LOCUS       NM_030215               2642 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Werner helicase interacting protein 1 (Wrnip1), mRNA.
ACCESSION   NM_030215
VERSION     NM_030215.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2642)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2642)
  AUTHORS   Kawabe,Y., Seki,M., Yoshimura,A., Nishino,K., Hayashi,T.,
            Takeuchi,T., Iguchi,S., Kusa,Y., Ohtsuki,M., Tsuyama,T.,
            Imamura,O., Matsumoto,T., Furuichi,Y., Tada,S. and Enomoto,T.
  TITLE     Analyses of the interaction of WRNIP1 with Werner syndrome protein
            (WRN) in vitro and in the cell
  JOURNAL   DNA Repair (Amst) 5 (7), 816-828 (2006)
   PUBMED   16769258
  REMARK    GeneRIF: Mutations in the Walker A motifs of the two proteins
            revealed that WRNIP1, but not WRN, must bind ATP before an
            efficient interaction can occur.
REFERENCE   3  (bases 1 to 2642)
  AUTHORS   Hamatani,T., Falco,G., Carter,M.G., Akutsu,H., Stagg,C.A.,
            Sharov,A.A., Dudekula,D.B., VanBuren,V. and Ko,M.S.
  TITLE     Age-associated alteration of gene expression patterns in mouse
            oocytes
  JOURNAL   Hum Mol Genet 13 (19), 2263-2278 (2004)
   PUBMED   15317747
REFERENCE   4  (bases 1 to 2642)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 2642)
  AUTHORS   Kaiserman,D., Knaggs,S., Scarff,K.L., Gillard,A., Mirza,G.,
            Cadman,M., McKeone,R., Denny,P., Cooley,J., Benarafa,C.,
            Remold-O'Donnell,E., Ragoussis,J. and Bird,P.I.
  TITLE     Comparison of human chromosome 6p25 with mouse chromosome 13
            reveals a greatly expanded ov-serpin gene repertoire in the mouse
  JOURNAL   Genomics 79 (3), 349-362 (2002)
   PUBMED   11863365
REFERENCE   6  (bases 1 to 2642)
  AUTHORS   Kawabe,Yi., Branzei,D., Hayashi,T., Suzuki,H., Masuko,T., Onoda,F.,
            Heo,S.J., Ikeda,H., Shimamoto,A., Furuichi,Y., Seki,M. and
            Enomoto,T.
  TITLE     A novel protein interacts with the Werner's syndrome gene product
            physically and functionally
  JOURNAL   J Biol Chem 276 (23), 20364-20369 (2001)
   PUBMED   11301316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK167570.1, AK041886.1 and AV237237.1.
            
            On Jul 21, 2009 this sequence version replaced NM_030215.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.273095.1, AK167570.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AK167570.1         2-46
            46-2639             AK041886.1         2-2595
            2640-2642           AV237237.1         221-223
FEATURES             Location/Qualifiers
     source          1..2642
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.74 cM"
     gene            1..2642
                     /gene="Wrnip1"
                     /gene_synonym="4833444L21Rik; WHIP; Wrnip"
                     /note="Werner helicase interacting protein 1"
                     /db_xref="GeneID:78903"
                     /db_xref="MGI:MGI:1926153"
     exon            1..1015
                     /gene="Wrnip1"
                     /gene_synonym="4833444L21Rik; WHIP; Wrnip"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2191
