LOCUS       NM_025830               5004 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus WW domain containing E3 ubiquitin protein ligase 2
            (Wwp2), mRNA.
ACCESSION   NM_025830
VERSION     NM_025830.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5004)
  AUTHORS   Wang,X., Gui,N., Ma,X., Zeng,Y., Mo,T. and Zhang,M.
  TITLE     Proliferation, migration and phenotypic transformation of VSMC
            induced via Hcy related to up-expression of WWP2 and p-STAT3
  JOURNAL   PLoS One 19 (1), e0296359 (2024)
   PUBMED   38166045
  REMARK    GeneRIF: Proliferation, migration and phenotypic transformation of
            VSMC induced via Hcy related to up-expression of WWP2 and p-STAT3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5004)
  AUTHORS   Chen,H., Chew,G., Devapragash,N., Loh,J.Z., Huang,K.Y., Guo,J.,
            Liu,S., Tan,E.L.S., Chen,S., Tee,N.G.Z., Mia,M.M., Singh,M.K.,
            Zhang,A., Behmoaras,J. and Petretto,E.
  TITLE     The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte
            infiltration and activity in heart fibrosis
  JOURNAL   Nat Commun 13 (1), 7375 (2022)
   PUBMED   36450710
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5004)
  AUTHORS   Fu,J., Zhang,X., Zheng,H., Yang,G., Chen,Z. and Yuan,G.
  TITLE     A WWP2-PTEN-KLF5 signaling axis regulates odontoblast
            differentiation and dentinogenesis in mice
  JOURNAL   J Biol Chem 298 (8), 102220 (2022)
   PUBMED   35780838
  REMARK    GeneRIF: A WWP2-PTEN-KLF5 signaling axis regulates odontoblast
            differentiation and dentinogenesis in mice.
REFERENCE   4  (bases 1 to 5004)
  AUTHORS   Song,Y., Ren,X., Gao,F., Li,F., Zhou,J., Chen,J. and Zhang,Y.
  TITLE     LINC01588 regulates WWP2-mediated cardiomyocyte injury by
            interacting with HNRNPL
  JOURNAL   Environ Toxicol 37 (7), 1629-1641 (2022)
   PUBMED   35258167
  REMARK    GeneRIF: LINC01588 regulates WWP2-mediated cardiomyocyte injury by
            interacting with HNRNPL.
REFERENCE   5  (bases 1 to 5004)
  AUTHORS   Fu,J., Zheng,H., Xue,Y., Jin,R., Yang,G., Chen,Z. and Yuan,G.
  TITLE     WWP2 Promotes Odontoblastic Differentiation by Monoubiquitinating
            KLF5
  JOURNAL   J Dent Res 100 (4), 432-439 (2021)
   PUBMED   33164644
  REMARK    GeneRIF: WWP2 Promotes Odontoblastic Differentiation by
            Monoubiquitinating KLF5.
REFERENCE   6  (bases 1 to 5004)
  AUTHORS   Lu,J., Qian,J., Izvolsky,K.I. and Cardoso,W.V.
  TITLE     Global analysis of genes differentially expressed in branching and
            non-branching regions of the mouse embryonic lung
  JOURNAL   Dev Biol 273 (2), 418-435 (2004)
   PUBMED   15328023
REFERENCE   7  (bases 1 to 5004)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
REFERENCE   8  (bases 1 to 5004)
  AUTHORS   Xu,H.M., Liao,B., Zhang,Q.J., Wang,B.B., Li,H., Zhong,X.M.,
            Sheng,H.Z., Zhao,Y.X., Zhao,Y.M. and Jin,Y.
  TITLE     Wwp2, an E3 ubiquitin ligase that targets transcription factor
            Oct-4 for ubiquitination
  JOURNAL   J Biol Chem 279 (22), 23495-23503 (2004)
   PUBMED   15047715
REFERENCE   9  (bases 1 to 5004)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5004)
  AUTHORS   Huang,K., Johnson,K.D., Petcherski,A.G., Vandergon,T., Mosser,E.A.,
            Copeland,N.G., Jenkins,N.A., Kimble,J. and Bresnick,E.H.
  TITLE     A HECT domain ubiquitin ligase closely related to the mammalian
            protein WWP1 is essential for Caenorhabditis elegans embryogenesis
  JOURNAL   Gene 252 (1-2), 137-145 (2000)
   PUBMED   10903445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132126.3.
