LOCUS       NM_001083919           11969 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus xin actin-binding repeat containing 2 (Xirp2),
            transcript variant 2, mRNA.
ACCESSION   NM_001083919
VERSION     NM_001083919.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11969)
  AUTHORS   Wagner EL, Im JS, Sala S, Nakahata MI, Imbery TE, Li S, Chen D,
            Nimchuk K, Noy Y, Archer DW, Xu W, Hashisaki G, Avraham KB, Oakes
            PW and Shin JB.
  TITLE     Repair of noise-induced damage to stereocilia F-actin cores is
            facilitated by XIRP2 and its novel mechanosensor domain
  JOURNAL   Elife 12, e72681 (2023)
   PUBMED   37294664
  REMARK    GeneRIF: Repair of noise-induced damage to stereocilia F-actin
            cores is facilitated by XIRP2 and its novel mechanosensor domain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11969)
  AUTHORS   Guo H, Lu YW, Lin Z, Huang ZP, Liu J, Wang Y, Seok HY, Hu X, Ma Q,
            Li K, Kyselovic J, Wang Q, Lin JL, Lin JJ, Cowan DB, Naya F, Chen
            Y, Pu WT and Wang DZ.
  TITLE     Intercalated disc protein Xinbeta is required for Hippo-YAP
            signaling in the heart
  JOURNAL   Nat Commun 11 (1), 4666 (2020)
   PUBMED   32938943
  REMARK    GeneRIF: Intercalated disc protein Xinbeta is required for
            Hippo-YAP signaling in the heart.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11969)
  AUTHORS   Farrell E, Armstrong AE, Grimes AC, Naya FJ, de Lange WJ and Ralphe
            JC.
  TITLE     Transcriptome Analysis of Cardiac Hypertrophic Growth in
            MYBPC3-Null Mice Suggests Early Responders in Hypertrophic
            Remodeling
  JOURNAL   Front Physiol 9, 1442 (2018)
   PUBMED   30410445
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11969)
  AUTHORS   Huang L, Wu KH, Zhang L, Wang Q, Tang S, Wu Q, Jiang PH, Lin JJ,
            Guo J, Wang L, Loh SH and Cheng J.
  TITLE     Critical Roles of Xirp Proteins in Cardiac Conduction and Their
            Rare Variants Identified in Sudden Unexplained Nocturnal Death
            Syndrome and Brugada Syndrome in Chinese Han Population
  JOURNAL   J Am Heart Assoc 7 (1), e006320 (2018)
   PUBMED   29306897
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11969)
  AUTHORS   Leber Y, Ruparelia AA, Kirfel G, van der Ven PF, Hoffmann B, Merkel
            R, Bryson-Richardson RJ and Furst DO.
  TITLE     Filamin C is a highly dynamic protein associated with fast repair
            of myofibrillar microdamage
  JOURNAL   Hum Mol Genet 25 (13), 2776-2788 (2016)
   PUBMED   27206985
REFERENCE   6  (bases 1 to 11969)
  AUTHORS   Tran PV, Haycraft CJ, Besschetnova TY, Turbe-Doan A, Stottmann RW,
            Herron BJ, Chesebro AL, Qiu H, Scherz PJ, Shah JV, Yoder BK and
            Beier DR.
  TITLE     THM1 negatively modulates mouse sonic hedgehog signal transduction
            and affects retrograde intraflagellar transport in cilia
  JOURNAL   Nat Genet 40 (4), 403-410 (2008)
   PUBMED   18327258
REFERENCE   7  (bases 1 to 11969)
  AUTHORS   Gustafson-Wagner EA, Sinn HW, Chen YL, Wang DZ, Reiter RS, Lin JL,
            Yang B, Williamson RA, Chen J, Lin CI and Lin JJ.
  TITLE     Loss of mXinalpha, an intercalated disk protein, results in cardiac
            hypertrophy and cardiomyopathy with conduction defects
  JOURNAL   Am J Physiol Heart Circ Physiol 293 (5), H2680-H2692 (2007)
   PUBMED   17766470
REFERENCE   8  (bases 1 to 11969)
  AUTHORS   Huang HT, Brand OM, Mathew M, Ignatiou C, Ewen EP, McCalmon SA and
            Naya FJ.
  TITLE     Myomaxin is a novel transcriptional target of MEF2A that encodes a
            Xin-related alpha-actinin-interacting protein
  JOURNAL   J Biol Chem 281 (51), 39370-39379 (2006)
   PUBMED   17046827
  REMARK    GeneRIF: Myomaxin functions directly downstream of MEF2A at the
            peripheral Z-disc complex in striated muscle potentially playing a
            role in regulating cytoarchitectural integrity
REFERENCE   9  (bases 1 to 11969)
  AUTHORS   Duka A, Schwartz F, Duka I, Johns C, Melista E, Gavras I and Gavras
            H.
