LOCUS       NM_001037713            2598 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus XIAP associated factor 1 (Xaf1), transcript variant 1,
            mRNA.
ACCESSION   NM_001037713 XM_282966 XM_894999 XM_902351 XM_910277
VERSION     NM_001037713.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2598)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2598)
  AUTHORS   Kuang,M., Zhao,Y., Yu,H., Li,S., Liu,T., Chen,L., Chen,J., Luo,Y.,
            Guo,X., Wei,X., Li,Y., Zhang,Z., Wang,D. and You,F.
  TITLE     XAF1 promotes anti-RNA virus immune responses by regulating
            chromatin accessibility
  JOURNAL   Sci Adv 9 (33), eadg5211 (2023)
   PUBMED   37595039
  REMARK    GeneRIF: XAF1 promotes anti-RNA virus immune responses by
            regulating chromatin accessibility.
REFERENCE   3  (bases 1 to 2598)
  AUTHORS   Chen,M., Wang,K., Han,Y., Yan,S., Yuan,H., Liu,Q., Li,L., Li,N.,
            Zhu,H., Lu,D., Wang,K., Liu,F., Luo,D., Zhang,Y., Jiang,J., Li,D.,
            Zhang,L., Ji,H., Zhou,H., Chen,Y., Qin,J. and Gao,D.
  TITLE     Identification of XAF1 as an endogenous AKT inhibitor
  JOURNAL   Cell Rep 42 (7), 112690 (2023)
   PUBMED   37384528
  REMARK    GeneRIF: Identification of XAF1 as an endogenous AKT inhibitor.
REFERENCE   4  (bases 1 to 2598)
  AUTHORS   Liu,B.Q., Liu,R.B., Li,W.P., Mao,X.T., Li,Y.N., Huang,T.,
            Wang,H.L., Chen,H.T., Zhong,J.Y., Yang,B., Chai,R.J., Cao,Q.,
            Jin,J. and Li,Y.Y.
  TITLE     XAF1 prevents hyperproduction of type I interferon upon viral
            infection by targeting IRF7
  JOURNAL   EMBO Rep 24 (1), e55387 (2023)
   PUBMED   36394357
  REMARK    GeneRIF: XAF1 prevents hyperproduction of type I interferon upon
            viral infection by targeting IRF7.
REFERENCE   5  (bases 1 to 2598)
  AUTHORS   Han,Y., Bai,X., Liu,S., Zhu,J., Zhang,F., Xie,L., Liu,G., Jiang,X.,
            Zhang,M., Huang,Y., Wang,J., Li,D., Zhang,H., He,Y., He,S., Xia,Y.,
            Xu,X., Xu,F. and Ma,F.
  TITLE     XAF1 Protects Host against Emerging RNA Viruses by Stabilizing
            IRF1-Dependent Antiviral Immunity
  JOURNAL   J Virol 96 (17), e0077422 (2022)
   PUBMED   35972291
  REMARK    GeneRIF: XAF1 Protects Host against Emerging RNA Viruses by
            Stabilizing IRF1-Dependent Antiviral Immunity.
REFERENCE   6  (bases 1 to 2598)
  AUTHORS   Choo,Z., Koh,R.Y., Wallis,K., Koh,T.J., Kuick,C.H., Sobrado,V.,
            Kenchappa,R.S., Loh,A.H., Soh,S.Y., Schlisio,S., Chang,K.T. and
            Chen,Z.X.
  TITLE     XAF1 promotes neuroblastoma tumor suppression and is required for
            KIF1Bbeta-mediated apoptosis
  JOURNAL   Oncotarget 7 (23), 34229-34239 (2016)
   PUBMED   27097110
  REMARK    GeneRIF: XAF1 may be a candidate tumor suppressor in neuroblastoma
REFERENCE   7  (bases 1 to 2598)
  AUTHORS   Mannion,N.M., Greenwood,S.M., Young,R., Cox,S., Brindle,J.,
            Read,D., Nellaker,C., Vesely,C., Ponting,C.P., McLaughlin,P.J.,
            Jantsch,M.F., Dorin,J., Adams,I.R., Scadden,A.D., Ohman,M.,
            Keegan,L.P. and O'Connell,M.A.
  TITLE     The RNA-editing enzyme ADAR1 controls innate immune responses to
            RNA
  JOURNAL   Cell Rep 9 (4), 1482-1494 (2014)
   PUBMED   25456137
REFERENCE   8  (bases 1 to 2598)
  AUTHORS   Bai,Y., Ahmad,U., Wang,Y., Li,J.H., Choy,J.C., Kim,R.W.,
            Kirkiles-Smith,N., Maher,S.E., Karras,J.G., Bennett,C.F.,
            Bothwell,A.L., Pober,J.S. and Tellides,G.
