LOCUS       NM_001271730            2238 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus X-box binding protein 1 (Xbp1), transcript variant 2,
            mRNA.
ACCESSION   NM_001271730
VERSION     NM_001271730.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2238)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2238)
  AUTHORS   Joshi,A.S., Castillo,M.B., Tomaz da Silva,M., Vuong,A.T.,
            Gunaratne,P.H., Darabi,R., Liu,Y. and Kumar,A.
  TITLE     Single-nucleus transcriptomic analysis reveals the regulatory
            circuitry of myofiber XBP1 during regenerative myogenesis
  JOURNAL   iScience 27 (12), 111372 (2024)
   PUBMED   39650729
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2238)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   4  (bases 1 to 2238)
  AUTHORS   Borisova,E., Newman,A.G., Couce Iglesias,M., Dannenberg,R.,
            Schaub,T., Qin,B., Rusanova,A., Brockmann,M., Koch,J., Daniels,M.,
            Turko,P., Jahn,O., Kaplan,D.R., Rosario,M., Iwawaki,T.,
            Spahn,C.M.T., Rosenmund,C., Meierhofer,D., Kraushar,M.L.,
            Tarabykin,V. and Ambrozkiewicz,M.C.
  TITLE     Protein translation rate determines neocortical neuron fate
  JOURNAL   Nat Commun 15 (1), 4879 (2024)
   PUBMED   38849354
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2238)
  AUTHORS   Zhou,W., Ren,S., Lu,Y., Wang,Y., Feng,L. and Gao,Q.
  TITLE     Specific Knockout of Notch-1 in Macrophages Modulate the
            Progression of Hepatic Insulin Resistance in HFD Fed Mice via
            Regulating IRE1alpha-XBP1 Signals
  JOURNAL   J Coll Physicians Surg Pak 34 (5), 527-532 (2024)
   PUBMED   38720211
  REMARK    GeneRIF: Specific Knockout of Notch-1 in Macrophages Modulate the
            Progression of Hepatic Insulin Resistance in HFD Fed Mice via
            Regulating IRE1alpha-XBP1 Signals.
REFERENCE   6  (bases 1 to 2238)
  AUTHORS   Reimold,A.M., Etkin,A., Clauss,I., Perkins,A., Friend,D.S.,
            Zhang,J., Horton,H.F., Scott,A., Orkin,S.H., Byrne,M.C.,
            Grusby,M.J. and Glimcher,L.H.
  TITLE     An essential role in liver development for transcription factor
            XBP-1
  JOURNAL   Genes Dev 14 (2), 152-157 (2000)
   PUBMED   10652269
REFERENCE   7  (bases 1 to 2238)
  AUTHORS   Masaki,T., Yoshida,M. and Noguchi,S.
  TITLE     Targeted disruption of CRE-binding factor TREB5 gene leads to
            cellular necrosis in cardiac myocytes at the embryonic stage
  JOURNAL   Biochem Biophys Res Commun 261 (2), 350-356 (1999)
   PUBMED   10425189
REFERENCE   8  (bases 1 to 2238)
  AUTHORS   ten Berge,D., Brouwer,A., el Bahi,S., Guenet,J.L., Robert,B. and
            Meijlink,F.
  TITLE     Mouse Alx3: an aristaless-like homeobox gene expressed during
            embryogenesis in ectomesenchyme and lateral plate mesoderm
  JOURNAL   Dev Biol 199 (1), 11-25 (1998)
   PUBMED   9676189
REFERENCE   9  (bases 1 to 2238)
  AUTHORS   Clauss,I.M., Chu,M., Zhao,J.L. and Glimcher,L.H.
  TITLE     The basic domain/leucine zipper protein hXBP-1 preferentially binds
            to and transactivates CRE-like sequences containing an ACGT core
  JOURNAL   Nucleic Acids Res 24 (10), 1855-1864 (1996)
   PUBMED   8657566
REFERENCE   10 (bases 1 to 2238)
  AUTHORS   Clauss,I.M., Gravallese,E.M., Darling,J.M., Shapiro,F.,
            Glimcher,M.J. and Glimcher,L.H.
  TITLE     In situ hybridization studies suggest a role for the basic
            region-leucine zipper protein hXBP-1 in exocrine gland and skeletal
            development during mouse embryogenesis
  JOURNAL   Dev Dyn 197 (2), 146-156 (1993)
   PUBMED   7693055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662876.23, BG800705.1 and BF453945.1.
