LOCUS       NM_011724               5807 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus xin actin-binding repeat containing 1 (Xirp1),
            transcript variant 1, mRNA.
ACCESSION   NM_011724
VERSION     NM_011724.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5807)
  AUTHORS   Li,C., Zhang,H., Xie,Y., Liu,S., Zhao,R., Huang,J., Huang,J. and
            Wei,Y.
  TITLE     Effects of CMYA1 overexpression on cardiac structure and function
            in mice
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (5), 593-600 (2021)
   PUBMED   33792654
  REMARK    GeneRIF: Effects of CMYA1 overexpression on cardiac structure and
            function in mice.
REFERENCE   2  (bases 1 to 5807)
  AUTHORS   Kebir,S., Orfanos,Z., Schuld,J., Linhart,M., Lamberz,C., van der
            Ven,P.F., Schrickel,J., Kirfel,G., Furst,D.O. and Meyer,R.
  TITLE     Sarcomeric lesions and remodeling proximal to intercalated disks in
            overload-induced cardiac hypertrophy
  JOURNAL   Exp Cell Res 348 (1), 95-105 (2016)
   PUBMED   27639425
REFERENCE   3  (bases 1 to 5807)
  AUTHORS   Leber,Y., Ruparelia,A.A., Kirfel,G., van der Ven,P.F., Hoffmann,B.,
            Merkel,R., Bryson-Richardson,R.J. and Furst,D.O.
  TITLE     Filamin C is a highly dynamic protein associated with fast repair
            of myofibrillar microdamage
  JOURNAL   Hum Mol Genet 25 (13), 2776-2788 (2016)
   PUBMED   27206985
REFERENCE   4  (bases 1 to 5807)
  AUTHORS   Sharma,P., Abbasi,C., Lazic,S., Teng,A.C.T., Wang,D., Dubois,N.,
            Ignatchenko,V., Wong,V., Liu,J., Araki,T., Tiburcy,M., Ackerley,C.,
            Zimmermann,W.H., Hamilton,R., Sun,Y., Liu,P.P., Keller,G.,
            Stagljar,I., Scott,I.C., Kislinger,T. and Gramolini,A.O.
  TITLE     Evolutionarily conserved intercalated disc protein Tmem65 regulates
            cardiac conduction and connexin 43 function
  JOURNAL   Nat Commun 6, 8391 (2015)
   PUBMED   26403541
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5807)
  AUTHORS   Al-Sajee,D., Nissar,A.A., Coleman,S.K., Rebalka,I.A., Chiang,A.,
            Wathra,R., van der Ven,P.F., Orfanos,Z. and Hawke,T.J.
  TITLE     Xin-deficient mice display myopathy, impaired contractility,
            attenuated muscle repair and altered satellite cell functionality
  JOURNAL   Acta Physiol (Oxf) 214 (2), 248-260 (2015)
   PUBMED   25582411
  REMARK    GeneRIF: Xin deficiency leads to a myopathic condition
            characterized by increased muscle fatigability
REFERENCE   6  (bases 1 to 5807)
  AUTHORS   Gustafson-Wagner,E.A., Sinn,H.W., Chen,Y.L., Wang,D.Z.,
            Reiter,R.S., Lin,J.L., Yang,B., Williamson,R.A., Chen,J., Lin,C.I.
            and Lin,J.J.
  TITLE     Loss of mXinalpha, an intercalated disk protein, results in cardiac
            hypertrophy and cardiomyopathy with conduction defects
  JOURNAL   Am J Physiol Heart Circ Physiol 293 (5), H2680-H2692 (2007)
   PUBMED   17766470
REFERENCE   7  (bases 1 to 5807)
  AUTHORS   Jung-Ching Lin,J., Gustafson-Wagner,E.A., Sinn,H.W., Choi,S.,
            Jaacks,S.M., Wang,D.Z., Evans,S. and Li-Chun Lin,J.
  TITLE     Structure, Expression, and Function of a Novel Intercalated Disc
            Protein, Xin
  JOURNAL   J Med Sci 25 (5), 215-222 (2005)
   PUBMED   16708114
REFERENCE   8  (bases 1 to 5807)
  AUTHORS   Sinn,H.W., Balsamo,J., Lilien,J. and Lin,J.J.
