LOCUS       NM_019653               2490 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus WD repeat and SOCS box-containing 1 (Wsb1), transcript
            variant 1, mRNA.
ACCESSION   NM_019653
VERSION     NM_019653.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2490)
  AUTHORS   Chong,L., Zou,L., Xiang,L., Song,X., Miao,W., Yan,X., Xu,M.,
            Ling,G., El Agha,E., Bellusci,S., Lou,Z., Zhang,H. and Zhang,J.S.
  TITLE     WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast
            Accumulation and Attenuates Alveolar Epithelial Regeneration in
            Mouse Lung Fibrosis
  JOURNAL   Am J Pathol 194 (5), 656-672 (2024)
   PUBMED   38325552
  REMARK    GeneRIF: WSB1, a Hypoxia-Inducible E3 Ligase, Promotes
            Myofibroblast Accumulation and Attenuates Alveolar Epithelial
            Regeneration in Mouse Lung Fibrosis.
REFERENCE   2  (bases 1 to 2490)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2490)
  AUTHORS   Kim,J.J., Lee,S.B., Yi,S.Y., Han,S.A., Kim,S.H., Lee,J.M.,
            Tong,S.Y., Yin,P., Gao,B., Zhang,J. and Lou,Z.
  TITLE     WSB1 overcomes oncogene-induced senescence by targeting ATM for
            degradation
  JOURNAL   Cell Res 27 (2), 274-293 (2017)
   PUBMED   27958289
  REMARK    GeneRIF: WSB1 is one of the key players of early oncogenic events
            through ATM degradation and destruction of the tumorigenesis
            barrier.
REFERENCE   4  (bases 1 to 2490)
  AUTHORS   Nucifora,F.C. Jr., Nucifora,L.G., Ng,C.H., Arbez,N., Guo,Y.,
            Roby,E., Shani,V., Engelender,S., Wei,D., Wang,X.F., Li,T.,
            Moore,D.J., Pletnikova,O., Troncoso,J.C., Sawa,A., Dawson,T.M.,
            Smith,W., Lim,K.L. and Ross,C.A.
  TITLE     Ubiqutination via K27 and K29 chains signals aggregation and
            neuronal protection of LRRK2 by WSB1
  JOURNAL   Nat Commun 7, 11792 (2016)
   PUBMED   27273569
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2490)
  AUTHORS   Werneck de Castro,J.P., Fonseca,T.L., Ueta,C.B., McAninch,E.A.,
            Abdalla,S., Wittmann,G., Lechan,R.M., Gereben,B. and Bianco,A.C.
  TITLE     Differences in hypothalamic type 2 deiodinase ubiquitination
            explain localized sensitivity to thyroxine
  JOURNAL   J Clin Invest 125 (2), 769-781 (2015)
   PUBMED   25555216
REFERENCE   6  (bases 1 to 2490)
  AUTHORS   Choi,D.W., Seo,Y.M., Kim,E.A., Sung,K.S., Ahn,J.W., Park,S.J.,
            Lee,S.R. and Choi,C.Y.
  TITLE     Ubiquitination and degradation of homeodomain-interacting protein
            kinase 2 by WD40 repeat/SOCS box protein WSB-1
  JOURNAL   J Biol Chem 283 (8), 4682-4689 (2008)
   PUBMED   18093972
REFERENCE   7  (bases 1 to 2490)
  AUTHORS   Dentice,M., Bandyopadhyay,A., Gereben,B., Callebaut,I.,
            Christoffolete,M.A., Kim,B.W., Nissim,S., Mornon,J.P.,
            Zavacki,A.M., Zeold,A., Capelo,L.P., Curcio-Morelli,C., Ribeiro,R.,
            Harney,J.W., Tabin,C.J. and Bianco,A.C.
  TITLE     The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates
            thyroid hormone activation and PTHrP secretion in the developing
            growth plate
  JOURNAL   Nat Cell Biol 7 (7), 698-705 (2005)
   PUBMED   15965468
  REMARK    GeneRIF: WSB-1 is part of an E3 ubiquitin ligase for the
            thyroid-hormone-activating type 2 iodothyronine deiodinase (D2).
REFERENCE   8  (bases 1 to 2490)
  AUTHORS   Kamura,T., Maenaka,K., Kotoshiba,S., Matsumoto,M., Kohda,D.,
            Conaway,R.C., Conaway,J.W. and Nakayama,K.I.