  TITLE     A novel gene (Cmya3) induced in the heart by angiotensin
            II-dependent but not salt-dependent hypertension in mice
  JOURNAL   Am J Hypertens 19 (3), 275-281 (2006)
   PUBMED   16500513
  REMARK    GeneRIF: upregulation due to Ang II-induced myocardial damage and
            not to blood pressure elevation per se
REFERENCE   10 (bases 1 to 11969)
  AUTHORS   Jung-Ching Lin,J., Gustafson-Wagner,E.A., Sinn,H.W., Choi,S.,
            Jaacks,S.M., Wang,D.Z., Evans,S. and Li-Chun Lin,J.
  TITLE     Structure, Expression, and Function of a Novel Intercalated Disc
            Protein, Xin
  JOURNAL   J Med Sci 25 (5), 215-222 (2005)
   PUBMED   16708114
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF119716.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF119716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..11969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 39.31 cM"
     gene            1..11969
                     /gene="Xirp2"
                     /gene_synonym="2310003D02Rik; 2310008C07Rik;
                     A530024P18Rik; Cmya3; Gm352; Xin2"
                     /note="xin actin-binding repeat containing 2"
                     /db_xref="GeneID:241431"
                     /db_xref="MGI:MGI:2685198"
     exon            1..153
                     /gene="Xirp2"
                     /gene_synonym="2310003D02Rik; 2310008C07Rik;
                     A530024P18Rik; Cmya3; Gm352; Xin2"
                     /inference="alignment:Splign:2.1.0"
     exon            154..302
                     /gene="Xirp2"
                     /gene_synonym="2310003D02Rik; 2310008C07Rik;
                     A530024P18Rik; Cmya3; Gm352; Xin2"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..10097
                     /gene="Xirp2"
                     /gene_synonym="2310003D02Rik; 2310008C07Rik;
                     A530024P18Rik; Cmya3; Gm352; Xin2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cardiomyopathy associated 3; xin actin-binding
                     repeat-containing protein 2; xeplin; xin-beta; myomaxin;
                     beta-xin; mXinbeta; cardiomyopathy-associated protein 3;
                     myogenic MEF2-activated Xin-related protein; Xin
                     actin-binding repeat containing 2 short splice form"
                     /codon_start=1
                     /product="xin actin-binding repeat-containing protein 2
                     isoform 2"
                     /protein_id="NP_001077388.1"
                     /db_xref="CCDS:CCDS38133.1"
                     /db_xref="GeneID:241431"
                     /db_xref="MGI:MGI:2685198"
                     /translation="MARYQAAVSRGDTRSFSANVMEESDVCTVPGGLAKMKRQFEKDK
                     MTSTCNAFSEYQYRHESRAEQEAIHSSQEIIRRNEQEVSKGHGTDVFKAEMMSHLEKH
                     TEETKQASQFHQYVQETVIDSPEEEELPKVSTKILKEQFEKSAQENFLRSDKETSPPA
                     KCMKIENDIEETLKPSSAVGTSSSYTSTRQRKETSTSSYSNHSLTSTTLAQDNGTPSG
                     KMEEFPPPPPDVCQTPMDVTAFSQSPEFPSPPRRLPMPKDLYSKQRNLYELNRLYRHI
                     HPELRKNLEKDYISEVSEIVSSQINSGNALSADVQKARYVFENTNDSSQKDLNSEREN
                     LEWDEILKGEVQSIRWIFENQPLDSINHGSTDEGYTSKGIADQELIAGSDVKYTTWMF
                     ETQPIDALGIPSAGTEGNTEKIPELARGDVYTARWMFETRPLDSMNKMHECQEETAST
                     LTKDITGGDVKTVRYMFETQQLDQLGQLHSVDELNLLQLRSELKEIKGNVKRSIKCFE
                     TQPLYVIRDGSGQMLEIKTVQREDIEKGDVRTARWMFETQPLDTINKDITEIKVVRGI
