LOCUS       NM_019573               2180 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus WW domain-containing oxidoreductase (Wwox), transcript
            variant 1, mRNA.
ACCESSION   NM_019573
VERSION     NM_019573.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2180)
  AUTHORS   Zeng,Z., Abdelwahid,E., Chen,W., Ascoli,C., Pham,T., Jacobson,J.R.,
            Dudek,S.M., Natarajan,V., Aldaz,C.M., Machado,R.F. and Singla,S.
  TITLE     Endothelial knockdown of the tumor suppressor, WWOX, increases
            inflammation in ventilator-induced lung injury
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (6), L687-L697 (2024)
   PUBMED   38563965
  REMARK    GeneRIF: Endothelial knockdown of the tumor suppressor, WWOX,
            increases inflammation in ventilator-induced lung injury.
REFERENCE   2  (bases 1 to 2180)
  AUTHORS   Bidany-Mizrahi,T., Shweiki,A., Maroun,K., Abu-Tair,L., Mali,B. and
            Aqeilan,R.I.
  TITLE     Unveiling the relationship between WWOX and BRCA1 in mammary
            tumorigenicity and in DNA repair pathway selection
  JOURNAL   Cell Death Discov 10 (1), 145 (2024)
   PUBMED   38499540
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2180)
  AUTHORS   Akkawi,R., Hidmi,O., Haj-Yahia,A., Monin,J., Diment,J., Drier,Y.,
            Stein,G.S. and Aqeilan,R.I.
  TITLE     WWOX promotes osteosarcoma development via upregulation of Myc
  JOURNAL   Cell Death Dis 15 (1), 13 (2024)
   PUBMED   38182577
  REMARK    GeneRIF: WWOX promotes osteosarcoma development via upregulation of
            Myc.
            Erratum:[Cell Death Dis. 2024 Feb 14;15(2):141. doi:
            10.1038/s41419-024-06518-8.. PMID: 38355659]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2180)
  AUTHORS   Shin,M.J., Kim,H.S., Lee,P., Yang,N.G., Kim,J.Y., Eun,Y.S., Lee,W.,
            Kim,D., Lee,Y., Jung,K.E., Hong,D., Shin,J.M., Lee,S.H., Lee,S.Y.,
            Kim,C.D. and Kim,J.E.
  TITLE     Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin
            Inflammation in Psoriasis
  JOURNAL   Int J Mol Sci 25 (1), 167 (2023)
   PUBMED   38203337
  REMARK    GeneRIF: Mechanistic Investigation of WWOX Function in
            NF-kB-Induced Skin Inflammation in Psoriasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2180)
  AUTHORS   Cheng,H.C., Huang,P.H., Lai,F.J., Jan,M.S., Chen,Y.L., Chen,S.Y.,
            Chen,W.L., Hsu,C.K., Huang,W. and Hsu,L.J.
  TITLE     Loss of fragile WWOX gene leads to senescence escape and genome
            instability
  JOURNAL   Cell Mol Life Sci 80 (11), 338 (2023)
   PUBMED   37897534
  REMARK    GeneRIF: Loss of fragile WWOX gene leads to senescence escape and
            genome instability.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2180)
  AUTHORS   Chang,N.S., Doherty,J. and Ensign,A.
  TITLE     JNK1 physically interacts with WW domain-containing oxidoreductase
            (WOX1) and inhibits WOX1-mediated apoptosis
  JOURNAL   J Biol Chem 278 (11), 9195-9202 (2003)
   PUBMED   12514174
  REMARK    GeneRIF: phosphorylation of JNK1 and WOX1 is necessary for their
            physical interaction and functional antagonism
REFERENCE   7  (bases 1 to 2180)
  AUTHORS   Krummel,K.A., Denison,S.R., Calhoun,E., Phillips,L.A. and
            Smith,D.I.
  TITLE     The common fragile site FRA16D and its associated gene WWOX are
            highly conserved in the mouse at Fra8E1
  JOURNAL   Genes Chromosomes Cancer 34 (2), 154-167 (2002)
   PUBMED   11979549
  REMARK    GeneRIF: The intron/exon boundaries of Wox1 have been identified;
            the genomic organization has been found to be almost identical to
            that of human WWOX.