  TITLE     VHL-box and SOCS-box domains determine binding specificity for
            Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases
  JOURNAL   Genes Dev 18 (24), 3055-3065 (2004)
   PUBMED   15601820
REFERENCE   9  (bases 1 to 2490)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2490)
  AUTHORS   Hilton,D.J., Richardson,R.T., Alexander,W.S., Viney,E.M.,
            Willson,T.A., Sprigg,N.S., Starr,R., Nicholson,S.E., Metcalf,D. and
            Nicola,N.A.
  TITLE     Twenty proteins containing a C-terminal SOCS box form five
            structural classes
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 114-119 (1998)
   PUBMED   9419338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY097910.1, AK167394.1 and BB431254.1.
            
            On Dec 22, 2005 this sequence version replaced NM_019653.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145974.1, AK167394.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY097910.1         2-24
            24-2485             AK167394.1         2-2463
            2486-2490           BB431254.1         281-285
FEATURES             Location/Qualifiers
     source          1..2490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..2490
                     /gene="Wsb1"
                     /gene_synonym="1110056B13Rik; 2700038M07Rik"
                     /note="WD repeat and SOCS box-containing 1"
                     /db_xref="GeneID:78889"
                     /db_xref="MGI:MGI:1926139"
     exon            1..343
                     /gene="Wsb1"
                     /gene_synonym="1110056B13Rik; 2700038M07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..1569
                     /gene="Wsb1"
                     /gene_synonym="1110056B13Rik; 2700038M07Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     WD-40-repeat-containing protein with a SOCS box 1; WD
                     repeat and SOCS box-containing protein 1; WSB-1"
                     /codon_start=1
                     /product="WD repeat and SOCS box-containing protein 1
                     isoform 1"
                     /protein_id="NP_062627.3"
                     /db_xref="CCDS:CCDS25118.1"
                     /db_xref="GeneID:78889"
                     /db_xref="MGI:MGI:1926139"
                     /translation="MASFPPRVNEKEIVRSRTIGELLAPAAPFDKKCGGENWTVAFAP
                     DGSYFAWSQGYRIVKLVPWSQCRKNFLLHGSKNVTNSSCLKLARQNSNGGQKNKPPEH
                     VIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTG
                     KLLLNLVDHIEMVRDLTFAPDGSLLLVSASRDKTLRVWDLKDDGNMVKVLRAHQNWVY
                     SCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASY
                     DTRVYVWDPHNGDLLMEFGHLFPSPTPIFAGGANDRWVRAVSFSHDGLHVASLADDKM
                     VRFWRIDEDCPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHICR
                     MSIRRVMSTQEVQKLPVPSKILAFLSYRG"
     exon            344..512
                     /gene="Wsb1"
                     /gene_synonym="1110056B13Rik; 2700038M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            513..781
                     /gene="Wsb1"
                     /gene_synonym="1110056B13Rik; 2700038M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            782..913
                     /gene="Wsb1"
                     /gene_synonym="1110056B13Rik; 2700038M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1014
                     /gene="Wsb1"
                     /gene_synonym="1110056B13Rik; 2700038M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1187
                     /gene="Wsb1"
                     /gene_synonym="1110056B13Rik; 2700038M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1301
                     /gene="Wsb1"
                     /gene_synonym="1110056B13Rik; 2700038M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1409
