LOCUS       NP_001258659             371 aa            linear   ROD 12-JUN-2025
DEFINITION  X-box-binding protein 1 isoform XBP1(S) [Mus musculus].
ACCESSION   NP_001258659
VERSION     NP_001258659.1
DBSOURCE    REFSEQ: accession NM_001271730.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 371)
  AUTHORS   Touvier,T., Veneri,F.A., Claessens,A., Ferri,C., Mastrangelo,R.,
            Sorgiati,N., Bianchi,F., Valenzano,S., Del Carro,U., Rivellini,C.,
            Duong,P., Shy,M.E., Kelly,J.W., Svaren,J., Wiseman,R.L. and
            D'Antonio,M.
  TITLE     Activation of XBP1s attenuates disease severity in models of
            proteotoxic Charcot-Marie-Tooth type 1B
  JOURNAL   Brain 148 (6), 1978-1993 (2025)
   PUBMED   39979221
REFERENCE   2  (residues 1 to 371)
  AUTHORS   Zhao,T., Jin,K., Wang,X., Su,X., Wang,Y., Gao,M., Luo,W., Yang,H.
            and Yang,Z.
  TITLE     GPAT4 sustains endoplasmic reticulum homeostasis in endocardial
            cells and safeguards heart development
  JOURNAL   Nat Commun 16 (1), 3345 (2025)
   PUBMED   40199910
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 371)
  AUTHORS   Barton,B.M., Son,F., Verma,A., Bal,S.K., Tang,Q., Wang,R.,
            Umphred-Wilson,K., Khan,R., Trichka,J., Dong,H., Lentucci,C.,
            Chen,X., Chen,Y., Hong,Y., Duy,C., Elemento,O., Melnick,A.M.,
            Cao,J., Chen,X., Glimcher,L.H. and Adoro,S.
  TITLE     IRE1alpha-XBP1 safeguards hematopoietic stem and progenitor cells
            by restricting pro-leukemogenic gene programs
  JOURNAL   Nat Immunol 26 (2), 200-214 (2025)
   PUBMED   39789376
REFERENCE   4  (residues 1 to 371)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 371)
  AUTHORS   Joshi,A.S., Castillo,M.B., Tomaz da Silva,M., Vuong,A.T.,
            Gunaratne,P.H., Darabi,R., Liu,Y. and Kumar,A.
  TITLE     Single-nucleus transcriptomic analysis reveals the regulatory
            circuitry of myofiber XBP1 during regenerative myogenesis
  JOURNAL   iScience 27 (12), 111372 (2024)
   PUBMED   39650729
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 371)
  AUTHORS   Reimold,A.M., Etkin,A., Clauss,I., Perkins,A., Friend,D.S.,
            Zhang,J., Horton,H.F., Scott,A., Orkin,S.H., Byrne,M.C.,
            Grusby,M.J. and Glimcher,L.H.
  TITLE     An essential role in liver development for transcription factor
            XBP-1
  JOURNAL   Genes Dev 14 (2), 152-157 (2000)
   PUBMED   10652269
REFERENCE   7  (residues 1 to 371)
  AUTHORS   Masaki,T., Yoshida,M. and Noguchi,S.
  TITLE     Targeted disruption of CRE-binding factor TREB5 gene leads to
            cellular necrosis in cardiac myocytes at the embryonic stage
  JOURNAL   Biochem Biophys Res Commun 261 (2), 350-356 (1999)
   PUBMED   10425189
REFERENCE   8  (residues 1 to 371)
  AUTHORS   ten Berge,D., Brouwer,A., el Bahi,S., Guenet,J.L., Robert,B. and
            Meijlink,F.
  TITLE     Mouse Alx3: an aristaless-like homeobox gene expressed during
            embryogenesis in ectomesenchyme and lateral plate mesoderm
  JOURNAL   Dev Biol 199 (1), 11-25 (1998)
   PUBMED   9676189
REFERENCE   9  (residues 1 to 371)
  AUTHORS   Clauss,I.M., Chu,M., Zhao,J.L. and Glimcher,L.H.
  TITLE     The basic domain/leucine zipper protein hXBP-1 preferentially binds
            to and transactivates CRE-like sequences containing an ACGT core
  JOURNAL   Nucleic Acids Res 24 (10), 1855-1864 (1996)
   PUBMED   8657566
REFERENCE   10 (residues 1 to 371)
  AUTHORS   Clauss,I.M., Gravallese,E.M., Darling,J.M., Shapiro,F.,
            Glimcher,M.J. and Glimcher,L.H.
  TITLE     In situ hybridization studies suggest a role for the basic
            region-leucine zipper protein hXBP-1 in exocrine gland and skeletal
            development during mouse embryogenesis
  JOURNAL   Dev Dyn 197 (2), 146-156 (1993)
   PUBMED   7693055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662876.23, BG800705.1 and BF453945.1.
            
            Transcript Variant: This variant (2) lacks a 26 nt segment in the
            CDS compared to variant 1, that causes a frameshift. The resulting
            isoform, XBP1(S), has the same N-terminus, but a longer and
            distinct C-terminus compared to isoform XBP1(U). Isoform XBP1(S)
            functions as a transcription factor.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF443192.1, CF616395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.61 cM"
     Protein         1..371
                     /product="X-box-binding protein 1 isoform XBP1(S)"
                     /note="tax-responsive element-binding protein 5 homolog"
                     /calculated_mol_wt=39757
     Region          35..56
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O35426.2)"
     Site            61
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17861; propagated from
                     UniProtKB/Swiss-Prot (O35426.2)"
     Region          63..119
                     /region_name="bZIP_XBP1"
                     /note="Basic leucine zipper (bZIP) domain of X-box binding
                     protein 1 (XBP1) and similar proteins: a DNA-binding and
                     dimerization domain; cd14691"
                     /db_xref="CDD:269839"
     Region          65..87
                     /region_name="Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (O35426.2)"
     Region          66..117
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269839"
     Region          69..85
                     /region_name="Nuclear localization signal (NLS).
                     /evidence=ECO:0000250|UniProtKB:P17861"
                     /note="propagated from UniProtKB/Swiss-Prot (O35426.2)"
     Site            order(69..70,72..74,76..81,83..85)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269839"
     Site            order(84,87..88,91..92,94..95,98..99,101..102,105..106,
                     108..109,112..113,115..116)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269839"
     Region          91..126
                     /region_name="Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (O35426.2)"
     CDS             1..371
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
                     /coded_by="NM_001271730.1:355..1470"
                     /note="isoform XBP1(S) is encoded by transcript variant 2"
                     /db_xref="GeneID:22433"
                     /db_xref="MGI:MGI:98970"
ORIGIN      
        1 mvvvaaapsa ataapkvlll sgqpasggra lplmvpgpra agseasgtpq arkrqrlthl
       61 speekalrrk lknrvaaqta rdrkkarmse leqqvvdlee enhklqlenq llrekthglv
      121 venqelrtrl gmdtldpdev peveakgsgv rlvagsaesa agagpvvtsp ehlpmdsdtv
      181 assdsesdil lgildkldpv mffkcpspes asleelpevy pegpsslpas lslsvgtssa
      241 kleainelir fdhvytkplv leipsetesq tnvvvkieea plssseedhp efivsvkkep
      301 leddfipelg isnllssshc lrppscllda hsdcgyegsp spfsdmsspl gtdhswedtf
      361 anelfpqlis v
//