            
            On Feb 8, 2019 this sequence version replaced NM_025830.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JN712751.1, BC048184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC132126.3         132568-132639       c
            73-157              AC132126.3         115946-116030       c
            158-305             AC132126.3         111419-111566       c
            306-427             AC132126.3         111008-111129       c
            428-565             AC132126.3         85540-85677         c
            566-662             AC132126.3         83367-83463         c
            663-790             AC132126.3         62575-62702         c
            791-1001            AC132126.3         50898-51108         c
            1002-1091           AC132126.3         35720-35809         c
            1092-1266           AC132126.3         28211-28385         c
            1267-1321           AC132126.3         23511-23565         c
            1322-1403           AC132126.3         20459-20540         c
            1404-1532           AC132126.3         19852-19980         c
            1533-1608           AC132126.3         19474-19549         c
            1609-1680           AC132126.3         19157-19228         c
            1681-1769           AC132126.3         18874-18962         c
            1770-1929           AC132126.3         16573-16732         c
            1930-2063           AC132126.3         14907-15040         c
            2064-2204           AC132126.3         14436-14576         c
            2205-2325           AC132126.3         13908-14028         c
            2326-2430           AC132126.3         13491-13595         c
            2431-2527           AC132126.3         12452-12548         c
            2528-2600           AC132126.3         12225-12297         c
            2601-5004           AC132126.3         9719-12122          c
FEATURES             Location/Qualifiers
     source          1..5004
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 54.15 cM"
     gene            1..5004
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /note="WW domain containing E3 ubiquitin protein ligase 2"
                     /db_xref="GeneID:66894"
                     /db_xref="MGI:MGI:1914144"
     exon            1..72
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            73..157
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2700
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /EC_number="2.3.2.26"
                     /note="WW domain-containing protein 4; WW
                     domain-containing protein 2; HECT-type E3 ubiquitin
                     transferase WWP2"
                     /codon_start=1
                     /product="NEDD4-like E3 ubiquitin-protein ligase WWP2"
                     /protein_id="NP_080106.1"
                     /db_xref="CCDS:CCDS40467.1"
                     /db_xref="GeneID:66894"
                     /db_xref="MGI:MGI:1914144"
                     /translation="MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEV
                     AVDGLPSETKKTGKRIGSSELLWNEIIVLNVTAQSHLDLKVWSCHTLRNELLGTASVN
                     LSNVLKNNGGKMENTQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGSVPNGSAVTDG
                     SQPPSRESSGTAIAPETRHQPPSTNCFGGRSRTHRHSGGSARTATAASEQSPGARNRH
                     RQPVKNSSSSGLANGTVNEEPTPASEPEESSVVGVTSLPAAALSVSSNPNTTSLPAQS
                     TPAEGEEASTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPP
                     GWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLY
                     QSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGW
                     EMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHS
                     NALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFL
                     LSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDT
                     GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELFFIQDMEILGKV
                     TTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYF
                     DEKELELMLCGMQEIDMSDWQKNAIYRHYTKSSKQIQWFWQVVKEMDNEKRIRLLQFV
