LOCUS       NM_011798               4453 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus chemokine (C motif) receptor 1 (Xcr1), mRNA.
ACCESSION   NM_011798
VERSION     NM_011798.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4453)
  AUTHORS   Mitchell,J.S., Spanier,J.A., Dwyer,A.J., Knutson,T.P.,
            Alkhatib,M.H., Qian,G., Weno,M.E., Chen,Y., Shaheen,Z.R.,
            Tucker,C.G., Kangas,T.O., Morales,M.S., Silva,N., Kaisho,T.,
            Farrar,M.A. and Fife,B.T.
  TITLE     CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin
            A adopt a distinct effector fate and are pathogenic in autoimmune
            diabetes
  JOURNAL   Immunity 57 (10), 2399-2415 (2024)
   PUBMED   39214091
REFERENCE   2  (bases 1 to 4453)
  AUTHORS   Mahadevan,K.K., Dyevoich,A.M., Chen,Y., Li,B., Sugimoto,H.,
            Sockwell,A.M., McAndrews,K.M., Sthanam,L.K., Wang,H., Shalapour,S.,
            Watowich,S.S. and Kalluri,R.
  TITLE     Type I conventional dendritic cells facilitate immunotherapy in
            pancreatic cancer
  JOURNAL   Science 384 (6703), eadh4567 (2024)
   PUBMED   38935717
REFERENCE   3  (bases 1 to 4453)
  AUTHORS   Xiao,H., Ulmert,I., Bach,L., Huber,J., Narasimhan,H., Kurochkin,I.,
            Chang,Y., Holst,S., Morbe,U., Zhang,L., Schlitzer,A., Pereira,C.F.,
            Schraml,B.U., Baumjohann,D. and Lahl,K.
  TITLE     Genomic deletion of Bcl6 differentially affects conventional
            dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses
  JOURNAL   Nat Commun 15 (1), 3554 (2024)
   PUBMED   38688934
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4453)
  AUTHORS   Kumar,S.R.P., Biswas,M., Cao,D., Arisa,S., Munoz-Melero,M.,
            Lam,A.K., Pineros,A.R., Kapur,R., Kaisho,T., Kaufman,R.J., Xiao,W.,
            Shayakhmetov,D.M., Terhorst,C., de Jong,Y.P. and Herzog,R.W.
  TITLE     TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer
            through IL-1R1-MyD88 signaling
  JOURNAL   Mol Ther 32 (2), 325-339 (2024)
   PUBMED   38053332
REFERENCE   5  (bases 1 to 4453)
  AUTHORS   Brabec,T., Schwarzer,M., Kovacova,K., Dobesova,M., Schierova,D.,
            Brezina,J., Pacakova,I., Srutkova,D., Ben-Nun,O., Goldfarb,Y.,
            Splichalova,I., Kolar,M., Abramson,J., Filipp,D. and Dobes,J.
  TITLE     Segmented filamentous bacteria-induced epithelial MHCII regulates
            cognate CD4+ IELs and epithelial turnover
  JOURNAL   J Exp Med 221 (1) (2024)
   PUBMED   37902602
  REMARK    Erratum:[J Exp Med. 2024 Jan 1;221(1):e2023019411132023c. doi:
            10.1084/jem.2023019411132023c.. PMID: 37987749]
REFERENCE   6  (bases 1 to 4453)
  AUTHORS   Crozat,K., Tamoutounour,S., Vu Manh,T.P., Fossum,E., Luche,H.,
            Ardouin,L., Guilliams,M., Azukizawa,H., Bogen,B., Malissen,B.,
            Henri,S. and Dalod,M.
  TITLE     Cutting edge: expression of XCR1 defines mouse lymphoid-tissue
            resident and migratory dendritic cells of the CD8alpha+ type
  JOURNAL   J Immunol 187 (9), 4411-4415 (2011)
   PUBMED   21948982
REFERENCE   7  (bases 1 to 4453)
  AUTHORS   Yamazaki,C., Miyamoto,R., Hoshino,K., Fukuda,Y., Sasaki,I.,
            Saito,M., Ishiguchi,H., Yano,T., Sugiyama,T., Hemmi,H., Tanaka,T.,
            Hamada,E., Hirashima,T., Amakawa,R., Fukuhara,S., Nomura,S., Ito,T.
            and Kaisho,T.
