LOCUS       NM_144824               1821 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus WD repeat containing, antisense to Trp53 (Wrap53),
            transcript variant 1, mRNA.
ACCESSION   NM_144824
VERSION     NM_144824.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1821)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1821)
  AUTHORS   Guo,T., Han,X., He,J., Feng,J., Jing,J., Janeckova,E., Lei,J.,
            Ho,T.V., Xu,J. and Chai,Y.
  TITLE     KDM6B interacts with TFDP1 to activate P53 signaling in regulating
            mouse palatogenesis
  JOURNAL   Elife 11, e74595 (2022)
   PUBMED   35212626
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1821)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1821)
  AUTHORS   Chen,L., Roake,C.M., Freund,A., Batista,P.J., Tian,S., Yin,Y.A.,
            Gajera,C.R., Lin,S., Lee,B., Pech,M.F., Venteicher,A.S., Das,R.,
            Chang,H.Y. and Artandi,S.E.
  TITLE     An Activity Switch in Human Telomerase Based on RNA Conformation
            and Shaped by TCAB1
  JOURNAL   Cell 174 (1), 218-230 (2018)
   PUBMED   29804836
REFERENCE   5  (bases 1 to 1821)
  AUTHORS   Kannan,M., Bayam,E., Wagner,C., Rinaldi,B., Kretz,P.F., Tilly,P.,
            Roos,M., McGillewie,L., Bar,S., Minocha,S., Chevalier,C., Po,C.,
            Chelly,J., Mandel,J.L., Borgatti,R., Piton,A., Kinnear,C., Loos,B.,
            Adams,D.J., Herault,Y., Collins,S.C., Friant,S., Godin,J.D. and
            Yalcin,B.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     WD40-repeat 47, a microtubule-associated protein, is essential for
            brain development and autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), E9308-E9317 (2017)
   PUBMED   29078390
REFERENCE   6  (bases 1 to 1821)
  AUTHORS   Sun,Y., Yang,C., Chen,J., Song,X., Li,Z., Duan,M., Li,J., Hu,X.,
            Wu,K., Yan,G., Yang,C., Liu,J., Tan,W. and Ye,M.
  TITLE     Overexpression of WDR79 in non-small cell lung cancer is linked to
            tumour progression
  JOURNAL   J Cell Mol Med 20 (4), 698-709 (2016)
   PUBMED   26849396
  REMARK    GeneRIF: Overexpression of WDR79 in non-small cell lung cancer is
            linked to tumor progression.
REFERENCE   7  (bases 1 to 1821)
  AUTHORS   Mahmoudi,S., Henriksson,S., Corcoran,M., Mendez-Vidal,C.,
            Wiman,K.G. and Farnebo,M.
  TITLE     Wrap53, a natural p53 antisense transcript required for p53
            induction upon DNA damage
  JOURNAL   Mol Cell 33 (4), 462-471 (2009)
   PUBMED   19250907
  REMARK    Erratum:[Mol Cell. 2016 Dec 1;64(5):1009. doi:
            10.1016/j.molcel.2016.11.027.. PMID: 27912092]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731687.13.
            
            On Jul 6, 2018 this sequence version replaced NM_144824.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021790.1, AK145219.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-580               AL731687.13        72797-73376         c
            581-679             AL731687.13        72574-72672         c
            680-791             AL731687.13        71753-71864         c
            792-880             AL731687.13        57986-58074         c
            881-971             AL731687.13        57674-57764         c
            972-1104            AL731687.13        57431-57563         c
            1105-1313           AL731687.13        56776-56984         c
            1314-1417           AL731687.13        56521-56624         c
            1418-1555           AL731687.13        56249-56386         c
            1556-1821           AL731687.13        55881-56146         c
FEATURES             Location/Qualifiers
     source          1..1821
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.81 cM"
     gene            1..1821
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /note="WD repeat containing, antisense to Trp53"
                     /db_xref="GeneID:216853"
                     /db_xref="MGI:MGI:2384933"
     exon            1..580
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1796
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /note="WD repeat-containing protein 79; WD40
                     repeat-containing protein encoded by RNA antisense to p53;
                     WD repeat domain 79; WD repeat containing, antisense to
