LOCUS       NM_009531               3634 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus xeroderma pigmentosum, complementation group C (Xpc),
            mRNA.
ACCESSION   NM_009531
VERSION     NM_009531.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3634)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3634)
  AUTHORS   Larsen,M.C., Rondelli,C.M., Almeldin,A., Song,Y.S., N'Jai,A.,
            Alexander,D.L., Forsberg,E.C., Sheibani,N. and Jefcoate,C.R.
  TITLE     AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor
            Cells: The Enrichment of Multiple Olfactory Receptors as Potential
            Microbiome Sensors
  JOURNAL   Int J Mol Sci 24 (23), 16884 (2023)
   PUBMED   38069208
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3634)
  AUTHORS   Morgado-Palacin,L., Brown,J.A., Martinez,T.F., Garcia-Pedrero,J.M.,
            Forouhar,F., Quinn,S.A., Reglero,C., Vaughan,J., Heydary,Y.H.,
            Donaldson,C., Rodriguez-Perales,S., Allonca,E., Granda-Diaz,R.,
            Fernandez,A.F., Fraga,M.F., Kim,A.L., Santos-Juanes,J., Owens,D.M.,
            Rodrigo,J.P., Saghatelian,A. and Ferrando,A.A.
  TITLE     The TINCR ubiquitin-like microprotein is a tumor suppressor in
            squamous cell carcinoma
  JOURNAL   Nat Commun 14 (1), 1328 (2023)
   PUBMED   36899004
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3634)
  AUTHORS   Mulderrig,L., Garaycoechea,J.I., Tuong,Z.K., Millington,C.L.,
            Dingler,F.A., Ferdinand,J.R., Gaul,L., Tadross,J.A., Arends,M.J.,
            O'Rahilly,S., Crossan,G.P., Clatworthy,M.R. and Patel,K.J.
  TITLE     Aldehyde-driven transcriptional stress triggers an anorexic DNA
            damage response
  JOURNAL   Nature 600 (7887), 158-163 (2021)
   PUBMED   34819667
REFERENCE   5  (bases 1 to 3634)
  AUTHORS   Mickler,E.A., Zhou,H., Phang,T.L., Geraci,M.W., Stearman,R.S. and
            Sears,C.R.
  TITLE     Low-Coverage Whole Genome Sequencing Using Laser Capture Microscopy
            with Combined Digital Droplet PCR: An Effective Tool to Study Copy
            Number and Kras Mutations in Early Lung Adenocarcinoma Development
  JOURNAL   Int J Mol Sci 22 (21), 12034 (2021)
   PUBMED   34769463
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3634)
  AUTHORS   Li,L., Peterson,C. and Legerski,R.
  TITLE     Sequence of the mouse XPC cDNA and genomic structure of the human
            XPC gene
  JOURNAL   Nucleic Acids Res 24 (6), 1026-1028 (1996)
   PUBMED   8604333
REFERENCE   7  (bases 1 to 3634)
  AUTHORS   Sands,A.T., Abuin,A., Sanchez,A., Conti,C.J. and Bradley,A.
  TITLE     High susceptibility to ultraviolet-induced carcinogenesis in mice
            lacking XPC
  JOURNAL   Nature 377 (6545), 162-165 (1995)
   PUBMED   7675084
REFERENCE   8  (bases 1 to 3634)
  AUTHORS   Masutani,C., Sugasawa,K., Yanagisawa,J., Sonoyama,T., Ui,M.,
            Enomoto,T., Takio,K., Tanaka,K., van der Spek,P.J., Bootsma,D. et
            al.
  TITLE     Purification and cloning of a nucleotide excision repair complex
            involving the xeroderma pigmentosum group C protein and a human
            homologue of yeast RAD23
  JOURNAL   EMBO J 13 (8), 1831-1843 (1994)
   PUBMED   8168482
REFERENCE   9  (bases 1 to 3634)
  AUTHORS   Legerski,R. and Peterson,C.
  TITLE     Expression cloning of a human DNA repair gene involved in xeroderma
            pigmentosum group C
  JOURNAL   Nature 359 (6390), 70-73 (1992)
   PUBMED   1522891
  REMARK    Erratum:[Nature. 1992 Dec 10;360(6404):610. doi: 10.1038/360610b0..
            PMID: 1461286]
REFERENCE   10 (bases 1 to 3634)
  AUTHORS   Lynch,H.T., Fusaro,R.M. and Johnson,J.A.
  TITLE     Xeroderma pigmentosum. Complementation group C and malignant
            melanoma
  JOURNAL   Arch Dermatol 120 (2), 175-179 (1984)
   PUBMED   6696469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY238377.1, AK028595.1 and DV645509.1.