  TITLE     Conservation of a chemokine system, XCR1 and its ligand, XCL1,
            between human and mice
  JOURNAL   Biochem Biophys Res Commun 397 (4), 756-761 (2010)
   PUBMED   20541533
  REMARK    GeneRIF: The expression patterns of XCR1 and XCL1 were conserved in
            human and mice blood cells, including certain dendritic cell
            subsets.
REFERENCE   8  (bases 1 to 4453)
  AUTHORS   Crozat,K., Guiton,R., Contreras,V., Feuillet,V., Dutertre,C.A.,
            Ventre,E., Vu Manh,T.P., Baranek,T., Storset,A.K., Marvel,J.,
            Boudinot,P., Hosmalin,A., Schwartz-Cornil,I. and Dalod,M.
  TITLE     The XC chemokine receptor 1 is a conserved selective marker of
            mammalian cells homologous to mouse CD8alpha+ dendritic cells
  JOURNAL   J Exp Med 207 (6), 1283-1292 (2010)
   PUBMED   20479118
  REMARK    GeneRIF: XCR1 constitutes the first conserved specific marker for
            cell subsets homologous to mouse CD8alpha+ dendritic cells in
            higher vertebrates.
REFERENCE   9  (bases 1 to 4453)
  AUTHORS   Dorner,B.G., Dorner,M.B., Zhou,X., Opitz,C., Mora,A., Guttler,S.,
            Hutloff,A., Mages,H.W., Ranke,K., Schaefer,M., Jack,R.S., Henn,V.
            and Kroczek,R.A.
  TITLE     Selective expression of the chemokine receptor XCR1 on
            cross-presenting dendritic cells determines cooperation with CD8+ T
            cells
  JOURNAL   Immunity 31 (5), 823-833 (2009)
   PUBMED   19913446
REFERENCE   10 (bases 1 to 4453)
  AUTHORS   Yoshida,T., Izawa,D., Nakayama,T., Nakahara,K., Kakizaki,M.,
            Imai,T., Suzuki,R., Miyasaka,M. and Yoshie,O.
  TITLE     Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor
  JOURNAL   FEBS Lett 458 (1), 37-40 (1999)
   PUBMED   10518929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040878.1.
            
            [WARNING] On Feb 19, 2025 this sequence was replaced by
            NM_011798.5.
            
            On Mar 28, 2008 this sequence version replaced NM_011798.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040878.1, AK089908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4353              AK040878.1         2-4354
            4354-4453           AK040878.1         4356-4455
FEATURES             Location/Qualifiers
     source          1..4453
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 74.71 cM"
     gene            1..4453
                     /gene="Xcr1"
                     /gene_synonym="Ccxcr1; Gpr5; mXcr1"
                     /note="chemokine (C motif) receptor 1"
                     /db_xref="GeneID:23832"
                     /db_xref="MGI:MGI:1346338"
     exon            1..88
                     /gene="Xcr1"
                     /gene_synonym="Ccxcr1; Gpr5; mXcr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1089
                     /gene="Xcr1"
                     /gene_synonym="Ccxcr1; Gpr5; mXcr1"
                     /note="SCM1 receptor; lymphotactin receptor; XC chemokine
                     receptor 1; C motif-1/lymphotactin receptor; chemokine (C
                     motif) XC receptor 1"
                     /codon_start=1
                     /product="chemokine XC receptor 1"
                     /protein_id="NP_035928.2"
                     /db_xref="GeneID:23832"
                     /db_xref="MGI:MGI:1346338"
                     /translation="MDSESDALSIPASRVQMESSTAFYDYHDKLSLLCENNVIFFSTI
