LOCUS       NM_009688               6566 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus X-linked inhibitor of apoptosis (Xiap), transcript
            variant 3, mRNA.
ACCESSION   NM_009688
VERSION     NM_009688.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6566)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6566)
  AUTHORS   Hong,R., Tan,Y., Tian,X., Huang,Z., Wang,J., Ni,H., Yang,J., Bu,W.,
            Yang,S., Li,T., Yu,F., Zhong,W., Sun,T., Wang,X., Li,D., Liu,M.,
            Yang,Y. and Zhou,J.
  TITLE     XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate
            HSC activation and liver fibrosis
  JOURNAL   EMBO Rep 25 (3), 1055-1074 (2024)
   PUBMED   38351372
  REMARK    GeneRIF: XIAP-mediated degradation of IFT88 disrupts HSC cilia to
            stimulate HSC activation and liver fibrosis.
REFERENCE   3  (bases 1 to 6566)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   4  (bases 1 to 6566)
  AUTHORS   Reigada,D., Maza,R.M., Munoz-Galdeano,T., Barreda-Manso,M.A.,
            Soto,A., Lindholm,D., Navarro-Ruiz,R. and Nieto-Diaz,M.
  TITLE     Overexpression of the X-Linked Inhibitor of Apoptosis Protein
            (XIAP) in Neurons Improves Cell Survival and the Functional Outcome
            after Traumatic Spinal Cord Injury
  JOURNAL   Int J Mol Sci 24 (3), 2791 (2023)
   PUBMED   36769152
  REMARK    GeneRIF: Overexpression of the X-Linked Inhibitor of Apoptosis
            Protein (XIAP) in Neurons Improves Cell Survival and the Functional
            Outcome after Traumatic Spinal Cord Injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6566)
  AUTHORS   Verhagen,A.M., Ekert,P.G., Pakusch,M., Silke,J., Connolly,L.M.,
            Reid,G.E., Moritz,R.L., Simpson,R.J. and Vaux,D.L.
  TITLE     Identification of DIABLO, a mammalian protein that promotes
            apoptosis by binding to and antagonizing IAP proteins
  JOURNAL   Cell 102 (1), 43-53 (2000)
   PUBMED   10929712
REFERENCE   6  (bases 1 to 6566)
  AUTHORS   Kobayashi,K., Hatano,M., Otaki,M., Ogasawara,T. and Tokuhisa,T.
  TITLE     Expression of a murine homologue of the inhibitor of apoptosis
            protein is related to cell proliferation
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1457-1462 (1999)
   PUBMED   9990045
REFERENCE   7  (bases 1 to 6566)
  AUTHORS   Deveraux,Q.L. and Reed,J.C.
  TITLE     IAP family proteins--suppressors of apoptosis
  JOURNAL   Genes Dev 13 (3), 239-252 (1999)
   PUBMED   9990849
  REMARK    Review article
REFERENCE   8  (bases 1 to 6566)
  AUTHORS   LaCasse,E.C., Baird,S., Korneluk,R.G. and MacKenzie,A.E.
  TITLE     The inhibitors of apoptosis (IAPs) and their emerging role in
            cancer
  JOURNAL   Oncogene 17 (25), 3247-3259 (1998)
   PUBMED   9916987
  REMARK    Review article
REFERENCE   9  (bases 1 to 6566)
  AUTHORS   Farahani,R., Fong,W.G., Korneluk,R.G. and MacKenzie,A.E.
  TITLE     Genomic organization and primary characterization of miap-3: the
            murine homologue of human X-linked IAP
  JOURNAL   Genomics 42 (3), 514-518 (1997)
   PUBMED   9205126
REFERENCE   10 (bases 1 to 6566)
  AUTHORS   Uren,A.G., Pakusch,M., Hawkins,C.J., Puls,K.L. and Vaux,D.L.
  TITLE     Cloning and expression of apoptosis inhibitory protein homologs
            that function to inhibit apoptosis and/or bind tumor necrosis
            factor receptor-associated factors
  JOURNAL   Proc Natl Acad Sci U S A 93 (10), 4974-4978 (1996)
   PUBMED   8643514
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ111937.1, CJ126958.1,
            AK147447.1, BC138528.1, CN535777.1, CD548741.1, AK041844.1,
            CK389763.1, BG091082.1, CN527460.1 and AI848625.1.
            
            On Aug 27, 2014 this sequence version replaced NM_009688.2.