                     TGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEK
                     LLYAIEETEGFGQE"
     exon            158..305
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..427
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            428..565
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            566..662
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..790
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1001
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1091
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1266
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1321
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1403
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1532
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1608
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1680
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1769
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1929
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2063
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2204
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2325
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2430
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2527
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2600
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..5004
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2901..2906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /note="hexamer: AATAAA"
     polyA_site      2927
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /note="major polyA site"
     regulatory      4291..4296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /note="hexamer: AATAAA"
     polyA_site      4309
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
     regulatory      4974..4979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
                     /note="hexamer: AATAAA"
     polyA_site      4996
                     /gene="Wwp2"
                     /gene_synonym="1300010O06Rik; AIP2"
ORIGIN      
        1 acccggcccg agtgcgggcg ctggaaggcg gaagtggagc ggagttaggc gccgctggtg
       61 tggccgcggc agttccattg tgatgacatg gcatctgcca gctccagccg ggcaggagtg
      121 gccctgcctt ttgagaagtc ccagcttacc ctgaaagtgg tgtcagcaaa gcccaaggtg
      181 cacaaccgcc agcccagaat caactcctac gtggaggtgg cagtggatgg actccccagc
      241 gagaccaaga agacggggaa gcgcatcggg agctctgaac tgctctggaa tgaaatcatc
      301 gttctgaatg tcacagccca gagtcatttg gatctgaagg tctggagctg tcataccttg
      361 aggaatgaac tactgggcac tgcctctgtc aacctctcca atgtcctgaa gaacaatggc
      421 ggcaaaatgg agaacacaca actgaccctg aacctgcaga cagagaacaa aggcagtgtt
      481 gtctcgggag gagagctgac aattttcctg gatgggccaa ctgttgatct gggaagtgtg
      541 cctaatggca gtgcagtgac agacggatca cagccacctt caagagaatc cagtgggact
      601 gctatagctc cagagacccg gcaccagccc cccagtacaa actgctttgg tggcagatcc
      661 cggacgcaca gacactcagg tggctcagcc aggacagcca cagcagccag tgaacaaagc
      721 cctggcgcta ggaaccgcca ccgccagcct gtgaagaact ctagcagcag tggcttagcc
      781 aatggcacag tgaatgagga acctactcca gccagtgaac ctgaagaatc gtcggttgtt
      841 ggtgtaacat ccctgcctgc agcagccttg agtgtgtcct caaatcccaa cacaacatct
      901 ctccctgcac agtccacacc agcagaggga gaggaggcca gcacttccgg gacacagcag
      961 ctccctgctg ccgcccaggc ccctgatgct cttcctgctg gatgggaaca gagagagctg
     1021 cccaatgggc gtgtctatta tgttgatcac aacaccaaga ccaccacctg ggagcggcct
     1081 cttcctccag ggtgggaaaa gcgcacggac ccccgaggga ggttttacta cgtggaccac
     1141 aacacccgga caaccacctg gcagcgccca actgctgagt acgtgcgcaa ctatgagcag
     1201 tggcagtccc agcggaacca gctgcagggg gccatgcagc acttcagcca aagattcctc
     1261 taccagtctt cgagtgcttc gactgaccat gatcccttgg gccccctccc acctggctgg
     1321 gagaagaggc aggacaatgg acgggtgtat tatgtcaacc acaacactcg cactacccag
     1381 tgggaggacc ctcggaccca ggggatgata caggagccag ccctgccccc agggtgggag
     1441 atgaaataca ccagcgaggg cgtgcggtac tttgtggacc acaatacccg caccactacc
     1501 tttaaggatc ctcgcccagg gttcgagtca gggacaaagc aaggctcacc tggtgcctat
     1561 gaccgaagtt ttcggtggaa gtatcaccag ttccgtttcc tctgccactc aaatgctcta
     1621 cccagccatg tgaagatcag cgtttccagg cagacactct ttgaggattc tttccaacag
