LOCUS       NM_008510                518 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus chemokine (C motif) ligand 1 (Xcl1), mRNA.
ACCESSION   NM_008510
VERSION     NM_008510.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Ghilas,S., Ambrosini,M., Cancel,J.C., Brousse,C., Masse,M.,
            Lelouard,H., Dalod,M. and Crozat,K.
  TITLE     Natural killer cells and dendritic epidermal gammadelta T cells
            orchestrate type 1 conventional DC spatiotemporal repositioning
            toward CD8+ T cells
  JOURNAL   iScience 24 (9), 103059 (2021)
   PUBMED   34568787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Leiter,O., Bernas,S.N., Seidemann,S., Overall,R.W., Horenburg,C.,
            Kowal,S., Kempermann,G. and Walker,T.L.
  TITLE     The systemic exercise-released chemokine lymphotactin/XCL1
            modulates in vitro adult hippocampal precursor cell proliferation
            and neuronal differentiation
  JOURNAL   Sci Rep 9 (1), 11831 (2019)
   PUBMED   31413355
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 518)
  AUTHORS   Matsuo,K., Kitahata,K., Kawabata,F., Kamei,M., Hara,Y.,
            Takamura,S., Oiso,N., Kawada,A., Yoshie,O. and Nakayama,T.
  TITLE     A Highly Active Form of XCL1/Lymphotactin Functions as an Effective
            Adjuvant to Recruit Cross-Presenting Dendritic Cells for Induction
            of Effector and Memory CD8+ T Cells
  JOURNAL   Front Immunol 9, 2775 (2018)
   PUBMED   30542351
  REMARK    GeneRIF: A highly active form of XCL1 is a promising vaccine
            adjuvant for cross-presenting DCs to induce antigen-specific
            effector and memory CD8(+) T cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 518)
  AUTHORS   Matsumoto,N., Kon,S., Nakatsuru,T., Miyashita,T., Inui,K.,
            Saitoh,K., Kitai,Y., Muromoto,R., Kashiwakura,J.I., Uede,T. and
            Matsuda,T.
  TITLE     A Novel alpha9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in
            the Development of Murine Models of Autoimmune Diseases
  JOURNAL   J Immunol 199 (1), 82-90 (2017)
   PUBMED   28550205
  REMARK    GeneRIF: study provides in vitro and in vivo evidence that the
            interaction between XCL1 and alpha9 integrin has an important role
            for autoimmune diseases
REFERENCE   5  (bases 1 to 518)
  AUTHORS   Zychowska,M., Rojewska,E., Piotrowska,A., Kreiner,G. and Mika,J.
  TITLE     Microglial Inhibition Influences XCL1/XCR1 Expression and Causes
            Analgesic Effects in a Mouse Model of Diabetic Neuropathy
  JOURNAL   Anesthesiology 125 (3), 573-589 (2016)
   PUBMED   27387353
  REMARK    GeneRIF: The interaction between XCL1 and XCR1 plays a crucial role
            in the classical immunology response.
REFERENCE   6  (bases 1 to 518)
  AUTHORS   Rumsaeng,V., Vliagoftis,H., Oh,C.K. and Metcalfe,D.D.
  TITLE     Lymphotactin gene expression in mast cells following Fc(epsilon)
            receptor I aggregation: modulation by TGF-beta, IL-4,
            dexamethasone, and cyclosporin A
  JOURNAL   J Immunol 158 (3), 1353-1360 (1997)
   PUBMED   9013979
REFERENCE   7  (bases 1 to 518)
  AUTHORS   Boismenu,R., Feng,L., Xia,Y.Y., Chang,J.C. and Havran,W.L.
  TITLE     Chemokine expression by intraepithelial gamma delta T cells.
            Implications for the recruitment of inflammatory cells to damaged
            epithelia
  JOURNAL   J Immunol 157 (3), 985-992 (1996)
   PUBMED   8757601
REFERENCE   8  (bases 1 to 518)
  AUTHORS   Kennedy,J., Kelner,G.S., Kleyensteuber,S., Schall,T.J., Weiss,M.C.,
            Yssel,H., Schneider,P.V., Cocks,B.G., Bacon,K.B. and Zlotnik,A.