            
            Summary: The protein encoded by this gene is a member of the
            inhibitor of apoptosis (IAP) family of proteins. While first
            identified for its role in blocking apoptosis, this protein
            modulates many other signaling processes including nuclear factor
            kappa-light-chain-enhancer of activated B cells (NF-kB) pathways
            and inflammatory responses. This protein blocks apoptosis by
            binding and inhibiting target caspases after they have been
            activated. Binding occurs to some, but not all, caspases. This
            protein has several conserved regions, including baculoviral IAP
            repeat (BIR) motifs and a RING finger E3 ligase domain. In humans,
            mutations in this gene are linked to immunodeficiency in X-linked
            lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this
            gene is found on chromosome 7. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660813.33710.1, SRR1660819.45837.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849375, SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               CJ111937.1         2-143
            143-143             CJ126958.1         142-142
            144-323             CJ111937.1         145-324
            324-423             CJ126958.1         323-422
            424-1186            AK147447.1         553-1315
            1187-2284           BC138528.1         1110-2207
            2285-2610           CN535777.1         165-490
            2611-3205           CD548741.1         21-615
            3206-5042           AK041844.1         383-2219
            5043-5310           CK389763.1         219-486
            5311-5599           BG091082.1         5-293
            5600-6125           CN527460.1         48-573
            6126-6566           AI848625.1         1-441               c
FEATURES             Location/Qualifiers
     source          1..6566
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 23.19 cM"
     gene            1..6566
                     /gene="Xiap"
                     /gene_synonym="1110015C02Rik; Aipa; Api3; Birc4; IAP3;
                     ILP-1; MIHA"
                     /note="X-linked inhibitor of apoptosis"
                     /db_xref="GeneID:11798"
                     /db_xref="MGI:MGI:107572"
     exon            1..221
                     /gene="Xiap"
                     /gene_synonym="1110015C02Rik; Aipa; Api3; Birc4; IAP3;
                     ILP-1; MIHA"
                     /inference="alignment:Splign:2.1.0"
     exon            222..347
                     /gene="Xiap"
                     /gene_synonym="1110015C02Rik; Aipa; Api3; Birc4; IAP3;
                     ILP-1; MIHA"
                     /inference="alignment:Splign:2.1.0"
     exon            348..1253
                     /gene="Xiap"
                     /gene_synonym="1110015C02Rik; Aipa; Api3; Birc4; IAP3;
                     ILP-1; MIHA"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..1870
                     /gene="Xiap"
                     /gene_synonym="1110015C02Rik; Aipa; Api3; Birc4; IAP3;
                     ILP-1; MIHA"
                     /EC_number="2.3.2.27"
                     /note="baculoviral IAP repeat-containing protein 4;
                     X-linked IAP; IAP homolog A; inhibitor of apoptosis
                     protein 3; RING-type E3 ubiquitin transferase XIAP"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase XIAP"
                     /protein_id="NP_033818.2"
