LOCUS       NM_001011874            3652 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus X-linked Kx blood group related 4 (Xkr4), mRNA.
ACCESSION   NM_001011874 XM_911601
VERSION     NM_001011874.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3652)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3652)
  AUTHORS   Maruoka,M., Zhang,P., Mori,H., Imanishi,E., Packwood,D.M.,
            Harada,H., Kosako,H. and Suzuki,J.
  TITLE     Caspase cleavage releases a nuclear protein fragment that
            stimulates phospholipid scrambling at the plasma membrane
  JOURNAL   Mol Cell 81 (7), 1397-1410 (2021)
   PUBMED   33725486
  REMARK    GeneRIF: Caspase cleavage releases a nuclear protein fragment that
            stimulates phospholipid scrambling at the plasma membrane.
REFERENCE   3  (bases 1 to 3652)
  AUTHORS   Suzuki,J., Imanishi,E. and Nagata,S.
  TITLE     Exposure of phosphatidylserine by Xk-related protein family members
            during apoptosis
  JOURNAL   J Biol Chem 289 (44), 30257-30267 (2014)
   PUBMED   25231987
  REMARK    GeneRIF: Unlike Xkr8, which is ubiquitously expressed, Xkr4 and
            Xkr9 expression is tissue-specific.
REFERENCE   4  (bases 1 to 3652)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY534250.1.
            
            On Dec 7, 2005 this sequence version replaced XM_911601.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY534250.1, SRR7345562.3730440.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3652
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 1.6 cM"
     gene            1..3652
                     /gene="Xkr4"
                     /gene_synonym="Gm210; mKIAA1889; XRG4"
                     /note="X-linked Kx blood group related 4"
                     /db_xref="GeneID:497097"
                     /db_xref="MGI:MGI:3528744"
     exon            1..947
                     /gene="Xkr4"
                     /gene_synonym="Gm210; mKIAA1889; XRG4"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..2094
                     /gene="Xkr4"
                     /gene_synonym="Gm210; mKIAA1889; XRG4"
                     /note="X Kell blood group precursor related family member
                     4"
                     /codon_start=1
                     /product="XK-related protein 4"
                     /protein_id="NP_001011874.1"
                     /db_xref="CCDS:CCDS14803.1"
                     /db_xref="GeneID:497097"
                     /db_xref="MGI:MGI:3528744"
                     /translation="MAAKSDGRLKMKKSSDVAFTPLQNSDNSGSVQGLAPGLPSGSGA
                     EDTEAAGGGCCPDGGGCSRCCCCCAGSGGSAGSGGSGGGGRGSGAGSAALCLRLGREQ
                     RRYSLWDCLWILAAVAVYFADVGTDIWLAVDYYLRGQRWWFGLTLFFVVLGSLSVQVF
                     SFRWFVHDFSTEDSSTTTTSSCQQPGADCKTVVSSGSAAGEGEVRPSTPQRQASNASK
                     SNIAATNSGSNSNGATRTSGKHRSASCSFCIWLLQSLIHILQLGQIWRYLHTIYLGIR
                     SRQSGESGRWRFYWKMVYEYADVSMLHLLATFLESAPQLVLQLCIIVQTHSLQALQGF
                     TAAASLVSLAWALASYQKALRDSRDDKKPISYMAVIIQFCWHFFTIAARVITFALFAS
                     VFQLYFGIFIVLHWCIMTFWIVHCETEFCITKWEEIVFDMVVGIIYIFSWFNVKEGRT
                     RCRLFIYYFVILLENTALSALWYLYKAPQIADAFAIPALCVVFSSFLTGVVFMLMYYA
                     FFHPNGPRFGQSPSCACDDPATAFSLPPEVATSTLRSISNNRSVASDRDQKFAERDGC
                     VPVFQVRPTAPPTPSSRPPRIEESVIKIDLFRNRYPAWERHVLDRSLRKAILAFECSP
                     SPPRLQYKDDALIQERLEYETTL"
     exon            948..1147
                     /gene="Xkr4"
                     /gene_synonym="Gm210; mKIAA1889; XRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..3634
                     /gene="Xkr4"
                     /gene_synonym="Gm210; mKIAA1889; XRG4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3612..3617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xkr4"
                     /gene_synonym="Gm210; mKIAA1889; XRG4"
                     /note="hexamer: ATTAAA"
     polyA_site      3634
                     /gene="Xkr4"
                     /gene_synonym="Gm210; mKIAA1889; XRG4"
                     /note="major polyA site"
ORIGIN      
        1 gcggcggcgg gcgagcgggc gctggagtag gagctgggga gcggcgcggc cggggaagga
       61 agccagggcg aggcgaggag gtggcgggag gaggagacag cagggacagg tgtcagataa
      121 aggagtgctc tcctccgctg ccgaggcatc atggccgcta agtcagacgg gaggctgaag