                     SMEENVKGGVSRAKWLFETQPLEKIKEESGEAVLKTEAVIGTDVSKKCWMFETQPLDI
                     LKDSPDTDSVSPEERIGGDVKTTKHLFETLPIEALKDSPDIGKLQKITASEEEKGDVK
                     HQKWVFETQRLEDIREDKKEYTRTVRLEAVDRGHVKNYTHIFESNNLIKVDASHQIEV
                     EGVTRGTVELNKSLFETTPLYAIQDHLGKYHQVKTVQQEEIVRGDVRSCRWLFETRPI
                     DQFDESLHKFQIIRGISAQEIQAGNVKSARWLFETQPLDSIKYFSNVEETDSKTEQST
                     DIVKGDVKTCKWLFETQPMESLYEKASLMTNSEDIHKGDVRTCMWLFETQPLDAIKDD
                     SEATVKLQTVKQEEIQGGDVQTACFLFETENLDNIQGDEGKENKPLEMDIQSGDVSGM
                     KFKFENQSLDSINCSSENVLSKIKTLKAEDIQKGNVLKCRWLFENQPIDMIKESQECD
                     GLVKTVTDVQGGDVRKGCFIFETFSLDEIKDESDGISMRETNLGEIIKGDVKSYKMLF
                     ETQPLYAIQDHEGFYHEVTTVKKEETIHGDVRGTRWLFETKPLDSIHESEDVYVIKSV
                     TQEDIQKGDVSSVRYRFETQPLDMISDKSHNIVPTVDYIQGGNVQMNKQLFESEGGNK
                     KNYVRTVSVNEIQKGNVKTSTWLFETHRIDELGEESRYENIKTVTQEDVQKGDVKQAV
                     WLFENQTLDSINELDENDTKMTKEEIPPSDVKTTTWLFETTPIHEFNKTRVEKEEIIG
                     KSIKETLEDLYSQRVVEAPGIIIEADEVGDVRMAKYKLMNQTTPEIQKEEVIRADLGN
                     IMMNLLSQRDCTKKEIFVSEEEKGNVNFTKTQLLNRSMEFHAEKEEIVRGDVKQAIQK
                     LFSEERRAKKGILIQEDEKGDINMTIYCLLHENAGDKTEREDILGGDVRRTIHNLLSS
                     ASNGKISERTKIDASERGNVQFFTTCIETGALDYLKQLQTGSNESTLTASKQEGEEEI
                     IGGDVEGTKFLLKKRQSSFERTVSETDIIPGDVRHTVKVFMTEPQSSSYKTVKDEIIK
                     GDLKSTLNSLNQAMNQKTVAKAEEIVKDDRLAILKSLKESGDRQKEPKQSGGMSRDIG
                     QAIECLERATNTRTEILKKELILDDLKTSLRSLKEEQCGFKEVDKQGIVKDVLPGMLG
                     FSERPKIGIHPAAVQRDKKSLLQPVPGPFEPAIKQQAGPGTLDETTQKPCLRSLIEER
                     TEANLPKAPKGTVKIVIDREQNNDALEKSLRKMSNSEHRAMKNVLDMSDRMGIWTESK
                     EYLCSDDHMSKHLSATMSIKESLKSKESENMREAKDDVISSTQSVDKTFRKQQTQTCE
                     LGNDQKSRFQDSYGKNQKNIQNIEITRDFQKQALLSQEKQYSNKEMKKNEASLQPLPV
                     GKEVHSVPGVTVSGKNHKRIQATDKRQKTDVCLESQDFLMKTNTSKELKMAMERSFNP
                     INLHPECGIKENEDSLPPPSPPPLPPSNASSEIEFPLPPPPPLMLLPGKNESPPSSPT
                     EKTRTEFESLSTLPLPPPPVDEKAEQECLSTTLPPPPPPTPCQPGHLLPSSVLGHHRE
                     AFLQQFSQKEALGVHLPHSQAKILTGKSPPPTLPKPKLPKRIKDKMNQYSSSGELERS
                     LSDVEIKATLSKDQKRSMVTMSSEHRETKQDVFGKGLVGRKQLPVDSANSLSQTVPEI
                     PAPKEKQTAPLVKSHSFPSGSEQQSPKPYMRKFKTPLMIAEEKYRQQREELEKQRQES
                     SSHNVIKTETQHQSLSEKEEEIELQKATEAISTPRKESDFPRARPNLDSESRAVIAGE
                     CSESQLATASTLTVATERLQHVLAASEDELTLRQEGIQNSSDASQSKLACETSQSHKE
                     CKAQQTFEQHVKRLPFPQTKPSSPSFKVKTIKLSTLDHTGTETDLSSKHHTKQSEVDI
                     QTSTEQTDKEIKKTQASIQCDDKPSVPEKYFQLPKTEKRVTIQMPKEYAEKSHKSKLQ
                     TVPKKQGIFGEFDRGNVLGREGKNQDSSVSCSKEDRLIDERKQEHLQNQRVPRSVQQK
                     VINERLDSQMQNFQQTEIQTSRSTIECEEFSQSYNATQEKTCLKDKGKQQGQVTSNTE
                     ESKQELRQNQSAFSSVKDSQHDDGKCTINILEFLRKREELQQILSRVKQFEAESSKSG
                     LKTFQILLNIVPVWLISEEKREYGVRVAMENNFEKVKEEITHIKTQAEEMLLQCEHVI
                     QTAMMASQTGKQRDKPTNLNEMPLNVSNVNLSSSKCTEQKESKTVEEKLTHRQVTTHP
                     EAATRNPVKPYQEAKGEDGKMAPPSLKTRPPSPTFITIESTARRAETSTKSELSQSPK
                     NNRCIEPPPRRPVEHASGLPRSRTPPSPPRSRSEQLVRLKDTTARLAKGTIPCSPGTP
                     VPIVEKRSEVVMSPATLRRQIKIESRGGDSPPTITIPVSVNHVVSGSFRESVDAQEAV
                     KKTEKTETYVHKDKMNSVNRAMPETESYDAVEIIRKVEGPHLSEHTERFEATNQTVQR
