LOCUS       NM_001347075            6058 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus X-prolyl aminopeptidase 3, mitochondrial (Xpnpep3),
            transcript variant 2, mRNA.
ACCESSION   NM_001347075 XM_006521086
VERSION     NM_001347075.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6058)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6058)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 6058)
  AUTHORS   O'Toole,J.F., Liu,Y., Davis,E.E., Westlake,C.J., Attanasio,M.,
            Otto,E.A., Seelow,D., Nurnberg,G., Becker,C., Nuutinen,M.,
            Karppa,M., Ignatius,J., Uusimaa,J., Pakanen,S., Jaakkola,E., van
            den Heuvel,L.P., Fehrenbach,H., Wiggins,R., Goyal,M., Zhou,W.,
            Wolf,M.T., Wise,E., Helou,J., Allen,S.J., Murga-Zamalloa,C.A.,
            Ashraf,S., Chaki,M., Heeringa,S., Chernin,G., Hoskins,B.E.,
            Chaib,H., Gleeson,J., Kusakabe,T., Suzuki,T., Isaac,R.E.,
            Quarmby,L.M., Tennant,B., Fujioka,H., Tuominen,H., Hassinen,I.,
            Lohi,H., van Houten,J.L., Rotig,A., Sayer,J.A., Rolinski,B.,
            Freisinger,P., Madhavan,S.M., Herzer,M., Madignier,F., Prokisch,H.,
            Nurnberg,P., Jackson,P.K., Khanna,H., Katsanis,N. and
            Hildebrandt,F.
  TITLE     Individuals with mutations in XPNPEP3, which encodes a
            mitochondrial protein, develop a nephronophthisis-like nephropathy
  JOURNAL   J Clin Invest 120 (3), 791-802 (2010)
   PUBMED   20179356
  REMARK    Erratum:[J Clin Invest. 2010 Apr;120(4):1362. Jackson, Peter
            [corrected to Jackson, Peter K]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109153.13, BB663087.1, CK635306.1, AK035269.1 and EH097540.1.
            
            On Nov 15, 2016 this sequence version replaced XM_006521086.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.17772.1,
                                           SRR9219380.67933.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC109153.13        131719-131732       c
            15-540              BB663087.1         5-530
            541-675             AC109153.13        104187-104321       c
            676-852             AC109153.13        101004-101180       c
            853-1560            CK635306.1         1-708
            1561-2685           AC109153.13        77761-78885         c
            2686-4705           AK035269.1         1-2020
            4706-5756           AC109153.13        74690-75740         c
            5757-6058           EH097540.1         48-349              c
FEATURES             Location/Qualifiers
     source          1..6058
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.08 cM"
     gene            1..6058
                     /gene="Xpnpep3"
                     /gene_synonym="APP3; E430012M05Rik"
                     /note="X-prolyl aminopeptidase 3, mitochondrial"
                     /db_xref="GeneID:321003"
                     /db_xref="MGI:MGI:2445217"
     exon            1..150
                     /gene="Xpnpep3"
                     /gene_synonym="APP3; E430012M05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1607
                     /gene="Xpnpep3"
                     /gene_synonym="APP3; E430012M05Rik"
                     /EC_number="3.4.11.9"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable Xaa-Pro aminopeptidase 3; aminopeptidase P3;
                     X-Pro aminopeptidase 3; xaa-Pro aminopeptidase 3"
                     /codon_start=1