                     /gene="Wsb1"
                     /gene_synonym="1110056B13Rik; 2700038M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..2490
                     /gene="Wsb1"
                     /gene_synonym="1110056B13Rik; 2700038M07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2468..2473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wsb1"
                     /gene_synonym="1110056B13Rik; 2700038M07Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2486
                     /gene="Wsb1"
                     /gene_synonym="1110056B13Rik; 2700038M07Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtgccgccc gccatcttgt ctcagtgtct ggtttggcgg cggaagcatt ggcgggctgt
       61 gtgagtctgt gagtggaagg cgcgccggct cttttgtctg agtgtgaccc ggtggctttg
      121 ttccaggcat tccggtgatt tcctccgggc agtccgcaga agccgcagcg gccgcccgcg
      181 ctctctctgc agtctccaca cccgggagag cctgagcccg cgtcacgccc ctcagccccc
      241 gctgagtccc ttctctgttg tcgcgtccga atcgagttcc cggaatcaga cggtgcccca
      301 tagatggcca gctttccccc gagggttaac gagaaagaga tcgtgagatc acgtactata
      361 ggggaactct tggctccagc agctcctttt gacaagaaat gtggtggtga gaactggacg
      421 gttgcttttg ctcctgatgg ttcctacttt gcgtggtcac aaggatatcg catagtgaag
      481 cttgtcccgt ggtcccagtg ccgtaagaac tttcttttgc atggttccaa aaatgttacc
      541 aattcaagct gtctaaaatt ggcaagacaa aacagtaatg gtggtcagaa aaacaagcct
      601 cctgagcacg ttatagactg tggagacata gtctggagtc ttgcttttgg gtcttcagtt
      661 ccagaaaaac agagtcgttg cgttaatata gaatggcatc ggttccgatt tggacaggat
      721 cagctactcc ttgccacagg attaaacaat ggtcgcatca aaatctggga tgtatataca
      781 ggaaaactcc tccttaattt ggtagaccac attgaaatgg ttagagattt aacttttgct
      841 ccagatggga gcttactcct tgtatcagct tcaagagaca aaactctaag agtgtgggac
      901 ctgaaagatg atggaaacat ggtgaaagta ttgcgggcac atcagaattg ggtgtacagt
      961 tgtgcattct ctcccgactg ttctatgctg tgttcagttg gcgccagtaa agcagttttc
     1021 ctttggaata tggataaata caccatgatt aggaagctgg aaggtcatca ccatgatgtt
     1081 gtagcttgtg acttttctcc tgatggagca ttgctagcta ctgcatccta tgacactcgt
     1141 gtgtatgtct gggatccaca caatggagac cttctgatgg agtttgggca cctgtttccc
     1201 tcgcccactc caatatttgc tggaggagca aatgaccgat gggtgagagc tgtgtctttc
     1261 agtcatgatg gactgcatgt tgccagcctt gctgatgata aaatggtgag gttctggaga
     1321 atcgatgagg attgtccggt acaagttgca cctttgagca atggtctttg ctgtgccttt
     1381 tctactgatg gcagtgtttt agctgctggg acacatgatg gaagtgtgta tttttgggcc
     1441 actccaaggc aagtccctag ccttcaacat atatgtcgca tgtcaatccg aagagtgatg
     1501 tccacccaag aagtccaaaa actgcctgtt ccttccaaaa tattggcgtt tctctcctac
     1561 cgcggttaga ctgaagactg cctttcctgg taggcctgcc agacagagcg ccctttacaa
     1621 gacacacctc aagctttacc agctcaagcg tctgtccttg gaggctcagc agatttattt
     1681 aattggaatc cactcttatt cttcatttca ttagttggac ttttaaagca ttatttatac
     1741 accatagaaa tatttctgaa catatcatgt aattttttta agataactgt gaaaacatta
     1801 catacatgta tatatttaga catgagctgc tgctatatat tgaatgggcc ctttagtttt
     1861 ctcttagttc tgacctgtat atattgcttt aatagagcca cgatttgtat atgtgctgtt
     1921 cattagagca aattcagggg aatttttgtt cttttttttt ttatttgggg gcactaagtt
     1981 tagatgagat gaattgcctc ataggaaatg gaattggtca ggatagatgg tgtgaaactg
     2041 ataagaggtt ttggatgtga aaaagagttt ccaaaagaat ggtgtctggg agtttgaatg
     2101 tgatgattaa aaaaagagcc aaggaaaaag gtagctagaa aaaaaggttg gctctcatca
     2161 gccttaattt tggaaagcag ctacttaccc ctcagagaat aaagtattat gcattcttgt
     2221 caatttgaaa actacatcta ctgtattatt gctgaatatt ttgttaatac taagggacaa
     2281 ttattttaag accatgggtt ttgtttttaa catattttat ttctgcagag gatattggta
     2341 acttaccaaa gagaagcaat acacagtatg tctgctttag ccttctttta tttatctcat
     2401 ctgcagatgt tgagaatgta tgcattatgt aaaatgcttg tttttttatc cctgttgagt
     2461 ttttttaatt aaacgacaca aaactactac
//
