LOCUS       NM_023500               5062 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus X-linked Kx blood group (Xk), mRNA.
ACCESSION   NM_023500
VERSION     NM_023500.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5062)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5062)
  AUTHORS   Chhetri,G., Ke,Y., Wang,P., Usman,M., Li,Y., Sapp,E., Wang,J.,
            Ghosh,A., Islam,M.A., Wang,X., Boudi,A., DiFiglia,M. and Li,X.
  TITLE     Impaired XK recycling for importing manganese underlies striatal
            vulnerability in Huntington's disease
  JOURNAL   J Cell Biol 221 (10) (2022)
   PUBMED   36099524
  REMARK    GeneRIF: Impaired XK recycling for importing manganese underlies
            striatal vulnerability in Huntington's disease.
REFERENCE   3  (bases 1 to 5062)
  AUTHORS   Ryoden,Y., Segawa,K. and Nagata,S.
  TITLE     Requirement of Xk and Vps13a for the P2X7-mediated phospholipid
            scrambling and cell lysis in mouse T cells
  JOURNAL   Proc Natl Acad Sci U S A 119 (7) (2022)
   PUBMED   35140185
REFERENCE   4  (bases 1 to 5062)
  AUTHORS   Hung,C.H., Lee,T.L., Huang,A.Y., Yang,K.C., Shyu,Y.C., Wen,S.C.,
            Lu,M.J., Yuan,S. and Shen,C.J.
  TITLE     A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL
            Sustaining the Erythropoiesis
  JOURNAL   Int J Mol Sci 22 (15), 8024 (2021)
   PUBMED   34360789
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5062)
  AUTHORS   Suzuki,J., Imanishi,E. and Nagata,S.
  TITLE     Exposure of phosphatidylserine by Xk-related protein family members
            during apoptosis
  JOURNAL   J Biol Chem 289 (44), 30257-30267 (2014)
   PUBMED   25231987
REFERENCE   6  (bases 1 to 5062)
  AUTHORS   Means,G.D., Toy,D.Y., Baum,P.R. and Derry,J.M.
  TITLE     A transcript map of a 2-Mb BAC contig in the proximal portion of
            the mouse X chromosome and regional mapping of the scurfy mutation
  JOURNAL   Genomics 65 (3), 213-223 (2000)
   PUBMED   10857745
REFERENCE   7  (bases 1 to 5062)
  AUTHORS   Stanfield,G.M. and Horvitz,H.R.
  TITLE     The ced-8 gene controls the timing of programmed cell deaths in C.
            elegans
  JOURNAL   Mol Cell 5 (3), 423-433 (2000)
   PUBMED   10882128
REFERENCE   8  (bases 1 to 5062)
  AUTHORS   Collec,E., Colin,Y., Carbonnet,F., Hattab,C., Bertrand,O.,
            Cartron,J.P. and Kim,C.L.
  TITLE     Structure and expression of the mouse homologue of the XK gene
  JOURNAL   Immunogenetics 50 (1-2), 16-21 (1999)
   PUBMED   10541802
REFERENCE   9  (bases 1 to 5062)
  AUTHORS   Uwechue,I.C., Cooper,B.F., Goble,C., Hacker,T., Blair,H.J.,
            Burke,D.T., Herman,G. and Boyd,Y.
  TITLE     The mouse X-linked developmental mutant, tattered, lies between
            DXMit55 and Xkh and is associated with hyperkeratinization
  JOURNAL   Genomics 37 (2), 238-241 (1996)
   PUBMED   8921395
REFERENCE   10 (bases 1 to 5062)
  AUTHORS   Blair,H.J., Ho,M., Monaco,A.P., Fisher,S., Craig,I.W. and Boyd,Y.
  TITLE     High-resolution comparative mapping of the proximal region of the
            mouse X chromosome
  JOURNAL   Genomics 28 (2), 305-310 (1995)
   PUBMED   8530041
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007734.1, AL672060.9 and BP764926.1.
