LOCUS       NM_170779               4532 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus WW, C2 and coiled-coil domain containing 1 (Wwc1),
            mRNA.
ACCESSION   NM_170779 XM_109956 XM_906579 XM_919926 XM_919938
VERSION     NM_170779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4532)
  AUTHORS   Dunham,T.L., Wilkerson,J.R., Johnson,R.C., Huganir,R.L. and
            Volk,L.J.
  TITLE     WWC2 modulates GABAA-receptor-mediated synaptic transmission,
            revealing class-specific mechanisms of synapse regulation by WWC
            family proteins
  JOURNAL   Cell Rep 43 (10), 114841 (2024)
   PUBMED   39388350
REFERENCE   2  (bases 1 to 4532)
  AUTHORS   Han,C., He,C., Ding,X., Li,Z., Peng,T., Zhang,C., Chen,H., Zuo,Z.,
            Huang,J. and Hu,W.
  TITLE     WWC1 upregulation accelerates hyperuricemia by reduction in renal
            uric acid excretion through Hippo signaling pathway
  JOURNAL   J Biol Chem 300 (8), 107485 (2024)
   PUBMED   38906255
  REMARK    GeneRIF: WWC1 upregulation accelerates hyperuricemia by reduction
            in renal uric acid excretion through Hippo signaling pathway.
REFERENCE   3  (bases 1 to 4532)
  AUTHORS   Tsokas,P., Hsieh,C., Flores-Obando,R.E., Bernabo,M.,
            Tcherepanov,A., Hernandez,A.I., Thomas,C., Bergold,P.J.,
            Cottrell,J.E., Kremerskothen,J., Shouval,H.Z., Nader,K.,
            Fenton,A.A. and Sacktor,T.C.
  TITLE     KIBRA anchoring the action of PKMzeta maintains the persistence of
            memory
  JOURNAL   Sci Adv 10 (26), eadl0030 (2024)
   PUBMED   38924398
  REMARK    GeneRIF: KIBRA anchoring the action of PKMzeta maintains the
            persistence of memory.
REFERENCE   4  (bases 1 to 4532)
  AUTHORS   Nasello,C., Poppi,L.A., Wu,J., Kowalski,T.F., Thackray,J.K.,
            Wang,R., Persaud,A., Mahboob,M., Lin,S., Spaseska,R., Johnson,C.K.,
            Gordon,D., Tissir,F., Heiman,G.A., Tischfield,J.A., Bocarsly,M. and
            Tischfield,M.A.
  TITLE     Human mutations in high-confidence Tourette disorder genes affect
            sensorimotor behavior, reward learning, and striatal dopamine in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (19), e2307156121 (2024)
   PUBMED   38683996
REFERENCE   5  (bases 1 to 4532)
  AUTHORS   Zhang,S., Zhang,B., Liao,Z., Chen,Y., Guo,W., Wu,J., Liu,H.,
            Weng,R., Su,D., Chen,G., Zhang,Z., Li,C., Long,J., Xiao,Y., Ma,Y.,
            Zhou,T., Xu,C. and Su,P.
  TITLE     Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA
            and inhibiting Hippo signaling pathway
  JOURNAL   Mol Ther 32 (5), 1461-1478 (2024)
   PUBMED   38414246
  REMARK    GeneRIF: Hnrnpk protects against osteoarthritis through targeting
            WWC1 mRNA and inhibiting Hippo signaling pathway.
REFERENCE   6  (bases 1 to 4532)
  AUTHORS   Yoshihama,Y., Sasaki,K., Horikoshi,Y., Suzuki,A., Ohtsuka,T.,
            Hakuno,F., Takahashi,S., Ohno,S. and Chida,K.
  TITLE     KIBRA suppresses apical exocytosis through inhibition of aPKC
            kinase activity in epithelial cells
  JOURNAL   Curr Biol 21 (8), 705-711 (2011)
   PUBMED   21497093
REFERENCE   7  (bases 1 to 4532)
  AUTHORS   Xiao,L., Chen,Y., Ji,M. and Dong,J.
  TITLE     KIBRA regulates Hippo signaling activity via interactions with
            large tumor suppressor kinases
  JOURNAL   J Biol Chem 286 (10), 7788-7796 (2011)
   PUBMED   21233212
  REMARK    GeneRIF: KIBRA associates with and activates Lats (large tumor
            suppressor) 1 and 2 kinases by stimulating their phosphorylation on
            the hydrophobic motif
REFERENCE   8  (bases 1 to 4532)
  AUTHORS   Yoshihama,Y., Hirai,T., Ohtsuka,T. and Chida,K.
  TITLE     KIBRA Co-localizes with protein kinase Mzeta (PKMzeta) in the mouse
            hippocampus
  JOURNAL   Biosci Biotechnol Biochem 73 (1), 147-151 (2009)
   PUBMED   19129633
  REMARK    GeneRIF: KIBRA functions in memory performance via interaction with
            PKMzeta.
