LOCUS       NM_133784               4767 bp    mRNA    linear   ROD 15-MAR-2025
DEFINITION  Mus musculus WW domain containing transcription regulator 1
            (Wwtr1), transcript variant 2, mRNA.
ACCESSION   NM_133784
VERSION     NM_133784.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4767)
  AUTHORS   Moldovan,G.E., Massri,N., Vegter,E.L., Pauneto-Delgado,I.N.,
            Burns,G.W., Joshi,N., Gu,B., Arora,R. and Fazleabas,A.T.
  TITLE     YAP1 and WWTR1 are required for murine pregnancy initiation
  JOURNAL   Reproduction 169 (1), e240355 (2025)
   PUBMED   39503541
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4767)
  AUTHORS   Warren,R., Klinkhammer,K., Lyu,H., Knopp,J., Yuan,T., Yao,C.,
            Stripp,B. and De Langhe,S.P.
  TITLE     Cell competition drives bronchiolization and pulmonary fibrosis
  JOURNAL   Nat Commun 15 (1), 10624 (2024)
   PUBMED   39639058
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4767)
  AUTHORS   Chen,R., Fan,R., Chen,F., Govindasamy,N., Brinkmann,H.,
            Stehling,M., Adams,R.H., Jeong,H.W. and Bedzhov,I.
  TITLE     Analyzing embryo dormancy at single-cell resolution reveals dynamic
            transcriptional responses and activation of integrin-Yap/Taz
            prosurvival signaling
  JOURNAL   Cell Stem Cell 31 (9), 1262-1279 (2024)
   PUBMED   39047740
  REMARK    GeneRIF: Analyzing embryo dormancy at single-cell resolution
            reveals dynamic transcriptional responses and activation of
            integrin-Yap/Taz prosurvival signaling.
REFERENCE   4  (bases 1 to 4767)
  AUTHORS   Ren,Y., Zhou,L., Li,X., Zhu,X., Zhang,Z., Sun,X., Xue,X. and Dai,C.
  TITLE     Taz/Tead1 Promotes Alternative Macrophage Activation and Kidney
            Fibrosis via Transcriptional Upregulation of Smad3
  JOURNAL   J Immunol Res 2024, 9512251 (2024)
   PUBMED   39108258
  REMARK    GeneRIF: Taz/Tead1 Promotes Alternative Macrophage Activation and
            Kidney Fibrosis via Transcriptional Upregulation of Smad3.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4767)
  AUTHORS   Zhu,M., Gu,B., Thomas,E.C., Huang,Y., Kim,Y.K., Tao,H., Yung,T.M.,
            Chen,X., Zhang,K., Woolaver,E.K., Nevin,M.R., Huang,X.,
            Winklbauer,R., Rossant,J., Sun,Y. and Hopyan,S.
  TITLE     A fibronectin gradient remodels mixed-phase mesoderm
  JOURNAL   Sci Adv 10 (29), eadl6366 (2024)
   PUBMED   39028807
REFERENCE   6  (bases 1 to 4767)
  AUTHORS   Hossain,Z., Ali,S.M., Ko,H.L., Xu,J., Ng,C.P., Guo,K., Qi,Z.,
            Ponniah,S., Hong,W. and Hunziker,W.
  TITLE     Glomerulocystic kidney disease in mice with a targeted inactivation
            of Wwtr1
  JOURNAL   Proc Natl Acad Sci U S A 104 (5), 1631-1636 (2007)
   PUBMED   17251353
  REMARK    GeneRIF: Wwtr1 is critical for the integrity of renal cilia and its
            absence in mice leads to the development of renal cysts
REFERENCE   7  (bases 1 to 4767)
  AUTHORS   Hong,J.H., Hwang,E.S., McManus,M.T., Amsterdam,A., Tian,Y.,
            Kalmukova,R., Mueller,E., Benjamin,T., Spiegelman,B.M., Sharp,P.A.,
            Hopkins,N. and Yaffe,M.B.
  TITLE     TAZ, a transcriptional modulator of mesenchymal stem cell
            differentiation
  JOURNAL   Science 309 (5737), 1074-1078 (2005)
   PUBMED   16099986
  REMARK    GeneRIF: coactivates Runx2-dependent gene transcription while
            repressing PPARgamma-dependent gene transcription; results indicate
            that TAZ functions as a molecular rheostat that modulates
            mesenchymal stem cell differentiation
REFERENCE   8  (bases 1 to 4767)
  AUTHORS   Park,K.S., Whitsett,J.A., Di Palma,T., Hong,J.H., Yaffe,M.B. and
            Zannini,M.
