LOCUS       NM_001113533            2051 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus WT1 associating protein (Wtap), transcript variant 1,
            mRNA.
ACCESSION   NM_001113533
VERSION     NM_001113533.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2051)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2051)
  AUTHORS   Li,Y., Yang,Y., Niu,Y., Li,Y., Hu,Z., Sun,S., Chen,Y., Hu,B.,
            Huang,Y. and Deng,X.
  TITLE     The role of WTAP in regulating macrophage-mediated osteoimmune
            responses and tissue regeneration in periodontitis
  JOURNAL   Front Immunol 15, 1423378 (2024)
   PUBMED   39081311
  REMARK    GeneRIF: The role of WTAP in regulating macrophage-mediated
            osteoimmune responses and tissue regeneration in periodontitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2051)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2051)
  AUTHORS   Shi,L., Li,X., Zhang,M., Qin,C., Zhang,Z. and Chen,Z.
  TITLE     Downregulation of Wtap causes dilated cardiomyopathy and heart
            failure
  JOURNAL   J Mol Cell Cardiol 188, 38-51 (2024)
   PUBMED   38224851
REFERENCE   5  (bases 1 to 2051)
  AUTHORS   Li,X., Liu,C., Zhang,Z., Li,X., Yao,Z., Dong,Y., Wang,X. and
            Chen,Z.
  TITLE     Hepatocyte-specific Wtap deficiency promotes hepatocellular
            carcinoma by activating GRB2-ERK depending on downregulation of
            proteasome-related genes
  JOURNAL   J Biol Chem 299 (11), 105301 (2023)
   PUBMED   37777158
  REMARK    GeneRIF: Hepatocyte-specific Wtap deficiency promotes
            hepatocellular carcinoma by activating GRB2-ERK depending on
            downregulation of proteasome-related genes.
REFERENCE   6  (bases 1 to 2051)
  AUTHORS   Niksic,M., Slight,J., Sanford,J.R., Caceres,J.F. and Hastie,N.D.
  TITLE     The Wilms' tumour protein (WT1) shuttles between nucleus and
            cytoplasm and is present in functional polysomes
  JOURNAL   Hum Mol Genet 13 (4), 463-471 (2004)
   PUBMED   14681305
REFERENCE   7  (bases 1 to 2051)
  AUTHORS   Tomsig,J.L., Snyder,S.L. and Creutz,C.E.
  TITLE     Identification of targets for calcium signaling through the copine
            family of proteins. Characterization of a coiled-coil
            copine-binding motif
  JOURNAL   J Biol Chem 278 (12), 10048-10054 (2003)
   PUBMED   12522145
REFERENCE   8  (bases 1 to 2051)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2051)
  AUTHORS   Little,N.A., Hastie,N.D. and Davies,R.C.
  TITLE     Identification of WTAP, a novel Wilms' tumour 1-associating protein
  JOURNAL   Hum Mol Genet 9 (15), 2231-2239 (2000)
   PUBMED   11001926
REFERENCE   10 (bases 1 to 2051)
  AUTHORS   Sakano,H., Kurosawa,Y., Weigert,M. and Tonegawa,S.
  TITLE     Identification and nucleotide sequence of a diversity DNA segment
            (D) of immunoglobulin heavy-chain genes
  JOURNAL   Nature 290 (5807), 562-565 (1981)
   PUBMED   6783961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589878.12.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156334.1, SRR13422598.1364199.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               AL589878.12        44387-44569
            184-221             AL589878.12        50693-50730
            222-277             AL589878.12        53134-53189
            278-336             AL589878.12        54838-54896
            337-464             AL589878.12        55697-55824
            465-643             AL589878.12        61172-61350
            644-798             AL589878.12        67087-67241
            799-2051            AL589878.12        68595-69847
FEATURES             Location/Qualifiers
     source          1..2051
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.73 cM"
     gene            1..2051
                     /gene="Wtap"
                     /gene_synonym="2810408K05Rik; 9430038B09Rik"
                     /note="WT1 associating protein"
                     /db_xref="GeneID:60532"
                     /db_xref="MGI:MGI:1926395"
     exon            1..183
                     /gene="Wtap"
                     /gene_synonym="2810408K05Rik; 9430038B09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            184..221
                     /gene="Wtap"
                     /gene_synonym="2810408K05Rik; 9430038B09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1382
                     /gene="Wtap"
                     /gene_synonym="2810408K05Rik; 9430038B09Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     pre-mRNA-splicing regulator WTAP; WT1-associated protein;
                     female-lethal(2)D homolog; wilms tumor 1-associating
                     protein; Wilms' tumour 1-associating protein; Wilms tumour
                     1-associating protein"
                     /codon_start=1
