LOCUS       NM_207212               1975 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus WT1 interacting protein (Wtip), mRNA.
ACCESSION   NM_207212 XM_149921
VERSION     NM_207212.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1975)
  AUTHORS   Xie,X., Sun,L., Duan,Y., Lv,Z., Yao,X., Wang,C., Chen,X., Tian,S.,
            Yan,L., Shao,Y., Luo,H. and Liu,J.
  TITLE     SRSF2 in Sertoli cells is essential for testicular development and
            spermatogenesis in mice
  JOURNAL   FASEB J 37 (5), e22918 (2023)
   PUBMED   37039821
REFERENCE   2  (bases 1 to 1975)
  AUTHORS   Madhavan,S.M., Konieczkowski,M., Bruggeman,L.A., DeWalt,M.,
            Nguyen,J.K., O'Toole,J.F. and Sedor,J.R.
  TITLE     Essential role of Wtip in mouse development and maintenance of the
            glomerular filtration barrier
  JOURNAL   Am J Physiol Renal Physiol 323 (3), F272-F287 (2022)
   PUBMED   35862649
REFERENCE   3  (bases 1 to 1975)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1975)
  AUTHORS   West,D.B., Engelhard,E.K., Adkisson,M., Nava,A.J., Kirov,J.V.,
            Cipollone,A., Willis,B., Rapp,J., de Jong,P.J. and Lloyd,K.C.
  TITLE     Transcriptome Analysis of Targeted Mouse Mutations Reveals the
            Topography of Local Changes in Gene Expression
  JOURNAL   PLoS Genet 12 (2), e1005691 (2016)
   PUBMED   26839965
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1975)
  AUTHORS   Moon,S., Um,S.J. and Kim,E.J.
  TITLE     Role of Asxl1 in kidney podocyte development via its interaction
            with Wtip
  JOURNAL   Biochem Biophys Res Commun 466 (3), 560-566 (2015)
   PUBMED   26385183
  REMARK    GeneRIF: implicate Asxl1 in the maintenance of podocyte structure
            via its association with Wtip and in the regulation of WT1
            signaling during early kidney development
REFERENCE   6  (bases 1 to 1975)
  AUTHORS   Langer,E.M., Feng,Y., Zhaoyuan,H., Rauscher,F.J. 3rd, Kroll,K.L.
            and Longmore,G.D.
  TITLE     Ajuba LIM proteins are snail/slug corepressors required for neural
            crest development in Xenopus
  JOURNAL   Dev Cell 14 (3), 424-436 (2008)
   PUBMED   18331720
REFERENCE   7  (bases 1 to 1975)
  AUTHORS   Ayyanathan,K., Peng,H., Hou,Z., Fredericks,W.J., Goyal,R.K.,
            Langer,E.M., Longmore,G.D. and Rauscher,F.J. 3rd.
  TITLE     The Ajuba LIM domain protein is a corepressor for SNAG domain
            mediated repression and participates in nucleocytoplasmic Shuttling
  JOURNAL   Cancer Res 67 (19), 9097-9106 (2007)
   PUBMED   17909014
REFERENCE   8  (bases 1 to 1975)
  AUTHORS   Weber,M.J.
  TITLE     Mammalian small nucleolar RNAs are mobile genetic elements
  JOURNAL   PLoS Genet 2 (12), e205 (2006)
   PUBMED   17154719
  REMARK    Erratum:[PLoS Genet. 2007 Feb;3(2):e36]
REFERENCE   9  (bases 1 to 1975)
  AUTHORS   Srichai,M.B., Konieczkowski,M., Padiyar,A., Konieczkowski,D.J.,
            Mukherjee,A., Hayden,P.S., Kamat,S., El-Meanawy,M.A., Khan,S.,
            Mundel,P., Lee,S.B., Bruggeman,L.A., Schelling,J.R. and Sedor,J.R.
  TITLE     A WT1 co-regulator controls podocyte phenotype by shuttling between
            adhesion structures and nucleus
  JOURNAL   J Biol Chem 279 (14), 14398-14408 (2004)
   PUBMED   14736876
  REMARK    GeneRIF: WTIP monitors slit diaphragm protein assembly as part of a
            multiple protein complex, linking this specialized adhesion
            junction to the actin cytoskeleton, and shuttles into the nucleus
            after podocyte injury
REFERENCE   10 (bases 1 to 1975)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX539331.7.
