LOCUS       NM_011725               1056 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus X-linked lymphocyte-regulated (Xlr), transcript
            variant 1, mRNA.
ACCESSION   NM_011725 XM_006535357
VERSION     NM_011725.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1056)
  AUTHORS   Kang TH, Noh KH, Kim JH, Bae HC, Lin KY, Monie A, Pai SI, Hung CF,
            Wu TC and Kim TW.
  TITLE     Ectopic expression of X-linked lymphocyte-regulated protein pM1
            renders tumor cells resistant to antitumor immunity
  JOURNAL   Cancer Res 70 (8), 3062-3070 (2010)
   PUBMED   20395201
  REMARK    GeneRIF: X-linked lymphocyte-regulated protein pM1 (XMR), XLR, and
            SCP3 render tumor cells resistant to antitumor immunity
REFERENCE   2  (bases 1 to 1056)
  AUTHORS   Naillat F, Prunskaite-Hyyrylainen R, Pietila I, Sormunen R, Jokela
            T, Shan J and Vainio SJ.
  TITLE     Wnt4/5a signalling coordinates cell adhesion and entry into meiosis
            during presumptive ovarian follicle development
  JOURNAL   Hum Mol Genet 19 (8), 1539-1550 (2010)
   PUBMED   20106871
REFERENCE   3  (bases 1 to 1056)
  AUTHORS   Reynard LN, Turner JM, Cocquet J, Mahadevaiah SK, Toure A, Hoog C
            and Burgoyne PS.
  TITLE     Expression analysis of the mouse multi-copy X-linked gene
            Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a
            spermatid-expressed cytoplasmic protein, SLX/XMR
  JOURNAL   Biol Reprod 77 (2), 329-335 (2007)
   PUBMED   17475928
REFERENCE   4  (bases 1 to 1056)
  AUTHORS   Escalier D, Eloy L and Garchon HJ.
  TITLE     Sex-specific gene expression during meiotic prophase I: Xlr (X
            linked, lymphocyte regulated), not its male homologue Xmr (Xlr
            related, meiosis regulated), is expressed in mouse oocytes
  JOURNAL   Biol Reprod 67 (5), 1646-1652 (2002)
   PUBMED   12390899
  REMARK    GeneRIF: Xlr (X linked, lymphocyte regulated) was expressed in
            oocytes throughout meiotic prophase I. These findings indicate a
            sex-specific expression of two closely related members of the Xlr
            gene family during meiotic prophase I.
REFERENCE   5  (bases 1 to 1056)
  AUTHORS   Bergsagel PL, Timblin CR, Kozak CA and Kuehl WM.
  TITLE     Sequence and expression of murine cDNAs encoding Xlr3a and Xlr3b,
            defining a new X-linked lymphocyte-regulated Xlr gene subfamily
  JOURNAL   Gene 150 (2), 345-350 (1994)
   PUBMED   7821804
REFERENCE   6  (bases 1 to 1056)
  AUTHORS   Calenda A, Allenet B, Escalier D, Bach JF and Garchon HJ.
  TITLE     The meiosis-specific Xmr gene product is homologous to the
            lymphocyte Xlr protein and is a component of the XY body
  JOURNAL   EMBO J 13 (1), 100-109 (1994)
   PUBMED   8306953
REFERENCE   7  (bases 1 to 1056)
  AUTHORS   Garchon HJ, Loh E, Ho WY, Amar L, Avner P and Davis MM.
  TITLE     The XLR sequence family: dispersion on the X and Y chromosomes of a
            large set of closely related sequences, most of which are
            pseudogenes
  JOURNAL   Nucleic Acids Res 17 (23), 9871-9888 (1989)
   PUBMED   2602144
REFERENCE   8  (bases 1 to 1056)
  AUTHORS   Siegel JN, Turner CA, Klinman DM, Wilkinson M, Steinberg AD,
            MacLeod CL, Paul WE, Davis MM and Cohen DI.
  TITLE     Sequence analysis and expression of an X-linked,
            lymphocyte-regulated gene family (XLR)
  JOURNAL   J Exp Med 166 (6), 1702-1715 (1987)
   PUBMED   3681192
REFERENCE   9  (bases 1 to 1056)
  AUTHORS   Cohen,D.I., Hedrick,S.M., Nielsen,E.A., D'Eustachio,P., Ruddle,F.,
            Steinberg,A.D., Paul,W.E. and Davis,M.M.
