LOCUS       NP_997095                398 aa            linear   ROD 14-FEB-2025
DEFINITION  Wilms tumor protein 1-interacting protein [Mus musculus].
ACCESSION   NP_997095 XP_149921
VERSION     NP_997095.1
DBSOURCE    REFSEQ: accession NM_207212.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 398)
  AUTHORS   Xie,X., Sun,L., Duan,Y., Lv,Z., Yao,X., Wang,C., Chen,X., Tian,S.,
            Yan,L., Shao,Y., Luo,H. and Liu,J.
  TITLE     SRSF2 in Sertoli cells is essential for testicular development and
            spermatogenesis in mice
  JOURNAL   FASEB J 37 (5), e22918 (2023)
   PUBMED   37039821
REFERENCE   2  (residues 1 to 398)
  AUTHORS   Madhavan,S.M., Konieczkowski,M., Bruggeman,L.A., DeWalt,M.,
            Nguyen,J.K., O'Toole,J.F. and Sedor,J.R.
  TITLE     Essential role of Wtip in mouse development and maintenance of the
            glomerular filtration barrier
  JOURNAL   Am J Physiol Renal Physiol 323 (3), F272-F287 (2022)
   PUBMED   35862649
REFERENCE   3  (residues 1 to 398)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (residues 1 to 398)
  AUTHORS   West,D.B., Engelhard,E.K., Adkisson,M., Nava,A.J., Kirov,J.V.,
            Cipollone,A., Willis,B., Rapp,J., de Jong,P.J. and Lloyd,K.C.
  TITLE     Transcriptome Analysis of Targeted Mouse Mutations Reveals the
            Topography of Local Changes in Gene Expression
  JOURNAL   PLoS Genet 12 (2), e1005691 (2016)
   PUBMED   26839965
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 398)
  AUTHORS   Moon,S., Um,S.J. and Kim,E.J.
  TITLE     Role of Asxl1 in kidney podocyte development via its interaction
            with Wtip
  JOURNAL   Biochem Biophys Res Commun 466 (3), 560-566 (2015)
   PUBMED   26385183
  REMARK    GeneRIF: implicate Asxl1 in the maintenance of podocyte structure
            via its association with Wtip and in the regulation of WT1
            signaling during early kidney development
REFERENCE   6  (residues 1 to 398)
  AUTHORS   Langer,E.M., Feng,Y., Zhaoyuan,H., Rauscher,F.J. 3rd, Kroll,K.L.
            and Longmore,G.D.
  TITLE     Ajuba LIM proteins are snail/slug corepressors required for neural
            crest development in Xenopus
  JOURNAL   Dev Cell 14 (3), 424-436 (2008)
   PUBMED   18331720
REFERENCE   7  (residues 1 to 398)
  AUTHORS   Ayyanathan,K., Peng,H., Hou,Z., Fredericks,W.J., Goyal,R.K.,
            Langer,E.M., Longmore,G.D. and Rauscher,F.J. 3rd.
  TITLE     The Ajuba LIM domain protein is a corepressor for SNAG domain
            mediated repression and participates in nucleocytoplasmic Shuttling
  JOURNAL   Cancer Res 67 (19), 9097-9106 (2007)
   PUBMED   17909014
REFERENCE   8  (residues 1 to 398)
  AUTHORS   Weber,M.J.
  TITLE     Mammalian small nucleolar RNAs are mobile genetic elements
  JOURNAL   PLoS Genet 2 (12), e205 (2006)
   PUBMED   17154719
  REMARK    Erratum:[PLoS Genet. 2007 Feb;3(2):e36]
REFERENCE   9  (residues 1 to 398)
  AUTHORS   Srichai,M.B., Konieczkowski,M., Padiyar,A., Konieczkowski,D.J.,
            Mukherjee,A., Hayden,P.S., Kamat,S., El-Meanawy,M.A., Khan,S.,
            Mundel,P., Lee,S.B., Bruggeman,L.A., Schelling,J.R. and Sedor,J.R.
  TITLE     A WT1 co-regulator controls podocyte phenotype by shuttling between
            adhesion structures and nucleus
  JOURNAL   J Biol Chem 279 (14), 14398-14408 (2004)
   PUBMED   14736876
  REMARK    GeneRIF: WTIP monitors slit diaphragm protein assembly as part of a
            multiple protein complex, linking this specialized adhesion
            junction to the actin cytoskeleton, and shuttles into the nucleus
            after podocyte injury
REFERENCE   10 (residues 1 to 398)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX539331.7.
            
            On Aug 30, 2004 this sequence version replaced XP_149921.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054125.1, CB183969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.4 cM"
     Protein         1..398
                     /product="Wilms tumor protein 1-interacting protein"
                     /calculated_mol_wt=42123
     Region          16..166
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQJ8.1)"
     Region          <23..>186
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          193..246
                     /region_name="LIM1_Ajuba_like"
                     /note="The first LIM domain of Ajuba-like proteins;
                     cd09352"
                     /db_xref="CDD:188738"
     Site            order(193,196,215,218,221,224,242,245)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188738"
     Region          258..310
                     /region_name="LIM2_Ajuba_like"
                     /note="The second LIM domain of Ajuba-like proteins;
                     cd09355"
                     /db_xref="CDD:188741"
     Site            order(258,261,278,281,284,287,306,309)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188741"
     Region          318..379
                     /region_name="LIM3_Ajuba_like"
                     /note="The third LIM domain of Ajuba-like proteins;
                     cd09438"
                     /db_xref="CDD:188822"
     Site            order(318,321,345,348,351,354,375,378)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188822"
     CDS             1..398
                     /gene="Wtip"
                     /coded_by="NM_207212.3:221..1417"
                     /db_xref="CCDS:CCDS21135.1"
                     /db_xref="GeneID:101543"
                     /db_xref="MGI:MGI:2141920"
ORIGIN      
        1 mqrsrtaadd aalllaglgl reseptagsp grvrrgprav deaapasgrr gkggcggpea
       61 apdvpsrper gpraslagsd ggsarssgis lgydqrhgpg pgppsggsar ssvsslgsrg
      121 sagacadllp pgvgpapars pepaqfpfpl pslplppgre ggpsaaerrl ealtrelera
      181 leartardyf gicikcglgi ygarqacqam gslyhtdcfi cdscgrrlrg kafynvgekv
      241 ycqedflysg fqqtadkcsv cghlimemil qalgksyhpg cfrcsvcnec ldgvpftvdv
      301 dnniycvrdy htvfapkcas carpilpaqg cettirvvsm drdyhvecyh cedcglqlsg
      361 eegrrcyple ghllcrrchl rrlgqgplps pavhvtel
//