            
            On Mar 28, 2023 this sequence version replaced NM_207212.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054125.1, CB183969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-791               BX539331.7         62938-63728         c
            792-893             BX539331.7         55934-56035         c
            894-961             BX539331.7         49588-49655         c
            962-1024            BX539331.7         49386-49448         c
            1025-1155           BX539331.7         49124-49254         c
            1156-1207           BX539331.7         47761-47812         c
            1208-1276           BX539331.7         47043-47111         c
            1277-1975           BX539331.7         39990-40688         c
FEATURES             Location/Qualifiers
     source          1..1975
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.4 cM"
     gene            1..1975
                     /gene="Wtip"
                     /note="WT1 interacting protein"
                     /db_xref="GeneID:101543"
                     /db_xref="MGI:MGI:2141920"
     exon            1..791
                     /gene="Wtip"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1417
                     /gene="Wtip"
                     /codon_start=1
                     /product="Wilms tumor protein 1-interacting protein"
                     /protein_id="NP_997095.1"
                     /db_xref="CCDS:CCDS21135.1"
                     /db_xref="GeneID:101543"
                     /db_xref="MGI:MGI:2141920"
                     /translation="MQRSRTAADDAALLLAGLGLRESEPTAGSPGRVRRGPRAVDEAA
                     PASGRRGKGGCGGPEAAPDVPSRPERGPRASLAGSDGGSARSSGISLGYDQRHGPGPG
                     PPSGGSARSSVSSLGSRGSAGACADLLPPGVGPAPARSPEPAQFPFPLPSLPLPPGRE
                     GGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGARQACQAMGSLYHTDC
                     FICDSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKS
                     YHPGCFRCSVCNECLDGVPFTVDVDNNIYCVRDYHTVFAPKCASCARPILPAQGCETT
                     IRVVSMDRDYHVECYHCEDCGLQLSGEEGRRCYPLEGHLLCRRCHLRRLGQGPLPSPA
                     VHVTEL"
     exon            792..893
                     /gene="Wtip"
                     /inference="alignment:Splign:2.1.0"
     exon            894..961
                     /gene="Wtip"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1024
                     /gene="Wtip"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1155
                     /gene="Wtip"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1207
                     /gene="Wtip"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1276
                     /gene="Wtip"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1975
                     /gene="Wtip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1949..1954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wtip"
                     /note="hexamer: AATATA"
     polyA_site      1963
                     /gene="Wtip"
                     /note="major polyA site"
     polyA_site      1975
                     /gene="Wtip"
                     /note="major polyA site"
ORIGIN      
        1 gcattcctcc gccgcgcgcc tccgttcctc cctccctccc cgccacggcc ccgcgcgaga
       61 gtgcggccca cgccgagcga ccgcgacccg ggccccgccc cgccccgcgc ccaggggtcc
      121 cggggcgggc tgcgggccgg cggacgatgc ggcggcgctg ccggagcggc ggcggcgggc
      181 ggcggaggcg gaggtgacgc gccgcggcgg gccgacggcc atgcagcgct cgcggacggc
      241 cgcggacgac gcggctctgc tcctggccgg gctgggcctg cgcgagtcgg agccgaccgc
      301 cggctcccca gggcgcgtgc ggcgcgggcc gagggccgtg gacgaggcgg cgccagcgtc
      361 gggccgccga ggcaagggtg gctgcggcgg ccccgaggcc gcgcccgacg tcccgagccg
      421 ccccgagcga ggcccgcgcg ccagcctcgc gggctcggac ggcggcagcg cgcgctcgag
      481 cggtatcagc ctgggctatg accagcgcca cggccccggc cccgggccgc cgtcgggggg
      541 cagcgcgcgc tccagcgtgt ccagcctggg ttcccgtggc tcagcgggcg cctgtgcaga
      601 cctgctgccg cccggcgtcg gcccggcgcc cgcccgctct ccggagcctg cccagttccc
      661 cttcccgttg ccgtcgctgc cgctgccccc gggccgggag ggcggcccga gtgcggccga
      721 gcggcggctg gaggcgctca cgcgggaact ggagcgcgcg ctcgaggcgc gcacggcgcg
      781 agactacttt ggcatttgta tcaagtgtgg ccttggcatc tacggagcga ggcaggcgtg
      841 ccaggcgatg gggagcctgt atcacaccga ctgcttcatc tgtgactcct gtgggagacg
      901 gctccgtggg aaggccttct ataacgtggg tgagaaagtg tactgccagg aggacttcct
      961 gtactccggg ttccagcaaa cagctgacaa gtgtagcgtg tgtggacacc tcatcatgga
     1021 gatgattctg caggcccttg gcaagtccta ccacccaggc tgcttccgct gctcagtgtg
     1081 caacgagtgc ttggatgggg ttcccttcac tgtggatgtg gacaacaaca tttactgcgt
     1141 tagagactat catacggtgt ttgcaccaaa atgtgcctcc tgtgcccgtc ccatcctccc
     1201 tgcacagggc tgtgagacaa ccattcgtgt ggtgtccatg gacagagact accatgtgga
     1261 gtgttaccac tgtgaggact gtgggctgca gctgagtggg gaggagggac gccgctgcta
     1321 tcccctggag gggcacctgc tctgccggcg atgccacctg aggcgccttg ggcagggccc
     1381 gctcccctcg cctgctgtgc atgtgactga gctctgagaa gcagcggtca cagagaggag
     1441 aggagtggcc cacgctcctc cccacccgca ggggccggac ccccgcaaca aagaagcgat
     1501 ttctatttat tcaccttctg tgcctcaagt cacttcccct gctggattcc aggacactcg
     1561 cacagtagac taccttcctc cgaccggtct cagctcccat ggcagggatt ggagggtctt
     1621 ggagctggtg ggggacaggt gccttatttg tgtgcgacca cagagccagg gagtatcaac
     1681 atcctgggaa ataccacgat ttggccttga tgggtatttt cagctgcagt tctcctcctc
     1741 tctggatcct ggcttggggt gcttttccag catccacagt ctcagaagac ccaggagcag
     1801 aggggggtgg ggctcatgag ggggctccct tacagaccct gccagcgaac atctgtgcac
     1861 actatatcag gctccactac caaagcgtat gatttgactt aaattaagtt ttttcccttc
     1921 tggaggatgt ttgcattttc tttaaaagaa tatagttttc ttctaaaaac ttgga
//