  TITLE     Localization of the novel Xin protein to the adherens junction
            complex in cardiac and skeletal muscle during development
  JOURNAL   Dev Dyn 225 (1), 1-13 (2002)
   PUBMED   12203715
  REMARK    GeneRIF: Xin has a role in the formation of cell-cell contacts and
            possibly in myofibrillogenesis
REFERENCE   9  (bases 1 to 5807)
  AUTHORS   Wang,D.Z., Reiter,R.S., Lin,J.L., Wang,Q., Williams,H.S.,
            Krob,S.L., Schultheiss,T.M., Evans,S. and Lin,J.J.
  TITLE     Requirement of a novel gene, Xin, in cardiac morphogenesis
  JOURNAL   Development 126 (6), 1281-1294 (1999)
   PUBMED   10021346
REFERENCE   10 (bases 1 to 5807)
  AUTHORS   Wang,D.Z., Hu,X., Lin,J.L., Kitten,G.T., Solursh,M. and Lin,J.J.
  TITLE     Differential displaying of mRNAs from the atrioventricular region
            of developing chicken hearts at stages 15 and 21
  JOURNAL   Front Biosci 1, a1-15 (1996)
   PUBMED   9159189
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117245.3 and AEKQ02157273.1.
            
            On May 13, 2022 this sequence version replaced NM_011724.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF051945.2, SRR10223969.9547.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC117245.3         73805-73937
            134-2945            AC117245.3         77552-80363
            2946-3146           AEKQ02157273.1     4629-4829           c
            3147-3527           AC117245.3         80565-80945
            3528-5807           AC117245.3         81337-83616
FEATURES             Location/Qualifiers
     source          1..5807
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.36 cM"
     gene            1..5807
                     /gene="Xirp1"
                     /gene_synonym="Cmya1"
                     /note="xin actin-binding repeat containing 1"
                     /db_xref="GeneID:22437"
                     /db_xref="MGI:MGI:1333878"
     exon            1..133
                     /gene="Xirp1"
                     /gene_synonym="Cmya1"
                     /inference="alignment:Splign:2.1.0"
     exon            134..3527
                     /gene="Xirp1"
                     /gene_synonym="Cmya1"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..3536
                     /gene="Xirp1"
                     /gene_synonym="Cmya1"
                     /note="cardiomyopathy associated 1; Xin alpha;
                     cardiomyopathy-associated protein 1; mXin alpha"
                     /codon_start=1
                     /product="xin actin-binding repeat-containing protein 1"
                     /protein_id="NP_035854.4"
                     /db_xref="CCDS:CCDS52966.1"
                     /db_xref="GeneID:22437"
                     /db_xref="MGI:MGI:1333878"
                     /translation="MADAQMQVAPTPTIQMRTEEDLSLPHPSAPEGLPPPPPKETFSK
                     FQQQRQASELRRLYKHIHPELRKNLEEAVAEDLAEVLGSEEPTEGDVQCMRWIFENWR
                     LDAIGDHERPAAREPVSGGNVQATSRKFEEGSFTNSSDQEPEGLRPSGGDVQAARQMF