            
            On Mar 24, 2007 this sequence version replaced NM_023500.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007734.1, AY534248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1711              AK007734.1         1-1711
            1712-4558           AL672060.9         120446-123292
            4559-5062           BP764926.1         28-531              c
FEATURES             Location/Qualifiers
     source          1..5062
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 4.22 cM"
     gene            1..5062
                     /gene="Xk"
                     /gene_synonym="1810038K19Rik; Xkh; XRG1"
                     /note="X-linked Kx blood group"
                     /db_xref="GeneID:22439"
                     /db_xref="MGI:MGI:103569"
     exon            1..451
                     /gene="Xk"
                     /gene_synonym="1810038K19Rik; Xkh; XRG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1547
                     /gene="Xk"
                     /gene_synonym="1810038K19Rik; Xkh; XRG1"
                     /note="McLeod syndrome gene homolog; membrane transport
                     protein XK; Kell blood group precursor (McLeod phenotype)
                     homolog; XK homolog; XK-related protein 1"
                     /codon_start=1
                     /product="endoplasmic reticulum membrane adapter protein
                     XK"
                     /protein_id="NP_075989.1"
                     /db_xref="CCDS:CCDS30008.1"
                     /db_xref="GeneID:22439"
                     /db_xref="MGI:MGI:103569"
                     /translation="MKFPASVIASVFLFVAETAAALYLSSTYRSAGDRMWQVLTLLFS
                     LMPCALVQFTLLFVHRDLSRDRPLALLMHLLQLGPLYRCCEVFCIYCQSDQNEEPYVS
                     ITKKRQMPKDGLSEEVEKEVGQAEGKLITHRSAFSRASVIQAFLGSAPQLTLQLYITV
                     LEQNITTGRCFIMTLSLLSIVYGALRCNILAIKIKYDEYEVKVKPLAYVCIFLWRSFE
                     IATRVIVLVLFTSVLKIWVVAVILVNFFSFFLYPWIVFWCSGSPFPENIEKALSRVGT
                     TIVLCFLTLLYAGINMFCWSAVQLKIDNPELISKSQNWYRLLIYYMTRFIENSVLLLL
                     WYFFKTDIYMYVCAPLLILQLLIGYCTGILFMLVFYQFFHPCKKLFSSSVSESFRALL
                     RCACWSSLRRKSSEPVGRIDTDLKACTEQDVMPTTSKVIPEATDIWTAVDLCSA"
     exon            452..714
                     /gene="Xk"
                     /gene_synonym="1810038K19Rik; Xkh; XRG1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..5043
                     /gene="Xk"
                     /gene_synonym="1810038K19Rik; Xkh; XRG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1691..1696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xk"
                     /gene_synonym="1810038K19Rik; Xkh; XRG1"
                     /note="hexamer: ATTAAA"
     polyA_site      1714
                     /gene="Xk"
                     /gene_synonym="1810038K19Rik; Xkh; XRG1"
ORIGIN      
        1 gctgtttcgg ttgcccccag gccgggtggc agcgcgcgcc ggggcccgcg agccctcagc
       61 gggctgagct gcgcgcgagc cgctcggggc tgagcatgct gggagtcgtt cgggaaaccg
      121 ccaccgtcgc cgctaccgcc accgctaccg ccgtcgctgc caccgccgcc gccgccggcc
