LOCUS       NM_021539               2408 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus WD repeat and SOCS box-containing 2 (Wsb2), mRNA.
ACCESSION   NM_021539
VERSION     NM_021539.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2408)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2408)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2408)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 2408)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2408)
  AUTHORS   Sarraj,M.A., McClive,P.J., Szczepny,A., Daggag,H., Loveland,K.L.
            and Sinclair,A.H.
  TITLE     Expression of Wsb2 in the developing and adult mouse testis
  JOURNAL   Reproduction 133 (4), 753-761 (2007)
   PUBMED   17504919
REFERENCE   6  (bases 1 to 2408)
  AUTHORS   Erkeland,S.J., Aarts,L.H., Irandoust,M., Roovers,O., Klomp,A.,
            Valkhof,M., Gits,J., Eyckerman,S., Tavernier,J. and Touw,I.P.
  TITLE     Novel role of WD40 and SOCS box protein-2 in steady-state
            distribution of granulocyte colony-stimulating factor receptor and
            G-CSF-controlled proliferation and differentiation signaling
  JOURNAL   Oncogene 26 (14), 1985-1994 (2007)
   PUBMED   17001306
  REMARK    GeneRIF: Wsb-2 binding to the G-CSF-R reduced its cell surface
            expression and inhibited proliferation signaling.
REFERENCE   7  (bases 1 to 2408)
  AUTHORS   Vasiliauskas,D., Hancock,S. and Stern,C.D.
  TITLE     SWiP-1: novel SOCS box containing WD-protein regulated by
            signalling centres and by Shh during development
  JOURNAL   Mech Dev 82 (1-2), 79-94 (1999)
   PUBMED   10354473
REFERENCE   8  (bases 1 to 2408)
  AUTHORS   Hilton,D.J., Richardson,R.T., Alexander,W.S., Viney,E.M.,
            Willson,T.A., Sprigg,N.S., Starr,R., Nicholson,S.E., Metcalf,D. and
            Nicola,N.A.
  TITLE     Twenty proteins containing a C-terminal SOCS box form five
            structural classes
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 114-119 (1998)
   PUBMED   9419338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110234.11 and AC113299.14.
            
            On Aug 22, 2018 this sequence version replaced NM_021539.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055100.1, AF072881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC110234.11        16841-17009         c
            170-338             AC110234.11        10555-10723         c
            339-583             AC110234.11        3379-3623           c
            584-715             AC110234.11        3094-3225           c
            716-816             AC110234.11        101-201             c
            817-989             AC113299.14        36098-36270
            990-1100            AC113299.14        36826-36936
            1101-1208           AC113299.14        37020-37127
            1209-2408           AC113299.14        37719-38918
FEATURES             Location/Qualifiers
     source          1..2408
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.88 cM"
     gene            1..2408
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /note="WD repeat and SOCS box-containing 2"
                     /db_xref="GeneID:59043"
                     /db_xref="MGI:MGI:2144041"
     exon            1..169
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1371
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /note="WD-40-repeat-containing protein with a SOCS box 2;
                     SOCS box-containing WD protein SWiP-2"
                     /codon_start=1
                     /product="WD repeat and SOCS box-containing protein 2"
                     /protein_id="NP_067514.2"
                     /db_xref="CCDS:CCDS19604.1"
                     /db_xref="GeneID:59043"
                     /db_xref="MGI:MGI:2144041"
                     /translation="MEAGEEPLLLAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWS
                     QGHCVVKLVPWPLEEQFIPKGFEAKSRSSKNDPKGRGSLKEKTLDCGQIVWGLAFSPW
                     PSPPSRKLWARHHPQAPDVSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLS
                     FTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGE
                     KSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRS
                     LHHTQLEPTMDDSDVHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMT
                     NGLCCTFFPHGGIIATGTRDGHVQFWTAPRVLSSLKHLCRKALRSFLTTYQVLALPIP
                     KKMKEFLTYRTF"
     exon            170..338
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            339..583
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..715
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..816
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            817..989
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1100
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1208
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..2408
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1607..1612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /note="hexamer: AATAAA"
     polyA_site      1629
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /note="major polyA site"
     polyA_site      1919
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /note="major polyA site"
     regulatory      2237..2242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /note="hexamer: AATATA"
     polyA_site      2264
                     /gene="Wsb2"
                     /gene_synonym="Swip2; WSB-2"
                     /note="major polyA site"
ORIGIN      
        1 gggaagcagc tgatggcctc tgcgggcggc agcggcggcg gcattggcgg cggtggtggc
       61 ggcggcgggc gcggccgcgg cggggcgggc gcggaatgaa ggcccacggc cctgggggct
      121 gaggcgcccg ccgcctgggg cgggccgcgc gtcctcatgg aggccggaga ggagccgctg
      181 ctgctggctg aactcaagcc tgggcgcccc caccagttcg actggaagtc aagctgtgag
      241 acctggagcg tggccttctc gccagacggt tcctggttcg cctggtctca aggacactgc
      301 gtggtcaagc tggtcccctg gcccttagag gaacagttca tccctaaagg attcgaagcc
      361 aagagccgaa gcagcaagaa tgacccaaaa ggacggggca gtctgaagga gaagacgctg
      421 gactgtggcc agattgtgtg ggggctggcc ttcagcccat ggccctctcc acccagcagg
      481 aaactctggg cacgtcacca tccccaggcg cctgatgttt cttgcctgat cctggccaca
      541 ggtctcaacg atgggcagat caagatttgg gaggtacaga caggcctcct gcttctgaat
      601 ctttctggcc accaagacgt cgtgagagat ctgagcttca cgcccagcgg cagtttgatt
      661 ttggtctctg catcccggga taagacactt cgaatttggg acctgaataa gcacggtaag
      721 cagatccagg tgttatccgg ccatctgcag tgggtttact gctgctccat ctcccctgac
      781 tgtagcatgc tgtgctctgc agctggggag aagtcggtct ttctgtggag catgcggtcc
      841 tacacactaa tccggaaact agaaggccac caaagcagtg ttgtctcctg tgatttctct
      901 cctgattcag ccttgcttgt cacagcttcg tatgacacca gtgtgattat gtgggacccc
      961 tacaccggcg agaggctgag gtcacttcat cacacacagc ttgaacccac catggatgac
     1021 agtgacgtcc acatgagctc cctgaggtcc gtgtgcttct cacctgaagg cttgtatctc
     1081 gctacggtgg cagatgacag gctgctcagg atctgggctc tggaactgaa ggctccggtt
     1141 gcctttgctc cgatgaccaa tggtctttgc tgcacgttct tcccacacgg tggaattatt
     1201 gccacaggga cgagagatgg ccatgtccag ttctggacag ctccccgggt cctgtcctca
     1261 ctgaagcact tatgcaggaa agccctccga agtttcctga caacgtatca agtcctagca
     1321 ctgccaatcc ccaagaagat gaaagagttc ctcacataca ggactttcta gcagtgccgg
     1381 ctcccccacc tcctgcagca gcagcagtac aagggactgg ctaggatgga gtcaggcagc
     1441 tcacactgga ccagtgtgga ccttccttcc tcccatggca tgtgcaagta ggtctgcgtg
     1501 accccacttc tgtggtgccg gccttacctc gtcttcatcc gtggtgagca gccttcgtca
     1561 gtctagttgt gttgaagcca agtgcagttg tggatgttgc tggggtaata aaggcaagcg
     1621 ggctccagag cctctctggt ggcggccaag ccacactccc ttaactggga agtacctgcc
     1681 acgtagggca tttctgctgc ctatttccag ccagcggctg catggtttga agttcctccg
     1741 ttgtggtcag aggaactctg gtgtttggtt ccctgctcag ctgcgcgtgg actgggctga
     1801 gctcctcacc atacactagt gccggctttt gtttcctgta aacagtggtt gcatgtgtag
     1861 gaagtaacaa gcgagtattc agatcatacg aggaggcgtt cctcggtgca tgacggtcag
     1921 atggccattt atcagcatat ttatttgtat tttctcagca gatagtaagg tacaactgtg
     1981 ttttctcaat tgtctcgaag aaccagagtt cttaagtggc ccagttgtgg agccaagtct
     2041 aagtcgtgtg gagtcagtgc tgacatcact ggcttgtgct gtctgtcaca tgtgtttgtc
     2101 tctgctgctt gacctcatgg gatgtaccct ccagttcaac tgcccaaaac agacagcccc
     2161 ttccaagcac cgttctttga cagcggtagc agctacctat tcaagacgcc tcacacaaaa
     2221 tctgccttag aaagttaata tattttaaat tattttaaaa gaaactcaac atcttattct
     2281 ttggcctttc ttaattgatg ctttatggag gcagtgttaa cattgtacag tgtatgcata
     2341 gaggagtctc ctctatttga agaacaatgc aaaatgaggc tttcattgaa gggagaaaag
     2401 agaaaaaa
//
