LOCUS       NM_183319               3925 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus X-linked Kx blood group related, X-linked (Xkrx),
            transcript variant 1, mRNA.
ACCESSION   NM_183319
VERSION     NM_183319.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3925)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3925)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ045765.1, CJ046079.1, CJ045779.1, AY534249.1 and BQ174759.1.
            
            On Jul 29, 2018 this sequence version replaced NM_183319.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY534249.1, BC150897.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849381,
                                           SAMN01164131 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               CJ045765.1         2-483
            483-883             CJ046079.1         7-407
            884-1031            CJ045779.1         148-295
            1032-3905           AY534249.1         1-2874
            3906-3925           BQ174759.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..3925
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 55.85 cM"
     gene            1..3925
                     /gene="Xkrx"
                     /gene_synonym="A630026F04"
                     /note="X-linked Kx blood group related, X-linked"
                     /db_xref="GeneID:331524"
                     /db_xref="MGI:MGI:3584011"
     exon            1..1384
                     /gene="Xkrx"
                     /gene_synonym="A630026F04"
                     /inference="alignment:Splign:2.1.0"
     CDS             1050..2399
                     /gene="Xkrx"
                     /gene_synonym="A630026F04"
                     /note="isoform 1 is encoded by transcript variant 1;
                     XK-related protein 2; Kell blood group complex
                     subunit-related, X-linked; X Kell blood group precursor
                     related X linked"
                     /codon_start=1
                     /product="XK-related protein 2 isoform 1"
                     /protein_id="NP_899142.2"
                     /db_xref="CCDS:CCDS30391.1"
                     /db_xref="GeneID:331524"
                     /db_xref="MGI:MGI:3584011"
                     /translation="MDRVYEIPEEPNVVPISSLEEDVIRGPNPRFTFPFSILFSTFLY
                     CGEAASALYMVRIYRKNNETFWMTYTFSFFMFSSIMVQLTLIFVHRDLAKDRPLSLFM
                     HLILLGPVIRCLEAMIKYLTLWKKEGQEEPYVSLTRKKMLIAGQEVLIEWEVGHSIRT
                     LAMHRNAYKRMSQIQAFLGSVPQLTYQLYVSLISAEVPLGRAVLMAFSLISVTYGATL
                     CNMLAIQIKYDDYKIRLGPLEVLCITVWRTLEITSRLVILVLFSATLKLKAVPFLVLN
                     FLIILFEPWVKFWRSGAQMPNNIEKNFSRVGTLVVLISVTILYAGINFSCWSAMQLKL
                     ADRDLVDKGQNWGHMGLHYSVRLVENVIMVLVFKYFGVKVLLNYCHSLIAVQLIIAYL
                     ISIGVMLLFFQYLHPLRSLFTNNVVDYLHCICCRRPRPERVENSETSCEADTTQSIV"
     exon            1385..1653
                     /gene="Xkrx"
                     /gene_synonym="A630026F04"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..3907
                     /gene="Xkrx"
                     /gene_synonym="A630026F04"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3884..3889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xkrx"
                     /gene_synonym="A630026F04"
                     /note="hexamer: AATAAA"
     polyA_site      3907
                     /gene="Xkrx"
                     /gene_synonym="A630026F04"
                     /note="major polyA site"
ORIGIN      
        1 aagtgggtgc atgctgctgc tccctagaga agaggaaaag ctgtggctcc ctcctggatc
       61 ccgaggtcac ggtgagaaat actgctgaag actggtgcag gctcctcttg tgttgtgcct
      121 cgctacctgg agcatccttt ggctattctt cttggaactc cggcttattt tgttttgcct
      181 ggctgtctct ccctctcgcc gggccaacgc caccactacc ccacccgaag tcatccaggt
      241 gccatagtta ccaaagctca ggacccacag tacttctcga actgtgcctt tcggtagcaa
      301 agtgtctccg tgaacacacc cctccagcat cctctatctg gtgccacgcg ctccgcttct
      361 ttccgaggag acatcattca ggacagtggc cttactttgg cccctaacca ggcggtctta
      421 ggggcggggc ctggagaacc tacttgagaa catttgcctc cctacaggtc ctgagacagc
      481 accgctgagc ctgcgagcag gctagctaat aggcacaacc tagcagcaca ttggatggat