                     ETKPLDALRGQEEATQTTMREPAATGDVQGTRKLFETRPLDRLGSRPSIQEQSPLELR
                     SEIQELKGDVKKTVKLFQTEPLCAIQDAEGTIHEVKAACREEIQSNAVRSARWLFETR
                     PLDAFNQDPSQVRVIRGISLEEGALPDVSATRWIFETQPLDAIREIEVDEKDFQPSPD
                     LIPPGPDVQHQRHLFETCSLDTLKGERETEAEVPPKEEVIPGDVRSTLWLFETKPLDA
                     FRDQVQVGHLQRVGHQEGEGLVTECLPSNGTSVLPLSQGVPQNDGLKGDVKTFKNLFE
                     TLPLDSIGQGEPSAYGNINRGQNTDSAEQSQGSDAPVYAMQDSRGQLHALTSVSREQV
                     VGGDVQGYKWMFETQPLDTLGRSPSTIDVVRGITRQEVVAGDVGTTRWLFETQPLEMI
                     HQQEQQKPEEEEGKGPGGPPPELPKKGDVQTIRWLFETYPMSELAEKRESEVTDPVSK
                     AETQSCTWMFGPQSLNPAEGSGEQHLQTSQVPAGDRQTDRHVFETESLPASNQSSGRK
                     PVRYCSRVEIPSGQVSRQKEVFQALEAGKKEVPETTINLGSIPTGSVHKFTWLFENCP
                     MGSLAAESIRGDNLQEEQPKGSAGHGTPERQETAAERTLRTLHATPGILHHGGILMEA
                     RGPGELCLAKYVLPSPGQGRPYIRKEELVCGELPRIVRQVLRRTDVDQQGLLVQEDTA
                     GQLQLHPLTLPGPGDPGNIEDMDPELQQLLACGLGVSVSKTGLVMQETGQGLVALTAY
                     SLQPQLTSRAPERSSVQLLASCIDKGDLHSLHSLRWEPPTDPSSGPATEESQRVPPTE
                     SIIHVTPLDSTMEMGQLRISGSTPCPPPSRAAGKVVLPNGKPVAQAPLQEARKKTDIS
                     HAGQKGKAASGRPEGTIASPLGSGAPDLQEAMQNLRLATAEAQSLHQQVLSRHPQGSD
                     PVATSMPVQDVLQASTPATGVTQGSIRPVAGSEARIPAFPRKLL"
     exon            3528..5807
                     /gene="Xirp1"
                     /gene_synonym="Cmya1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5784..5789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xirp1"
                     /gene_synonym="Cmya1"
                     /note="hexamer: AATAAA"
     polyA_site      5807
                     /gene="Xirp1"
                     /gene_synonym="Cmya1"
                     /note="major polyA site"
ORIGIN      
        1 ggagacctag agccaaggta gagagaggca ggggacccag gaacagaaca gaactgacaa
       61 caaagaatcc cggcagagcg acagacccca aggctagaca cccaaaagca cccagacacc
      121 agccagaccc ttgaaggatg gctgatgccc agatgcaggt agctcctaca ccaaccatcc
      181 aaatgaggac agaagaggac ctgtccctcc ctcatccctc agccccagag ggtctgccgc
      241 caccaccccc caaagaaacc ttctccaagt tccagcagca gcggcaagcc agtgagctcc
      301 ggcgtctcta caaacacatc caccctgagc ttcggaagaa cctcgaggag gctgtggctg
      361 aggacctggc ggaggtcctc ggttcggagg agcccactga gggcgatgtt cagtgtatgc
      421 gctggatctt tgagaactgg cggctagatg ccattggcga tcacgagagg ccggctgcca
      481 gggaacctgt gtcaggtggc aacgtccagg ccacctctcg aaagtttgag gaaggctcct
      541 ttaccaacag ctcagatcag gagccggagg gactccggcc atcagggggt gatgtccaag
      601 ctgccagaca gatgtttgag accaagccac tggatgcgct gagaggccag gaggaggcaa
      661 cacagacaac catgagggaa cctgcagcca ctggagatgt acagggaacc agaaagctct
      721 ttgagactag gcccctggac cgactgggct cccgcccctc tatccaggag cagagtcctt
      781 tagagctgcg ctcagagatt caggagctga agggcgatgt gaagaagacg gtgaagctgt
      841 ttcagacgga acctctatgc gccatccagg atgccgaggg caccatccac gaagtcaagg
      901 ctgcctgtcg ggaggagatt caaagcaatg cagtgaggtc tgctcgctgg ctctttgaga
