LOCUS       NM_133791               6548 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus WW, C2 and coiled-coil domain containing 2 (Wwc2),
            mRNA.
ACCESSION   NM_133791 XM_992562
VERSION     NM_133791.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6548)
  AUTHORS   Dunham,T.L., Wilkerson,J.R., Johnson,R.C., Huganir,R.L. and
            Volk,L.J.
  TITLE     WWC2 modulates GABAA-receptor-mediated synaptic transmission,
            revealing class-specific mechanisms of synapse regulation by WWC
            family proteins
  JOURNAL   Cell Rep 43 (10), 114841 (2024)
   PUBMED   39388350
REFERENCE   2  (bases 1 to 6548)
  AUTHORS   Hoffken,V., Di Persio,S., Laurentino,S., Wyrwoll,M.J., Terwort,N.,
            Hermann,A., Ropke,A., Oud,M.S., Wistuba,J., Kliesch,S.,
            Pavenstadt,H.J., Tuttelmann,F., Neuhaus,N. and Kremerskothen,J.
  TITLE     WWC2 expression in the testis: Implications for spermatogenesis and
            male fertility
  JOURNAL   FASEB J 37 (5), e22912 (2023)
   PUBMED   37086090
  REMARK    GeneRIF: WWC2 expression in the testis: Implications for
            spermatogenesis and male fertility.
REFERENCE   3  (bases 1 to 6548)
  AUTHORS   Qi,S., Zhu,Y., Liu,X., Li,P., Wang,Y., Zeng,Y., Yu,A., Wang,Y.,
            Sha,Z., Zhong,Z., Zhu,R., Yuan,H., Ye,D., Huang,S., Ling,C., Xu,Y.,
            Zhou,D., Zhang,L. and Yu,F.X.
  TITLE     WWC proteins mediate LATS1/2 activation by Hippo kinases and imply
            a tumor suppression strategy
  JOURNAL   Mol Cell 82 (10), 1850-1864 (2022)
   PUBMED   35429439
REFERENCE   4  (bases 1 to 6548)
  AUTHORS   Brucher,V.C., Egbring,C., Plagemann,T., Nedvetsky,P.I., Hoffken,V.,
            Pavenstadt,H., Eter,N., Kremerskothen,J. and Heiduschka,P.
  TITLE     Lack of WWC2 Protein Leads to Aberrant Angiogenesis in Postnatal
            Mice
  JOURNAL   Int J Mol Sci 22 (10), 5321 (2021)
   PUBMED   34070186
  REMARK    GeneRIF: Lack of WWC2 Protein Leads to Aberrant Angiogenesis in
            Postnatal Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6548)
  AUTHORS   Hermann,A., Wu,G., Nedvetsky,P.I., Brucher,V.C., Egbring,C.,
            Bonse,J., Hoffken,V., Wennmann,D.O., Marks,M., Krahn,M.P.,
            Scholer,H., Heiduschka,P., Pavenstadt,H. and Kremerskothen,J.
  TITLE     The Hippo pathway component Wwc2 is a key regulator of embryonic
            development and angiogenesis in mice
  JOURNAL   Cell Death Dis 12 (1), 117 (2021)
   PUBMED   33483469
  REMARK    GeneRIF: The Hippo pathway component Wwc2 is a key regulator of
            embryonic development and angiogenesis in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6548)
  AUTHORS   Hermann,A., Wennmann,D.O., Gromnitza,S., Edeling,M., Van Marck,V.,
            Sudol,M., Schaefer,L., Duning,K., Weide,T., Pavenstadt,H. and
            Kremerskothen,J.
  TITLE     WW and C2 domain-containing proteins regulate hepatic cell
            differentiation and tumorigenesis through the hippo signaling
            pathway
  JOURNAL   Hepatology 67 (4), 1546-1559 (2018)
   PUBMED   29116649
REFERENCE   7  (bases 1 to 6548)
  AUTHORS   Lavado,A., He,Y., Pare,J., Neale,G., Olson,E.N., Giovannini,M. and
            Cao,X.
  TITLE     Tumor suppressor Nf2 limits expansion of the neural progenitor pool
            by inhibiting Yap/Taz transcriptional coactivators
  JOURNAL   Development 140 (16), 3323-3334 (2013)
   PUBMED   23863479
REFERENCE   8  (bases 1 to 6548)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161202.15 and AC110509.21.