      181 atgaagaaga gcagcgacgt ggcgttcacc ccgctgcaga actcggacaa ttcgggctct
      241 gtgcaaggac tggctccagg cttgccgtcg gggtccggag ccgaggacac ggaggcggcc
      301 ggaggcggct gctgcccgga cggcggtggc tgctcgcgct gctgctgctg ctgcgcgggg
      361 agcggcggct cggcgggctc gggcggctcg ggcggcggcg gccggggcag cggggcgggc
      421 tctgcggcgc tgtgcctgcg cctgggcagg gagcagcggc gttactcgct gtgggactgc
      481 ctctggatcc tggccgccgt ggccgtgtac ttcgcggatg tgggaacgga catctggctc
      541 gcggtggact actacctgcg tggccagcgc tggtggtttg ggctcaccct cttcttcgtg
      601 gtgctgggct ccctttctgt gcaagtgttc agcttccgct ggtttgtgca tgatttcagc
      661 accgaggaca gctccacgac caccacctcc agctgccagc agcctggagc agattgcaag
      721 acggtggtca gcagtgggtc tgcagccggg gaaggcgagg ttcgtccttc cacgccgcag
      781 aggcaagcat ccaacgccag caagagcaac atcgccgcca ccaacagcgg cagcaacagc
      841 aacggggcca cccggaccag cggcaaacac aggtctgcgt cctgctcctt ttgcatctgg
      901 ctcctgcagt cactcatcca catcttgcag cttgggcaaa tctggaggta tttgcacaca
      961 atatacttag gtatccggag ccggcagagt ggggagagcg gcaggtggcg gttttactgg
     1021 aagatggtgt acgagtatgc agatgtgagc atgctgcatc tgctagccac ttttctggaa
     1081 agtgctccac aattggtcct gcagctctgc attattgtac agactcacag cttacaggcc
     1141 ctccaaggtt tcacagcagc agcctccctt gtgtccttgg cttgggccct agcctcctac
     1201 cagaaggctc ttcgggactc ccgagatgac aaaaagccca tcagctacat ggctgtcatc
     1261 attcagttct gctggcattt cttcaccatc gctgccaggg tcatcacatt cgccctcttt
     1321 gcctcggttt tccagctgta ttttgggata tttattgtcc tccattggtg catcatgact
     1381 ttctggattg tccactgtga gacagaattc tgtatcacca aatgggaaga gattgtgttt
     1441 gacatggtgg tgggcatcat ctacatcttc agttggttca atgtcaagga aggcaggaca
     1501 cgctgcaggc tgttcattta ctattttgta atccttttgg aaaatacagc cttgagtgca
     1561 ctctggtacc tctacaaagc tccccagatt gcagatgcat ttgccatccc tgcattgtgc
     1621 gtggttttca gcagcttttt aacaggtgtt gtttttatgc tgatgtacta tgccttcttt
     1681 catcccaatg ggcccagatt tgggcaatca ccaagttgtg cttgtgatga tccagccact
     1741 gccttctctc tgcctccaga agtagccaca agcacactac ggtccatctc caacaaccgc
     1801 agtgttgcca gtgaccgtga tcagaaattt gcagagcggg atggatgtgt acctgtgttt
     1861 caagtgagac caactgcacc acccacccca tcatctcgac caccacggat tgaagaatca
     1921 gtcattaaaa ttgacctgtt caggaataga tatccagcat gggagagaca tgtgttagat
     1981 cgaagcctga gaaaggccat tttagccttt gaatgttccc catctcctcc aaggctgcag
     2041 tacaaggatg atgcccttat tcaggagagg ctggaatatg aaaccacttt ataaaataca
     2101 aggagccgca atgtccacat gaaggggtaa cagcagggct gtggcaataa tgacacctta
     2161 tccaagagta gggcagcgag ctgtatgttc ttagttgtgg tatggtttga tcttccatca
     2221 gctgactgcc tgctgctggt gtctattcaa gccagcagtg ctgagagtct cttacactgt
     2281 cagcttaata tgactgttgc tacaaactcc tccagcagag atttggggca cattcactgg
     2341 aggataacat tattgtgaaa aatgttgcct ctaatcatta gggtattttg atgggtttta
     2401 ctaagttttg cataaatata ttcacacacc accataccac ccctcaatca aaggagttaa
     2461 ggtggggatg gagagatgac tcattagtta agagcactga ctgctcttgc aaaggaccca
     2521 ggcttgagta gttcactgca actctaattc cagaagatct aatgtccatt tttggcctcc
     2581 tcaagcactg cacacacatg gtgcatagac atatatgcag gcaaaatacc catacacata
     2641 gcataaaaat aaatctcaaa gaaaaaaagc ttaggtgatt tccttgatgc aaagctcaca
     2701 acatactcca ggaagaaagc agcatacttg ggacaattat ataaactgtt ctctcctttg
     2761 caaaccagta gcatcaatga agtggacagc aagactcaag tgtttacact cgtactaact
     2821 agctttgatg ggatgattct ttttctacat atttcaggat ttgtttttac ttttaggttt
     2881 tgcagatgag aacattcttc atgacagaaa tcctatgcag cacttatatg gcttttgatg
     2941 agaccaagga gctcaatatc tgtaatgtaa attaaatgct aatcataatt cagtattcag
     3001 ttgcaaaaat acaatatata aaaagagtct ttggggaagg gacagagtga gattcagatt
     3061 ctcaggtgtg tgcatcttat attggaatgc acccacagag ccacaggaga ggaacaggga
     3121 ctatttcaag gtctgtgttc atgtctgttt ccagaactgt ttccaggtgc agaatgacat
     3181 gggtcagcag gtatgattcc ggaaaccacg tgccacatct ttcgagtgcc aaattttgtc
     3241 caattacaga actgatatgg aatccccaaa atctgagaat aagtggtttc ccaaaacaga
     3301 caaaagaaga ataatcaggt tccctgctgt gtacagactt accctcttcc catccaaggt
     3361 caaaatgatg tgtctactag agactttggg acacaattta gcaagtgaga gcatacagat
     3421 gcaatgtgta tgccattaaa aatactgcct ggactgcttg agggcttacc actccatcag
     3481 ctaagatttg tatttgaatc atctgtaaat tcgtgctctt acaagcttct gagttttaaa
     3541 tacctccaca cagcaagtaa acattcccgc tttctgtttt cggtgtcctt ggtcatggtg
     3601 ctttttgttg cattaaaagt gccggtcaaa ctttaaaaaa aaaaaaaaaa aa
//