                     STIVLYSLVFLLSLVGNSLVLWVLVKYENLESLTNIFILNLCLSDLMFSCLLPVLISA
                     QWSWFLGDFFCKFFNMIFGISLYSSIFFLTIMTIHRYLSVVSPISTLGIHTLRCRVLV
                     TSCVWAASILFSIPDAVFHKVISLNCKYSEHHGFLASVYQHNIFFLLSMGIILFCYVQ
                     ILRTLFRTRSRQRHRTVRLIFTVVVAYFLSWAPYNLTLFLKTGIIQQSCESLQQLDIA
                     MIICRHLAFSHCCFNPVLYVFVGIKFRRHLKHLFQQVWLCRKTSSTVPCSPGTFTYEG
                     PSFY"
     exon            89..4453
                     /gene="Xcr1"
                     /gene_synonym="Ccxcr1; Gpr5; mXcr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2329..2334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xcr1"
                     /gene_synonym="Ccxcr1; Gpr5; mXcr1"
                     /note="hexamer: AATAAA"
     polyA_site      2350
                     /gene="Xcr1"
                     /gene_synonym="Ccxcr1; Gpr5; mXcr1"
                     /note="major polyA site"
     regulatory      3367..3372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xcr1"
                     /gene_synonym="Ccxcr1; Gpr5; mXcr1"
                     /note="hexamer: AATAAA"
     polyA_site      3388
                     /gene="Xcr1"
                     /gene_synonym="Ccxcr1; Gpr5; mXcr1"
ORIGIN      
        1 gttacctacg tgaaactcta gcactggagg agatcaaagg aagcacaaag cgtacagact
       61 tgaaaccctg acatggactc agagtcagat gctctcagta tccctgcatc ccgcgtccag
      121 atggagtcct ctacagcctt ttatgattat catgataaat tgagtcttct atgtgagaac
      181 aatgtcatct tcttttccac catctctacc attgtcctgt actctctggt atttctcctc
      241 agccttgtgg gtaacagcct ggttttgtgg gtcttggtga agtatgagaa tctagagtca
      301 ctcaccaata tcttcatcct caacctgtgt ctctcagacc tgatgttctc ctgtctactg
      361 cctgtgttga tctcagcaca atggagttgg tttctaggtg acttcttctg caagttcttc
      421 aacatgatct tcggcatcag cctctacagc agcatcttct tccttaccat catgaccatc
      481 caccgatacc tgtctgtagt gagccccatc tctactctgg gtatccatac cctccgctgc
      541 cgtgtgctgg tgacatcatg tgtgtgggca gccagcatcc tgttctccat ccctgatgct
      601 gtcttccaca aagtgatctc cttaaattgt aaatattctg aacatcatgg gttcttggcc
      661 tcagtctacc agcacaacat cttcttcctc ctctccatgg gaatcatcct attctgttat
      721 gtacagattc tcaggacttt gtttcgcaca aggtccagac agagacaccg aacagtcagg
      781 ctcatcttca ccgtcgtggt agcatacttc ctcagctggg ctccctacaa cctcacactc
      841 ttcctgaaaa ctggaatcat ccagcagagc tgtgagagcc ttcagcaact ggacattgct
      901 atgattatct gtcgccattt ggccttctct cattgctgtt tcaacccagt gctttatgtc
      961 tttgttggga tcaagttccg cagacaccta aaacatctct tccagcaggt ctggctgtgc
     1021 cggaagacat ccagcactgt tccctgctcc cctggtacct ttacatatga gggaccctcc
     1081 ttctactgag aggagaggat gggcacatgg agatgactat gggaggtaaa ggaagacaag
     1141 gagaagtgga tcaggaagga aaatataact gaagatacta cagagtgtgg aggaaagaca
     1201 tgatacccat ggggaagtgg cttccagctg ggcaagccaa agcaacactt cgtgcactca
     1261 gttcatcatt tattctctta cttagacata gattgcttgt tagtgatggt cagaagatcc
     1321 taaatagaag gatttctaga ctttaggagg gcttgaagct tatagtatgt gctaactgtg
     1381 cagtgatgtt gctggtacat agggttgccc caaactattt ttttttcacc ttggtgatag
     1441 ctgactctgt gattcttagc agctacagaa agaaaaaaaa ctctcttcag gacaagaata
     1501 atcacatctt taaataagta cagtcacaat gaagtctata ccataaaatc ccactaaaat
     1561 gaagatggtt ctgagccggg tgtggtggcg catgccttta atcccagcac tcaggaggca
     1621 gagacaggca gatttctgag tttgaggcca gcctggtcta cagagtgagt tccaggacag
     1681 ccagggctac acagagaaac cctgtcttga aaaacaaaac aaaacaaaac aaaacaaaac