            
            Transcript Variant: This variant (2) lacks a 26 nt segment in the
            CDS compared to variant 1, that causes a frameshift. The resulting
            isoform, XBP1(S), has the same N-terminus, but a longer and
            distinct C-terminus compared to isoform XBP1(U). Isoform XBP1(S)
            functions as a transcription factor.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF443192.1, CF616395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-369               AL662876.23        148998-149366
            370-957             BG800705.1         1-588
            958-1852            AL662876.23        153087-153981
            1853-2238           BF453945.1         3-388               c
FEATURES             Location/Qualifiers
     source          1..2238
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.61 cM"
     gene            1..2238
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
                     /note="X-box binding protein 1"
                     /db_xref="GeneID:22433"
                     /db_xref="MGI:MGI:98970"
     exon            1..560
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1470
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
                     /note="isoform XBP1(S) is encoded by transcript variant 2;
                     tax-responsive element-binding protein 5 homolog"
                     /codon_start=1
                     /product="X-box-binding protein 1 isoform XBP1(S)"
                     /protein_id="NP_001258659.1"
                     /db_xref="GeneID:22433"
                     /db_xref="MGI:MGI:98970"
                     /translation="MVVVAAAPSAATAAPKVLLLSGQPASGGRALPLMVPGPRAAGSE
                     ASGTPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEEN
                     HKLQLENQLLREKTHGLVVENQELRTRLGMDTLDPDEVPEVEAKGSGVRLVAGSAESA
                     AGAGPVVTSPEHLPMDSDTVASSDSESDILLGILDKLDPVMFFKCPSPESASLEELPE
                     VYPEGPSSLPASLSLSVGTSSAKLEAINELIRFDHVYTKPLVLEIPSETESQTNVVVK
                     IEEAPLSSSEEDHPEFIVSVKKEPLEDDFIPELGISNLLSSSHCLRPPSCLLDAHSDC
                     GYEGSPSPFSDMSSPLGTDHSWEDTFANELFPQLISV"
     exon            561..657
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..792
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..831
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..912
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..2221
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2100..2105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2120
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
                     /note="major polyA site"
     regulatory      2191..2196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
                     /note="hexamer: ACTAAA"
     polyA_site      2221
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
ORIGIN      
        1 ctagggtaaa accgtgagac tcggtctgga aatctggcct gagaggacag cctggcaatc
       61 ctcagccggg gtggggacgt ctgccgaaga tccttggact ccagcaacca gtggtcgcca
      121 ccgtccatcc accctaaggc ccagtttgca cggcggagaa cagctgtgca gccacgctgg
      181 acactcaccc cgcccgagtt gagcccgccc ccgggactac aggaccaata agtgatgaat
      241 atacccgcgc gtcacggagc accggccaat cgcggacggc cacgacccta gaaaggctgg
      301 gcgcggcagg aggccacggg gcggtggcgg cgctggcgta gacgtttcct ggctatggtg
      361 gtggtggcag cggcgccgag cgcggccacg gcggccccca aagtgctact cttatctggc
      421 cagcccgcct ccggcggccg ggcgctgccg ctcatggtac ccggtccgcg ggcagcaggg
      481 tcggaggcga gcgggacacc gcaggctcgc aagcggcagc ggctcacgca cctgagcccg
      541 gaggagaaag cgctgcggag gaaactgaaa aacagagtag cagcgcagac tgctcgagat
      601 agaaagaaag cccggatgag cgagctggag cagcaagtgg tggatttgga agaagagaac
      661 cacaaactcc agctagaaaa tcagctttta cgggagaaaa ctcacggcct tgtggttgag
      721 aaccaggagt taagaacacg cttgggaatg gacacgctgg atcctgacga ggttccagag
      781 gtggaggcca aggggagtgg agtaaggctg gtggccgggt ctgctgagtc cgcagcaggt
      841 gcaggcccag ttgtcacctc cccagaacat cttcccatgg actctgacac tgttgcctct
      901 tcagattctg agtctgatat ccttttgggc attctggaca agttggaccc tgtcatgttt
      961 ttcaaatgtc cttccccaga gtctgctagt ctggaggaac tcccagaggt ctacccagaa
     1021 ggacctagtt ccttaccagc ctccctttct ctgtcagtgg ggacctcatc agccaagctg
     1081 gaagccatta atgaactcat tcgttttgac catgtataca ccaagcctct agttttagag
     1141 atcccctctg agacagagag tcaaactaac gtggtagtga aaattgagga agcacctcta
     1201 agctcttcag aagaggatca ccctgaattc attgtctcag tgaagaaaga gcctttggaa
     1261 gatgacttca tcccagagct gggcatctca aacctgcttt catccagcca ttgtctgaga
     1321 ccaccttctt gcctgctgga cgctcacagt gactgtggat atgagggctc cccttctccc
     1381 ttcagtgaca tgtcttctcc acttggtaca gaccactcct gggaggatac ttttgccaat
     1441 gaacttttcc cccagctgat tagtgtctaa agagccacat aacactgggc ccctttccct
     1501 gaccatcaca ttgcctagag gatagcatag gcctgtctct ttcgttaaaa gccaaagtag
     1561 aggctgtctg gccttagaag aattcctcta aagtatttca aatctcatag atgacttcca
     1621 agtattgtcg tttgacactc agctgtctaa ggtattcaaa ggtattccag tactacagct
     1681 tttgagattc tagtttatct taaaggtggt agtatactct aaatcgcagg gagggtcatt
     1741 tgacagtttt ttcccagcct ggcttcaaac tatgtagccg aggctaggca gaaacttctg
     1801 accctcttga ccccacctcc caagtgctgg gcttcaccag gtgtgcacct ccacacctgc
     1861 ccccccgaca tgtcaggtgg acatgggatt catgaatggc ccttagcatt tctttctcca
     1921 ctctctgctt cccaggtttc gtaacctgag ggggcttgtt ttcccttatg tgcattttaa
     1981 atgaagatca agaatctttg taaaatgatg aaaatttact atgtaaatgc ttgatggatc
     2041 ttcttgctag tgtagcttct agaaggtgct ttctccattt atttaaaact acccttgcaa
     2101 ttaaaaaaaa agcaacacag cgtcctgttc tgtgatttct agggctgttg taatttctct
     2161 ttattgttgg ctaaaggagt aatttatcca actaaagtga gcataccact ttttaaagtc
     2221 aaaaaaaaaa aaaaaaaa
//