                     /product="xaa-Pro aminopeptidase 3 isoform 2"
                     /protein_id="NP_001334004.1"
                     /db_xref="CCDS:CCDS84182.1"
                     /db_xref="GeneID:321003"
                     /db_xref="MGI:MGI:2445217"
                     /translation="MPSLLSTPKLAPVLARLRGLSGCMSCLQRRYSLQPAPVKKIPNR
                     YLGQPSPVTHPHLLRPGEVTPGLSQVEYALRRHKLMALVHKEAQGHSGTDHTVVVLSN
                     PTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSFSGKQLPSHKAMLFVPRRDPGR
                     ELWDGPRSGTDGAIALTGVDEAYPLEEFQHLLPKLRAETNMVWYDWMKPSHAQLHSDY
                     MQPLTEAKARSKNKVRSVQQLIQRLRLVKSPSEIKRMQIAGKLTSEAFIETMFASKAP
                     IDEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGC
                     ESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRACLTLCSPGTSLENIYSMMLTLI
                     GQKLKDLGITKTSKESAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITVE
                     PGIYIPEDDRDAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDIEQICSRTS"
     exon            151..267
                     /gene="Xpnpep3"
                     /gene_synonym="APP3; E430012M05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            268..675
                     /gene="Xpnpep3"
                     /gene_synonym="APP3; E430012M05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            676..878
                     /gene="Xpnpep3"
                     /gene_synonym="APP3; E430012M05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            879..941
                     /gene="Xpnpep3"
                     /gene_synonym="APP3; E430012M05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1055
                     /gene="Xpnpep3"
                     /gene_synonym="APP3; E430012M05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1141
                     /gene="Xpnpep3"
                     /gene_synonym="APP3; E430012M05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1319
                     /gene="Xpnpep3"
                     /gene_synonym="APP3; E430012M05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1440
                     /gene="Xpnpep3"
                     /gene_synonym="APP3; E430012M05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..6058
                     /gene="Xpnpep3"
                     /gene_synonym="APP3; E430012M05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6030..6035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xpnpep3"
                     /gene_synonym="APP3; E430012M05Rik"
                     /note="hexamer: AATATA"
     polyA_site      6048
                     /gene="Xpnpep3"
                     /gene_synonym="APP3; E430012M05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagcagttga ctggtttcct ggcgacgcgg ctgtgctagt ggctttcccc agagtttgta
       61 cttttcctga ccagtggtta caggccatgc cgtctctgct ctcaaccccc aagctggctc
      121 ccgttctagc aaggctccgc ggcctctcag gatgcatgtc atgtttacag cgaaggtact
      181 ccctccagcc tgcgccggta aagaagattc caaaccggta cttaggccag cccagcccgg
      241 ttacacatcc acacctcctc agaccagggg aggtgacacc agggctatct caggtggaat
      301 atgcacttcg aagacataaa cttatggctc tggtccacaa agaagcacaa gggcacagtg
      361 gaacagacca cacagtggtg gtactctcta accctacgta ctatatgagc aacgacatcc
      421 cctacacatt ccatcaagac aacaacttcc tgtatctctg tggattccaa gagcctgata
      481 gcattctggt ccttcagagc ttctctggga agcagttacc atcccataag gccatgcttt