                     AERFLNGHENEINRWFREFENDPVFRAKTERGAYANGEINHNMKQESHTFCKEEFGLA
                     SSETANFTGFSYRHPKVPAMQPRVHSEARSLNEHFSSVDAFDSQIVGSKVATSSSRST
                     EAGRSGFDFKHAPPTYEDVISGHILDVADSPTNLRRNFQKTWQESERVFQRVGYETSD
                     AHATEMSRAFQEESAFLSETVGPRQGNLHNLSKDSLSNGVPHSRQAEFS"
     exon            303..440
                     /gene="Xirp2"
                     /gene_synonym="2310003D02Rik; 2310008C07Rik;
                     A530024P18Rik; Cmya3; Gm352; Xin2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..530
                     /gene="Xirp2"
                     /gene_synonym="2310003D02Rik; 2310008C07Rik;
                     A530024P18Rik; Cmya3; Gm352; Xin2"
                     /inference="alignment:Splign:2.1.0"
     exon            531..603
                     /gene="Xirp2"
                     /gene_synonym="2310003D02Rik; 2310008C07Rik;
                     A530024P18Rik; Cmya3; Gm352; Xin2"
                     /inference="alignment:Splign:2.1.0"
     exon            604..737
                     /gene="Xirp2"
                     /gene_synonym="2310003D02Rik; 2310008C07Rik;
                     A530024P18Rik; Cmya3; Gm352; Xin2"
                     /inference="alignment:Splign:2.1.0"
     exon            738..10002
                     /gene="Xirp2"
                     /gene_synonym="2310003D02Rik; 2310008C07Rik;
                     A530024P18Rik; Cmya3; Gm352; Xin2"
                     /inference="alignment:Splign:2.1.0"
     exon            10003..10136
                     /gene="Xirp2"
                     /gene_synonym="2310003D02Rik; 2310008C07Rik;
                     A530024P18Rik; Cmya3; Gm352; Xin2"
                     /inference="alignment:Splign:2.1.0"
     exon            10137..11969
                     /gene="Xirp2"
                     /gene_synonym="2310003D02Rik; 2310008C07Rik;
                     A530024P18Rik; Cmya3; Gm352; Xin2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11952..11957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xirp2"
                     /gene_synonym="2310003D02Rik; 2310008C07Rik;
                     A530024P18Rik; Cmya3; Gm352; Xin2"
ORIGIN      
        1 atagactctt cggtggagct ggtctccact ctgctggttg ctttcagggg actgggaaat
       61 ttgctgtgtg tcaaacaggg aggagccttt caagtgaaga gttgcaaatc catagagcat
      121 ttctacggag ctagggtcaa ttctggtaca aagtgacctt taaccttact aagcccggag
      181 acgtcagtac tgctgggagt gaggaccagt cggatctcct ggaggcgctg tccctgaagg
      241 agaggatggc aaggtaccag gcagctgttt cacggggtga cacccgcagc ttctcggcta
      301 atgtcatgga agaatcagat gtgtgcaccg tgcctggtgg tttagccaag atgaaaagac
      361 aatttgagaa ggataaaatg acttcaacct gcaacgcctt ttctgagtat cagtaccgac
      421 atgagagcag agctgagcag gaggcaatcc acagcagtca agaaataata agaaggaatg
      481 aacaagaagt ttctaaagga catggaactg atgtcttcaa agcagaaatg atgtcacatc
      541 ttgaaaagca cactgaggaa acaaagcaag cttcacagtt tcatcaatat gttcaagaaa
      601 cagtcattga ttcgccagaa gaagaagagc ttcctaaggt ttccactaag attttaaaag
      661 agcaatttga aaagtctgcc caggaaaact tcctccgctc tgataaagaa acatcacccc
      721 cagccaagtg tatgaagatt gaaaatgaca ttgaagaaac cttaaagcca tcatcggctg
      781 tgggtacctc ttcttcttat acttcaacca ggcagaggaa ggaaacttca acctcaagtt
      841 atagtaatca cagtctgact tcaacaactc tggcacaaga taatggcact ccttcaggga
      901 agatggaaga gtttcctcct cccccacctg atgtttgtca gacaccaatg gatgtgacag
      961 cattttccca gtcccctgaa ttccccagcc ctcctagaag actgccaatg cccaaagatt