REFERENCE   8  (bases 1 to 2180)
  AUTHORS   Paige,A.J., Taylor,K.J., Taylor,C., Hillier,S.G., Farrington,S.,
            Scott,D., Porteous,D.J., Smyth,J.F., Gabra,H. and Watson,J.E.
  TITLE     WWOX: a candidate tumor suppressor gene involved in multiple tumor
            types
  JOURNAL   Proc Natl Acad Sci U S A 98 (20), 11417-11422 (2001)
   PUBMED   11572989
REFERENCE   9  (bases 1 to 2180)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 2180)
  AUTHORS   Chang,N.S., Pratt,N., Heath,J., Schultz,L., Sleve,D., Carey,G.B.
            and Zevotek,N.
  TITLE     Hyaluronidase induction of a WW domain-containing oxidoreductase
            that enhances tumor necrosis factor cytotoxicity
  JOURNAL   J Biol Chem 276 (5), 3361-3370 (2001)
   PUBMED   11058590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151980.3, AC110576.12 and AC129777.4.
            
            On Dec 21, 2022 this sequence version replaced NM_019573.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014716.1, AK078528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC151980.3         98405-98562         c
            159-223             AC151980.3         93751-93815         c
            224-281             AC151980.3         92886-92943         c
            282-460             AC151980.3         89945-90123         c
            461-567             AC151980.3         49279-49385         c
            568-656             AC110576.12        98650-98738
            657-842             AC110576.12        125064-125249
            843-1107            AC110576.12        130850-131114
            1108-2180           AC129777.4         86412-87484
FEATURES             Location/Qualifiers
     source          1..2180
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 60.99 cM"
     gene            1..2180
                     /gene="Wwox"
                     /gene_synonym="5330426P09Rik; 9030416C10Rik; WOX1"
                     /note="WW domain-containing oxidoreductase"
                     /db_xref="GeneID:80707"
                     /db_xref="MGI:MGI:1931237"
     exon            1..158
                     /gene="Wwox"
                     /gene_synonym="5330426P09Rik; 9030416C10Rik; WOX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1296
                     /gene="Wwox"
                     /gene_synonym="5330426P09Rik; 9030416C10Rik; WOX1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     WW-domain oxidoreductase"
                     /codon_start=1
                     /product="WW domain-containing oxidoreductase isoform 1"
                     /protein_id="NP_062519.2"
                     /db_xref="CCDS:CCDS22691.1"
                     /db_xref="GeneID:80707"
                     /db_xref="MGI:MGI:1931237"
                     /translation="MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQW
                     EHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPT
                     TRQRYDGSTTAMEILQGRDFTGKVVLVTGANSGIGFETAKSFALHGAHVILACRNLSR
                     ASEAVSRILEEWHKAKVEAMTLDLAVLRSVQHFAEAFKAKNVSLHVLVCNAGTFALPW
                     GLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSSPARVIVVSSESHRFTDINDSSGKLD
                     LSRLSPPRSDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSAIHRN
                     SWVYKLLFTLARPFTKSMQQGAATTVYCAVAPELEGLGGMYFNNCCRCLPSEEAQSEE
                     TARALWELSERLIQDRLGSPSS"
     exon            159..223
                     /gene="Wwox"
                     /gene_synonym="5330426P09Rik; 9030416C10Rik; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            224..281
                     /gene="Wwox"
                     /gene_synonym="5330426P09Rik; 9030416C10Rik; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            282..460
                     /gene="Wwox"
                     /gene_synonym="5330426P09Rik; 9030416C10Rik; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            461..567