            
            On Jan 5, 2007 this sequence version replaced NM_009531.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166981.1, AK028595.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BY238377.1         2-64
            64-3629             AK028595.1         2-3567
            3630-3634           DV645509.1         348-352
FEATURES             Location/Qualifiers
     source          1..3634
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 40.55 cM"
     gene            1..3634
                     /gene="Xpc"
                     /note="xeroderma pigmentosum, complementation group C"
                     /db_xref="GeneID:22591"
                     /db_xref="MGI:MGI:103557"
     exon            1..183
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2882
                     /gene="Xpc"
                     /note="p125; xeroderma pigmentosum group C-complementing
                     protein homolog"
                     /codon_start=1
                     /product="DNA repair protein complementing XP-C cells
                     homolog"
                     /protein_id="NP_033557.2"
                     /db_xref="CCDS:CCDS39569.1"
                     /db_xref="GeneID:22591"
                     /db_xref="MGI:MGI:103557"
                     /translation="MAPKRTADGRRRKRGQKTEDNKVARHEESVADDFEDEKQKPRRK
                     SSFPKVSQGKRKRGCSDPGDPTNGAAKKKVAKATAKSKNLKVLKEEALSDGDDFRDSP
                     ADCKKAKKHPKSKVVDQGTDEDDSEDDWEEVEELTEPVLDMGENSATSPSDMPVKAVE
                     IEIETPQQAKERERSEKIKMEFETYLRRMMKRFNKEVQENMHKVHLLCLLASGFYRNS
                     ICRQPDLLAIGLSIIPIRFTKVPLQDRDAYYLSNLVKWFIGTFTVNADLSASEQDDLQ
                     TTLERRIAIYSARDNEELVHIFLLILRALQLLTRLVLSLQPIPLKSAVTKGRKSSKET
                     SVEGPGGSSELSSNSPESHNKPTTSRRIKEEETLSEGRGKATARGKRGTGTAGSRQRR
                     KPSCSEGEEAEQKVQGRPHARKRRVAAKVSYKEESESDGAGSGSDFEPSSGEGQHSSD
                     EDCEPGPRKQKRASAPQRTKAGSKSASKTQRGSQCEPSSFPEASSSSSGCKRGKKVSS
                     GAEEMADRKPAGVDQWLEVYCEPQAKWVCVDCVHGVVGQPVACYKYATKPMTYVVGID
                     SDGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPYRSLLTEREKKEDQEFQAKHLD
                     QPLPTSISTYKNHPLYALKRHLLKFQAIYPETAAVLGYCRGEAVYSRDCVHTLHSRDT
                     WLKQARVVRLGEVPYKMVKGFSNRARKARLSEPQLHDHNDLGLYGHWQTEEYQPPIAV
                     DGKVPRNEFGNVYLFLPSMMPVGCVQMTLPNLNRVARKLGIDCVQAITGFDFHGGYCH
                     PVTDGYIVCEEFRDVLLAAWENEQAIIEKKEKEKKEKRALGNWKLLVRGLLIRERLKL
                     RYGAKSEAAAPHAAGGGLSSDEEEGTSSQAEAARVLAASWPQNREDPEQKSEYTKMTR
                     KRRAAEASHLFPFEKL"
     exon            184..385
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            386..492
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            493..613
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            614..698
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            699..856
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            857..977
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1067
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1940
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2101
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2183
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2318
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2488
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2582
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2672
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..3634
                     /gene="Xpc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3614..3619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xpc"
                     /note="hexamer: AATAAA"
     polyA_site      3634
                     /gene="Xpc"
                     /note="major polyA site"
ORIGIN      
        1 ggccaggcgt ggcccgcctc cgggcggggc gggcacgcgg agacctgcgg cgtcctgcgc
       61 ggtagtcccg aggaacgcct ctggctagca tggccccaaa gcgcaccgca gacggaaggc
      121 ggcggaagcg gggccagaaa accgaggaca acaaagtagc ccggcacgag gagagcgttg
      181 cggatgactt tgaagatgag aagcagaaac cccgaaggaa gagctctttc ccgaaagtct
      241 ctcaaggaaa gaggaagagg ggctgcagtg atccagggga ccccacaaat ggtgcagcaa