     1021 tatactccaa gcaaagaaat ttatatgaat taaaccgttt atataggcat atccatccag
     1081 agttaagaaa aaacttagaa aaagattaca tcagtgaggt ttctgaaatt gtttctagcc
     1141 agataaactc agggaacgcg ttatcagcag atgtacaaaa agctcggtat gttttcgaaa
     1201 atacaaatga cagttctcag aaagatttga actcagaaag agaaaacctg gagtgggatg
     1261 aaatcctcaa aggagaggtg cagtcgattc gatggatttt tgagaatcag ccattagatt
     1321 ctatcaacca tggttctaca gatgaagggt acacttccaa aggcattgct gaccaagaac
     1381 taattgctgg aagtgatgtg aaatatacaa cttggatgtt tgaaactcag ccaatagatg
     1441 cactggggat tccttctgct ggcactgaag gaaacactga gaaaattcct gaactagcta
     1501 gaggagatgt ttacacagca aggtggatgt ttgaaacaag gcctttagac tccatgaaca
     1561 aaatgcatga atgtcaagaa gaaacagcat ctactcttac aaaggatata actggtggag
     1621 atgtcaagac tgtgagatac atgtttgaaa ctcaacaact agatcaactt ggacagcttc
     1681 actcagtgga tgaattgaac ttgttacaac tcagatcaga actcaaagaa attaaaggaa
     1741 atgttaagag aagcataaag tgttttgaaa ctcaaccatt gtatgtcatt agagatggtt
     1801 caggccaaat gctagaaatt aaaactgtgc agagagaaga cattgaaaag ggcgatgtaa
     1861 ggacagcacg ttggatgttt gaaacacagc ctttggacac aataaacaaa gacatcacag
     1921 aaattaaggt tgttcgagga atatccatgg aggaaaatgt caaaggtggg gtgagtagag
     1981 caaagtggtt atttgaaact caaccactgg agaaaatcaa agaagagtca ggcgaggctg
     2041 tcctgaaaac agaagcagtc ataggtacag atgtttctaa aaagtgttgg atgtttgaaa
     2101 cacagccatt agacattcta aaagactctc ctgatacgga cagtgtatca cctgaagaga
     2161 gaataggagg tgatgtaaag accaccaaac atctatttga aacactccca atagaggctt
     2221 taaaagacag cccggatatc ggaaagcttc aaaaaatcac tgcctctgaa gaagaaaagg
     2281 gggatgttaa gcaccaaaaa tgggtttttg aaactcaacg cttagaagat attagagaag
     2341 ataagaaaga atacaccaga acagtgaggc tagaagcagt tgatagagga catgtaaaga
     2401 actacactca tatcttcgaa tccaataatc taattaaggt tgacgcatca catcaaattg
     2461 aggtagaagg agtcacaaga ggcactgtgg agttgaataa atctctcttt gagacaaccc
     2521 cactctatgc cattcaagat catcttggaa aataccacca agtaaagaca gtccagcaag
     2581 aagaaatagt aagaggtgat gtaagaagct gtagatggct ttttgaaaca aggcctattg
     2641 accaatttga tgaaagcctt cataaatttc agataattag aggaatatct gctcaagaaa
     2701 tacaggcagg gaatgtgaaa tctgctaggt ggttatttga gacccaaccc cttgattcaa
     2761 ttaaatattt tagtaatgtg gaagaaacag acagcaaaac tgaacaaagt actgatattg
     2821 ttaaagggga tgtcaaaaca tgtaaatggc tatttgagac ccagccaatg gagtctcttt
     2881 atgaaaaagc ttccttgatg accaactctg aagatattca taaaggtgat gttagaacct
     2941 gcatgtggct gtttgaaact cagccacttg atgccataaa agatgactct gaagcaacag
     3001 taaaactgca aactgtgaaa caggaggaga tacaaggtgg ggatgttcag acagcatgtt
     3061 ttctttttga gacagaaaat ctggacaaca tacaggggga tgaagggaaa gaaaataagc
     3121 ccttggagat ggatatacaa tctggggatg tctctggcat gaagtttaag tttgaaaatc
     3181 agtccttaga ctctataaat tgcagttcag agaatgttct aagtaagatc aaaacgctaa
     3241 aagccgaaga cattcagaaa ggcaatgttc taaaatgcag gtggctattt gaaaaccaac
     3301 ctattgatat gataaaagaa agtcaagaat gtgatggatt ggttaaaaca gtgacagacg
     3361 tacaaggtgg agatgtaaga aagggatgct tcatttttga gacattttct ttagatgaga
     3421 ttaaagatga atccgatggc atcagcatga gagaaacaaa tctcggggaa ataataaaag
     3481 gtgatgtgaa aagctacaaa atgctttttg aaacacaacc actctatgca attcaagacc
     3541 atgaagggtt ttatcatgaa gtgacaacag ttaaaaaaga agaaacaata catggagatg
     3601 tacgaggaac aaggtggctc tttgaaacaa aaccattaga ctcaattcac gaatcagaag
     3661 atgtatacgt tattaaatcc gtcacccagg aagacattca gaagggggat gtgagttctg
     3721 tcagatacag gtttgaaact caaccactgg atatgatttc agacaaatcc cataatattg
