LOCUS       NP_033557                930 aa            linear   ROD 10-FEB-2025
DEFINITION  DNA repair protein complementing XP-C cells homolog [Mus musculus].
ACCESSION   NP_033557
VERSION     NP_033557.2
DBSOURCE    REFSEQ: accession NM_009531.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 930)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 930)
  AUTHORS   Larsen,M.C., Rondelli,C.M., Almeldin,A., Song,Y.S., N'Jai,A.,
            Alexander,D.L., Forsberg,E.C., Sheibani,N. and Jefcoate,C.R.
  TITLE     AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor
            Cells: The Enrichment of Multiple Olfactory Receptors as Potential
            Microbiome Sensors
  JOURNAL   Int J Mol Sci 24 (23), 16884 (2023)
   PUBMED   38069208
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 930)
  AUTHORS   Morgado-Palacin,L., Brown,J.A., Martinez,T.F., Garcia-Pedrero,J.M.,
            Forouhar,F., Quinn,S.A., Reglero,C., Vaughan,J., Heydary,Y.H.,
            Donaldson,C., Rodriguez-Perales,S., Allonca,E., Granda-Diaz,R.,
            Fernandez,A.F., Fraga,M.F., Kim,A.L., Santos-Juanes,J., Owens,D.M.,
            Rodrigo,J.P., Saghatelian,A. and Ferrando,A.A.
  TITLE     The TINCR ubiquitin-like microprotein is a tumor suppressor in
            squamous cell carcinoma
  JOURNAL   Nat Commun 14 (1), 1328 (2023)
   PUBMED   36899004
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 930)
  AUTHORS   Mulderrig,L., Garaycoechea,J.I., Tuong,Z.K., Millington,C.L.,
            Dingler,F.A., Ferdinand,J.R., Gaul,L., Tadross,J.A., Arends,M.J.,
            O'Rahilly,S., Crossan,G.P., Clatworthy,M.R. and Patel,K.J.
  TITLE     Aldehyde-driven transcriptional stress triggers an anorexic DNA
            damage response
  JOURNAL   Nature 600 (7887), 158-163 (2021)
   PUBMED   34819667
REFERENCE   5  (residues 1 to 930)
  AUTHORS   Mickler,E.A., Zhou,H., Phang,T.L., Geraci,M.W., Stearman,R.S. and
            Sears,C.R.
  TITLE     Low-Coverage Whole Genome Sequencing Using Laser Capture Microscopy
            with Combined Digital Droplet PCR: An Effective Tool to Study Copy
            Number and Kras Mutations in Early Lung Adenocarcinoma Development
  JOURNAL   Int J Mol Sci 22 (21), 12034 (2021)
   PUBMED   34769463
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 930)
  AUTHORS   Li,L., Peterson,C. and Legerski,R.
  TITLE     Sequence of the mouse XPC cDNA and genomic structure of the human
            XPC gene
  JOURNAL   Nucleic Acids Res 24 (6), 1026-1028 (1996)
   PUBMED   8604333
REFERENCE   7  (residues 1 to 930)
  AUTHORS   Sands,A.T., Abuin,A., Sanchez,A., Conti,C.J. and Bradley,A.
  TITLE     High susceptibility to ultraviolet-induced carcinogenesis in mice
            lacking XPC
  JOURNAL   Nature 377 (6545), 162-165 (1995)
   PUBMED   7675084
REFERENCE   8  (residues 1 to 930)
  AUTHORS   Masutani,C., Sugasawa,K., Yanagisawa,J., Sonoyama,T., Ui,M.,
            Enomoto,T., Takio,K., Tanaka,K., van der Spek,P.J., Bootsma,D. et
            al.
  TITLE     Purification and cloning of a nucleotide excision repair complex
            involving the xeroderma pigmentosum group C protein and a human
            homologue of yeast RAD23
  JOURNAL   EMBO J 13 (8), 1831-1843 (1994)
   PUBMED   8168482
REFERENCE   9  (residues 1 to 930)
  AUTHORS   Legerski,R. and Peterson,C.
  TITLE     Expression cloning of a human DNA repair gene involved in xeroderma
            pigmentosum group C
  JOURNAL   Nature 359 (6390), 70-73 (1992)
   PUBMED   1522891
  REMARK    Erratum:[Nature. 1992 Dec 10;360(6404):610. doi: 10.1038/360610b0..
            PMID: 1461286]
REFERENCE   10 (residues 1 to 930)
  AUTHORS   Lynch,H.T., Fusaro,R.M. and Johnson,J.A.