  TITLE     Interferon-gamma induces X-linked inhibitor of apoptosis-associated
            factor-1 and Noxa expression and potentiates human vascular smooth
            muscle cell apoptosis by STAT3 activation
  JOURNAL   J Biol Chem 283 (11), 6832-6842 (2008)
   PUBMED   18192275
  REMARK    GeneRIF: Interferon gamma induces XAF1 and Noxa expression and
            potentiates apoptosis by STAT3 activation
REFERENCE   9  (bases 1 to 2598)
  AUTHORS   Qiao,L., Gu,Q., Dai,Y., Shen,Z., Liu,X., Qi,R., Ma,J., Zou,B.,
            Li,Z., Lan,H.Y. and Wong,B.C.
  TITLE     XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse
            endothelial cells
  JOURNAL   Tumour Biol 29 (2), 122-129 (2008)
   PUBMED   18544999
  REMARK    GeneRIF: XAF1 possesses a potential antiangiogenesis effect.
            Suppressed expression of Tie-1, Ang-1, Ang-2 and c-Myc may be
            mechanistically responsible for the observed antiangiogenesis
            effect.
REFERENCE   10 (bases 1 to 2598)
  AUTHORS   Wang,X., Zhu,C., Wang,X., Hagberg,H., Korhonen,L., Sandberg,M.,
            Lindholm,D. and Blomgren,K.
  TITLE     X-linked inhibitor of apoptosis (XIAP) protein protects against
            caspase activation and tissue loss after neonatal hypoxia-ischemia
  JOURNAL   Neurobiol Dis 16 (1), 179-189 (2004)
   PUBMED   15207275
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929071.6, AK140315.1 and AK046736.1.
            
            On Mar 27, 2014 this sequence version replaced NM_001037713.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV044707.1, SRR5189685.52485.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AL929071.6         71881-71916
            37-502              AK140315.1         2-467
            503-631             AK046736.1         274-402
            632-820             AL929071.6         78988-79176
            821-2598            AL929071.6         82208-83985
FEATURES             Location/Qualifiers
     source          1..2598
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.99 cM"
     gene            1..2598
                     /gene="Xaf1"
                     /gene_synonym="Fbox39"
                     /note="XIAP associated factor 1"
                     /db_xref="GeneID:327959"
                     /db_xref="MGI:MGI:3772572"
     exon            1..81
                     /gene="Xaf1"
                     /gene_synonym="Fbox39"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..871
                     /gene="Xaf1"
                     /gene_synonym="Fbox39"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     protein 39; novel TRAF-type zinc finger protein;
                     BIRC4-binding protein"
                     /codon_start=1
                     /product="XIAP-associated factor 1 isoform 1"
                     /protein_id="NP_001032802.2"
                     /db_xref="CCDS:CCDS24984.2"
                     /db_xref="GeneID:327959"
                     /db_xref="MGI:MGI:3772572"
                     /translation="MEADFQVCRNCKRNVASLHFMLHEAHCLRFIVLCPECEEPIPES
                     KMKEHMEVVHQQTKESQQHPAKCKFCELAVQLSNLDVHESHCGSRTEHCPHCNQPITL
                     QVLSQHKAMCLSAKGRPEEGKRIVSSPGRKTRCDLCKQMIPENTYASHMKQCSAPNTV
                     TRIRDESIIVIPSTLAFMDSGNRRSTVSKDVRPKTKNRNSSTKRETKKQNGTVALPLK
                     SGLQQRADLPTGDETAYDTLQNCCQCRILLPLPILNEHQEKCQRLAHQKKLQWGW"
     exon            82..217
                     /gene="Xaf1"
                     /gene_synonym="Fbox39"
                     /inference="alignment:Splign:2.1.0"
     exon            218..413
                     /gene="Xaf1"
                     /gene_synonym="Fbox39"
                     /inference="alignment:Splign:2.1.0"
     exon            414..502