            
            On Feb 7, 2019 this sequence version replaced NM_133791.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147648.1, BC067050.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-479               AC161202.15        91872-92350
            480-589             AC161202.15        161718-161827
            590-793             AC110509.21        6454-6657
            794-870             AC110509.21        7798-7874
            871-950             AC110509.21        20159-20238
            951-1080            AC110509.21        23687-23816
            1081-1227           AC110509.21        27063-27209
            1228-1301           AC110509.21        28409-28482
            1302-1544           AC110509.21        31839-32081
            1545-1634           AC110509.21        37442-37531
            1635-2254           AC110509.21        38519-39138
            2255-2384           AC110509.21        42676-42805
            2385-2465           AC110509.21        43178-43258
            2466-2552           AC110509.21        43371-43457
            2553-2745           AC110509.21        48388-48580
            2746-2910           AC110509.21        50962-51126
            2911-3032           AC110509.21        55284-55405
            3033-3216           AC110509.21        57821-58004
            3217-3381           AC110509.21        59752-59916
            3382-3474           AC110509.21        61071-61163
            3475-3717           AC110509.21        64203-64445
            3718-3845           AC110509.21        75571-75698
            3846-6548           AC110509.21        78526-81228
FEATURES             Location/Qualifiers
     source          1..6548
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 26.91 cM"
     gene            1..6548
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /note="WW, C2 and coiled-coil domain containing 2"
                     /db_xref="GeneID:52357"
                     /db_xref="MGI:MGI:1261872"
     exon            1..479
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            480..589
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            590..793
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            794..870
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            871..950
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1080
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1227
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1301
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1544
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1634
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..2254
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2384
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2465
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2552
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2745
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2910
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..3032
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            3033..3216
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3381
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3474
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3717
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            3718..3845
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..6548
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6110..6115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /note="hexamer: AATAAA"
     polyA_site      6135
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
     regulatory      6526..6531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /note="hexamer: AATACA"
     polyA_site      6548
                     /gene="Wwc2"
                     /gene_synonym="5330431C14Rik; D8Ertd594e"
                     /note="major polyA site"
ORIGIN      
        1 agtcgccgcc gggccgttgc tccgcggagc ttcccggatc cgagcccaga cggcgtcggc
       61 cggggcagcc tgggcgccgc gaccctcggc ggccacaggg ggacggggag gaggaggaag