      541 tcctaggtgc taaactgaat ctttgacagg acacccaggc tgcgctccct cttctacctt
      601 ggctcagttc tctgatgatt tgagaggata cacggatgag aatccctaag gagaagctgc
      661 tgagtatgtg atgtgcctcc tcaaagtggc tactcccctg aaaggagcct cgggggaaac
      721 agctgttcct tgccttttca cacgcctgga attggacacc agattcagtg ctggagtgct
      781 tgtccaagtt tctcagcaca tatgttgaag attgcatttc agggccaatc acgagtgaag
      841 ttcaaagaga cactcctgga ctctccactc cagacttaga gttaagtcta gaagtgaagt
      901 gtctcctgta ctgacttgtt ggtctacatt cagggactca actagccacg gtcctcctga
      961 ctgatccctg aacagcagtg gctacggggc ctcttttcag gatggatggc gaagagctct
     1021 gaactccaga cagtaagaga gtctcaacaa tggacagagt ttatgaaatt cctgaggagc
     1081 caaatgtggt tcccatttca tctctggaag aagatgtcat ccgggggcct aacccacgct
     1141 ttaccttccc gtttagtatc ctcttctcca cctttttgta ctgtggggag gctgcgtctg
     1201 ctttgtacat ggttagaatt taccgaaaga ataatgaaac cttctggatg acatacacat
     1261 tttccttttt catgttttca tctatcatgg ttcagttgac cctcattttt gtccacagag
     1321 acctggccaa agatagacca ctatcattat ttatgcatct aatcctcttg ggacctgtta
     1381 tcagatgttt ggaggccatg attaaatacc ttacactgtg gaagaaagag gggcaggagg
     1441 agccatatgt cagcctcacc cgaaagaaga tgctaatagc tggccaggag gtgctgatag
     1501 aatgggaggt gggccactcc atccggaccc tggctatgca tcgcaatgcc tacaaacgta
     1561 tgtcacagat tcaagccttc ctgggctcag tgccccagct gacctatcag ctatatgtga
     1621 gtctgatctc agcagaagtc cccctgggta gagctgtgtt aatggctttt tccctgatat
     1681 ctgtcaccta cggggctacc ctgtgcaata tgttggctat ccagatcaag tatgatgact
     1741 acaagattag actggggcca ctggaagtcc tttgtatcac cgtctggagg acattggaga
     1801 tcacttcccg cctcgtgatt ctggtgctct tctcggccac cttgaagttg aaggctgtgc
     1861 ccttcttagt gctcaacttc ttgatcatcc tctttgagcc ctgggtcaag ttctggagga
     1921 gtggtgccca aatgccaaac aatattgaga aaaacttcag ccgagttggc actctggtgg
     1981 tactgatttc ggtcaccatt ctctatgctg gcatcaactt ctcttgctgg tcagccatgc
     2041 agttgaagtt ggcagacaga gaccttgttg acaaaggtca gaactgggga catatgggac
     2101 tgcactatag tgtgaggctg gtagagaatg tgatcatggt cttggttttt aagtacttcg
     2161 gagtcaaagt gttactgaat tattgtcatt ccttgattgc agtgcagctt attattgctt
     2221 atctgatttc cattggggtc atgcttctct tcttccagta cttgcacccc ctgcgctcac
     2281 tcttcaccaa taacgtagta gactacctcc attgtatctg ctgccgcaga ccccgtccgg
     2341 aaagggttga gaactcagag acatcctgtg aagctgacac aacacaaagt attgtctgat
     2401 tttttttttc ttctgtacat tataggatgg gtctgggtta acacaagcaa ctgtgaaatt
     2461 gaaggagttg gtgagatccc tgtgtgtgag tactcacagg atcatttgct tgacacttct
     2521 agtaaaccta ttgaaagaaa gagtgacctg caaagaggtt ttacttcttt aggattgact
     2581 gctaggtttg gataccagca ctaaccctaa ccctagccct agccctagcc ctaaccctaa
     2641 ccctagccct aaccctaacc ctaaccctag ccctaaccct agccctaacc ctaaccctag
     2701 ccctaaccct agccctaacg ctaaccctag ccctagccct aaccctagcc ctaacgctaa
     2761 ccctagccct agccctaacc ctagctctaa tgctaaccct agccctaacg ctaaccctag
     2821 ccctagccct agccctaacc ctaaccctaa ccctaaccct aaccctaacc ctaaccctaa
     2881 ccctaaccct ggaataacct ctatgtcctt cactcaggct ctgaatttcc agctttgctc
     2941 atttgcttaa ggtattgctg agcttccctg ggctaatcta aactctgcca gaactcaact
     3001 gtactgatca gggaatgtga tggcttacta agaatgagcg ccttccagaa agtagtctga
     3061 ctgttgtact ttttgttttg ttttgattta ggtttttatt tgagacaggg tttctctgtg
     3121 tagccctggc tgtcctggaa ctcactttgt agaccaggct ggcctcaaac tcagaaatcc
     3181 accttcctct tcctcccaag tgctgagatt aaaggcatgc gccaccaccg cctggctggc
     3241 tgttgtactt ttaactgtga gagtggctgg gatatttgta ttctaatgag gaactgtggc
     3301 taagaagaag gctccattat tgaagaaagc tactccccaa atgagttaat accccatgag
     3361 tattttactg ggggtcattc agcaaagact tctcctttaa gaaatccttc ataggcactc
     3421 tctttggacg gcgtacagaa taagattcct tcctataggg aatgaggcgg gatctcatga
     3481 ctctcggact gggctcaacg tcactatgta gctaagaact acgtggcctg atctttctgc
     3541 ctttaccttc tgtgtgctgg aattgcagat gcgtaccact gcatttggtt tatataatgc
     3601 tgaggactga acccagggct aggcaagcac tatttataca gtactaggcc ctggaactgg
     3661 ggtcaggtaa acactctacc aactgagaca tccttggccc ccagaatgcc tcttaaggac
     3721 ctgtgtaggc ctccagcctc attgagagaa atgtttgaat gaaatttcgg gtgccccatt
     3781 agaggaattc cctccaattc agcttttctg tctctgcctt ttgttacttg atgtaaacct
     3841 cagagaagct aaactgtaat ttgaagtgtt tactgatatg tgaaataaat gaagatttct
     3901 ttgtgtcaaa aaaaaaaaaa aaaaa
//