     3781 tgcccactgt tgactatatt caaggaggca atgtgcagat gaataaacaa ttatttgagt
     3841 ctgaaggtgg taacaagaag aactatgtaa gaacagtaag tgtcaatgaa atacaaaagg
     3901 gcaatgttaa gacttctact tggctctttg aaactcacag aatagatgag ttgggagaag
     3961 agtccagata tgaaaatatc aagacagtca cccaggaaga cgtgcagaaa ggtgatgtga
     4021 agcaagcagt gtggcttttt gaaaaccaga ctttggattc tattaatgaa cttgatgaaa
     4081 atgataccaa aatgacaaag gaagaaattc ctccgtcgga tgtcaagaca actacgtggc
     4141 tctttgaaac aacacctatt cacgaattta acaaaactag agtagagaag gaagaaatta
     4201 ttggtaaaag tattaaagaa accttggaag acctctactc tcaaagagtt gttgaagctc
     4261 ccggaattat cattgaagct gatgaagttg gagatgtcag aatggccaaa tacaagctca
     4321 tgaaccaaac aactcctgag atccagaagg aagaagttat cagggctgat ctcggaaaca
     4381 tcatgatgaa cctgctttcc caaagagact gcacaaagaa agagatattt gtcagtgaag
     4441 aggagaaggg aaacgtcaat tttactaaaa ctcaattatt aaacagatcg atggaatttc
     4501 atgctgaaaa ggaagagata gtgagagggg atgtaaaaca agcaatccaa aagctgttct
     4561 cagaggaaag gcgtgcaaag aaaggcatat taattcaaga agatgaaaag ggagatatta
     4621 acatgactat ctattgtctt cttcatgaaa atgctggtga caagactgag agagaagaca
     4681 tactgggagg tgatgtgagg cgcaccattc ataatctgtt atcttctgca tcaaatggta
     4741 agatatccga aaggacaaaa atcgatgctt cggagagggg aaatgttcag ttcttcacaa
     4801 catgcatcga aactggagct ttggattacc tcaagcaact ccaaacaggg tcaaatgaaa
     4861 gcacactcac agctagcaag caggaaggag aggaagaaat aattggtggt gatgttgagg
     4921 gaacaaaatt cttactgaag aaaaggcagt cttcctttga acgtactgtt agtgagactg
     4981 acatcatccc aggcgatgtg cgtcatacag ttaaagtctt catgacagag cctcagagtt
     5041 catcttataa gacagtgaaa gacgagatta taaaaggtga tttgaaatca accttgaatt
     5101 ctctcaacca ggccatgaat cagaaaacag tggctaaagc agaagaaatt gtgaaagatg
     5161 acaggctggc catactcaag tcacttaagg agtcagggga cagacagaaa gaacccaaac
     5221 aatctggtgg catgtctaga gatatcgggc aagctattga gtgcctcgag agggctacaa
     5281 atacaaggac tgaaatcttg aaaaaagagc tgatattaga tgatcttaaa acatcactaa
     5341 ggtctttgaa agaagaacag tgtggtttca aagaggttga taaacaggga atagtcaaag
     5401 atgtactacc tgggatgcta ggattttcag aaaggccaaa aatagggatc catccagcag
     5461 ctgtccagag agacaaaaaa agtcttcttc aaccagtgcc aggaccattt gaaccagcaa
     5521 tcaagcagca agcaggacca ggcactcttg atgaaactac acagaaaccc tgccttcggt
     5581 ctttaataga agaaagaact gaagctaatc ttcccaaagc ccctaagggc actgtaaaga
     5641 ttgtcattga tcgtgaacaa aacaatgatg ctcttgagaa aagccttaga aaaatgtcta
     5701 attcagagca tagagctatg aaaaatgtct tagacatgag tgacagaatg ggtatctgga
     5761 ctgagagcaa agaatatctg tgtagtgatg accatatgag caaacactta agtgccacca
     5821 tgtcaattaa ggaaagtcta aaatccaagg aatcagagaa catgagagaa gcaaaggatg
     5881 atgtcattag ctccacccag tctgtggata aaacatttag aaagcaacag actcaaacct
     5941 gtgagctagg caatgatcag aagtctcggt tccaggattc ctatgggaag aatcaaaaaa
     6001 atatccaaaa cattgagatc acaagggact ttcagaagca agccttgctc agtcaggaaa
     6061 agcagtattc taataaagag atgaagaaaa atgaggcgag ccttcaacct ttgcctgtgg
     6121 gtaaggaggt acacagtgta ccaggagtga cagtctctgg gaaaaaccac aaaagaattc
     6181 aggcaactga caagagacag aaaactgatg tttgtctgga aagtcaagac tttctaatga
     6241 agacaaacac ttccaaggag ttaaaaatgg cgatggagag gtcctttaat ccaatcaacc
     6301 ttcaccctga atgtggtata aaagaaaatg aggactcact tccacctcca tctccccctc
     6361 ctcttccacc ttctaatgcc tcatctgaaa ttgaatttcc tctccctcct ccaccacctt
     6421 taatgctgtt gcctggaaaa aatgagtctc ctccctcatc tcccacagag aagacaagga