                     /gene="Wrnip1"
                     /gene_synonym="4833444L21Rik; WHIP; Wrnip"
                     /EC_number="3.6.1.3"
                     /note="Werner helicasae interacting protein 1; werner
                     helicase-interacting protein 1; Werner syndrome homolog
                     interacting protein"
                     /codon_start=1
                     /product="ATPase WRNIP1"
                     /protein_id="NP_084491.3"
                     /db_xref="CCDS:CCDS26427.1"
                     /db_xref="GeneID:78903"
                     /db_xref="MGI:MGI:1926153"
                     /translation="MEVSGPEDDPFLSQLHQVQCPVCQQMMPAAHINSHLDRCLLLHP
                     AGHAEPAAGSHRAGERAKGPSPPGAKRRRLSESSALKQPATPTAAESSEGEGEEGDDG
                     GETESRESYDAPPTPSGARLIPDFPVARSSSPARKGMGKRPAAAAAAGSASPRSWDEA
                     EAQEEEEAGVDGDGDADVDGEDDPGHWDADAADASFGVSAGRAHPRALAAEEIRQMLE
                     GKPLADKMRPDTLQDYIGQSRAVGQETLLRSLLEANEIPSLILWGPPGCGKTTLAHII
                     ANNSKKHSIRFVTLSATNAKTNDVRDVIKQAQNEKSFFKRKTILFIDEIHRFNKSQQD
                     TFLPHVECGTITLIGATTENPSFQVNAALLSRCRVIVLEKLPVEAMVTILMRAINSLG
                     IHVLDSSRPTDPLSHSSNCSSEPSVFIEDKAVDTLAYLSDGDARTGLNGLQLAVLARL
                     SSRKVFCKKSGQTYSPSRVLITENDVKEGLQRSHILYDRAGEEHYNCISALHKAMRGS
                     DQNASLYWLARMLEGGEDPLYVARRLVRFASEDIGLADPSALAQAVAAYQGCHFIGMP
                     ECEVLLAQCVVYFARAPKSIEVYSAYNNVKACLRSHQGPLPPVPLHLRNAPTRLMKDL
                     GYGKGYKYNPMYSEPVDQDYLPEELRGVDFFKQRRC"
     exon            1016..1207
                     /gene="Wrnip1"
                     /gene_synonym="4833444L21Rik; WHIP; Wrnip"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1449
                     /gene="Wrnip1"
                     /gene_synonym="4833444L21Rik; WHIP; Wrnip"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1679
                     /gene="Wrnip1"
                     /gene_synonym="4833444L21Rik; WHIP; Wrnip"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1835
                     /gene="Wrnip1"
                     /gene_synonym="4833444L21Rik; WHIP; Wrnip"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1915
                     /gene="Wrnip1"
                     /gene_synonym="4833444L21Rik; WHIP; Wrnip"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2642
                     /gene="Wrnip1"
                     /gene_synonym="4833444L21Rik; WHIP; Wrnip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2622..2627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wrnip1"
                     /gene_synonym="4833444L21Rik; WHIP; Wrnip"
                     /note="hexamer: AATAAA"
     polyA_site      2641
                     /gene="Wrnip1"
                     /gene_synonym="4833444L21Rik; WHIP; Wrnip"
                     /note="major polyA site"
ORIGIN      
        1 acgactcgcg aggcgttgcc agctgcgggc cgagggcgag ttgacgcggg agctcaggac
       61 gtgaggcatg agcggcgccc tccctcggcc cgtgcgtgtc ctgctcccta cccgcgcgag
      121 ggtcgcgcgg caccgggcct agcggcgggc atcggcgttc tcaggggcag gtgcagccgc