      961 cccgacctct ggatgccttc aaccaggacc ccagccaggt gcgggtgatt cgggggatct
     1021 cccttgagga gggagccctg ccggatgtca gtgcaactcg ttggatcttt gagacgcagc
     1081 ctttggatgc cattcgtgag atcgaggtgg acgagaagga cttccagcca tctccggatc
     1141 tcatccctcc tggcccagat gttcagcatc agcgacatct gtttgaaacc tgttccctgg
     1201 acactctgaa gggtgaaaga gaaacagagg cagaggtgcc acccaaggag gaggtgattc
     1261 ctggcgatgt ccgctctaca ctctggctat ttgaaacaaa acccctggat gctttcagag
     1321 accaggtcca agtgggtcac ctgcaacggg tgggtcacca ggagggtgag gggcttgtga
     1381 cagagtgtct acccagtaat ggtacttcgg tgttgcctct gtctcagggt gtcccccaga
     1441 atgatgggtt gaaaggggat gtgaaaacct tcaagaatct ttttgagacc cttcccttag
     1501 acagcattgg gcagggtgag ccttcagcct atgggaacat aaacagagga caaaacactg
     1561 attctgccga gcagtcccag ggttctgacg ccccggtata tgctatgcag gacagcaggg
     1621 gacagcttca tgccctgact tctgtcagca gagagcaggt agttggaggt gatgttcagg
     1681 gctacaagtg gatgtttgag acacagcccc tggacacgct gggtagaagc cccagtacca
     1741 tcgatgtggt acgaggtatc actcggcagg aagtggtggc tggggatgtc ggcaccactc
     1801 ggtggctctt tgagacgcag ccattggaga tgatccacca acaagagcaa cagaaaccag
     1861 aggaggaaga ggggaagggt ccaggaggcc ccccccctga gctccccaaa aagggtgatg
     1921 tacagactat ccgttggctg tttgagacct accctatgag cgagttggca gagaagcgag
     1981 aatctgaggt cacagacccc gtgagcaagg ctgagacaca gtcctgcacc tggatgtttg
     2041 ggccccaatc tctgaaccca gcagaaggct ctggggagca gcacctgcaa accagccagg
     2101 ttccggctgg agacaggcag acagacagac atgtctttga gactgaatct ctgccagcct
     2161 caaaccaatc cagtgggaga aagcctgtaa ggtactgcag ccgggtggag attccttccg
     2221 ggcaggtatc tcggcagaaa gaggttttcc aggccctgga ggcgggcaag aaggaggtcc
     2281 cggagaccac aatcaacctg gggtccatcc ccacaggctc tgtgcataaa ttcacctggc
     2341 tctttgaaaa ctgtcccatg ggctccctgg cagctgagag catcagaggg gacaacctcc
     2401 aggaagaaca gccaaaaggc tctgcaggcc atgggacacc agagaggcag gagacagcag
     2461 ccgagagaac ccttcggact ttgcatgcca cccccggcat cctgcaccat ggaggcatcc
     2521 tcatggaggc ccgagggcca ggggagctct gtcttgccaa gtatgtgctc ccaagcccag
     2581 ggcaggggcg cccctacata cggaaggagg agctggtgtg tggtgagctt cccaggatcg
     2641 tccgtcaagt gctgcgccgg acagacgtgg accagcaggg actgctggtt caggaggaca
     2701 cagctgggca gctccagctc cacccactca cgctgccagg gcctggtgac cctgggaata
     2761 ttgaagacat ggaccctgag ctccagcagc tgctggcctg tggcctggga gtctctgtgt
     2821 caaagacggg gctggtgatg caagagacag gacagggcct agtggcactg actgcctact
     2881 ccctccagcc ccagcttacc agcagggccc ctgaaagaag cagtgtgcag ctgctggcca
     2941 gctgcataga caaaggagac ctgcacagcc ttcacagttt gcggtgggag ccgccaacag
     3001 acccaagttc tggacctgct actgaggagt cccagagggt ccccccaact gagagcatca
     3061 tacatgttac cccattagac tccaccatgg agatggggca gctgagaatc tcaggatcca
     3121 caccctgccc acctccatct cgggcagctg gaaaagtggt ccttccaaat gggaaacctg
     3181 tagcccaagc tccattgcag gaagcaagga agaaaacgga tatcagccat gctgggcaga
     3241 aagggaaggc agcctcagga agaccagaag gaaccattgc ttcccctcta gggtctgggg
     3301 ctccagatct ccaggaagcc atgcagaatc tgcgtttggc aaccgctgag gcccaaagcc
     3361 tgcaccagca ggttctgagc aggcatccac agggctctga ccctgtagcc acctccatgc