  TITLE     Isolation of a cDNA clone corresponding to an X-linked gene family
            (XLR) closely linked to the murine immunodeficiency disorder xid
  JOURNAL   Nature 314 (6009), 369-372 (1985)
   PUBMED   2984575
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035025.1, AK012549.1 and BE686828.1.
            
            [WARNING] On Dec 5, 2023 this sequence was replaced by NM_011725.5.
            
            On or before Apr 25, 2014 this sequence version replaced
            XM_006535357.1, NM_011725.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1 and 2 both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012549.1, AK035341.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AK035025.1         3-12
            11-1042             AK012549.1         2-1033
            1043-1056           BE686828.1         3-16                c
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 30.06 cM"
     gene            1..1056
                     /gene="Xlr"
                     /note="X-linked lymphocyte-regulated"
                     /db_xref="GeneID:22441"
                     /db_xref="MGI:MGI:98976"
     exon            1..75
                     /gene="Xlr"
                     /inference="alignment:Splign:2.1.0"
     exon            76..201
                     /gene="Xlr"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..758
                     /gene="Xlr"
                     /note="isoform a is encoded by transcript variant 1;
                     X-linked lymphocyte-regulated protein pM1; X-linked gene
                     family of B-cell surface antigens; X-linked
                     lymphocyte-regulated complex"
                     /codon_start=1
                     /product="X-linked lymphocyte-regulated protein PM1
                     isoform a"
                     /protein_id="NP_035855.1"
                     /db_xref="CCDS:CCDS30139.1"
                     /db_xref="GeneID:22441"
                     /db_xref="MGI:MGI:98976"
                     /translation="MENWDLSSDEMQDGNAPELDVIEEHNPVTRDDENANPEEVVGDT
                     RSPVQNILGKFEGDINKRLHIKRKRMETYIKDSFKDSNVKLEQLWKTNKQERKKINNK
                     FCEQYITTFQKFDMDVQKFNEEQEKSVNNYQKEQQALKLSKCSQSQTLEAIKDMHENY
                     MEGLMNLETNNYNMLFDVDGELRKEMSVFKKDLMKHTLKYSSSFPSSD"
     exon            202..265
                     /gene="Xlr"
                     /inference="alignment:Splign:2.1.0"
     exon            266..300
                     /gene="Xlr"
                     /inference="alignment:Splign:2.1.0"
     exon            301..418
                     /gene="Xlr"
                     /inference="alignment:Splign:2.1.0"
     exon            419..518
                     /gene="Xlr"
                     /inference="alignment:Splign:2.1.0"
     exon            519..617
                     /gene="Xlr"
                     /inference="alignment:Splign:2.1.0"
     exon            618..1056
                     /gene="Xlr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtatgcttt gtggtggcca cgaagccgag ttcttgagga agcgaagttc ttgaggaagc
       61 cgagaagttc ttgagaaaac ctaaatttct tagtggaaag gcagtgtttt gaatattctc
      121 tagagacaac aatggaaaac tgggacttgt caagtgatga aatgcaagat gggaatgctc
      181 cagaattgga cgttattgaa gaacataatc cagtaactcg tgatgatgag aatgcaaatc
      241 ctgaagaagt agttggagat acacgatctc cagtacaaaa tattctggga aaatttgaag
      301 gtgacattaa caagaggctt cacataaaga gaaaacgcat ggaaacttat atcaaagatt
      361 ctttcaaaga cagcaacgtg aaattagaac aactttggaa aacgaacaaa caagagagaa
      421 agaagattaa caacaaattt tgtgagcagt atataactac atttcagaag tttgatatgg
      481 atgtccagaa attcaatgaa gaacaagaaa aatcagtgaa caattatcaa aaagaacaac
      541 aagcattaaa actgtccaaa tgtagtcaga gccagaccct ggaagcaatt aaagacatgc
      601 atgaaaacta catggagggt ctgatgaact tggagaccaa caactacaat atgctttttg
      661 atgtagatgg tgaactgaga aaagaaatgt cagtgtttaa aaaagacctc atgaagcata
      721 ctctgaagta ctcttctagt ttcccatctt cagactaagg aagcatgcat attttgcact
      781 tgctggtaca tttgtaacca aataaaaaat tcgctaactt ttttgtctcc tatgaaacag
      841 agtttgaaag gctctttaat ccttgttatt ctgatgattc taagaaggaa gttaaccccc
      901 agtgaagtta ttacaaagtt aactaggagg tataccttta gagtcaaaat agaactcctt
      961 tatttttaaa catctttaat cattttctta tttaagtgta agagcctgtt tatattaact
     1021 tccaaataaa atgttaataa atatgtgagt ggcaaa
//