      301 aaaagaaagt ggccaaagcc actgctaaat ccaagaatct caaggttctg aaggaggaag
      361 cactcagcga cggggatgac ttccgggact caccagctga ctgcaagaag gcaaagaaac
      421 acccaaaaag caaggtggtg gaccaaggca ctgatgaaga tgacagtgag gatgactggg
      481 aggaggtgga agagcttact gaacctgtgc tggacatggg agaaaattct gccacctcac
      541 cgtctgacat gcctgtgaag gcggtggaga ttgaaattga aacaccacag caggcgaaag
      601 aacgggaaag aagtgagaag ataaagatgg agtttgagac atacctgcgg aggatgatga
      661 agcgtttcaa taaagaagta caggagaaca tgcacaaggt tcacctgctg tgcctgctgg
      721 ccagtggctt ctatcgaaat agcatctgcc gacagccaga tctgctggcc attggcctct
      781 ccatcattcc aattcgcttt accaaggtgc cacttcaaga tagggatgcc tactaccttt
      841 caaacctggt aaagtggttc atcggaacct tcactgtcaa cgctgacctt tcagccagcg
      901 agcaggacga cctgcagacc accttggaaa ggaggattgc catttactct gcgagggata
      961 atgaagagtt ggtccatata tttcttctga ttcttcgggc tctgcagctg ctcacccggc
     1021 tggtcttgtc tctgcagccc attccactga agtcagctgt gacaaagggg aggaaatctt
     1081 ccaaggagac atctgtagag ggtcctggag gttcttcaga actctctagt aacagtccag
     1141 aaagccacaa caaacctacg accagcagga gaatcaaaga agaagaaacc ttgtctgagg
     1201 gcagaggcaa agcaaccgcc agggggaaga gaggcacagg cactgcgggc agcaggcagc
     1261 ggaggaagcc ctcttgcagc gagggagagg aggccgagca gaaagtccag ggccgtccac
     1321 atgcccggaa gcggcgtgtg gctgccaagg tgtcatacaa agaggagagt gagagcgatg
     1381 gggcaggcag cggctctgac tttgaaccgt ccagtgggga gggccagcat tcctctgatg
     1441 aggattgtga gcctggccct cgcaagcaga agagggcctc agctcctcag aggacaaagg
     1501 ctgggtctaa gagtgcttcc aagacccaac gcggaagcca gtgtgagccg tcaagctttc
     1561 cggaggcgtc ttcaagctct tcaggctgta agagaggcaa gaaggtttcc agtggtgctg
     1621 aagagatggc agataggaaa cctgctggtg tagaccagtg gctggaggtg tactgtgagc
     1681 cacaggcaaa gtgggtgtgt gtggactgtg tacatggtgt ggtgggccag cctgtggcct
     1741 gttacaaata tgccaccaaa cccatgacct atgttgtagg cattgacagt gatggctggg
     1801 tccgagatgt tactcagagg tatgacccag cctggatgac cgcaacccgc aagtgccggg
     1861 ttgatgctga gtggtgggct gagaccttga gaccctatcg gagcctactt acggagaggg
     1921 agaagaagga agaccaggag tttcaggcga agcacctgga ccagcctttg cccacctcca
     1981 tcagcacata caagaaccac cctctgtatg ccctgaagcg ccacctcttg aaattccagg
     2041 ctatctaccc tgagacagct gcggtgctcg ggtattgtcg tggagaagca gtctattcca
     2101 gggattgcgt gcataccttg cactccaggg acacatggct gaagcaagca agagtggtgc
     2161 ggcttggaga agtgccctat aagatggtga aaggcttctc taaccgtgcc cggaaagccc
     2221 ggctctcgga gccccagctg catgaccaca acgacttggg cctctatggt cactggcaga
     2281 cggaagagta tcagcctcct atagctgtcg atgggaaggt gcctcggaat gagtttggga
     2341 acgtgtacct cttcctgccc agcatgatgc ccgtcggctg tgtccagatg accctgccta
     2401 acctgaaccg ggtggcacgc aagctgggca tcgactgcgt gcaggccatc actggcttcg
     2461 atttccatgg aggctattgc catccagtaa ctgatggcta cattgtctgt gaggaattca
     2521 gagacgtgct gctggctgct tgggagaatg aacaggccat cattgaaaag aaggagaagg
     2581 agaaaaagga aaagcgggcg ctggggaact ggaagctgct ggtcagagga ctcctcatca
     2641 gagagaggct gaaactccgc tatggggcca agagcgaggc agcagctccc catgctgctg
     2701 gaggcggact ctcttctgat gaagaggaag ggaccagttc acaagcagaa gcagccagag
     2761 tcctggctgc ctcctggcca cagaaccgag aggatccaga acagaagtcc gagtacacta
     2821 agatgactcg gaagaggcgg gcggcagagg cttcccacct ctttccgttt gagaagctgt
     2881 gaagccagtg tcctccagcc agagaaggca gacagcaagc agatgggctg aggactacag
     2941 gccagatggg agctgtgcag cagatcagtc tgacaccaac ccagccggat ccccataggc
     3001 tggtgctggt gagctgctgt ttggaccact ttcctgggag ataccttcgg atccctggac
     3061 tttggtatct ttagaaatgt gagtttgttt tagagggtct tatttgttac cccagctggc
     3121 ttcaaattca aaatcgccct gacttatact gagggctgag attacaggcg tataccacaa
     3181 tgccttatct gtcctttatt tctgttttta aatagaactc actgggaaat tatgggtact
     3241 ggagcactga gacaaatctt cctttagtgc cgttcacaac gcttgctttc ctctccttca
     3301 gacccagggc atttgctttt caggcctgcc ttcctgagtc aggtttccag tactgcctgc
     3361 tgctcttttg tcagagaacg caggtcacct cttgtcaagg cacttttggg attttacact
     3421 gacagaagac tagaacaaag agctaaaaat caagaatgag aaaagaaaac agaattatga
     3481 aaatgttcat aaaagattag tttttggtta cattttattc aattctggat acatttactc
     3541 tgtactgatg atacattttc taagctgctg tatgctcttc tcaggaaaga gttcttttat
     3601 aggacctcca ggaaataaag catttaccta aaaa
//