                     /db_xref="CCDS:CCDS30098.1"
                     /db_xref="GeneID:11798"
                     /db_xref="MGI:MGI:107572"
                     /translation="MTFNSFEGTRTFVLADTNKDEEFVEEFNRLKTFANFPSSSPVSA
                     STLARAGFLYTGEGDTVQCFSCHAAIDRWQYGDSAVGRHRRISPNCRFINGFYFENGA
                     AQSTNPGIQNGQYKSENCVGNRNPFAPDRPPETHADYLLRTGQVVDISDTIYPRNPAM
                     CSEEARLKSFQNWPDYAHLTPRELASAGLYYTGADDQVQCFCCGGKLKNWEPCDRAWS
                     EHRRHFPNCFFVLGRNVNVRSESGVSSDRNFPNSTNSPRNPAMAEYEARIVTFGTWTS
                     SVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLDEKG
                     QEYINNIHLTHSLEESLGRTAEKTPSLTKKIDDTIFQNPMVQEAIRMGFSFKDIKKTM
                     EEKIQTSGSSYLSLEVLIADLVSAQKDNTEDESSQTSLQKDISTEEQLRRLQEEKLCK
                     ICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS"
     exon            1254..1353
                     /gene="Xiap"
                     /gene_synonym="1110015C02Rik; Aipa; Api3; Birc4; IAP3;
                     ILP-1; MIHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1432
                     /gene="Xiap"
                     /gene_synonym="1110015C02Rik; Aipa; Api3; Birc4; IAP3;
                     ILP-1; MIHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1475
                     /gene="Xiap"
                     /gene_synonym="1110015C02Rik; Aipa; Api3; Birc4; IAP3;
                     ILP-1; MIHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1676
                     /gene="Xiap"
                     /gene_synonym="1110015C02Rik; Aipa; Api3; Birc4; IAP3;
                     ILP-1; MIHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..6550
                     /gene="Xiap"
                     /gene_synonym="1110015C02Rik; Aipa; Api3; Birc4; IAP3;
                     ILP-1; MIHA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6524..6529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xiap"
                     /gene_synonym="1110015C02Rik; Aipa; Api3; Birc4; IAP3;
                     ILP-1; MIHA"
                     /note="hexamer: AATAAA"
     polyA_site      6550
                     /gene="Xiap"
                     /gene_synonym="1110015C02Rik; Aipa; Api3; Birc4; IAP3;
                     ILP-1; MIHA"
                     /note="major polyA site"
ORIGIN      
        1 gggggcgggg actgagaagt gacctgtgcg catgtgcagc cgctgggtca ggctctggct
       61 tggagctggg gaggcggggg ttggggggtg gggggggggt tgggctgcat aatgaggact
      121 ggggtttttc tcgatgtccc cttccggctc tgggaggcgg cgggaccttg gcggtccccc
      181 gagcgggcgc gacgctaatc gagggccgct cggccagaga ggccggggcc cgccgcccag
      241 cagagttgtg ttttcctgat ccgggctcgg gccgcccctc ctccgggacc ctcccctcgg
      301 gaacccgtcg cccgcggcgc ttagttagga ctggagtgct tggcgcgaaa aggtggacaa
      361 gtcctatttt ccagagaaga tgacttttaa cagttttgaa ggaactagaa cttttgtact
      421 tgcagacacc aataaggatg aagaatttgt agaagagttt aatagattaa aaacatttgc
      481 taacttccca agtagtagtc ctgtttcagc atcaacattg gcgcgagctg ggtttcttta
      541 taccggtgaa ggagacaccg tgcaatgttt cagttgtcat gcggcaatag atagatggca
      601 gtatggagac tcagctgttg gaagacacag gagaatatcc ccaaattgca gatttatcaa
      661 tggtttttat tttgaaaatg gtgctgcaca gtctacaaat cctggtatcc aaaatggcca
      721 gtacaaatct gaaaactgtg tgggaaatag aaatcctttt gcccctgaca ggccacctga
      781 gactcatgct gattatctct tgagaactgg acaggttgta gatatttcag acaccatata
      841 cccgaggaac cctgccatgt gtagtgaaga agccagattg aagtcatttc agaactggcc
      901 ggactatgct catttaaccc ccagagagtt agctagtgct ggcctctact acacaggggc