                     /gene="Xaf1"
                     /gene_synonym="Fbox39"
                     /inference="alignment:Splign:2.1.0"
     exon            503..820
                     /gene="Xaf1"
                     /gene_synonym="Fbox39"
                     /inference="alignment:Splign:2.1.0"
     exon            821..2598
                     /gene="Xaf1"
                     /gene_synonym="Fbox39"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgtgcaaa gaaacgaaac tccacagaag cactgcagga agcttgacca tggaggctga
       61 cttccaagtg tgcaggaact gcaaaagaaa tgtggcctct ctccacttca tgctccacga
      121 ggcccactgc ctgcgcttca tagtcctttg cccagaatgt gaagagccca tcccagagtc
      181 aaagatgaaa gagcacatgg aagttgtgca ccagcagacc aaggaaagcc aacagcaccc
      241 tgccaagtgc aagttctgtg agctggccgt gcagcttagc aatctggatg tccatgagtc
      301 ccactgtggc agccggacag agcattgtcc acactgcaac cagcccatca cactccaagt
      361 actgtctcag cacaaagcca tgtgtctgag tgcaaagggc aggcctgagg aagggaagag
      421 aattgtatca tctcctggaa gaaaaacccg ttgtgatctt tgcaaacaaa tgattccaga
      481 aaatacgtat gcctcccata tgaaacaatg ttccgcccca aacactgtga cacgtattcg
      541 ggatgaaagt ataatagtca ttccttcaac ccttgcattt atggactctg gaaatcgaag
      601 atccacagtg agtaaagatg ttcgtccaaa gacaaaaaat agaaacagct caacaaagcg
      661 agagacaaaa aaacaaaatg gcactgtggc tctgcctttg aagtctgggc tccagcagag
      721 ggctgatctt cccacaggag acgagacggc ctatgacact ctccagaact gttgtcagtg
      781 ccgaatttta cttcccttgc ccattctaaa tgagcaccag gagaagtgcc agaggttagc
      841 tcaccaaaag aaactccagt ggggctggtg agatggctca gcgggtaaga gcacccgact
      901 gctcttccga aggtccggag ttcaaatccc agcaaccaca tggtggctca caaccatctg
      961 taatgagatc tggctccctc ttctggactg tcagaagaca gctacagtgt acttacatat
     1021 aataaataaa taaatcttta aaaaaaaaaa aaacagcatc tcatggacaa gatatcttca
     1081 ttttaaaaaa aaaaaaagaa actccagtga ggatggccag ctggattccg aagattgaag
     1141 agcaccagtt cccactaact tcccagatcc cactagcttc ccagttccca ctagcttccc
     1201 agatcccact agcttcccag atcccactag cttcccagtt cccactagct ttccagcttc
     1261 ctttcctagt ggtcacaact ttgttttctt taccagtctc tgtaactgaa ttccccccac
     1321 cctttaattt ctaactgttt catatgagtt tacaatgtat tgtaatcatg cttatcccca
     1381 ttgccttccg ttgccccaac ctactcctat gaacctcttt tcttcccaat agttctctgc
     1441 tttcacatct tgagtccatg tttgcgggtg ctgtgtgtgc acgcgcacac acacatgcta
     1501 acatgcacat gcttatccag gtcttatgcc aacagtaacc acagctgatg tgtgcccgtt
     1561 tgcaacagcc atggccatgc ggaatccaga aaagagcatc tgatagtacc ccacccagcc
     1621 cctaatactt tggctcttgc cggctttggg cctcatcttc cacaatgtcc cctgggcctt
     1681 gggagggatg tgtcatcttg ggctcaggtc agggtcactc aactgtctca aagtgctctt
     1741 ggcactttgg gtgaccaaga aaagagacag gctttcatct ttggtcttca gaagatgtct
     1801 tttccttctt ctgagctaca gatgacctgg agaaaaggct ttcgcttctt gcactgaact
     1861 cgagcaccta ggctcaactg ctgggttggt ggctcaagaa acccctgctt tatcctaagt
     1921 ttctccctga cctttttctt tgccttcctc attggctctt ctggacaaga caggttagga
     1981 atatgaggcc tagaggggga gatgaagcag gagaaaggaa ggaaagaggg agggagggga
     2041 aagtggaaag aaagggaaag agaaggagag ggggagggag gggagggaag ggaaagaatg
     2101 ggagggggag gtagggaagg aaggggaggg gcagggcggg gcagaccagg gagaattaga
     2161 gttcccagaa agtctttata ctgggagttc ttaaaagact aattgttaga agggcaatcg
     2221 tcatagggag gttcacatgg tgcagggcca tcttgaacta tcttagcccc ttaaaaagaa
     2281 gccatttgcc cacatctgtg tgtgacctaa catcctgtga ctcctaggta aagttttgaa
     2341 acatatgagt ggatcccaac tgctaagaaa gtcatcacat atgcatctgg agcctatagc
     2401 aaggtctccc gctttgctat aaccgctcac ctgttgtacc accagaattt gtaaagtgac
     2461 tttctttgtt ttgttatttt aaaacttcac agaaattgtt accaaggtca gagcacagat
     2521 atctgaagca aactgaatct gtatttctgg accacagtca ctcatttggc tccaaaataa
     2581 acttatctct gcatcctt
//