      541 ttgtgcctcg gagagatcct ggccgagaat tgtgggatgg ccctcgatct ggcacagatg
      601 gagcaatagc cttaaccgga gtggatgaag cctacccgct ggaagaattt caacacctgc
      661 taccaaaact gagagctgag acgaacatgg tttggtatga ctggatgaag ccttctcatg
      721 cacaacttca ctctgactac atgcagcctc taactgaagc caaagccagg agcaagaaca
      781 aggttcggag tgtccagcag ctgatacagc gcctaaggct ggttaagtct ccttcagaga
      841 ttaagagaat gcagattgct gggaagctga cgtcagaggc tttcatagag accatgtttg
      901 ccagtaaagc tccgatagat gaagcctttc tttacgcgaa gtttgaattt gagtgccgtg
      961 ctcgaggtgc cgacatctta gcctacccac ctgtggttgc aggcggtaat cgctccaaca
     1021 ctttgcacta tgtgaagaat aatcaactca tcaaggatgg tgagatggtt cttcttgatg
     1081 gaggctgtga atcatcctgc tatgtgagtg acatcaccag gacatggcct gtcaatggca
     1141 gattcaccgc ccctcaggca gagctctatg aagctgttct ggaaatccaa agagcttgtt
     1201 tgactctgtg ttcccctggg acgagcttgg agaacatcta cagcatgatg ctgacgctga
     1261 taggacagaa gcttaaggat ctgggcatca caaagaccag caaggaaagc gccttcaagg
     1321 ctgctcgaaa atactgccct catcatgttg gccattacct cgggatggat gtccatgaca
     1381 ctccagacat gcctcggtca ctccctctgc agcctggaat ggtgatcaca gttgaaccag
     1441 gcatttatat cccagaggac gacagagatg ccccagagaa gttccgaggg ctcggagttc
     1501 ggattgagga tgatgtagtg gtgactcagg actcacctct tatcctttct gcagattgtc
     1561 ccaaagagat gaatgacatt gaacagatct gcagcaggac ctcgtgacca ccactgtggc
     1621 atccctgcta tgcaggtagt cagtgtctct ggggattaga cacagcttcc ctgggaactg
     1681 cacagccagt gagcgagggc atcttcatgt taaatggatg taaatctgga accgtggatt
     1741 gtggaataat ctgttactac aactttagtg acattaattc tgagacgtta atgatccaga
     1801 aagtttaaca tgtgaatgta aagtaagggc ttggttatgt gtccctgcat tccagttaac
     1861 acatttcaac agaaaactct cttcatccct ttctgcactt cttctgagat ccacttaaga
     1921 tgcttgtgtg aggcccacat gttttacttc tcaccaaagt ttcagcctat gctaatggct
     1981 acctgtcggc gtttgaggtg gccaatactt acttgccatg gcctctgcct cctggtccag
     2041 gttctgcaca cgcacaccca ctggaatctc tcaggcctca ggaaacacag gggtcctgct
     2101 gtgtttccat tcagccagaa tacagcaaca gtcagccaac aagagtcttg gatctttctt
     2161 gccatttgat tgcacagaac atggaaagtg tctaggttct tcttggaaag aaaatgaaag
     2221 agaaaggaaa gtatctatgt gtctccacag atccagctct gttttcttcc atttaaagga
     2281 gttttttttt tttttcaaat gtccaccttc ctctctttca caagttattt tctcagacaa
     2341 aatgtcacta tgttcctcag gtccttcata gttgctgtgc tttgtgacag gatcttatgt
     2401 agcccaggct ggcctcaaac tcaatataca gttattgctg gcctcaaaat attgatcttc
     2461 ctgcactgcg cccagctcac ttttatgggg ggggggttat gcgcaggtgt gtatggttgg
     2521 tcggttggtt ggttggttgg ttggttttta gcaaggtttc tctgtgtagc tctgactatc
     2581 ctggaactcg atctgttggc caggttcacc ttgaactcag agatctgcct ccttctgcct
     2641 ccctaaatgt tgggattaaa agcattatct accaccactc agttctttat aggttcttaa
     2701 tgaattgatc catgtagcta cttgcagcca tgtattgtca aaatcaatgc atactgctgc
     2761 ttctccttgt cttcgtctcc cccactcccc gtggtgactc ccctggcctc aatccttggg
     2821 gccagtgaaa ctgcctgact cagcttccca gtaaacctcc ttttaattta aaaaacaaaa
     2881 gcatgacaaa ctcagaatgg gcatagtgac tagtgcctgt aattcagcgt tctgaatgca
     2941 gtgtcaggaa tatggtcata gggtcaaggc ccagagcagc ctggtctgca gagcaagtca
     3001 cagccactca tggctatgtg atgaccctgt ctaaaaatta aaacaaaata aaaggttctg
     3061 cagtcttgtg ttagataaca ataaaattaa atatatggga tgcattcagt agttatgaat
     3121 accctatggt ccacctctta ctctaacgct aggggatgac atggcaaggc agtggcagag
     3181 tcatgtttct ttccctaaac acagcatctg gttcagttgt acaacccaga ttgcaaggtg
     3241 agcaagtcag ggctggatga atacaaatgg ttaattaaga gcttgtgtga ggggctgaag
