LOCUS       NP_080432                855 aa            linear   ROD 04-FEB-2025
DEFINITION  pre-mRNA-splicing factor SYF1 [Mus musculus].
ACCESSION   NP_080432
VERSION     NP_080432.1
DBSOURCE    REFSEQ: accession NM_026156.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 855)
  AUTHORS   Shen,C.L., Tsai,Y.Y., Chou,S.J., Chang,Y.M. and Tarn,W.Y.
  TITLE     RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar
            foliation
  JOURNAL   Commun Biol 7 (1), 1712 (2024)
   PUBMED   39738787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 855)
  AUTHORS   Goulielmaki,E., Tsekrekou,M., Batsiotos,N., Ascensao-Ferreira,M.,
            Ledaki,E., Stratigi,K., Chatzinikolaou,G., Topalis,P., Kosteas,T.,
            Altmuller,J., Demmers,J.A., Barbosa-Morais,N.L. and Garinis,G.A.
  TITLE     The splicing factor XAB2 interacts with ERCC1-XPF and XPG for
            R-loop processing
  JOURNAL   Nat Commun 12 (1), 3153 (2021)
   PUBMED   34039990
  REMARK    GeneRIF: The splicing factor XAB2 interacts with ERCC1-XPF and XPG
            for R-loop processing.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 855)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (residues 1 to 855)
  AUTHORS   Masuda,T., Kai,N., Sakuma,C., Kobayashi,K., Koga,H. and Yaginuma,H.
  TITLE     Laser capture microdissection and cDNA array analysis for
            identification of mouse KIAA/FLJ genes differentially expressed in
            the embryonic dorsal spinal cord
  JOURNAL   Brain Res 1249, 61-67 (2009)
   PUBMED   19026994
REFERENCE   5  (residues 1 to 855)
  AUTHORS   Zhang,X.M., Chen,B.Y., Ng,A.H., Tanner,J.A., Tay,D., So,K.F.,
            Rachel,R.A., Copeland,N.G., Jenkins,N.A. and Huang,J.D.
  TITLE     Transgenic mice expressing Cre-recombinase specifically in retinal
            rod bipolar neurons
  JOURNAL   Invest Ophthalmol Vis Sci 46 (10), 3515-3520 (2005)
   PUBMED   16186328
REFERENCE   6  (residues 1 to 855)
  AUTHORS   Yonemasu,R., Minami,M., Nakatsu,Y., Takeuchi,M., Kuraoka,I.,
            Matsuda,Y., Higashi,Y., Kondoh,H. and Tanaka,K.
  TITLE     Disruption of mouse XAB2 gene involved in pre-mRNA splicing,
            transcription and transcription-coupled DNA repair results in
            preimplantation lethality
  JOURNAL   DNA Repair (Amst) 4 (4), 479-491 (2005)
   PUBMED   15725628
  REMARK    GeneRIF: XAB2 has an essential function in mouse embryogenesis.
REFERENCE   7  (residues 1 to 855)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002890.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002890.1, AK132434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..855
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.92 cM"
     Protein         1..855
                     /product="pre-mRNA-splicing factor SYF1"
                     /calculated_mol_wt=99857
     Region          15..47
                     /region_name="HAT 1. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          48..80
                     /region_name="HAT 2. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          55..>187
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          90..122
                     /region_name="HAT 3. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          124..158
                     /region_name="HAT 4. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          160..192
                     /region_name="HAT 5. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          198..230
                     /region_name="HAT 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          235..268
                     /region_name="HAT 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          259..584
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          270..305
                     /region_name="HAT 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          369..407
                     /region_name="HAT 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          389..424
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            420
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9HCS7; propagated from
                     UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          433..459
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          466..513
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          498..530
                     /region_name="HAT 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          518..546
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          532..566
                     /region_name="HAT 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          571..605
                     /region_name="HAT 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          643..677
                     /region_name="HAT 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          679..713
                     /region_name="HAT 14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Region          808..855
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD2.1)"
     Site            851
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HCS7; propagated from
                     UniProtKB/Swiss-Prot (Q9DCD2.1)"
     CDS             1..855
                     /gene="Xab2"
                     /gene_synonym="0610041O14Rik"
                     /coded_by="NM_026156.2:19..2586"
                     /db_xref="CCDS:CCDS22065.1"
                     /db_xref="GeneID:67439"
                     /db_xref="MGI:MGI:1914689"
ORIGIN      
        1 mvvmarvprs erpdlvfeee dlpyeeeimr nqfsvkcwlr yiefkqgapk prlnqlyera
       61 lkllpcsykl wyrylkarra qvkhrcvtdp ayedvnnche rafvfmhkmp rlwldycqfl
      121 mdqgrvthtr rtfdralral pitqhsriwp lylrflrshp lpetavrgyr rflklspesa
      181 eeyieylkss drldeaaqrl atvvnderfv skagksnyql whelcdlisq npdkvqslnv
      241 daiirggltr ftdqlgklwc sladyyirsg hfekardvye eairtvmtvr dftqvfdsya
      301 qfeesmiaak metaselgre eeddvdlelr larfeqlisr rplllnsvll rqnphhvhew
      361 hkrvalhqgr preiintyte avqtvdpfka tgkphtlwva fakfyedngq lddarvilek
      421 atkvnfkqvd dlasvwcqcg elelrhenyd ealkllrkat alparraeyf dgsepvqnrv
      481 ykslkvwsml adleeslgtf qstkavydri ldlriatpqi vinyamflee hkyfeesfka
      541 yergislfkw pnvsdiwsty ltkfisrygg rklerardlf eqaldgcppk yaktlyllya
      601 qleeewglar hamavydrat ravepaqqyd mfniyikraa eiygvthtrg iyqkaievls
      661 deharemclr fadmecklge idraraiysf csqicdprtt gafwqtwkdf evrhgnedti
      721 remlrirrsv qatyntqvnf masqmlkvsg satgtvsdla pgqsgmddmk lleqraeqla
      781 aeaerdqppr aqskiffvrs dasreelael aqqanpeeiq lgedededem dlepnevrle
      841 qqsvpaavfg slked
//