      181 gcggtgcgag tccctgaggc acggagatga aattcccggc ctcggtgata gcgtccgtgt
      241 tcctgttcgt ggccgagacg gcggcggcgc tctacttgag cagcacctac cgctccgcag
      301 gggaccgcat gtggcaggtg ctgacgctgc tcttctcctt gatgccctgc gccctggtgc
      361 agttcacgct cctcttcgtc caccgcgacc tcagccgcga tcgcccactg gcgctgctca
      421 tgcacctgct ccagctcggg cccctgtaca ggtgttgtga agtcttttgt atctactgtc
      481 agtccgacca gaatgaagaa ccttatgtga gcatcactaa gaaacgacag atgccaaaag
      541 atggcctttc agaggaggtg gagaaagagg ttggccaggc agaaggcaag ctgattaccc
      601 accgttctgc attcagccgg gcatcagtga tacaggcttt cctaggctct gccccacaac
      661 tgaccctaca actgtatata actgtcttgg agcagaacat cactactgga agatgcttca
      721 tcatgacctt gtccctgctg tctattgtct atggcgcctt acgttgcaac atcttagcca
      781 tcaaaatcaa gtatgatgag tatgaggtca aagtcaaacc cctggcttat gtctgtatct
      841 tcctctggag aagctttgag attgccaccc gagtcatcgt cctggtcctc tttacctctg
      901 tcctgaagat ctgggtggtg gcagtcatac tcgtcaactt cttcagcttc ttcttatatc
      961 cctggatcgt tttctggtgc agtggctccc cattccctga gaacatagag aaggccctaa
     1021 gtagggtggg taccaccatc gtgctctgct tcctcacttt actctatgcc ggcatcaaca
     1081 tgttctgctg gtcagctgtt cagctgaaaa tcgacaatcc ggagctcatc agcaagtccc
     1141 agaactggta ccgcctgctc atttactaca tgacgagatt catcgagaac tccgtcctcc
     1201 tgctcctgtg gtattttttt aaaactgaca tatacatgta tgtgtgtgcg cctctgttga
     1261 tcttgcagct gcttattggg tactgcactg gcattctctt catgcttgtg ttctatcagt
     1321 ttttccaccc ttgcaaaaag ctcttctcct ccagtgtttc ggaaagcttt agggcacttc
     1381 tcaggtgtgc ctgttggtcc tccctgagga gaaaatccag cgagccagta ggaaggatag
     1441 acacagactt aaaggcgtgc acagagcaag atgtaatgcc tactaccagt aaagtgatcc
     1501 ccgaggccac tgacatctgg actgctgttg atctgtgctc tgcttaatga gacccgaggc
     1561 ttctgacaag taatgagcct tcacacacat catgagccct gcgcagggac taaggcacga
     1621 agttagctgt cagttccctg tgagctgcta ccttttataa accccttggc tttgaggcag
     1681 ctttgagtgc attaaagaag cctactaccc cacagtttgt ttcgcatttg actctgttct
     1741 gttcttgcat cctcactggc catttcattg attgacacag tatccctgaa gtttcagttg
     1801 agctggtcat actcatcatt agaatgaaga gaaatgctcg ttttctagtt cctagcctgt
     1861 tgtctcagta gcctaatgct ttactactac tgaatatagc tttatacaag agtcaccatg
     1921 atagctggga taggttccta gggattttac aactttgttc caattatagc ttataggaga
     1981 gctatttaag tttgttttat tggtatgttc cattttcacc tcactaagac tttttgtaca
     2041 taaccaactg tagccactct ggcatgcaat gtgcattttg tttcaagggc ctacatttgg
     2101 gactttagga tccattggta cagttactta ggaaagccgt gtttcattcc acatgttgaa
     2161 gaaagtaggg atcaggatcg attgagacaa ctgttaaaac atcaaaaacg atggaagctc
     2221 atacaaatat ctaaatgttt aaaatatgaa ttgctcagaa ggtaggcttc attctcctca
     2281 taattcaggc ttgtcctata attctgagaa atttctagta gaattttcta agattaatat
     2341 tttaagaagg aagaaaataa aactaatagt ctccacctct atctttccct tccttgcgtg
     2401 ccaggcaagt tttaaacaag ccttttaacc tcagttcatt tgctgttgtt tctagaaagc
     2461 tctgtagaaa tctgtttcct gatgcaagta tacaggacat tttatttttc acaatcttaa
     2521 gaaaaagaag tgttttcctc actaccatcc ttagttagaa atgttgatct tagaaacttt
     2581 ttaagttata gaaagtaatg aaatgatcaa gtttttgttc ctcatgaaat ccattttgac