     3301 agatggctca gaggttaaga acactgacta gaggtcctga gttcagttcc cagcaaccac
     3361 atggtggctc acaaccatct gtaatagaat ctgatgccct cttgtggtgt gtctaaagac
     3421 agctgcaatg tactcattat acatcaaata aataaataaa tcctttaaaa aaaaaaaaaa
     3481 agcttgtgtg aactgggcat agtcccttag cacttgaagc aggcagatct ctgagttcaa
     3541 agtcagcctg atctacagat caaattccag aacagctaca cagaaaaacc ctgtctcaaa
     3601 aataaaatac gcttatgtga cagagggaag ccctaagagc tagtgtgtaa acttctttta
     3661 aatctgagta tgtgtagtcc catggtaaac aaaacctgct aactgctaca acataaatcc
     3721 aagggttttg tgggatctgc ccctactttc catatttctg ttagggaagt gcaagctaga
     3781 agattagcaa acagtctctg cagtgcaggt agctgacaca tcttaagaaa tttcacagta
     3841 cacctagaaa ccagcagggg acaaaggtag tgtgagaact aaacattagg acacaaatgg
     3901 ccctctgact actcatcctc aaggccttat cagtctctcc tgagggctgt aacagtggcg
     3961 gctgcccgcc cagtctgtcc tttctgcccg ttgtccgtct tctgggtctc agacctaacc
     4021 tacttttaaa gaaggaagaa taaatccatt accatggctt ctcacccacc tggctctgtg
     4081 cccaaacagc cttcgcttgg agtgactttc ctttctttct gtaagacaac gtcgtctgca
     4141 gttctcacct ttgtagctga aagcctgggc cgcttttatg tatagcagag ttagagagga
     4201 aactgacttc tgcttacatt acagtcaagt tctgcagatg taactggtgg ttagggtggc
     4261 tttgatggag ttgtggtgaa tttggtctat ggtccaacct gctacccatt gagtcccaga
     4321 ttaagccaag catttcagtt ggactgttag aaccatccag aaaacagtgg agatggctca
     4381 gctgcctcag atgtgtggcc aggctggtct tgctgggatt ccaggtgcac cagcacatac
     4441 agtaagactc actgagcggg tgagtaactt actcacaggg caacttacta cacatcgtgt
     4501 ttctagagtt agtgttttgt gcatgtgtgc cccagtcttt cctcttaaaa gggcttttta
     4561 cctgtcagct tgccatttag tgtgcttgtt ggtttggttt ggtttggttt ggtttggttt
     4621 ggtttggttt ggtttggttt ttgagacagg gtctctcctg gaactcatta tatagactag
     4681 gctaatacca tactgaaaga gatccacctg cctctgcctc ccaagtgctg aagttaaaag
     4741 cgtgcaccac caccacaacc agcaactttt ttttttatga tgctgtaatt gaatacagga
     4801 atgctttaga catgctaaat aagctctgca cctctgaatg aactacatcc tcagctcaat
     4861 tctctttcct agattggaga gagatggctg catcattaat gtaagcattt aagtgaaggg
     4921 taccctatct ggtacccagt gtcacatggt tttatgtgat tagttcagaa tctggtatat
     4981 gtctcctgta acaaagggac tgcacccagg cattgtagct cacacctaaa accatggcac
     5041 ttacaagact gaagcaggag gattgttatg agttataaga ctagtctggg ctacagatta
     5101 agaccctgat tcaaaaatga aaataataat aacatagaga aagtttttta taacagtgtt
     5161 ccagtaatcc ctgccaactc cacagttgaa gctgagttgg aagcggctgt catcactgac
     5221 tagaagataa gagatgaaag caccacttac caagccagga ggtgacagca cacaccttca
     5281 atcccagcgc tcgctcatag ggcacacctc tgagtttaag ctctacagcc tgatctacat
     5341 agcaagtacc aggacagcct agaaagactc tgcttcaaaa caccaaaaga aagaaagaaa
     5401 ttgaagtaga tacccaggct aatggtgtca taaagaaccc tgtacagcca ggcggtggtg
     5461 gcgcatgcct taaatcccaa cacttgggag gcagaggcag gcggatttct gagcttgagg
     5521 cagcctggtc tacacagtga gttccaggac agccagggct acacagagaa accctatctt
     5581 gaaaacaaaa aaaaaattcc taaagtggca tccatctaag ccccaagttg agcagattat
     5641 gtaagtttta gaccttggca gatcttcttt aaactgaagt gttttcagac gttcctggtg
     5701 gtgagaaggt ggtgatgtca tcgtgtatgt tcgcaacact gcagcagaat ccacatgggg
     5761 agggggcttc tgtagccact gaggagcttt gactatcagt attgtatggg tctggggtca
     5821 cccctggact tcaggcccta cagggcatgc gcccaccaga acccagaaac tacagtcttg
     5881 ttcgacattt cttaacgctt tgtatgactt ttgtgcaatt atataagttc tgtttggaca
     5941 aaatgctgtt accttctatg gccccattca atgaaaatgg atctctcatt cccaagtaag
     6001 aggaatacat ttgttattgt tgtttttaaa atatactata aaacaatacc gagtggtc
//