     1681 attatgaaca tgaaacctta cgacctgcgc cgccggctct acatcatcat gcgtggtgag
     1741 gagggcctgg actacggcgg catcgccaga gagtggtttt tcctcctgtc ccatgaggtg
     1801 ctcaacccta tgtactgttt gtttgaatat gctgggaaga acaattactg cctgcagatc
     1861 aacccggcct cttccatcaa ccctgaccac ctcacctact tccgctttat cggcagattc
     1921 atcgccatgg ctctgtacca tgggaagttc atcgacacag gcttcactct ccctttctac
     1981 aagcggatgc tcaacaagag accgactctg aaggacctgg agtctattga ccctgagttt
     2041 tacaactcca ttgtctggat caaagagaac aacctggaag agtgtggtct ggagctgttt
     2101 ttcatccagg acatggagat tctgggcaag gtgacaaccc atgaactgaa ggagggcggt
     2161 gagaacatcc gagttaccga ggagaacaag gaggagtata tcatgctgct gactgactgg
     2221 cgattcaccc gaggcgtgga agagcagacc aaagctttcc tggatggctt caatgaggtt
     2281 gcccctctgg agtggttgag atattttgat gagaaagagc tggagctcat gctctgcggc
     2341 atgcaggaga tagacatgag cgactggcag aagaacgcca tctatcggca ctacaccaag
     2401 agcagcaagc agatccagtg gttctggcag gttgtcaagg agatggacaa tgagaagagg
     2461 atccggctac tgcagtttgt cacgggaacc tgccgtctgc ctgttggggg atttgctgag
     2521 ctcatcggga gcaatggccc gcagaagttc tgcatcgaca gagttggcaa ggaaacctgg
     2581 ctgcccagga gccatacgtg cttcaaccgt ctggacctgc ctccctataa gagctacgag
     2641 cagctgaaag agaagctgct gtacgccatc gaggagactg aggggttcgg acaggagtag
     2701 ctgaggctgc tgtctcacac cctctagcac atgtagtcct gagtccttcc tgccggagat
     2761 gccaccggtt gcacagccct caagaggccc ctttggatag tggccctgca cgagactgtg
     2821 ccttgatcat ttcggtgact gaagagtctg accccagagg ccttggggac cctttcttct
     2881 ctctgatgat ggcagtctgg aataaagcac tgtcaccttt gactctatta cctgttgcaa
     2941 agccagaggg ctgcccttct ctgcaaaact gccccttcca ctaggactga gtctgggtgt
     3001 gtgtgagagt gtgagggaac atgccctgcc ttagagggct gccactgaag ctgggcctca
     3061 tatgttccat gaggagctag gcctcgtgga atggctggct gactaaaccc agaaagccaa
     3121 ggctctgcca gtggaagaga cttcactttt gtagaccttc cctgaagtcc atggaacaga
     3181 cctaagggaa caactgagca tcaaaaccgg ctttgcttta cttcctggca ggctgcagcc
     3241 aaggggactg agcagcaggc acccaatgcc accagctcgt ctcttcctag caagcaaagg
     3301 gttaaagaag ccaccacctg ggtgtcagtg ggaaggagac agcagagctc aggctttgcc
     3361 ctttgacaga aacctaaaga cacatccaca tccatgcata gggctgttgc ttgttgtgtt
     3421 gtaggcatgc tcttctcacc ttctgtcaag gacctggtgc cctgggtggt ggagggctca
     3481 gccctcttga ttcagtagct tcccaagcag ctgctcctct caggagcctg cttaacactt
     3541 gcgccagctc agaggcctgc ctctatggtc cagtgcatcc ccgctgtgct cagatgctga
     3601 cgagactcct ttgctagact cccctagtta gggcctctgc agcttatggt ggcttaaaat
     3661 ggagagagca tcttgcctgg ccgagtgttt gtgctatgtg agcatgaggc tttatttgac
     3721 tgtggaagaa gacactaaga gccagcagaa gggcctgagc tgcctcatta gcctggcttc
     3781 atttggggag ctcctgacag tgtcccgagt aggtgcccag cccctcttgg gtaccagagt
     3841 ggttatagcg acacactcct catccaggct tcccaagata cactagctct gggacacccc
     3901 aggcatgctc tcaaactagt catggggcct tctgaggaca gttccatcct acctttgtcc
     3961 ttccctggta cagcctgtga ccctggcaca ctgcacatgc tgatctgagt ggctctgctc
     4021 actgtcgcac accccttcct ctcccatgca gtcacctcag gactcccgac atacatcaca
     4081 aaggctgctt catggctggg tgtgggacca gatgccagca aggatggaag catcaggctc
     4141 acaggtgtgt gtgtgtgtgt gcacgcgttc gcacatgcgt gagtgtgtag cagaagtgtg
     4201 tacagagagg cccgtgctag ctagcaccaa gttggttgac agattgtttt gtgatgcttg
     4261 ccctgcctcg gtattgccag tttcttgtgc aataaagaat cagcagccat gggtggtgtc
     4321 agtgtagctg tttatacaca ttctgttgca ggaagagtct tccattccca caggtcctct
     4381 agaatctcca gaccaagaga atctccacaa caatagtgct ccagccttgc tgcctttgcg
     4441 agtttgagta ccagtaacca aggtagcctg acttctggaa tagatggtag tccttctagc
     4501 tgaggcgagt gacctctggt cacggtgtca tactctctct acaccggttg tgcattttgg
     4561 aacaggagag ctgagatttg ggtagggctg ccatccattc aggaaatggc tcaggttgca
     4621 tgagcccatg acaaggggtt ccctgatgct gaattcaggg tcataccttt cttaccactc
     4681 aattgttttg actggtgagg cttcaaagat ggagctgggt atggtaacac atgcttacaa
     4741 tcctagcatt tagaaagctg aggtggtttt cttttaaact aattcagtaa gtaaattatc
     4801 tttgtgtggc agccatgttt aatccacagt tcaagtatgt tagtttgaaa agggcacttt
     4861 gaagctattc ccatgaatca gtggcagtag gaaaagttct ctttttttgt gtgtctcatt
     4921 tcagttttta gtttaaaatt attattgtcc tttttttgtt tatcttgaag cttaataaaa
     4981 tggcacataa ttaggacatt ttaa
//