     2641 ttaatagcag ttcattttca tgagatactc agttttgtcc tccacaccat ttcatctaat
     2701 ggataatttc tctctcatct ggaagtattt attttaattt aaaagggttg gatagaatat
     2761 tgtcagtact ctgacaaagg tgccagcaag caatgctatg atctctacca ctaaatgtgg
     2821 atgatgaaat gtctacaaac aagtgaccat gaaattcaca ccaacttaac ttgaaaattg
     2881 taacaaaatg taatgcattt ccaaaggcac ccctatttgt gattctatgg gatagaatag
     2941 atattcaatt ttctgatcac ctaaatacat aaaacacatt tatctggcca tcatactcct
     3001 cataattgct ttttaaaaac tcttttggta tcaaattgat gagaaatttc ataaacaaat
     3061 gaacattcag tttggtaagt attttactat actagaggct tcgtaaaata gtaagtattc
     3121 tttgatgtgt cattcacgct gttaatcttt gtaccatttt gtatgcacac atttcagtaa
     3181 ggttctgaac cacagagcgt ccgttttctt tcctgaaata tttttcctca tttgtacttc
     3241 ttctgtttta ccaggatttg tggtttacct gtatgagaat gcataggcag cccatcattt
     3301 ttgatcactt ttaacatata aaagtcaaat tgatgtttgt ctgtttgctg ttgacccctg
     3361 taccactttt cctgtttgta atacatctag atctagttag tgtacatcat caaagtgata
     3421 ctttatatga cagataaatc tttgtacttt tcttgctcag aggtacaaaa ctgttgaaca
     3481 tacatagcaa gtacagggaa agtacaggga aaacaagctt aaaatgctaa agcactcctg
     3541 tttgggttat taagaaatcc aaaatgattg aaagggtagg aagaacatcc ctaggtcaac
     3601 ccaaaatgct cttctctgtc aaatcatttc cttatgttta caggcaccag gtgttttcag
     3661 tctttaatgt gaagaaaatc ctttccttga agctttccag tgactgaggg gagagatggt
     3721 acccatttcc aatttcaggt catgccttga gagtgagatt agcgccactc tgacacttcc
     3781 taggcaggtt cggaattaga caagggtaag gatacttgta tttttccagc cttggtttag
     3841 aagcatgacc cagaaatact tttaaactct taattttcaa atatattgta agccctttta
     3901 ccttagtcag ttggtaagca tcttgaatga cctcaaacca aactaactag cagtgataaa
     3961 ctatcacaca acaaaggccc gcccaggtcc cgctttataa agacaggtgt ttttttattt
     4021 tgtattttta gctaattaga tattatttca gtctcttgat aagtaggctt tttccttgtg
     4081 cagtcccaca agcttactta attattctat gcatccattt cctaacttac caaattaaca
     4141 tgatacgata tagtattcca acttacctca taaacttgtt ggaaagattt cactaagtaa
     4201 tagacacaaa aatatttcaa agtaccataa agagttatta tattactcaa gtccataaac
     4261 tggttattgt ttgtggtttg gttttgttgt ttccccgact gaaatgacat aagtagcgtc
     4321 atccacatta gtctttagtg agtgcacagg tctttgggct ccactgcagt tgccctgtct
     4381 taccatcagt taattacaga aattagcact cagggcatgt gcgatggctc agccagggaa
     4441 ggttcgtgcc accaaaccca acaacccaac ttccatcctt ggggcctaca tggtggaagg
     4501 aaagaaagag ttcccacggc tgtctgattt ctaaaagcaa actatggtgt gtgtatgcat
     4561 gtacacagac tcacacaaca cacacacaca cacacacaca cacacacaca cacacacaca
     4621 cttaaaaaac aaaaacattt taaaaatccc ctaagagctt agactttgtg agaaaaaaag
     4681 acccagtggg tctcagaata tgcttctgat agcaaataag tttattgtct tcatattatc
     4741 ctttataaag aatgtaacag cttcttttga tagttataca ttacaactta aatggctgat
     4801 ttgaagcatt aattaaatgt gaatgtaatc tgtacagttt tgtaaacgga aaaataagct
     4861 tagtattgat tgtcttgaaa atgcagcatt tccttgggat ctgttttaca gcattggcat
     4921 ggttgcatgt gccagtgcgt ctcagccagt ggattgtggg tatgcacttt tgtggactgc
     4981 ttctcagcgt cattgactca aatgttgttt atgtttcttc atacaataaa ttaatttttt
     5041 caaaaaaaaa aaaaaaaaaa aa
//