                     TP53; WD repeat-containing protein WRAP53; WD40
                     repeat-containing protein antisense to TP53 gene homolog"
                     /codon_start=1
                     /product="telomerase Cajal body protein 1"
                     /protein_id="NP_659073.1"
                     /db_xref="CCDS:CCDS24897.1"
                     /db_xref="GeneID:216853"
                     /db_xref="MGI:MGI:2384933"
                     /translation="MKTSEERLLAPDSLPPDLAPAPVPQGSPAEKNTDFEPVPPPCGG
                     DDQPQLATDPVASLVVSQELQQGDSVPLEVEFNTSSELSPGIEEQDVSEHASLPGEET
                     NLPELESGEATEGVSEERAEVDEGDTFWTYSFSQVPRYLSGSWSEFSTRSENFLKGCK
                     WAPDGSCILTNSADNVLRIYNLPPELYSEQEQVDYAEMVPVLRMVEGDTIYDYCWYSL
                     MSSTQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQL
                     FCGFNRTVRVFSTSRPGRDCEVRATFAKKQGQSGIISCIAFSPSQPLYACGSYGRTIG
                     LYAWDDGSPLALLGGHQGGITHLCFHPDGNLFFSGARKDAELLCWDLRQPGHLLWSLS
                     REVTTNQRIYFDLDPSGQFLVSGNTSGVVSVWDISGALSDDSKLEPVVTFLPQKDCTN
                     GVSLHPTLPLLATASGQRVFPEPTNSGDEGELELELPLLSLCHAHPECQLQLWWCGGG
                     PDPSSPVDDQDEKGQRRTEAVGMS"
     exon            581..679
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            680..791
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            792..880
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            881..971
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1104
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1313
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1417
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1555
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1821
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1797..1802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /note="hexamer: TATAAA"
     polyA_site      1821
                     /gene="Wrap53"
                     /gene_synonym="Wdr79"
                     /note="major polyA site"
ORIGIN      
        1 agcgacccta ggcgcttggc tttggacact cgttccctgg tgattgcttt aggttcggct
       61 tacattttcc ggaagaggaa agcggactcc ggtctctgag catccctggg aacggtaatg
      121 cactctagcc tcggcagctg gtagccggct cagcgagact tgcccgacct ctgccttccg
      181 ggggcttact ctacagaatg aagacgtcgg aggagcgact cttagctccg gatagcctcc
      241 ctcctgacct ggccccagct ccggtacccc aaggttcccc agcggagaaa aatacagact
      301 ttgaaccggt gcctccgcca tgcggtggtg atgaccaacc ccagctagcc acagatcccg
      361 tggctagctt ggttgtgtcc caggagcttc aacaagggga ctctgtacct ctggaagtag
      421 aatttaatac ttccagtgag ttgagtcctg gaatcgagga gcaagatgtt tctgaacatg
      481 cgagtcttcc cggagaagaa acgaatctcc ccgagttgga gtcaggagaa gccacggaag
      541 gtgtgtctga ggaacgcgct gaagtggatg agggggacac cttttggacc tacagcttct
      601 cgcaggtacc ccgatacctc agtggttcct ggtccgagtt cagcacccgc tccgagaact
      661 tcttgaaagg ttgcaagtgg gcccctgacg gttcctgtat cttgaccaat agtgctgata
      721 atgtccttcg gatttacaac ctgcccccag aattgtacag tgaacaagag caggtggatt
      781 acgccgaaat ggttcctgtc cttcgaatgg tggagggcga caccatctat gattactgct
      841 ggtattctct gatgtcctcc acccagccag acacctccta tgtggccagc agcagccggg
      901 agaacccgat tcacatctgg gatgcattca ctggagaact acgggcttcc tttcgcgctt
      961 acaaccacct ggatgagttg acagcagccc actcgctctg tttctccccg gatggttccc
     1021 aactcttctg tggcttcaac cggactgtgc gtgtcttttc cacatccaga cctggcagag
     1081 actgtgaggt gcgagccaca tttgccaaaa agcagggcca gagcggtatc atctcctgta
     1141 tagccttcag tccatcccag cccctctatg cctgtggctc ctacggccgc accataggcc
     1201 tgtatgcctg ggatgatggt tcgcctcttg ccttgctggg aggccaccaa gggggtatca
     1261 cccacctttg ctttcaccct gatggcaatc tcttcttctc gggagcccga aaggatgctg
     1321 aacttctgtg ctgggatctc cggcagccag gccacctcct gtggtctctg agtcgggaag
     1381 tgaccactaa tcagcgcatc tactttgatc tggacccgag cggtcagttc ctagtgagcg
     1441 gcaacaccag tggagttgtc tctgtgtggg atatcagtgg agctcttagt gacgacagca
     1501 agctggaacc cgtggtgact tttctgcctc agaaggactg caccaacgga gtcagccttc
     1561 accctacctt gcctctactg gccactgctt ctggccagcg cgtgttccct gagcccacca
     1621 atagcgggga tgaaggtgag ctggagctgg agcttcctct gctctccctg tgccacgccc
     1681 atcccgaatg tcagcttcag ctctggtggt gtggaggggg acctgacccc agtagccctg
     1741 ttgacgacca ggatgaaaag ggacaaagaa ggacagaggc tgtggggatg agttaatata
     1801 aagactttgt gtcacactgg a
//