REFERENCE   9  (bases 1 to 4532)
  AUTHORS   Hilton,H.N., Stanford,P.M., Harris,J., Oakes,S.R., Kaplan,W.,
            Daly,R.J. and Ormandy,C.J.
  TITLE     KIBRA interacts with discoidin domain receptor 1 to modulate
            collagen-induced signalling
  JOURNAL   Biochim Biophys Acta 1783 (3), 383-393 (2008)
   PUBMED   18190796
REFERENCE   10 (bases 1 to 4532)
  AUTHORS   Yoshida,S., Mears,A.J., Friedman,J.S., Carter,T., He,S., Oh,E.,
            Jing,Y., Farjo,R., Fleury,G., Barlow,C., Hero,A.O. and Swaroop,A.
  TITLE     Expression profiling of the developing and mature Nrl-/- mouse
            retina: identification of retinal disease candidates and
            transcriptional regulatory targets of Nrl
  JOURNAL   Hum Mol Genet 13 (14), 1487-1503 (2004)
   PUBMED   15163632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645912.18 and AL596084.13.
            
            On Jul 4, 2018 this sequence version replaced NM_170779.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ256090.1, SRR7974084.1335.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-557               AL645912.18        46069-46625         c
            558-667             AL596084.13        160377-160486       c
            668-871             AL596084.13        155377-155580       c
            872-948             AL596084.13        143820-143896       c
            949-1028            AL596084.13        142577-142656       c
            1029-1158           AL596084.13        136650-136779       c
            1159-1305           AL596084.13        134461-134607       c
            1306-1379           AL596084.13        133264-133337       c
            1380-1622           AL596084.13        128449-128691       c
            1623-1712           AL596084.13        121730-121819       c
            1713-2251           AL596084.13        120815-121353       c
            2252-2360           AL596084.13        116117-116225       c
            2361-2441           AL596084.13        115675-115755       c
            2442-2528           AL596084.13        114298-114384       c
            2529-2721           AL596084.13        112436-112628       c
            2722-2862           AL596084.13        107010-107150       c
            2863-2954           AL596084.13        105297-105388       c
            2955-3072           AL596084.13        98561-98678         c
            3073-3237           AL596084.13        97395-97559         c
            3238-3330           AL596084.13        89356-89448         c
            3331-3564           AL596084.13        86955-87188         c
            3565-3686           AL596084.13        85511-85632         c
            3687-4532           AL596084.13        83600-84445         c
FEATURES             Location/Qualifiers
     source          1..4532
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 21.96 cM"
     gene            1..4532
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /note="WW, C2 and coiled-coil domain containing 1"
                     /db_xref="GeneID:211652"
                     /db_xref="MGI:MGI:2388637"
     exon            1..557
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..3753
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /note="protein WWC1; kidney and brain protein; WW
                     domain-containing protein 1"
                     /codon_start=1
                     /product="protein KIBRA"
                     /protein_id="NP_740749.1"
                     /db_xref="CCDS:CCDS24545.1"
                     /db_xref="GeneID:211652"
                     /db_xref="MGI:MGI:2388637"
                     /translation="MPRPELPLPEGWEEARDFDGKVYYIDHRNRTTSWIDPRDRYTKP
                     LTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVV
                     AQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEIL
                     KAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDERMSDAQGGYKLDEAQAVL
                     RETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPMPKQ
                     FLDVSSQTDISGSFSTSSNNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVL
                     DSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARRRLEKDLQAARDTQSKAL
                     TERLKLNSKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLA
                     ASSLDSSTSASFTDLYYDPFEQLDSELQSKVELLFLEGATGFRPSGCITTIHEDEVAK
                     TQKAEGGSRLQALRSLSGTPRSMTSLSPRSSLSSPSPPCSPLITDPLLTGDAFLAPLE
                     FEDTELSTTLCELNLGGSGTQERYRLEEPGPEGKPLGQAASVAPGCGLKVACVSAAVS
                     DESVAGDSGVYEASAQRPGTSEAAAFDSDESEAVGATRVQIALKYDEKNKQFAILIIQ
                     LSHLSALSLQQDQKVNIRVAILPCSESSTCLFRTRPLDSANTLVFNEAFWVSISYPAL
                     HQKTLRVDVCTTDRSHTEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQCREPQ
                     PTEAPGPDHVDAVSALLEQTAVELEKRQEGRSSSQTLEGSWTYEEEASENEAVAEEEE
                     EGEEDVFTEKVSPEAEECPALKVDRETNTDSVAPSPTVVRPKDRRVGAPSTGPFLRGN
                     TIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVRNSLERRSVRMKRPSSVKSLR
                     TERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEHLEQAKNHGEKELPQWLREDE
                     RFRLLLRMLEKKVDRGEHKSELQADKMMRAAAKDVHRLRGQSCKEPPEVQSFREKMAF
                     FTRPRMNIPALSADDV"
     exon            558..667
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            668..871
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            872..948
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1028
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1158
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1305
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1379
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1622
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1712
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..2251
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2360
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2441
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2528
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2721
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2862
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..2954
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3072
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3237
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            3238..3330
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..3564
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            3565..3686
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     exon            3687..4532
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4509..4514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /note="hexamer: AATAAA"
     polyA_site      4530
                     /gene="Wwc1"
                     /gene_synonym="Kibra"
                     /note="major polyA site"
ORIGIN      
        1 ggggcagcgc agttacctgc accgccggag ccacacctgg cggaggcaga agtctcgggg
       61 cgcgcggcgg ggctccggca gaggctgcgg gcggcggcgg cggcggcggc ggcgtggagc
      121 gcagcgcgca gcggcagggg caggcaggcg gcggctcggg ccgctctcct ggctggctgg
      181 ccgcggactc gggccggctg ggcgccgcgg cgggcgcaca tggcagcgtg agaggcgggc
      241 ggcgtggggc tggggccgca gggccgcatg gacagaggcg ccaccccggc cggcccccgt
      301 tagggccccc gatccgtggg cgccactccc cgatcatgct gcctcggcgg ccgcctggac
      361 ccaaagcggc cagcccgagc cgctgagccc cgtggcggct gcgagctgca tgggggagcg
      421 cgggccaggc tcgggaagat gccccggccg gagttgcccc tgccggaggg ctgggaggag
      481 gcgcgcgact tcgacggcaa ggtctactac atagatcaca ggaaccgcac caccagctgg
      541 atcgacccgc gggacaggta caccaaacca ctcaccttcg ctgactgcat cagtgatgag
      601 ttaccgctgg gatgggaaga agcatacgac ccacaggtcg gagattactt catagaccac
      661 aataccaaaa ccactcagat cgaggatcca agggtgcaat ggcggcggga acaggagcac
      721 atgctgaagg attacctggt ggtggctcag gaagctctga gtgcacaaaa ggagatctac
      781 caggtgaagc agcagcgcct ggagctggca cagcaggagt atcagcagtt gcatgccgtc
      841 tgggagcata agctgggctc ccaggttagc ttggtctctg gatcctcgtc cagctccaag
      901 tatgaccccg agatcctgaa agctgaaatt gccactgcaa agtcccgggt caacaagctg
      961 aagagagaga tggttcacct acagcatgag ctgcagttca aggagcgtgg ctttcagacg
     1021 ctgaagaaaa ttgatgagag aatgtcagac gcacagggtg gctacaaact ggatgaggcc
     1081 caggctgtgc tgagggaaac caaagccatc aagaaagcca tcacctgcgg agaaaaggag
     1141 aaacaagacc tcattaagag tctcgccatg ctgaaggatg gcttccggac agacagaggg