                     /product="pre-mRNA-splicing regulator WTAP isoform a"
                     /protein_id="NP_001107005.1"
                     /db_xref="CCDS:CCDS49950.1"
                     /db_xref="GeneID:60532"
                     /db_xref="MGI:MGI:1926395"
                     /translation="MTNEEPLPKKVRLSETDFKVMARDELILRWKQYEAYVQALEGKY
                     TDLNSNDVTGLRESEEKLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQQ
                     PSVAQLRSTMVDPAINLFFLKMKGELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAK
                     CRMLIQENQELGRQLSQGRIAQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGM
                     QSTILVLQQQLKETRQQLAQYQQQQSQASAPSTSRTTSSEPVDQAEVTSKDCSRLANG
                     PSNGSSSRQRTSGSGFHREGSTPEDDFPSSSGNGNKASNSSEERTGRGGSSYINPLSA
                     GYESVDSPTGSENSLTHHSNDTDSSHDPQEEKAVSGKGNRTVGSRHVQNGLDSNVNVQ
                     GAVL"
     exon            222..277
                     /gene="Wtap"
                     /gene_synonym="2810408K05Rik; 9430038B09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            278..336
                     /gene="Wtap"
                     /gene_synonym="2810408K05Rik; 9430038B09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            337..464
                     /gene="Wtap"
                     /gene_synonym="2810408K05Rik; 9430038B09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            465..643
                     /gene="Wtap"
                     /gene_synonym="2810408K05Rik; 9430038B09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            644..798
                     /gene="Wtap"
                     /gene_synonym="2810408K05Rik; 9430038B09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            799..2051
                     /gene="Wtap"
                     /gene_synonym="2810408K05Rik; 9430038B09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2032..2037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wtap"
                     /gene_synonym="2810408K05Rik; 9430038B09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2051
                     /gene="Wtap"
                     /gene_synonym="2810408K05Rik; 9430038B09Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtccgggcg gggcggggcc ggcggcaggg ccggctttcc tccctcagcg ccattttgtg
       61 gctgcgagac ccgcaaataa aggttctcgc cagcgctgcg gcgggaggag cgcggggggg
      121 ccggcggcgg cgcggcctcg gcctgtgtga ctggcggcgc ccgcgcagcc tcgggctggg
      181 aagggtgcaa gatgaccaac gaagaacctc ttcctaaaaa ggtccgactg agtgaaacag
      241 acttcaaagt tatggcacgg gatgagttaa ttctaagatg gaaacaatat gaagcatatg
      301 ttcaagcttt ggagggaaag tacacagatc ttaattcaaa cgatgtgact ggtttaaggg
      361 aatctgaaga aaaactaaag cagcaacagc aggagtctgc acgcagggag aacattcttg
      421 tcatgcggct agcaaccaaa gagcaggaga tgcaagagtg caccactcaa atccagtacc
      481 tcaagcaagt tcagcagccg agtgtggccc aactgagatc aacaatggta gacccagcaa
      541 tcaacttgtt tttcctaaaa atgaaaggtg aactggaaca gactaaagac aaactggaac
      601 aagcccaaaa tgaactgagt gcctggaagt ttacgcctga tagccaaaca ggcaaaaagc
      661 taatggcgaa gtgtcgaatg cttatccagg agaaccaaga gcttggaagg cagctgtccc
      721 agggccgtat tgcacagctt gaagcagaat tggctttaca gaagaaatat agtgaggagc
      781 ttaaaagcag tcaggatgaa ctgaatgact tcatcattca acttgatgaa gaagtagagg
      841 gtatgcagag caccattcta gttcttcagc aacaattgaa ggagacacga cagcagttgg
      901 cacagtacca gcagcagcag tctcaagctt cagctccaag taccagcagg actacatctt
      961 ctgaacctgt agatcaggca gaggtcacaa gcaaagactg cagtcgtctg gcaaatggac
     1021 caagtaatgg cagctcctcc cgccagagga cgtctgggtc tggatttcac agggagggga
     1081 gcacacctga ggatgacttt ccttcttctt cagggaatgg taataaggcc tccaacagct
     1141 cagaggagag aactggcaga ggaggtagta gttacataaa cccactcagt gcggggtatg
     1201 aaagtgtaga ctctcccacg ggcagtgaaa actctctcac acatcactca aatgacacag
     1261 actccagtca tgaccctcaa gaggagaaag cagtgagtgg gaaaggtaat cgaactgtgg
     1321 gttcccgcca tgttcagaat ggcttggact caaatgtaaa tgtacagggt gcagttttgt
     1381 aatatttttc cagaaaattt ttatacagtg tcatttaatt ggggaaagga tactgtcaaa
     1441 aaattaatgc atacttttgt cacaatttac ctttttgtgg gtgtgttttt gttttgtttg
     1501 gttccttttt tttttttttt tttttttttt tttttttttt tttaattgct tcaatacctc
     1561 tgccactttg aaaattgtaa cagttaatta ctttgaacat tgctaaaagg acattttgtg
     1621 tagggtcaag ttatttttat atgagttaat gtgaagttgt aaatgggaat ctatagcaat
     1681 gatgtctgta taaatctgtc ttatctagaa cttgtgctgt cagggcactc ttcctcacgc
     1741 tgttgttact catgcaccat tcagacttgt tagagtagat gtgggtttag gactgccagg
     1801 tttgcccagt atagtagttt ttatcactaa aaagttggac ttggagtcct atagtagttt
     1861 cagcgttaga taaagttttt ccaccataca tctttaggtg cattcatctt taggtgactg
     1921 aatgttaaga aatctgtgtg catagttact aagtttttat gaactgttgt gtcctgttaa
     1981 tgcatattgc cctgtgactc cagtatatct cacctgtact gaccaaacct aaataaacat
     2041 ttttattacg a
//