  TITLE     TAZ interacts with TTF-1 and regulates expression of surfactant
            protein-C
  JOURNAL   J Biol Chem 279 (17), 17384-17390 (2004)
   PUBMED   14970209
  REMARK    GeneRIF: TAZ interacts with TTF-1 and regulates expression of
            surfactant protein-C
REFERENCE   9  (bases 1 to 4767)
  AUTHORS   Cui,C.B., Cooper,L.F., Yang,X., Karsenty,G. and Aukhil,I.
  TITLE     Transcriptional coactivation of bone-specific transcription factor
            Cbfa1 by TAZ
  JOURNAL   Mol Cell Biol 23 (3), 1004-1013 (2003)
   PUBMED   12529404
  REMARK    GeneRIF: TAZ is a transcription coactivator for Cbfa1 and may be
            involved in the regulation of osteoblast differentiation.
REFERENCE   10 (bases 1 to 4767)
  AUTHORS   Kanai,F., Marignani,P.A., Sarbassova,D., Yagi,R., Hall,R.A.,
            Donowitz,M., Hisaminato,A., Fujiwara,T., Ito,Y., Cantley,L.C. and
            Yaffe,M.B.
  TITLE     TAZ: a novel transcriptional co-activator regulated by interactions
            with 14-3-3 and PDZ domain proteins
  JOURNAL   EMBO J 19 (24), 6778-6791 (2000)
   PUBMED   11118213
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY145519.1, AK142720.1,
            AK009983.1, AK142299.1, AV026487.1 and AW457051.1.
            
            On Dec 4, 2009 this sequence version replaced NM_133784.2.
            
            Summary: This gene encodes a binding protein of the 14-3-3 family
            of proteins that regulate cell cycle progression, differentiation
            and apoptosis. The encoded protein is a transcriptional
            co-activator that binds to the PPXY motif present on transcription
            factors. The gene product contains a WW domain and, in the
            C-terminus, a conserved PDZ-binding motif. This gene is distinct
            from the gene encoding tafazzin. Both genes share the gene symbol
            Taz. Multiple transcript variants encoding different isoforms have
            been described. [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (2) has a shorter N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142720.1, AJ299430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BY145519.1         2-76
            76-1655             AK142720.1         1-1580
            1656-1898           AK009983.1         1587-1829
            1899-2307           AK142299.1         1821-2229
            2308-4712           AK142720.1         2233-4637
            4713-4744           AV026487.1         392-423
            4745-4767           AW457051.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..4767
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 27.74 cM"
     gene            1..4767
                     /gene="Wwtr1"
                     /gene_synonym="2310058J06Rik; 2610021I22Rik; Taz"
                     /note="WW domain containing transcription regulator 1"
                     /db_xref="GeneID:97064"
                     /db_xref="MGI:MGI:1917649"
     exon            1..276
                     /gene="Wwtr1"
                     /gene_synonym="2310058J06Rik; 2610021I22Rik; Taz"
                     /inference="alignment:Splign:2.1.0"
     exon            277..711
                     /gene="Wwtr1"
                     /gene_synonym="2310058J06Rik; 2610021I22Rik; Taz"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..1468
                     /gene="Wwtr1"
                     /gene_synonym="2310058J06Rik; 2610021I22Rik; Taz"
                     /note="isoform 2 is encoded by transcript variant 2; WW
                     domain-containing transcription regulator protein 1;
                     transcriptional coactivator with PDZ-binding motif"
                     /codon_start=1
                     /product="WW domain-containing transcription regulator
                     protein 1 isoform 2"
                     /protein_id="NP_598545.2"
                     /db_xref="CCDS:CCDS38434.1"
                     /db_xref="GeneID:97064"