      181 acgggcgcca gggagggcag ctgccaccat ggaggtgagc gggccggaag acgacccctt
      241 cctgtcgcag ttgcaccagg tgcagtgccc agtgtgccag cagatgatgc ccgccgcgca
      301 catcaattcg cacctggacc gctgcctgct gctgcaccct gcggggcacg cggagccagc
      361 ggccggctct caccgcgctg gggagcgggc caaggggccc tcgccacccg gcgccaagag
      421 gcgtcgactg tcggagagct cggcgctgaa gcagcccgcc accccgacgg cggccgaaag
      481 cagcgaaggc gagggcgagg agggcgatga cggcggcgag accgagagcc gtgagagcta
      541 cgacgcaccg cccacgccca gcggtgcgcg ccttatcccg gacttcccgg tggcccgctc
      601 cagcagcccc gccagaaagg gtatggggaa gagaccagcg gctgcagccg ccgcaggcag
      661 cgcatccccg cgcagctggg atgaggcgga ggcgcaggag gaggaggagg cgggggtgga
      721 cggcgatggc gacgcggacg tggacggtga ggacgatccc gggcactggg atgcggacgc
      781 cgccgacgcc tcgttcggag tcagcgcggg ccgcgcgcat ccccgggcgc tggcggcgga
      841 ggagatccga cagatgctgg agggcaagcc gctggctgac aagatgcgtc cagacacgct
      901 gcaggactac atcgggcaga gtagggccgt agggcaggag actctgctcc gctcgctact
      961 ggaggccaat gagatccctt cgctcatctt gtggggcccg ccaggttgcg gtaagaccac
     1021 cttggctcac atcatagcca acaacagcaa gaagcacagc ataaggtttg tgacattatc
     1081 tgcaacaaat gccaagacaa atgatgtgcg agatgtcata aagcaggctc agaatgagaa
     1141 gagctttttc aaaaggaaaa ccatcctttt tattgatgag attcatcgct tcaataaatc
     1201 tcagcaggac actttccttc ctcacgtgga gtgcgggaca atcacgctga ttggtgcgac
     1261 cactgagaac ccttccttcc aagtcaacgc cgcccttctg agccgctgtc gggtaattgt
     1321 tcttgagaag cttccagtag aggcaatggt gacgatttta atgagagcaa tcaactcact
     1381 gggaatccat gtcctagact ccagccgtcc tactgaccct ctgagccaca gcagcaactg
     1441 cagctctgag ccctctgtct tcatagaaga taaagcagtg gacactctgg cttacctcag
     1501 tgatggtgat gcccggacgg gcttgaatgg actgcaactg gcagtgctgg ccaggttaag
     1561 ctctaggaag gtgttctgta agaagagcgg tcaaacctat tctcctagtc gagttctgat
     1621 cactgagaat gatgtgaaag aaggcctaca gcggtcccac attttatatg accgtgcagg
     1681 agaagagcac tacaactgca tctctgccct acacaaggct atgcgtggct ctgaccagaa
     1741 tgcttccctg tattggctgg cccggatgct tgagggagga gaggacccac tctatgtggc
     1801 caggaggctg gtaaggtttg ccagcgagga catcggcctg gcagatccat cagcattagc
     1861 acaagcagtt gctgcctacc aaggctgtca ctttataggc atgcccgagt gtgaggtgct
     1921 tctggcccag tgtgtggtct attttgccag agccccaaag tccattgagg tgtacagtgc
     1981 ctataacaat gtaaaagcct gtctgcggag tcaccagggg cccctgcctc ctgtacccct
     2041 gcacctgagg aacgcgccca ccaggctgat gaaggatttg ggctatggca aagggtacaa
     2101 gtacaacccc atgtacagtg agcctgtgga ccaggactac ctgcctgagg agctgagagg
     2161 agttgacttc ttcaagcaga ggcggtgttg actctcgggc catgagtagg atgcttgtat
     2221 cttgaggaag gccaaaagtc actggatctt ggagttggtt gcctggggaa cattaaaaat
     2281 agaccaacat tttgtgccag aaattaaggg ttccatagat ggaggtggtt acttcagcta
     2341 aatgtgtacc attgaaattg tgttcatttg caccctgtgc aatgattatg cttatgaaaa
     2401 tacctggcag ctttgtgcaa ttaagtaatg ttataaggaa ttatctattt tgtcatagta
     2461 tttaagtcat aatgtcattt caaaattctg ttctgtaggc tttttttctt ttaaaaaatg
     2521 tatattctgg gtagttacaa ttggtacaag aaaatgtaat tgtgatttaa tactgcatag
     2581 tgatttgggt atttttttta tatgcaaagg tcttatgagc caataaaact atttcaaagt
     2641 ac
//