  TITLE     Xeroderma pigmentosum. Complementation group C and malignant
            melanoma
  JOURNAL   Arch Dermatol 120 (2), 175-179 (1984)
   PUBMED   6696469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY238377.1, AK028595.1 and DV645509.1.
            
            On Jan 5, 2007 this sequence version replaced NP_033557.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166981.1, AK028595.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 40.55 cM"
     Protein         1..930
                     /product="DNA repair protein complementing XP-C cells
                     homolog"
                     /note="p125; xeroderma pigmentosum group C-complementing
                     protein homolog"
                     /calculated_mol_wt=104391
     Region          1..134
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51612.2)"
     Site            93
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P51612.2)"
     Site            126
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q01831; propagated from
                     UniProtKB/Swiss-Prot (P51612.2)"
     Region          143..859
                     /region_name="rad4"
                     /note="DNA repair protein rad4; TIGR00605"
                     /db_xref="CDD:273170"
     Site            165
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q01831; propagated from
                     UniProtKB/Swiss-Prot (P51612.2)"
     Region          323..517
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51612.2)"
     Region          388..393
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P51612.2)"
     Site            395
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q01831; propagated from
                     UniProtKB/Swiss-Prot (P51612.2)"
     Site            397
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q01831; propagated from
                     UniProtKB/Swiss-Prot (P51612.2)"
     Region          489..727
                     /region_name="Interaction with RAD23B.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P51612.2)"
     Region          600..759
                     /region_name="Minimal sensor domain involved in damage
                     recognition. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P51612.2)"
     Region          600..734
                     /region_name="DNA-binding, preference for heteroduplex
                     DNA. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P51612.2)"
     Region          760..824
                     /region_name="DNA-binding, preference for single stranded
                     DNA, required for formation of stable nucleoprotein
                     complex. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P51612.2)"
     Region          809..930
                     /region_name="Interaction with ERCC2 and GTF2H1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P51612.2)"
     Region          840..859
                     /region_name="Interaction with CETN2.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P51612.2)"
     Region          867..930
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51612.2)"
     Site            875
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P51612.2)"
     Site            876
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P51612.2)"
     Site            883
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q01831; propagated from
                     UniProtKB/Swiss-Prot (P51612.2)"
     Site            895
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q01831; propagated from
                     UniProtKB/Swiss-Prot (P51612.2)"
     CDS             1..930
                     /gene="Xpc"
                     /coded_by="NM_009531.2:90..2882"
                     /db_xref="CCDS:CCDS39569.1"
                     /db_xref="GeneID:22591"
                     /db_xref="MGI:MGI:103557"
ORIGIN      
        1 mapkrtadgr rrkrgqkted nkvarheesv addfedekqk prrkssfpkv sqgkrkrgcs
       61 dpgdptngaa kkkvakatak sknlkvlkee alsdgddfrd spadckkakk hpkskvvdqg
      121 tdeddseddw eeveeltepv ldmgensats psdmpvkave ieietpqqak erersekikm
      181 efetylrrmm krfnkevqen mhkvhllcll asgfyrnsic rqpdllaigl siipirftkv
      241 plqdrdayyl snlvkwfigt ftvnadlsas eqddlqttle rriaiysard neelvhifll
      301 ilralqlltr lvlslqpipl ksavtkgrks sketsvegpg gsselssnsp eshnkpttsr
      361 rikeeetlse grgkatargk rgtgtagsrq rrkpscsege eaeqkvqgrp harkrrvaak
      421 vsykeesesd gagsgsdfep ssgegqhssd edcepgprkq krasapqrtk agsksasktq
      481 rgsqcepssf peasssssgc krgkkvssga eemadrkpag vdqwlevyce pqakwvcvdc
      541 vhgvvgqpva cykyatkpmt yvvgidsdgw vrdvtqrydp awmtatrkcr vdaewwaetl
      601 rpyrsllter ekkedqefqa khldqplpts istyknhply alkrhllkfq aiypetaavl
      661 gycrgeavys rdcvhtlhsr dtwlkqarvv rlgevpykmv kgfsnrarka rlsepqlhdh
      721 ndlglyghwq teeyqppiav dgkvprnefg nvylflpsmm pvgcvqmtlp nlnrvarklg
      781 idcvqaitgf dfhggychpv tdgyivceef rdvllaawen eqaiiekkek ekkekralgn
      841 wkllvrglli rerlklryga kseaaaphaa ggglssdeee gtssqaeaar vlaaswpqnr
      901 edpeqkseyt kmtrkrraae ashlfpfekl
//