     6481 ctgaatttga aagcctctca accctccctc ttcctccacc acctgtagat gagaaagctg
     6541 aacaagaatg cctatcaacc accctacctc ctccccctcc tccaactcca tgtcaaccag
     6601 gacatcttct tccatcgtct gttctaggac atcacaggga agcattttta caacagttct
     6661 cccaaaaaga agccttaggt gttcatctgc ctcactcaca ggctaaaatc ctaacaggaa
     6721 aatcaccacc tcccacactc cccaaaccca aacttcccaa gagaattaaa gataagatga
     6781 accagtattc ctcaagcggt gaattggaaa gatcgctgtc agatgtggaa attaaggcta
     6841 ccctctcaaa ggatcagaaa agatcaatgg tgacaatgag cagtgagcac agagagacaa
     6901 agcaagatgt gttcggaaaa ggtcttgttg gaagaaaaca gctgcctgtt gactctgcaa
     6961 actcgctctc tcagacagtt ccagaaatcc cagcacccaa ggaaaaacag acagcacccc
     7021 ttgttaaatc ccactcattc ccatcaggtt cagaacaaca aagtcctaag ccttacatga
     7081 ggaaatttaa gacaccttta atgattgctg aagaaaaata cagacagcaa agggaagagc
     7141 ttgagaaaca gagacaggag agttcttccc acaatgtcat caaaacagaa acacagcacc
     7201 aaagcttatc agagaaggag gaagaaatag agttacaaaa agcgactgag gcaatctcca
     7261 cacccagaaa ggagtcagac tttcctaggg cacggcccaa cctggactct gaaagcaggg
     7321 ctgtgattgc aggtgaatgc tctgaaagcc aactcgccac agcttctaca ttgacagtag
     7381 ctactgagag gctccagcat gttctagccg cttctgaaga tgagcttacc ttgagacagg
     7441 aaggcatcca gaactcaagt gatgcctcac aatcaaaatt ggcttgtgaa actagccaga
     7501 gtcacaaaga atgcaaggca cagcaaacat ttgagcagca tgtgaagaga ctgccctttc
     7561 cccaaaccaa acccagttcc ccaagtttca aagtgaaaac tatcaagctt tcaactctag
     7621 atcacacagg gactgaaaca gatcttagtt ctaagcacca cacaaagcaa tctgaagttg
     7681 acattcaaac cagtactgaa caaacagata aggaaatcaa gaaaacccag gcaagcatac
     7741 agtgtgatga taagccatct gtgcctgaaa aatattttca gttacctaaa acagagaaac
     7801 gggtgaccat acaaatgccc aaagaatatg cagagaaaag tcataaaagt aagctccaga
     7861 cagttcccaa gaagcaagga atatttgggg agtttgacag agggaatgtc ctggggaggg
     7921 aaggaaaaaa tcaggactcc tccgtgagct gttcaaaaga agacagacta atagatgaaa
     7981 gaaagcaaga acatctgcag aaccagaggg taccaaggtc agtccaacaa aaggttatca
     8041 atgaacgcct ggactcacag atgcagaatt ttcagcagac agaaatacaa acttctagaa
     8101 gtacaattga gtgtgaagaa ttctcccagt cttacaatgc tacgcaagag aaaacatgcc
     8161 ttaaagacaa gggcaaacaa cagggacagg tcacctctaa cactgaagag tcaaagcaag
     8221 agctaagaca gaaccaatct gcattttcct ctgtgaaaga ttcccagcac gatgatggaa
     8281 aatgtaccat aaatatattg gaattcttgc gaaaacgtga agaactacag cagattttgt
     8341 ctagggtaaa acagtttgaa gcagagtcaa gtaaaagtgg ccttaaaacg tttcagatac
     8401 tgttaaatat tgtcccggta tggctgataa gtgaggagaa aagagaatat ggagttcgtg
     8461 ttgccatgga gaataatttc gaaaaagtca aagaagaaat aacacatatt aaaactcaag
     8521 ccgaggagat gcttcttcag tgtgaacatg taattcagac agccatgatg gcttcccaaa
     8581 caggaaagca gagagataaa cctaccaacc ttaatgaaat gccactgaat gtgtctaatg
     8641 ttaatctcag ctcgagtaaa tgcaccgaac agaaagaaag taaaactgta gaagaaaaat
     8701 taacacaccg acaagtaaca actcatcctg aggcagcaac ccgtaatcct gttaaaccat
     8761 accaggaggc taagggggaa gacggtaaga tggctcctcc ctctttgaaa actcgccctc
     8821 catcaccaac tttcattaca atagagtcca ctgcccgtag agcagaaacc tccacgaaga
     8881 gtgagctttc tcagtcccct aaaaataacc gttgtattga acctccaccc cgaagacccg
     8941 tggaacatgc atctggactt cccagatcaa gaacaccacc ttccccacca aggagtcgtt
     9001 cagaacaact tgtcagactc aaagacacca cggccaggct agccaaaggc accatccctt
     9061 gttcaccagg aaccccagtt ccaattgtag agaagagatc tgaggttgtc atgtctccag
     9121 ccacactccg cagacaaatc aagatagaaa gtcgtggtgg ggactcacca cccaccatca
     9181 caatacctgt gagtgtaaac cacgtcgtta gtggctcctt cagagaatct gtagacgctc