                     /db_xref="MGI:MGI:1917649"
                     /translation="MNPSSVPHPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWR
                     KKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGA
                     AGGPAQQHAHLRQQSYDVTDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKVMN
                     QPLNHVNLHPSITSTSVPQRSMAVSQPNLAMNHQHQQVVATSLSPQNHPTQNQPTGLM
                     SVPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMETETMAPVNT
                     PAMSTDMRSVTNSSSDPFLNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNMDEMDT
                     GENSGQTPMTVNPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFL
                     TWL"
     exon            712..848
                     /gene="Wwtr1"
                     /gene_synonym="2310058J06Rik; 2610021I22Rik; Taz"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1048
                     /gene="Wwtr1"
                     /gene_synonym="2310058J06Rik; 2610021I22Rik; Taz"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1170
                     /gene="Wwtr1"
                     /gene_synonym="2310058J06Rik; 2610021I22Rik; Taz"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1283
                     /gene="Wwtr1"
                     /gene_synonym="2310058J06Rik; 2610021I22Rik; Taz"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..4750
                     /gene="Wwtr1"
                     /gene_synonym="2310058J06Rik; 2610021I22Rik; Taz"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4724..4729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wwtr1"
                     /gene_synonym="2310058J06Rik; 2610021I22Rik; Taz"
                     /note="hexamer: AATAAA"
     polyA_site      4745
                     /gene="Wwtr1"
                     /gene_synonym="2310058J06Rik; 2610021I22Rik; Taz"
                     /note="major polyA site"
ORIGIN      
        1 ataattcaac agctccactt tcggcccgcc tctttcctaa gggtgggagt ttgcttcaaa
       61 ctttgtttat gggacagtcc gggagccgcg gcggctgcgc tcgtctacgt cttctctgtc
      121 gcctcctcgc gcagtgggag cgcccgaggc cggttccggg gatgtaagag gataagcctt
      181 cggctgctgg gaatccgctc gggatctgcc agccgggacc gggttccagc tcgtcagttc
      241 gggaggcgcc caggcttggc ttccccgagt ccccagaaag atgaatccgt cctcggtgcc
      301 ccatccgctc ccgccgccag ggcagcaagt catccacgtc acgcaggacc tggacaccga
      361 cctcgaagcc ctcttcaact ctgtcatgaa ccccaagccc agctcatggc ggaaaaagat
      421 cctcccggag tccttcttta aggagcccga ttccggctcg cactcgcgcc aatccagcac
      481 agactcatca ggcggccacc cggggcctcg actagctggc ggcgcgcagc acgtccgctc
      541 gcactcgtcg cccgcatccc tgcagctggg caccggtgcg ggagccgctg gaggccctgc
      601 acagcagcat gcacatctcc gccagcagtc ctatgacgtg accgacgagc tgccgttgcc
      661 ccccgggtgg gagatgacct tcacggccac tggccagaga tacttcctta atcacataga
      721 gaaaatcacc acatggcaag accccaggaa ggtgatgaat cagcctctga atcatgtgaa
      781 cctccacccg tccatcactt ccacctcggt gccacagagg tccatggcag tgtcccagcc
      841 gaatctcgca atgaatcacc aacaccagca agtcgtggcc actagcctga gtccacagaa
      901 ccacccgact cagaaccaac ccacagggct catgagtgtg cccaatgcac tgaccactca
      961 gcagcagcag cagcagaaac tgcggcttca gaggatccag atggagagag agaggattag
     1021 gatgcgtcaa gaggagctca tgaggcagga agctgccctc tgccgacagc tccccatgga
     1081 aaccgagacc atggcccctg tcaacacgcc tgccatgagc acagatatga gatctgtcac
     1141 caacagtagc tcagatcctt tcctcaatgg agggccctat cattcacggg agcagagcac
     1201 agacagtggc ctggggttag ggtgctacag tgtccccaca actccagaag acttcctcag
     1261 caacatggac gagatggata caggtgaaaa ttccggtcag acacccatga ccgtcaatcc
     1321 ccagcagacc cgcttccctg atttcctgga ctgccttcca ggaacaaatg ttgacctcgg
     1381 gactttggag tctgaagatc tgatccctct cttcaatgat gtagagtctg ctctgaacaa
     1441 aagcgagccc tttctaacct ggctgtaatc actactgttg taacgtgatg cagctgtgag
     1501 ctgacgcgag tcttgggcct tgcggaccaa gtgatgaggc agagcgggcc tgcagctgca
     1561 ccacgttctg cctttgtact cacactcctt gtccgtgtgg ccacttaatc attgcctggt