  TITLE     Molecular cloning and functional characterization of human
            lymphotactin
  JOURNAL   J Immunol 155 (1), 203-209 (1995)
   PUBMED   7602097
REFERENCE   9  (bases 1 to 518)
  AUTHORS   Yoshida,T., Imai,T., Kakizaki,M., Nishimura,M. and Yoshie,O.
  TITLE     Molecular cloning of a novel C or gamma type chemokine, SCM-1
  JOURNAL   FEBS Lett 360 (2), 155-159 (1995)
   PUBMED   7875320
REFERENCE   10 (bases 1 to 518)
  AUTHORS   Kelner,G.S., Kennedy,J., Bacon,K.B., Kleyensteuber,S.,
            Largaespada,D.A., Jenkins,N.A., Copeland,N.G., Bazan,J.F.,
            Moore,K.W., Schall,T.J. et al.
  TITLE     Lymphotactin: a cytokine that represents a new class of chemokine
  JOURNAL   Science 266 (5189), 1395-1399 (1994)
   PUBMED   7973732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133891.13.
            
            On Oct 12, 2022 this sequence version replaced NM_008510.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX514722.1, AI323655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC133891.13        89475-89570
            97-211              AC133891.13        91991-92105
            212-518             AC133891.13        93047-93353
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 72.26 cM"
     gene            1..518
                     /gene="Xcl1"
                     /gene_synonym="ATAC; Lptn; LTN; SCM-1; SCM-1a; Scyc1"
                     /note="chemokine (C motif) ligand 1"
                     /db_xref="GeneID:16963"
                     /db_xref="MGI:MGI:104593"
     exon            1..96
                     /gene="Xcl1"
                     /gene_synonym="ATAC; Lptn; LTN; SCM-1; SCM-1a; Scyc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..380
                     /gene="Xcl1"
                     /gene_synonym="ATAC; Lptn; LTN; SCM-1; SCM-1a; Scyc1"
                     /note="lymphotaxin; cytokine SCM-1; c motif chemokine 1;
                     small-inducible cytokine C1; lymphotactin; small inducible
                     cytokine subfamily C, member 1 (lymphotactin); chemokine
                     XCL1"
                     /codon_start=1
                     /product="lymphotactin precursor"
                     /protein_id="NP_032536.1"
                     /db_xref="CCDS:CCDS15438.1"
                     /db_xref="GeneID:16963"
                     /db_xref="MGI:MGI:104593"
                     /translation="MRLLLLTFLGVCCLTPWVVEGVGTEVLEESSCVNLQTQRLPVQK
                     IKTYIIWEGAMRAVIFVTKRGLKICADPEAKWVKAAIKTVDGRASTRKNMAETVPTGA
                     QRSTSTAITLTG"
     exon            97..211
                     /gene="Xcl1"
                     /gene_synonym="ATAC; Lptn; LTN; SCM-1; SCM-1a; Scyc1"
                     /inference="alignment:Splign:2.1.0"
     exon            212..518
                     /gene="Xcl1"
                     /gene_synonym="ATAC; Lptn; LTN; SCM-1; SCM-1a; Scyc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      500..505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xcl1"
                     /gene_synonym="ATAC; Lptn; LTN; SCM-1; SCM-1a; Scyc1"
                     /note="hexamer: AATAAA"
     polyA_site      518
                     /gene="Xcl1"
                     /gene_synonym="ATAC; Lptn; LTN; SCM-1; SCM-1a; Scyc1"
                     /note="major polyA site"
ORIGIN      
        1 acattcttct tgcacagccc agcaagacct cagccatgag acttctcctc ctgactttcc
       61 tgggagtctg ctgcctcacc ccatgggttg tggaaggtgt ggggactgaa gtcctagaag
      121 agagtagctg tgtgaactta caaacccagc ggctgccagt tcaaaaaatc aagacctata
      181 tcatctggga gggggccatg agagctgtaa tttttgtcac caaacgagga ctaaaaattt
      241 gtgctgatcc agaagccaaa tgggtgaaag cagcgatcaa gactgtggat ggcagggcca
      301 gtaccagaaa gaacatggct gaaactgttc ccacaggagc ccagaggtcc accagcacag
      361 cgataaccct gactgggtaa cagcctccag gacaatgttt cctcactcgt taagcagctc
      421 atctcagttc ccaaacccat tgcacaaata cttattttta tttttaacga cattcacatt
      481 catttcaaat gttataagta ataaatattt attattga
//