     9241 aagaggcagt gaagaaaaca gaaaaaacgg agacttatgt tcataaagac aaaatgaatt
     9301 ctgtcaacag agcaatgcca gagactgaaa gctacgatgc agtcgaaatc atccgcaagg
     9361 tggaagggcc ccacctatca gaacacacag agagatttga agccaccaat caaactgttc
     9421 aaagggctga acgttttctg aatggccatg aaaatgaaat aaacagatgg tttagggaat
     9481 ttgagaatga cccagttttc agagcaaaaa cagagagagg agcttatgca aatggcgaaa
     9541 taaaccacaa catgaaacaa gagagtcaca cattttgcaa ggaggaattt ggattagcat
     9601 cttctgaaac tgctaatttt acaggctttt cttacagaca tccgaaagtt cctgcaatgc
     9661 agcccagggt tcactctgaa gcaaggtctc tgaatgagca tttctcgagc gtggatgcat
     9721 ttgacagtca gattgttggg tcaaaggtag caacctcatc atctcggagc acagaagctg
     9781 gcagatccgg ctttgacttc aagcatgccc caccgaccta tgaagatgtc atctctggcc
     9841 acatcctaga tgtcgcagat tcacctacaa acctcagacg gaattttcaa aagacatggc
     9901 aggagagcga gagagttttt cagcgcgtgg gatatgaaac ctcagatgcg catgcaacag
     9961 aaatgagcag ggccttccag gaggaatctg cctttttaag tgaaactgtt ggtccaagac
    10021 aaggaaattt gcataatttg tcaaaagaca gtttatccaa tggagtgcct catagcagac
    10081 aagcagaatt ttcataagtc ttgcttcaga tgccatcatt gcagcagtaa gctgagcttg
    10141 ggaaattacg catcacttca cggacgaata tactgcaagc ctcattttaa acaacttttt
    10201 aagtctaaag gaaattatga tgaagggttt ggacacaagc aacataaaga tcgatggaat
    10261 tgcaaaaacc aaagcagctt agttgatttt attcccagcg gagagcccga tgcgcatgaa
    10321 aaccctacag cagataccct cttgcttggg gatcttacta cccacccaga tgcttgtaac
    10381 agcaagcggc aagacaatga tttgagaaaa tggggggaca gggggaaatt aaaaattgtt
    10441 tggcctcctt gtcaggagat gcctaagaaa aactctcccc ctgaggaaga attcaaagtg
    10501 aataaagcta agtggccgcc tgaagtgacc atccctgttc cctcagattt taaaagggag
    10561 tcgctgaccg aacatgtgaa gacattggaa agtcaagggc aagaacaaga tagcgtccct
    10621 gacttgcagc cctgtaaaca cgtttgtcag aaggaggata ttacaggaat caaagaaata
    10681 aaagggtacg aagaaagaaa agatgagaaa gaagcgaagg atacgctgaa ggatgccgag
    10741 ggcttgagga gtaagagaaa aagtgggatg gagtttaatg accataatgc gcatgctcag
    10801 agtgatggaa aggaaaagaa tgctcttgtt aatgaagctg acagcgcaga cgttttacaa
    10861 gttgcaaaca ccgatgatga gggggggcca gaaaatcata gggagaactt caataacaat
    10921 aacaacaatt ctgtagctgt ctcctcgttg aataatggca ggcagaagat atctatttca
    10981 gaacgtcctc gtctattaca ggcagtcagt gaagcaaact attacacaag tgaataccag
    11041 attaagaact ttaacaacgc gtctaagatc tcagagttac ttggtatatt tgaatctcaa
    11101 aagttgtcct ccaagaaggt cctagccttg gctctggagc gaacagctga cagagggact
    11161 gcaggcagtc ccctgcagct ggtactggag ccaggcttgc agcagggttt ctcagttaaa
    11221 ggggaaaacc ttgcagcatc tcctgatgta agccccttac acattaaagg aaaccatgaa
    11281 aacaacaaaa atgtacacct tttcttctct aacactgtga aaatcacctc tttttccaag
    11341 aaacataaca tccttgggtg tgatttaatg gattctgttg atcaacttaa aaatatgtca
    11401 tgcttgtatt taagagagct tgggaaaaat gtcaaatgct ggcatggtga aaccgcagga
    11461 gcggctcggc atggtggaaa aatgtgtttt gatgctcaga gccaagggag tgccgctaag
    11521 cctgtgtttc ccagcatgca gtgccaggct caacatctaa ctgtggaaga gcagattaaa
    11581 cgggacaggt gctacagcga cagcgaggct gactgaacag tcttcggcca cttgcaggca
    11641 ctcaggcact gtgggggaat gttctcagag aagaccccgg gatcatcgct aaccttttga
    11701 tgaatttgta aagatcacgt ttcaaatctc tttcacagcg cattatttct tgtatgcact
    11761 ccgtaattct ttgtcacaat tcacaagaga ctactttgga tctgaatgga atgctgacag
    11821 gaaacaaggc ggccatgttt tctcctcaaa gggcacatgg gctaaagttt tcctgtgtgg
    11881 taaagcggaa gaagagtctg cactgccggt gttcatcgcc actcttatac cttctctata
    11941 atttctgata aaataaaatt ttgtcaact
//
