttcattaac tcaaagtgaa atggttaaaa atatttatcc
     4741 tgttagaata ggctgcatct ttttaacaac tcattaaaac aacaacaaca acaacgaaaa
     4801 caaaactctg gcttttgaga tgacttatac taatttacat tgtttaccaa gctgtagtgc
     4861 tttaagaaca ctacttaaaa ggcaaaataa acttggttta catttatttt cccttcactg
     4921 acttaaaatt attcctactt aatgaaggtg attttaagga ttgtaatact ttatatgaag
     4981 tttcgtactt gtcttgttaa aaggactcct acctgggagt ggtgcctcat gcttttagct
     5041 cagcactaca gtcagagact ggatctcttg agttggaggt taccttagtc tacctagtga
     5101 cttccagtac agttagggct actctgtctc caaaacaagg gttctaagat agttggtagg
     5161 ttttaacagt cagagctttg tgccaaagtc ttataatccc atcagagtct ggtggatctc
     5221 gagttttgtt ttacttttgg ttttttgagg gagtttctct gtgtagccct ggctgtcctg
     5281 gaagttgcta tgtagaccag gctggcctcg aactcagaaa ctggcttatc tctggattaa
     5341 aggcaggcat cacctctgcc cagcaggatc tcaagttttc taagagattg gtacacatgg
     5401 taaattttag gacagccagg gatatgtagg gaggtcttgt ctcaaaaaac taacaaaaaa
     5461 aagataacag ccttgatctt gataacagct tgagtcactg tggggtttag ggaacatctt
     5521 tttgtgcagc tctagttagt ggctgtgtaa gtagattagc tttggaagga gtacaggcat
     5581 actcttcatc ctcgcaactg gcacctgagg ctgtaggctt agagttttca agggtacctt
     5641 ggtcacttga gtcccaatgg aaataagtgt tagccaaaca gtggccctag aaagaaagat
     5701 gtttatagtg gtgcgtgtaa ctagttaatg tgttgtctta gagtctctgc ttgacaacaa
     5761 aactgttagg ctaatatgac caggatggca agaaaaaaaa ggctcactta tatttgaatt
     5821 gagatgtgga gttagtgtgt acagtgtgac aaggggttgt agttatggtt gtaagcctgc
     5881 atcaaggaga cagcctagct aatttggtag aggttatctt cttgggggtt gtggggggta
     5941 ggtagtccac ttactcagca tatcaggtat tcaaggattc aaagatcagg taggccaggg
     6001 aaagcaagaa agaccctgaa ttcccttgcc agtcttggaa aagagagctg gaactgtgct
     6061 taatgatgga tatcatttga gtaaatttta gaatacaata aaatgtctaa gcacacttaa
     6121 taaagtgctt aaattacagt gta
//
