LOCUS       NM_001374834            2345 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
            (Xpnpep1), transcript variant 2, mRNA.
ACCESSION   NM_001374834 XM_011247160
VERSION     NM_001374834.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2345)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2345)
  AUTHORS   Yoon,S.H., Bae,Y.S., Oh,S.P., Song,W.S., Chang,H. and Kim,M.H.
  TITLE     Altered hippocampal gene expression, glial cell population, and
            neuronal excitability in aminopeptidase P1 deficiency
  JOURNAL   Sci Rep 11 (1), 932 (2021)
   PUBMED   33441619
  REMARK    GeneRIF: Altered hippocampal gene expression, glial cell
            population, and neuronal excitability in aminopeptidase P1
            deficiency.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2345)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2345)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   5  (bases 1 to 2345)
  AUTHORS   Yoon,S.H., Bae,Y.S., Mun,M.S., Park,K.Y., Ye,S.K., Kim,E. and
            Kim,M.H.
  TITLE     Developmental retardation, microcephaly, and peptiduria in mice
            without aminopeptidase P1
  JOURNAL   Biochem Biophys Res Commun 429 (3-4), 204-209 (2012)
   PUBMED   23131567
  REMARK    GeneRIF: These results suggest an essential role for APP1-mediated
            peptide metabolism in body and brain development, and indicate a
            strong causal link between APP1 deficiency and peptiduria.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163221.5.
            
            On Oct 16, 2019 this sequence version replaced XM_011247160.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189673.177167.1,
                                           SRR9219381.102752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC163221.5         147382-147438       c
            58-182              AC163221.5         134127-134251       c
            183-246             AC163221.5         123479-123542       c
            247-351             AC163221.5         122267-122371       c
            352-444             AC163221.5         121057-121149       c
            445-588             AC163221.5         120634-120777       c
            589-684             AC163221.5         118936-119031       c
            685-766             AC163221.5         116739-116820       c
            767-977             AC163221.5         115023-115233       c
            978-1067            AC163221.5         113632-113721       c
            1068-1118           AC163221.5         112632-112682       c
            1119-1177           AC163221.5         111547-111605       c
            1178-1255           AC163221.5         111342-111419       c
            1256-1327           AC163221.5         109257-109328       c
            1328-1388           AC163221.5         108020-108080       c
            1389-1458           AC163221.5         106742-106811       c
            1459-1632           AC163221.5         105768-105941       c
            1633-1709           AC163221.5         105117-105193       c
            1710-1808           AC163221.5         104289-104387       c
            1809-2345           AC163221.5         100051-100587       c
FEATURES             Location/Qualifiers
     source          1..2345
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 46.91 cM"
     gene            1..2345
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /note="X-prolyl aminopeptidase (aminopeptidase P) 1,
                     soluble"
                     /db_xref="GeneID:170750"
                     /db_xref="MGI:MGI:2180003"
     exon            1..57
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            58..182
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1937
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /EC_number="3.4.11.9"
                     /note="isoform 2 is encoded by transcript variant 2;
                     xaa-Pro aminopeptidase 1; X-Pro aminopeptidase 1;
                     aminoacylproline aminopeptidase; cytosolic aminopeptidase
                     P"
                     /codon_start=1
                     /product="xaa-Pro aminopeptidase 1 isoform 2"
                     /protein_id="NP_001361763.1"
                     /db_xref="CCDS:CCDS89415.1"
                     /db_xref="GeneID:170750"
                     /db_xref="MGI:MGI:2180003"
                     /translation="MAPKVTSELLRQLRQAMRNSEYVAEPIQAYIIPSGDAHQSEYIA
                     PCDCRRAFVSGFDGSAGTAIITEEHAAMWTDGRYFLQAAKQMDNNWTLMKMGLKDTPT
                     QEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAGHHLVPVKENLVDKIWTDRPE
                     RPCKPLLTLGLDYTGISWKEKVADLRLKMAERSIAWFVVTALDEIAWLFNLRGSDVEH
                     NPVFFSYAIVGLETIMLFIDGDRVDAPGVKQHLLLDLGLEAEYRIQVLPYKSILSELK
                     ALCADLSPREKVWVSDKASYAVSEAIPKDHRCCMPYTPICIAKAVKNSAESDGMRRAH
                     IKDAVALCELFNWLEQEVPKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGA
                     IIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKG
                     HIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKT
                     FSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPAKTKYNFNNRGSLTFEPLTLVP
                     IQTKMIDVNALTDKECDWLNSYHQTCRDVVGKELQSQGRQEALEWLIRETEPVSRQH"
     exon            183..246
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            247..351
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            352..444
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            445..588
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            589..684
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            685..766
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            767..977
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1067
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1118
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1177
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1255
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1327
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1388
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1458
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1632
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1709
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1808
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..2345
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2327..2332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /note="hexamer: AATAAA"
     polyA_site      2345
                     /gene="Xpnpep1"
                     /gene_synonym="D230045I08Rik; sAMP"
                     /note="major polyA site"
ORIGIN      
        1 gtgggctggg gcacgtcacc gccgaatggc agcctccaga aagccgccgc gagtaagacc
       61 acaggatggc tccgaaggtg acttcagaac tgcttcggca gctgcgacaa gctatgagga
      121 actccgaata cgtggcagaa cccatccagg cctatatcat cccgtcagga gatgcccacc
      181 agagcgagta cattgcaccc tgtgactgtc ggagggcgtt tgtctctgga ttcgatggct
      241 ctgcaggcac agccatcatc acggaggagc atgcggccat gtggactgac gggcgctact
      301 tcctccaggc tgccaaacag atggacaaca actggactct catgaagatg ggtctgaaag
      361 acacaccaac tcaggaggac tggctggtga gtgtgcttcc agaaggatcc agggttggtg
      421 tggaccccct catcattccc acagattact ggaagaagat ggccaaggta ctgcgaagtg
      481 ctggtcacca cctcgtgcct gtgaaggaga accttgtgga caagatctgg acagaccggc
      541 cggagcgccc ttgcaagccc ctcctcacac tgggcctgga ttatacaggc atctcgtgga
      601 aggagaaggt tgcagacctc cggttgaaaa tggcagagag gagcatcgcg tggtttgtag
      661 tcacagccct agacgagatt gcatggctgt tcaatctccg cgggtcagat gtggaacaca
      721 atcctgtgtt tttctcctat gcgatcgtag gcctagagac gatcatgctc ttcattgacg
      781 gggaccgcgt cgacgcgccg ggcgtgaagc agcacctgct gcttgacttg ggcctggagg
      841 cggaatacag aatccaggtc ctgccataca agtccatcct gagtgagctc aaggccctgt
      901 gtgctgacct gtccccgagg gagaaagtgt gggtcagtga caaggccagc tacgctgtga
      961 gcgaggccat ccccaaggat caccgctgct gtatgcctta cacacccatc tgcattgcca
     1021 aagccgtgaa gaactccgct gagtcggacg gcatgaggcg ggctcacatt aaagatgccg
     1081 ttgccctctg cgaactcttc aactggctgg agcaagaggt tcccaaaggt ggcgttacgg
     1141 agatctctgc ggctgacaag gccgaggaat ttcgaaggca gcaggctgac tttgtggatc
     1201 tgagcttccc aacgatttcc agcacgggac ccaacggcgc catcatccac tacgcgccag
     1261 tccctgagac gaacaggacc ctgtccctgg acgaggttta cctcattgac tccggtgctc
     1321 agtacaagga tggaaccacg gacgtcaccc ggaccatgca ctttgggacc cccactgcct
     1381 atgagaagga atgcttcaca tacgtactga aaggccacat agctgtgagc gcagctgttt
     1441 tcccgacggg aaccaaaggc caccttctgg actcctttgc ccggtcagcc ttgtgggatt
     1501 ctggtctgga ttacctgcat ggaacaggac atggcgttgg gtcctttttg aatgttcacg
     1561 aggggccctg tggcatcagt tataaaacat tctccgatga gcccttggaa gcgggcatga
     1621 tcgtcactga tgagccaggg tattacgaag acggggcgtt tgggatccgc attgagaatg
     1681 ttgttctggt ggtcccagca aaaaccaagt ataatttcaa caaccgagga agcctgacct
     1741 ttgaacctct aactttggtt cccatccaga ccaaaatgat agatgtgaat gctcttacag
     1801 ataaagagtg tgactggctc aacagctacc accagacctg cagggacgtg gttgggaagg
     1861 agctgcagag ccagggccgc caggaagctc tcgagtggct catcagagag acagagcctg
     1921 tctccaggca gcattgatgt cgcctggcgt tggtttttcg taggatgctc tgggggaagg
     1981 aggacacaag gcagacccct gacttctctc tcctcacctc ctcctcctcc ccgactcctc
     2041 tttttacttt tagacactaa gaagagctga aactcttctt acctactttg atattttctt
     2101 gcaaacagtc ttttatgaat ttttaattgt tgagaatgag ccaggaataa aactgctaca
     2161 ccagaaggag gggccccacg aagccgaaga cttgacaagg gggagacacc ccaagccctc
     2221 tggccaggga tggccaacac tgactgctcc gcgatggtct cgttccaggt gctaggacct
     2281 cagtcacggt caccttgatg ttcatgagac cctcctatga tcagtgaata aaaccatcaa
     2341 aactc
//