     1741 aaaaaaacaa caacaacaaa gatggttcca tattctggca acagctgcta acacataagc
     1801 tggcttttaa atatttagct cataactgaa agaaaaaata caatatgtgc tactgtctgc
     1861 actaagtaat tatttggaca atacaaagat gaataggata ttgctgctaa ctttcagttg
     1921 acaccaatcc atccaagaag gtccagataa gaaaagtcca cttaacagag gcattcaggt
     1981 tgaatattcc tgtcatttca tctcttccag attgagagaa agatgacttc cttacatgtg
     2041 gataataatg ccagcattcc cctcttaacc attctccaga gctaaattct cctcatgcac
     2101 cacattccct ttcgcagagc caggtcccgt ggattctgcc ttcccaacat ctctccagct
     2161 tatgagcaca tacccttgac ttcatcttta tagtgccctc tgttccatag tatcttcctt
     2221 ttgcttctat ttttcctctg ttacatcttc ctccttcagg aagctgcctg cctgagattt
     2281 atcttttatt ttacagctcc tctgcctaga gtctgtcttt gacgctttaa taaaattgtc
     2341 ctcaagctcc cttctgagtt acttcttaaa ttcttttatt aataaaacta gtaacacaaa
     2401 agagggccca gatttccctg gtaatataag gttactccat cagaatgctc cagaatttca
     2461 ggtaacatta ttacctttgg ggcagtttag actgttatat ctgcatccag ggccaaagac
     2521 agaactcaga tcctgttctt tcaaccaaaa ataaatacat aaaaacatat aacagtagac
     2581 tttaaagaat taatgaaaaa attaaaagac ataaaatagt tatggattac ccagaagaag
     2641 taactttcaa gtggatagag ggatggctca gcagttaaga gcactggcta ctcctccaga
     2701 gggcctaaat tcagttccca aagcccacat ggtatctccc aaccatttta actgcagttc
     2761 caagggaatc cattgccctc ttctggcctc ctttcctttg tacacgaaga tgaacatttc
     2821 atatatctta caatgtgtcg gttagagatc cctcgggcac cttacacttc atcctagttt
     2881 atatctctgc ccattagcca ggtgggcttg aaattccttt tcttctaaaa gcctcaattt
     2941 catctttgaa gttcagaaat gaaccctacc tatagcacag agctgtgttg agttttaaac
     3001 ataacattat ataggctttt ggttagggta tgacatatta ggtttttaat atatacaata
     3061 atctactgca caatattttg gtcaatgttg gaccacatat cactgtgctc ccttaagact
     3121 aaatcatcta gtgatgtcat agtcatctta atttatctaa ctatactcca gatgaattgt
     3181 ctatgaaatt ctcaaaatac atcattgccc ttaaataacc catgattgct tgagacctgt
     3241 cttcctcttc tctgtaaatt tatttgggat ctaagtttca aacaagggtg tttgaaatcc
     3301 cttttgtggg aacaggactg aggatgggca tttagaggcg acagagtcac gtgacaactc
     3361 ctggtaaata aagctccaga gatcagtatc agtgtgcaga tctgcattta ttgccaagca
     3421 cataagctta tatacagtat ttgagccaat cccaagcccc taaatccttg gccaagcata
     3481 acttactaca tctcaccata tcccaataaa agctgtgact gatgaggtaa ctcagagaga
     3541 aggggtgtgg cgagcattgt cacctgtagg gacttttgtg aagactcaga agcagccact
     3601 gtcttgacct tagttccttt ttgctgtctc actggtgtcc cgggagccat cttagatctg
     3661 acaccatgta cagcagatca ggactctgtg gcacagtgct ctccacccca catattcctt
     3721 cacaaggttg tcttccacat gcctcacact ctcaatctta acatcccaaa gctgttcagg
     3781 ctgtagtcag agcaagtttt tcttagttca ctctattgat aaatctttat ttctgatgtc
     3841 atttcctccc acttcttccc ttttttttgt tttcctttgt taacagaaag gggaatcatt
     3901 tctcttcgtg aggttttttt tatcctcatc cacaaactga caactccatc aagttaatat
     3961 gttgtctcat atacctccag tataaaatat gaaattaact taaaagattt cttttccttc
     4021 ctgtatgaat ttatcctgag aacctggaat gctgaagtct ggcagatgcc actattagct
     4081 aagtcctgta aggtacacaa gcatttctag ctaacatgat gaaaataagg cagtgtgagg
     4141 agccagccag agctaagaag cgaacctaat catgggctga cattcctatg tactgtcccc
     4201 tgtctttagc atgttcatcc atactggact tggaatgcag tgttctattg caccaggctt
     4261 cagggtgctt tgcaactcag caacaagcaa acacgggact gaggaagcta agcatggtag
     4321 ttctttagca catattttca aacactgttt tttaagtgtc tgttaatgag ggggaaacaa
     4381 aaactgagaa cttaggtcca gcagtacata ctaagttcat ttttttttag cttcataaat
     4441 aaaacgtaat agt
//