     1621 gttgattcgc aggaacttgc gttacacaga aataaatact ctcttttcat tttctgcaag
     1681 cctgcatttc tgtggcagat aaagcaggat gggttgtgca gaatgacttt agagaatgtc
     1741 tgcagcccta tggctgggtt ttattacagt tagcttaaat tcatatatca actgattcta
     1801 agccatacaa agctgacctc aggcagtgaa ttctgatagg cagcttggtc caggaagtga
     1861 tttacagttt caaaagctgt attgataaca gtagtaacaa atgctttaaa acttatttaa
     1921 cttgagcttc aaaaaaaaaa aatcattgta tagatagtaa ttttctcctg tagggaatac
     1981 agtgtagttt ggaatccatg ctggctctga tggcttctct cattctgtgt ttacaagggc
     2041 acagagtacc aatgttgcca ccgttcatca ttttcctgct tagcagctcc attctgtgag
     2101 caggagagta acttcaacat ctgtcacaat tcttgcatga cagatcgtgt gaaagagacc
     2161 agtttggtca caatatgaat gattacagaa caaaattgtt ttgttttttt ttaattgcag
     2221 cttggttttt ttttcaaaat gcagcttaga atttgatgtt tgttatatat atatatatat
     2281 atatatatat atatatatat atatatataa actctgtaat tttgtagcta ttacagaggg
     2341 tagccaaatg tttttgataa atcagtggca actatatttt tatcttttgg acctgattct
     2401 gaaaacatca ggccaactag gtcgcagcct gatgaaccat gaattttgtg tgctgttttg
     2461 tattctgagg cattattaat tctgctttca agatttcaag tgtttaaaat aatcctgtct
     2521 atgaaactgt ttgaagaatg aagccgatct ctgattaaca catacagaaa ggccctcgtc
     2581 aggacatgag ctgtagattt gtacgtctga attcagtaaa attgtttcct aagtatacta
     2641 tcctaatcct tttgctaaat tggtaagaaa aaaagtccaa ggtatgtact caatgcctct
     2701 tatgtaacca acatattatt tgtttcgtta gcttttaagg accgagagct tcatgttcct
     2761 ctggcaggca ggccgcctgc acttggcaat gacgtcctta gctgtttagt attttgaact
     2821 gacattattt ataatctatg aatttaatct ctttttttaa tttttatttt gaaagacatc
     2881 aagaagctgg aaggaagctt ttagttgccg tgagggtgaa ggcttctcgg ttgaggatct
     2941 tcagtaagat cccttttgat ccattgaaat agaaacgcac agagtacatt tgatcttggt
     3001 gggaagaggc aagttgaaag gtcagaggca aagtagcaga gccagggaag gtggcggaaa
     3061 ggccaggtga tgtgaaatta agtagacatg tcagaacccc tcaaagacaa ggcaagcaag
     3121 acgtgtgaga agtgccccaa agtgctccgc tgcctttatg ccaaaagaca ccgctgttag
     3181 agagaagagg gtcagggtgc actttactgg gaagggcaga ggaggaagga gtggggctgt
     3241 gacattgtcc atgtattggc agacgagaac atggactgct gttgctttca gcactcttaa
     3301 agtgatctct ctttttctga aggaacccca atttatgtcc acgttaattc cttgctctct
     3361 ctctgagcac ttcaagagag acaagtagga attttttgtt gatactaggt tgaaagggag
     3421 cactctttcg tttcctcttt tgttagcaaa agttgcaaaa aagagttgta cattctttct
     3481 gaggaaaacc aaaaacaagc caaaaacaca agggacctaa caaaacttga cagtgttact
     3541 atatttaaaa atatttttat agatgcattg caggttatta agtgtaaaaa acaaaagata
     3601 ctcctttttt taaaaaaaaa ttagttaagt catctatgat ttatgttacc aagttttaga
     3661 agcaattttc taataagctt gtggcattat gaaatactag aataattttc ttagtaaatt
     3721 agtttaaaac tttttaatta atatagtatt tttctagagt gaaatatggc ccttgactgt
     3781 ttactaatag ataaagccag atattataat tgttgttgtt gtttttaaga acataaaata
     3841 tggtttgtta cagaacacta aagctagaag ccagaccttt ttccccctag ttctgagtga
     3901 actcaagagt tcatgtgtgc aagtggagcg ccatctccag ccctcagagc agtctctcag
     3961 tggttctttg ctgttataag tattaatatt ttctaagaat tcataataag gtgctattca
     4021 tatacatcat actataagcc aactgtcaga ctatctagtc ttcttagtcc taaatcaaca
     4081 aattttacca tgtcatctcc aaattttgtc ataggataga cacatttttt taaaaagttg
     4141 gattcaaaac acgtttttct tgataagata cacttcactg aagcatttaa atagctacac
     4201 accctgtcat ttgttaacag caggtggtat ttaggccttg ttttactgta gtatgtagga
     4261 tataaagtgt atttctttca gtgatttctc agtgcataag aagtgcataa gtctcagccg
     4321 cctgggcatt gctcagcaga aaggaatctg cagatggtga cgtgacttgt ccgtgatgga
     4381 catgtcacgg agtactgcgt tcttacgatg tcattagaag caccttgtga aagtgtaact
     4441 ttcgtggaac aaaacaagcc atttgaaaag gaaaacggtt attttaaaat ggtgattgac
     4501 agagacccct tcccctgacc ctgtattata cagtgtgcta atactttaac ttaatttttt
     4561 ttttacactt ctacgtttta ccaaataaac gtttacctgt gttgttgatt ataatccagt
     4621 atgttgtaca tacaggaact gtgccgccaa atccatcaga tgaaaccatt ttatctagag
     4681 tctggtacag ggtttacttc tcaattctat atataaaaaa aataataaat acgattgagc
     4741 ttccacttgg aaaaaaaaaa aaaaaaa
//