      961 tgatgatcaa gtgcaatgct tttgttgtgg gggaaaactg aaaaattggg aaccctgtga
     1021 tcgtgcctgg tcagaacaca ggagacactt tcccaattgc ttttttgttt tgggccggaa
     1081 cgttaatgtt cgaagtgaat ctggtgtgag ttctgatagg aatttcccaa attcaacaaa
     1141 ctctccaaga aatccagcca tggcagaata tgaagcacgg atcgttactt ttggaacatg
     1201 gacatcctca gttaacaagg agcagcttgc aagagctgga ttttatgctt taggtgaagg
     1261 cgataaagtg aagtgctttc actgtggagg agggctcacg gattggaagc caagtgaaga
     1321 cccttgggaa cagcatgcga agtggtaccc agggtgcaaa tacctattgg atgagaaggg
     1381 gcaagaatat ataaataata ttcatttaac ccattcactt gaggaatctt tgggaagaac
     1441 tgctgaaaaa acaccatcgc taactaaaaa aatcgatgat accatcttcc agaatcctat
     1501 ggtgcaagaa gctatacgaa tgggatttag cttcaaggac attaagaaaa caatggaaga
     1561 aaaaatccaa acatccggga gcagctatct atcacttgag gtcctgattg cagatcttgt
     1621 gagtgctcag aaagataata cggaggatga gtcaagtcaa acttcattgc agaaagacat
     1681 tagtactgaa gagcagctaa ggcgcctaca agaggagaag ctttgcaaaa tctgtatgga
     1741 tagaaatatt gctatcgttt ttgttccttg tggacatctg gtcacttgta aacagtgtgc
     1801 agaagcagtt gacaaatgtc ccatgtgcta caccgtcatt acgttcaagc aaaaaatttt
     1861 tatgtcttag tggggcacca catgttatgt tcttcttgct ctaattgaat gtgtgatggg
     1921 agcgaacttt aagtaatctg cattgcattc cattagcatc tgctgtttcc aaatggagac
     1981 caatgctaac agcactgttt ccgtctaaac attcaatttc tggatctttc gagttatcag
     2041 ctgtatcatt tagccagtgt tttactcgat tgaaacctta gacagagaag cattttatag
     2101 cttttcacat gtatattggt agtacactga cttgatttct atatgtaagt gaattcatca
     2161 cctgcatgtt tcatgccttt tgcataagct taacaaatgg agtgttctgt ataagcatgg
     2221 agatgtgatg gaatctgccc aatgacttta attggcttat tgtaaacacg gaaagaactg
     2281 ccccacgctg ctgggaggat aaagattgtt ttagatgctc acttctgtgt tttaggattc
     2341 tgcccattta cttggaattt attggagtta taaatgtact tatatgagta tttttaagtg
     2401 atttcgtcat ctcctaaaag atattgaatg gtagactacc atctaaccag catgtactga
     2461 catggaaagg caacacagat atagttaagt gtaaaataca aatggcaaaa cactgtatct
     2521 agttggagcc aaatcagctt gtgtgtattt tgtatctgta caggacaaaa aggtttgaaa
     2581 atataagtat cacactctta aatgtatttt ttcttcaggg ggtggggggt gggtcttaga
     2641 ggggcttata gagcccttca ctttattttt tcattttttt ctgtttaaag gttttataag
     2701 tatgtattac ttttataatc agagttctta gtaaatatgt tgctgattta aaggcttagg
     2761 catgttcaaa cgtctgcaaa actacttatc gctcagtttt agtttttcta atccaggaag
     2821 gcaggccagt taacttttct ggtgccaatg tgaactttaa atgtttttat tttacctgct
     2881 ttgtggatga aaaatatttc tgagtggtag ttttctgaca ggtagatcat gtctttttat
     2941 cttgtttcaa aataactatt tctgattttg taaaatgaaa tataaaatat gtctcagatc
     3001 ttccaattaa ttagtaagga ttcaccctta atccttgcta gttgaagcct gcctaagtca
     3061 ctttactaaa agatctttgt taacccagta ttgtaaccat ctgtccgctt acgtaggtaa
     3121 atgtagacgc ctggtgtata tggcttgtag ttttagtgtt ggctctccgt gttgagattc
     3181 tttctcagtg tcattctgtg tcctacaagt ttcatgtagg tttcgatgtt aggatggtta
     3241 agatgtatat agtacaaaat gttcagtctt tgattgtttt atgtttgttt gttttcatga
     3301 ctagtaatgg tagtggatac tttaaaaata ttttctgaag atccttaaaa ccttggaaat
     3361 tgtaacatac tgagaagagt ggttgtttga atatttttaa caacttgtat aagtcaatat
     3421 gaatacaatc aaaagctaaa gtgcttcata gaacacggga tttaccttaa gtaattatca
     3481 tgagagacct cttgtaaaga ctggtctatt ttactacaga gaacagtttg agagtgaaac
     3541 tgttacaatt tagacttttt gttgtatttt ctaagagaaa gagtattgtt aggttctcct
     3601 aacctctgtt gactactatg gtaagtgatg ttattttaat tgcaaattta aatagaaacc
     3661 aacagaatta agtaactgac tgtctctctc tctctctctc tctctgtctt cttcatgaaa
     3721 atccttagtt ctgtatactg ccttctgctt agatttagtt atatgatcat taggttacat