                     /gene="Wwox"
                     /gene_synonym="5330426P09Rik; 9030416C10Rik; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..656
                     /gene="Wwox"
                     /gene_synonym="5330426P09Rik; 9030416C10Rik; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..842
                     /gene="Wwox"
                     /gene_synonym="5330426P09Rik; 9030416C10Rik; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1107
                     /gene="Wwox"
                     /gene_synonym="5330426P09Rik; 9030416C10Rik; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..2180
                     /gene="Wwox"
                     /gene_synonym="5330426P09Rik; 9030416C10Rik; WOX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2159..2164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wwox"
                     /gene_synonym="5330426P09Rik; 9030416C10Rik; WOX1"
                     /note="hexamer: AATAAA"
     polyA_site      2180
                     /gene="Wwox"
                     /gene_synonym="5330426P09Rik; 9030416C10Rik; WOX1"
                     /note="major polyA site"
ORIGIN      
        1 gaagccagag tgagttgctg aggagagcag gcggctactt ctgtctccag catggcagct
       61 ctgcgctatg cgggcctgga cgacacggac agtgaggatg agctgcctcc gggctgggag
      121 gagagaacca ccaaggacgg ctgggtgtac tacgccaatc acactgagga gaagacccag
      181 tgggaacatc cgaaaaccgg caagaggaaa cgggtcgcag gagatttgcc gtatggatgg
      241 gaacaggaga ctgacgagaa cggacaagtg tttttcgttg accacataaa taaaagaact
      301 acctacttgg atccaagatt ggcatttacc gtggacgata atccgacgaa gccgaccacc
      361 agacagagat acgacgggag caccaccgcc atggagatcc tgcagggccg ggacttcaca
      421 ggcaaggtgg tcctggttac tggagcaaat tcgggaatag ggttcgagac tgccaagtcc
      481 tttgccctcc atggcgcgca tgtgatcctg gcctgtagga acctgagcag agccagcgag
      541 gccgtgtccc gcatcctgga ggagtggcac aaagccaagg tggaagcaat gaccctggac
      601 ctggccgtgc tccgtagcgt gcagcatttt gccgaagcat tcaaggccaa gaatgtgtct
      661 cttcacgtgc ttgtgtgtaa tgcagggacg tttgctctgc cctggggcct cacgaaggat
      721 ggcctggaga caacctttca ggtgaaccac ctgggacatt tctaccttgt ccaactcctg
      781 caggatgttc tgtgccgctc atcccccgcc cgtgtcatcg tggtctcttc cgagtcccac
      841 agatttacag atattaatga ctcctccggg aaacttgacc tcagccgcct gtctccaccg
      901 aggagcgact actgggccat gctggcttat aacagatcta aactctgcaa tatcctcttc
      961 tccaatgaac tgcaccgtcg cctctccccg cgcggggtca catccaacgc agtgcaccct
     1021 gggaacatga tgtactcagc catccatcgc aactcatggg tgtacaagct gctgttcacc
     1081 ttggccaggc cgttcaccaa gtccatgcaa cagggagctg ctaccactgt ctactgtgca
     1141 gtcgccccag agctggaggg cctcggaggg atgtatttca acaactgctg ccgttgcctg
     1201 ccatccgagg aggctcagag tgaagagaca gctcgggccc tgtgggaact cagtgagagg
     1261 ctcatccagg accgactggg tagtccatcc agctaattgg aaccccataa tattgggcaa
     1321 aaccccaccc atgctctgac cctcatcaca gtcagcccca tcatcctggg tgccctgaac
     1381 tccagtacag ggcaatgaga gtagataaga acaatcaatg ggagaaggtt ataactagtg
     1441 ggaagcaggg aatttcaaga gatgatgtcc cttttctagg actgggttag tcgtgggact
     1501 gcttgctttt ctggtgttgg cccgcttgaa aatggaatca tggttagcat gtaggttccc
     1561 ttgctcattg taaaagcaca cgtgattttc tatcaacctt agaataacct gatatcccct
     1621 cgacccaccc agctgccacc actgccaact ttgccaccca aggttggctt tctcctgtta
     1681 atggaagaaa aaaaaaacca cacacattgt tcacttcttc aggctgagtt caatcctgga
     1741 ggccatgttt cacacttccc taccaagtct gagcaggcgt ggcaacttga gagaaaaact
     1801 cagtacctag tcccaagaga accaatgcga cggtgccatc agagaggagc agtgtcggtg
     1861 tggtgtgcag agctggtggt tcccagaagc accattccct gacctccttg ccaaagttaa
     1921 cacaagcaat tctttagaga ttataacgag tgcattttac attttgcaaa ccattcccta
     1981 ggcaggcaag gaaggaggca cggtgtcctt aagatacatg ggatatgctg gaggtgggaa
     2041 gcaaggaagt agttccctcc agtcttcact cacagttcca agaacatctt ctttagcgac
     2101 tgtcccagcc tctaagtcct ctggagttca cttcccctgg ctcccccatc ctatgcttaa
     2161 taaaagaaca tgcttaacta
//