      121 aggcggaggc agcggcggca aggaggagga ggagggctcg ctcgtctgtt ccgacgcaga
      181 catggtggac tgatctccgg cagggctgag agcagggatc cccgaggctt ccccgcgcgt
      241 agctcgccgt gcccctcgcc ccgcacgccc ctcgccggca cccgcgttcc cgccgcgccc
      301 cgcgcccggt ccctatggag gcgccgctcg ccggcgaggc cgccgaccat gcctaggagg
      361 gccgggagcg ggcagctgcc gctaccccgg ggctgggagg aggccaggga ctacgacggc
      421 aaggttttct acatcgacca caacaccagg aggaccagct ggatcgaccc ccgggacagg
      481 ttaacgaagc ccctgtcctt cgctgactgt gtcggggatg agctgccctg gggatgggaa
      541 gcggggtttg accctcagat tggtgcctac tacatcgacc acatcaacaa aaccacacag
      601 attgaggatc cgaggaaaca gtggcggggc gagcaggaga agatgctcaa ggactatctc
      661 tccgtggccc aggacgcact caggacgcag aaggagctgt accacgtgaa ggaacagagg
      721 ctggcgctgg ccctcgatga atatgtgcgg ttaaatgatg cctacaaaga aaaatcaagc
      781 tctcatacca gcctcttctc agggtcttca tctagcacca aatatgatcc tgatatttta
      841 aaagctgaga tctccaccac acaattaagg gttaaaaagc tgaaaagaga actctcccac
      901 atgaagcaag aacttctcta taagcagcaa ggctttgaaa cgctgcaaca aattgatgag
      961 aagatgtccg gaggccagag tgggtatgaa cttaatgaag ccaaagccat cctgacagaa
     1021 ctgaagtcta tcagaaaggc catcagttca ggagaaaaag aaaagcaaga cctgatgcag
     1081 agtcttgcta agctgcagga gcgatttcat ttggatcaaa acatgggcag ttccgagcca
     1141 gatctgagat ctagtcctgt gaattctcat ctctctctgt ccagacagac ccttgacgct
     1201 gggtcacaga caagcatttc tggagatatt ggggttcgaa gcagatcaaa tttagctgaa
     1261 aaggtcagac tgagtctcca gtatgaagaa gccaaaagaa gcatggctaa cttgaaaatt
     1321 gaactgtcaa agttggatgg tgaggcctgg cctggggccc tggacatcga gaaggagaag
     1381 ttgatgctga ttaatgagaa agaagaactt ctgaaggagt tgcagtttat caccccgcag
     1441 aagcgctcgc aggaggagct ggagcgcctg gaagccgagc gccagcacct ggaggaagag
     1501 ctgatggccg cccggggctc acccagcagg gctctaaccg agagattgaa attggaagag
     1561 aaaagaaaag agctgctaca gaaacttgaa gaaactacta agttaactac ttccttgtac
     1621 tcgcaacttc aaagcctctc ctccagcaca ctgtccatgt catctgggag cagtctaggg
     1681 tccctggcct ccagtcgggg ctctctgaac acctccagca gggggtcact caactccctc
     1741 agttccagtg aactctatta cagcagccag ggcgaccaga tggacacaga ctatcagtat
     1801 aaactggact tccttcttca agagaagggt ggctacattc cttccggacc catcaccacc
     1861 atccacgaaa atgaggtggt caagtccccc agccagcccg gccagagtgg gctctgtggg
     1921 gtgggagtga cagccagcag ccacacaacc ccactgacgg aggcctccaa gtcagtggca
     1981 tccctgtcct ccaggtcctc tctctcctcc ttgtcgcctc ccggctctcc tcttgtcctg
     2041 gacagcgtat ttccagggtc ctcccatgac acctctccac accagttccc taccgacttt
     2101 gaggactgcg agctgagtcg ccgctttgct gacgttggcc ttggtgaaaa ccaggccttg
     2161 ctggattcag actcgggagg agcatcccaa cctctccttg aggataaagg cctgagcgat
     2221 tgccctgggg agctgctgtg tgagggcgca acagatgtgg aaaagtcgtt acccaaaaga
     2281 agaggactcc atcttcgagg agacaagacc actcgggtgt ccgctgctgc ctctgacgag
     2341 tcggtggctg gagacagtgg ggtctacgaa gcctccatga agcagcctgg tgaaatggaa
     2401 gatgttccct acagtgaaga ggatgtcacc attgtggaga ctgcccaggt gcagatagga
     2461 ctcagatacg atacaaagag ttcaagtttc atggtgatta tagcacaact ccgaaatctt
     2521 catgccttct cgatacctca ttcttcaaaa gtgtatttta gggtcgctct gcttccctcc
     2581 tctgcggatg tcagctgtct gtttcgaaca aaagtccatc cccccaccga atctgtgctg
     2641 tacaacgatg tgttcagggt ggccgtttcc caggcagccc ttcaacagaa gacgttgaga
     2701 gtggatctct gctccgccag taaacaccgc agggaggaat gcctggctgg gacgcagatc
     2761 agcctggcgg atttaccatt ttccaatgag atcttcatgc tgtggtataa tttgcttcct
     2821 tccaagcaaa tgccttgcaa gaagaatgaa gacggaaatg aggagcctgg agctcggtct
     2881 cagcagccca tgctcgaccc tatagacctg gacgccgtgt cagccttact tgcgagaact
     2941 tcagctgagc tcttggctgt ggaacaagaa ctggcccagg aggaggagga ggaggagcta
     3001 aggccagagc ggcggggtcc agggagagac tgcctaacga tgctaagaga ggcctctgac
     3061 gaacctgcgg ctttgagaga gtctggggtt cccttggcag agggcagccg ctgcacagag
     3121 gacccgaagc catgccctag ggggcctgag acaagccagt gtaggaagga gcctgctgaa
     3181 gaccctggtc agctgccatc tggacttccc accctggtcg ataaggagac gaatacagat
     3241 gaagtggttg acagcaatat ggcagttcgc cctaaagacc gaagcagcct cagctctcga
     3301 cagcatccat tcgtgagaaa cagcgtgata gtgcgctcac aaaccttctc cccaggcgag