     3781 ttgatctaag ttgactaaga tttcaatttc aatttatatt tcaagcattc tgccagggaa
     3841 tagttttaaa aattgtttcc aaggcacttc aggtacaagt catataggta gtttgtttaa
     3901 tctagtcctt agcctaggac tcaaggactg aatgttttca aataacactt ttcttgttct
     3961 cagagcctca gttcattaaa actcttttaa aacctgtgtg ctgagagtta agcaagacct
     4021 cttttcttgt cttcatgagt tgcgaaattg aattcatgga gctgatgtgg ctaacaagtt
     4081 tattttagga attgtttaga aaatgctgtt gcttcgggtt cttaaaatca cagcactcca
     4141 actctaatca aattattgga gacttagcag agctggtctg aaatcacact aaaaaaaaaa
     4201 aggtactgga tcctttccag tatggttgtg taaaaaatgg tcactcggaa ggtcacagaa
     4261 taaccggctc tgaatcacca cccctgagag agttcagtgt ctgcgtgctg atggtctttt
     4321 gctgtataaa gttcattcta gaattttgaa gtaaccaccc gttttactac atattagtca
     4381 tgtgaatttt gaagttattt tgtaatagtt actttcattt gttatttact gtgttgatca
     4441 agatgtgtgt gagtgtttag catttattaa agtattgtct ttcctcctag acttttgcct
     4501 cttcctgtag ttaggggtag aggtgaggtg agtggagtga ctacaatgtg attcgctggg
     4561 gtaggacagt ttgttgtctt gttagtcaca gtgtgttgct ctgtttttta ttttagtaag
     4621 atttatattt tgagctctct gaatggaaag tgccactgca accttagctg catgcattgt
     4681 tcccattaga cctaagtctt cctggacttc tgagtcccca gatactggat aaaggaagag
     4741 gagagatgga gtagcctgtc tgtcactgct atgagagaag caagaaagtg ggtagagaaa
     4801 tacttcacat tttagtcaca tcttctcttt ttaaaaaggt agccatcagt gaaggaaaga
     4861 actagtcaaa aataggcttg acaacctgaa ttcagatccc cagaacgggc ataaaagcag
     4921 ccaggtcatg gttagtgcac tcctttaatc ccagcatttg ggaggcaggg gtagacatat
     4981 ctgggtttga agccagcctg atctacagag tgagttccag gacagggaac cctgtcttat
     5041 tcataaaaga aaacaaaaca aacaaaaagc tgagcgcact agcccaagca cctgtaatcc
     5101 cagaatgcct acatgaaaca ggaagtagct aggagaatgc cccaaagctc atggtcagtt
     5161 aatggcttat gtattaatga agaggcacca tggtaaacaa agtgggaagg tgagagccca
     5221 ccaacatcca caagttatct gctgcctcca cacatgtaac atggcaggta accacttaca
     5281 cccagacaca tacacaaaag agagaagacc aagagtgtta acacaagaac atcttatata
     5341 ctcttaagtg ttaactctca tcctacaact tagaatcctc catggctttg tcttgatgga
     5401 agatcttaga ctaaagctta aaagaggccc agaactatta ctcagttaag agtacttgct
     5461 gctttttcag aggacttagg ttcagttccc agcacccaca tggacaaaga cacatgtagc
     5521 tctggtgccc tcttttggcc ttcaggggtg catgcatgtg tgtatacata cacagtcata
     5581 cacaagtaca cataaaataa aagtaatctt taaagcttaa atgaaactct ttatgttaac
     5641 ttttactcac tattatttgt ttctctggat gcttcttgta acaaagctat aaattgtaat
     5701 aaatagttca accctttaaa aatatttaaa ttaccttttc aaaaattaga gaaagtattc
     5761 ttactaaatt cagtcgaatt ttttccaata gaaacagtca acttattacc atcttaatat
     5821 tttagtttgg ctctgaaaca tttagtgcaa tgtagatttc ttccttatat aataaaatca
     5881 ctgactatca gagctagaaa tgaccttaga aagtcactta ttcacactac caccaccacc
     5941 ttcattttat tgttgaggca acttaaagga aaggtgattg gcccgaagct atatagctga
     6001 ttagtgatag attccttact ggaagtctca ggtgtttgtc aactcttcat tctattacac
     6061 tcttatcagg gcacagtaag tggtgctttg tagtttctac agtaagacgg ttgctgatac
     6121 tttcaaatta aacaatatga cagtaatgct tgagtggtaa agttctcttt tggaggctga
     6181 aatttgcaga tgtgagtaca gctgtttggc atttactatg tgcttatgta ttattaatga
     6241 gcatttaaga ttactctgta agtatatttt atcactgtct atacttacca acaaatttgc
     6301 attttgatgt aataatggct ttcgtgtaat ttctgttttg gcatttttgt tatactttac
     6361 ctgaaaaaaa aaaagaccaa ttcttttgtc atgtgttgta ctatatttgt gaatataatt
     6421 ttatgactcg tttatggaaa ctcctttatg gaattgcttt ctgctctata atctgtcatt
     6481 tgttgtagat taaagcttat ttttctgtga ataagactta ttcaataaag cactattctt
     6541 taaaatgtta aaaaaaaaaa aaaaaa
//