     3421 ctgtccaaga tgttctgcaa gcatccactc ctgccactgg ggttactcaa ggcagcatca
     3481 ggcctgtggc tggaagtgaa gccaggatcc cagcattccc cagaaagctg ctgtgacaga
     3541 agatcctgac cacccaactc aaggccacca ccaggaggac tccatccagc aggccccgga
     3601 gcccctgcag gaaccccttc ttcatattca caacagacct tctggccaga aaacccctga
     3661 agggtcagag acaaaaccct ccaaagcgga atccaccatg cttccaagaa agaaaccccc
     3721 agtgcctccc aaacctgcac atctaagcca aatccaccca cctcagaggc tgcccaagcc
     3781 cttagcaggc tctgccagag cctcagaagc aggacaagac cataagccag gtgagccagg
     3841 tatagccaac ccagggtcag acaaagctcc cacaatagca ggccaggact gcctgcctct
     3901 ggctgaaagc tccaagggcc agaagcaacc tgctcatcag cgtccactca gctctatggc
     3961 ttccaggcct agcaggggtc agataaccag cagcaacagc cagagccccg agtctcctaa
     4021 gttgaacgtt ctcaacaatg actccagccc accacaaaag cacaatagct ccccccaaaa
     4081 gcaggggacc cctgagagtc cacagggcag ccatcaggag ctccagggcc tcctgagcca
     4141 agtgcaaacc ctggagaagg aagcatctcg cagcgtggat gtgcaggccc tgcggaagct
     4201 cttcgagggc gtaccccagc tgggaggggg agtccctcag gctcccactg ccccccacat
     4261 gactgaggcc tccatggagc aggcctttgg ggaactgact cgggtgagta cagaggttgc
     4321 ccagctgaaa gaacagaccc tagccaggct gctggacatc gaagaagcag tgcacaaggc
     4381 tcttagctcc atgtctagcc tccagtctga ggctcccaca agcagccatc cacagggaac
     4441 tacaaaagat cccagtgtga acaaggtctc agtcagtagc agagccatac agacaagctc
     4501 cagccaggtc agagatccac ccctcgtcaa aacccaagaa aaggccgaga gccatcctga
     4561 ggacaagatg agaaatcacg cagaggccag aggccaggca gcagtgaacg tcctgccctc
     4621 caggaggctg gagacactga gaggagccga gcctggcctc ctacaagtct ctcctccctg
     4681 cacaggatcc tcctctccaa ctttcatctc agtccaatca gctacaaaga agcttccgga
     4741 agcttctagc cctcagggaa gccattatat ctcagggaaa aatacacacc taggtcagga
     4801 cataggtcaa gccctgctct accagagaga tatccaggat caggctggga caaaggagat
     4861 gtgcatcgag ggcgctgtgc tcacagggca gccaaagaat gttctggaat tccagactgg
     4921 gtcaactacc tccaagtcct atggagccat gagaacagtg accgagcagt atgaggagat
     4981 ggaccaattt gggaatacag tcctcacttc ctccaccacc atcacccagc acgcagaccc
     5041 actgacggac cccagacccc agctctgcct gcacacttct cccatgctaa ggcagttact
     5101 ccacagcccc tccaggctca acagtgacct ggcagaagct gagataacat ggactccctg
     5161 taacaacttc cacccggctg cccagtgagc ccctctgtct cccaccagtc ttgggtacct
     5221 ctcccagagc tcccccagga ctgagtcatg ggcctacctc cagcacatgt ggaacaagga
     5281 ccaagaaaaa aacgtggcct tcagagagct cacgagggct gtttgccttg ttagttcttg
     5341 gaaaagaggc aagaaacata aagcagccat ccacaggaaa gccggatggg agggacagga
     5401 cctgacaggt gcttgtggag aactagccca cactagccca gctcacactc acacatgtga
     5461 gcctgcacct cattgcctag agctggaggg tcaccctgca ctgtgtccct ccatagccag
     5521 cctttttctt tggttatgga atctggctgc cttaatccct ggtgaggacc cggggctgag
     5581 caaactggac atgacactgc tctctgtttg agattggact aaaggctcca gaaaaacccg
     5641 ggtgcctgcc tcttcatcgc cagtggtcca aagggcgcag agagcgcact agcagtcaat
     5701 agtgttccga gaagctgaat acacgaccct tcctgacccc atcaccccca ctctgcaccc
     5761 cgaatgggaa aaaatgaccc aaaaataaac ccaaaagaga ttcccta
//