     3361 cgaagtcagt acatctgcag gttaaatcgc agtgacagtg acagctcaac cttggccaaa
     3421 aaatccttgt ttgtgcggaa ctccactgag cggcgcagtt tgcgggtcaa aagggcggtt
     3481 tgccagccca ccctcaggag gactgctcag gaatgccccg tgcgcacttc tctggacctg
     3541 gagctggacc tgcaggcctc gctgacccgc cagagtcgcc tcaatgacga gctgcaggcc
     3601 ctgagaggct tacggcagaa gctagaggag ctgaaggctc agggagagac tgaccttccc
     3661 ccaggcgtgc tggaggacga gagattccag aagcttctga agcaagcaga gaagcaggct
     3721 gaacagacga aagaggagca gaagcaagac ttgaacgcag agaggttgat gaggcaggtc
     3781 tccaaggatg tgtgccgact gcgggagcag agccagaagg agcctcggca ggtgcagtcc
     3841 ttcagggaga agattgccta cttcacaaga gcgaagatta gcatcccatc actgcccgct
     3901 gacgacgtgt gaccctgcct gtggcttagc accgcctctc agctgctcac ttgccaaggg
     3961 aggggcaaag actgaatatt tacttttttt gttgttttca tttttgtttc attttggggg
     4021 cggggcttgt gtttcctgta atataactca actcttgaag agcttccgtt tcataccagt
     4081 ttcatcaggt ttatttgtaa agtactttga atgtaactct tacatgcttt gagaagaaaa
     4141 aaaaaatcac ataacaaaac tggggtaatc tggtccaaat ctggtccaca agtgttgtac
     4201 agtatgcatg tgttaccgct gggcttcgct gcaggctgga ctcaggtaac atgtgcccgg
     4261 tgtctgcccg ctgagccgac tgcagcaggc agctgtctag ctgcccggga gactggtgcc
     4321 acagcatacc tttgaactag agagccacac tctccatcca agtgagcatc tctgagccca
     4381 cctggaacac ctgcccggtt ccttccatca cccacgtctg accacctttt ctctgcaaaa
     4441 ccctttcttt ctgccctctt aaacttgtct ggagaaaaca agagtgtgaa agccgagggc
     4501 agaaatagag aagcagaggt gtactcctgc tgtagaaagc tgcggtcggg ggcagaaaga
     4561 aaactgtggg gaggggaggc agctttcaaa acccctgaga agactgcaga tgcttgcctg
     4621 gccactgctt ctatcacagt ctgcatctgc agggcaaggt ggccccggcc tctgatgacg
     4681 ctgcaggcag tgcagagggg gcacgcctct atccattaga ggagagctga ggtcggggcg
     4741 catcataatg agatcaaact tgccaaacag aagagagttt gttaccaggt ttctacactc
     4801 actaggaagt attttgtagc tgtcatcttc ctagagattc tgtccgggag attctgtcag
     4861 ggatgcataa aaggtagttg aatgcagaag caaagggtgt ggactggatc attttatatc
     4921 tatcttctgg atgaacaagc aagcttgacc tagaaattgg tcaaagagcc gtgttcttca
     4981 agctgggttt taacttacca gaccccgggc acttccttaa aaaaaaaaaa aaaaagactc
     5041 ggtttagcct agccagcata aacatgttaa aataaatact ttttcaggta atttaaacca
     5101 cactcacgta ctctgtcata ctggaagaag ccgtgttttg gtgagccatc ttatatagca
     5161 agctaaatta tttttatttt tttaatgcaa aataatttta taggaattaa tagaagaaag
     5221 gcgaagggga aaatctgttt taaaaaagtt acattctgct ggaatcccca ttagtaagga
     5281 tttttatttt cttgaatcta tgtatatttt agaaagttca tttttatcag aatcaaagtt
     5341 cgtactcagc cagaatttta attatcaagt gactgcacct aaaatgtaat catttccccc
     5401 taaacattcc acaacgtgta ccccgcttct cacaaggtgt aactggatag gacactactt
     5461 ggaactacaa gaagcctggt ggtgggctga gcacagacct cccacgctgc ccagcgccct
     5521 gtaggtaact ggaggaaggc catgctgtcc acccttcctg gccaggatcc agttgagcag
     5581 cagaggttga ctaaatgaag gtgccgtctt cagcatcata gtttgaccag tgaaaatgtt
     5641 catagaattt tgtgtagttg taccgtacga ttttatcttc ttcatttatt tatttacggt
     5701 cttatttatg ttctgtttaa tatatagttt ggttctggcc atcttaaatg ttgggcttac
     5761 aagaggctat attgaagtat ttacagctat atgatcttca tcagatttat cgctaacttt
     5821 ttgtaataca aaaagtgtca gactacgagt attaaagaat aaagtgtgtc tcaggctggt
     5881 agctcagagc tgtgactgag ggacttcggt tttattttat aaaacatgct catttctaac
     5941 atgagagaaa ctattctggt agaatccttt ctccactctg aaagtcagca gtcatgttgt
     6001 gcttatacag gccgctttct gtaggtctgt ctgtcacatt tgtattgacc caaatgattt
     6061 ttaaaaaaag tttttttttt actaacttga tcacaaaacc atatggatga ataaaaaatt
     6121 taatattatt aaaaatattt ttaaacttag aatttattct gcatagggta aaaagagttt
     6181 aatctttagc tctcaagttt ggattatcag tatattacat ttttgtctat cagactcaag
     6241 tgttacaggt acaaggagga tattaacttg ccaaataaca aagtttagct gagtctctgt
     6301 agcatacaaa ttacatacat ttaaaatctt tttgctatgt atttatattg tattaaatat
     6361 gagaagctca ggactcaaac atttaatcag gttacattct ggaaatgttt ctgttttcat
     6421 ttgtcctgtt tgtaatggtg tgtaaataca tcgcccatat taactcctgt tgctgcactt
     6481 gccccgtgtc tgtggatgaa aaaattcagt gatttttttt taaacaatac atatttccta
     6541 atactgca
//