     1201 tcacactccg acctatggtc cagcagcagc tctctggaga gttcaagctt cccgatgcca
     1261 aagcagttcc tggacgtgag ctcgcagaca gacatctctg ggagtttcag caccagcagc
     1321 aacaatcagt tggccgagaa ggtcagattg cgccttcggt atgaagaggc gaagagaagg
     1381 atcgccaacc tcaagatcca gctggccaaa cttgacagtg aggcctggcc tggggtgcta
     1441 gactcagaga gggaccgact gatcctcatc aatgagaagg aggaacttct gaaggaaatg
     1501 cgcttcatca gcccccggaa atggacccag ggagaggtgg agcaactgga gatggcccgg
     1561 aggcgacttg agaaggactt acaggcagcc cgggacaccc agagcaaggc gctgactgag
     1621 aggctgaagt taaatagcaa gaggaaccag ctggtgcgag aactggagga agccactcgg
     1681 caggtggcta ccctgcactc ccagttgaaa agcctctcaa gcagcatgca gtccctgtct
     1741 tcaggcagta gccctgggtc actcacctcc agccggggct ccctggccgc ctctagcctg
     1801 gactcctcca cctcagccag cttcactgac ctctattatg acccgttcga gcagttggac
     1861 tcggagctcc agagcaaggt ggagctgctg ttcctggagg gtgccacggg cttccggccc
     1921 tcaggctgca tcaccaccat ccacgaggat gaggtggcca agacccagaa ggcagaggga
     1981 ggcagccgcc tgcaggccct gcgctcccta tctggcactc caaggtccat gacctccctg
     2041 tctccacgct catctctctc ctccccatcc cctccctgtt cccctctcat cactgatccc
     2101 ctcctgactg gagatgcctt cctggccccg ctggagtttg aagacacaga gctgagtacc
     2161 actctctgtg agctgaacct cggcggtagc ggcacccagg aaagataccg gctggaggaa
     2221 ccaggacctg agggcaagcc actgggccaa gctgcaagtg tggccccagg atgtggcctc
     2281 aaagtagcct gtgtgtccgc tgcagtgtcc gacgagtcag tagccgggga cagtggcgtg
     2341 tatgaggctt cagcacagag accaggtact tctgaagctg ccgcattcga cagtgatgaa
     2401 tcggaagctg tgggtgccac tcgggttcag attgccctga aatatgatga gaagaataag
     2461 caatttgcaa tattaatcat tcagctgagt cacctctctg ctctgtcact acaacaagac
     2521 cagaaagtga acatccgtgt agccatcctg ccttgctctg aaagcagcac ctgcttgttc
     2581 agaacccggc ctctggactc ggcaaatacc ctcgtgttca atgaggcatt ctgggtgtcc
     2641 atctcctacc cagcccttca ccaaaagacc ttacgagtcg atgtctgcac cactgacagg
     2701 agccatacag aggagtgtct gggaggtgcc cagatcagcc tggccgaggt ctgccggtct
     2761 ggggagaggt caacgcgctg gtacaatctc ctgagctaca aatacttgaa gaagcagtgc
     2821 agggagcccc agccaacaga agctccaggg ccagaccatg tggacgctgt gtctgccttg
     2881 ctagaacaga cagccgtgga gctagagaag aggcaggagg gaagaagcag ctcccagacg
     2941 ctggagggca gctggacgta cgaggaagag gccagcgaga atgaggcagt cgctgaggag
     3001 gaagaggagg gagaggaaga tgtcttcact gaaaaggtct ctcccgaggc agaggagtgc
     3061 ccagcattaa aggtggacag agagaccaat actgacagcg tggccccatc ccccacagtg
     3121 gtgcgcccta aggaccggag ggtgggtgcc ccgtcgacag ggccatttct tcgagggaat
     3181 accatcatcc gctccaagac cttctcgcct ggaccccaga gccagtatgt gtgtcggcta
     3241 aaccgcagtg acagtgatag ttctacgctg tccaagaagc caccttttgt gcgaaactcc
     3301 ctggagcggc gcagcgtcag gatgaagcgg ccttcctccg tcaagtccct gcgcacagag
     3361 cgtctgatcc gcacctcgct ggacctagaa ctcgacctgc aggccacgag gacctggcac
     3421 agccagctga ctcaggagat ctcagtgctg aaggagctga aggagcattt ggagcaagcc
     3481 aagaaccacg gggagaagga gctgccacag tggctgcgtg aagacgagcg cttccgcttg
     3541 ctactgagga tgctggagaa gaaggtggat cgtggggagc acaagagtga gttgcaagcc
     3601 gacaagatga tgagagctgc tgccaaggat gtgcacaggc ttcgaggcca gagctgtaag
     3661 gagcccccag aagtgcagtc tttcagggag aaaatggcat ttttcacccg gcctcggatg
     3721 aacatcccag ctctctctgc agatgacgtc taaccaccag aaaagtattt cctttgtctc
     3781 gtgcgcgcgc gtgcagacca agctgtgaag gctgactgtg actaatgtta tttatgaggc
     3841 attatatgaa ggtactgagt cacaagtccc cgagcgctct tgttggtttg aagacagatt
     3901 ttttttttaa atttcaggtt ttcttgttat tatttaaaaa aaaaaatgac aaagcaacca
     3961 taacaacaaa aacaaaaacc aaacaaacaa aaaaaccagc attaaaatga caagattgta
     4021 tagtttgtat atttaggaat gtatttttgg gaaagaattt aaatgaacta aagcagcatt
     4081 aagtggctgc tagtcttaaa actgtctaga gttttctttt tgtacagcaa caactttcag
     4141 aggtttccct gcaataataa aaaaaaaaaa agttgtattt gaggggcgac aatcctcaaa
     4201 ggaggtcccg cgggtggcac agcacagcta gcctgccctg gttaacgtta ttttgtacaa
     4261 taatacaaag acaaggatgt acagtaatcg tgggggaatt cgaagactgt ccgcggatct
     4321 ttgtgagctg tgatgtgtct ttcatgtggc cacgtgaccg tgaccggaag caggtagcct
     4381 ggagctggct gaaccgcccg gactggtgac aggccacgcc caggccacgc ccatctcaga
     4441 tgcccagtga cgcagctgtg ggagtgaggg gagggctgcg gagaaccgca tttggatcta
     4501 tctctaacaa taaagtggcc ttttaagaaa ga
//
