LOCUS       NM_011720               3375 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 8B
            (Wnt8b), mRNA.
ACCESSION   NM_011720
VERSION     NM_011720.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3375)
  AUTHORS   Zhang,B., Zhao,C., Shen,W., Li,W., Zheng,Y., Kong,X., Wang,J.,
            Wu,X., Zeng,T., Liu,Y. and Zhou,Y.
  TITLE     KDM2B regulates hippocampal morphogenesis by transcriptionally
            silencing Wnt signaling in neural progenitors
  JOURNAL   Nat Commun 14 (1), 6489 (2023)
   PUBMED   37838801
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3375)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3375)
  AUTHORS   Simonson,L., Oldham,E. and Chang,H.
  TITLE     Overactive Wnt5a signaling disrupts hair follicle polarity during
            mouse skin development
  JOURNAL   Development 149 (22) (2022)
   PUBMED   36305473
REFERENCE   4  (bases 1 to 3375)
  AUTHORS   Murphy,P., Armit,C., Hill,B., Venkataraman,S., Frankel,P.,
            Baldock,R.A. and Davidson,D.R.
  TITLE     Integrated analysis of Wnt signalling system component gene
            expression
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831952
REFERENCE   5  (bases 1 to 3375)
  AUTHORS   Shi,C., Chen,X., Yin,W., Sun,Z., Hou,J. and Han,X.
  TITLE     Wnt8b regulates myofibroblast differentiation of lung-resident
            mesenchymal stem cells via the activation of Wnt/beta-catenin
            signaling in pulmonary fibrogenesis
  JOURNAL   Differentiation 125, 35-44 (2022)
   PUBMED   35487030
  REMARK    GeneRIF: Wnt8b regulates myofibroblast differentiation of
            lung-resident mesenchymal stem cells via the activation of
            Wnt/beta-catenin signaling in pulmonary fibrogenesis.
REFERENCE   6  (bases 1 to 3375)
  AUTHORS   Hansen,G.M., Tackles,D., Schwartz,C. and Justice,M.J.
  TITLE     A mouse chromosome 19 genetic map including the Lvis1 viral
            insertion site
  JOURNAL   Genomics 56 (2), 228-231 (1999)
   PUBMED   10051411
REFERENCE   7  (bases 1 to 3375)
  AUTHORS   Loureiro,J.J.
  TITLE     The Wnts
  JOURNAL   Curr Biol 9 (1), R4 (1999)
   PUBMED   9889131
REFERENCE   8  (bases 1 to 3375)
  AUTHORS   Lako,M., Lindsay,S., Bullen,P., Wilson,D.I., Robson,S.C. and
            Strachan,T.
  TITLE     A novel mammalian wnt gene, WNT8B, shows brain-restricted
            expression in early development, with sharply delimited expression
            boundaries in the developing forebrain
  JOURNAL   Hum Mol Genet 7 (5), 813-822 (1998)
   PUBMED   9536085
REFERENCE   9  (bases 1 to 3375)
  AUTHORS   Varlet,I., Collignon,J. and Robertson,E.J.
  TITLE     nodal expression in the primitive endoderm is required for
            specification of the anterior axis during mouse gastrulation
  JOURNAL   Development 124 (5), 1033-1044 (1997)
   PUBMED   9056778
REFERENCE   10 (bases 1 to 3375)
  AUTHORS   Varlet,I., Collignon,J., Norris,D.P. and Robertson,E.J.
  TITLE     Nodal signaling and axis formation in the mouse
  JOURNAL   Cold Spring Harb Symp Quant Biol 62, 105-113 (1997)
   PUBMED   9598342
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151478.1.
            
            On Dec 30, 2022 this sequence version replaced NM_011720.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF130349.1, AK050992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC151478.1         75731-75926
            197-230             AC151478.1         91056-91089
            231-369             AC151478.1         91800-91938
            370-495             AC151478.1         92682-92807
            496-638             AC151478.1         93490-93632
            639-3375            AC151478.1         93795-96531
FEATURES             Location/Qualifiers
     source          1..3375
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 37.98 cM"
     gene            1..3375
                     /gene="Wnt8b"
                     /note="wingless-type MMTV integration site family, member
                     8B"
                     /db_xref="GeneID:22423"
                     /db_xref="MGI:MGI:109485"
     exon            1..196
                     /gene="Wnt8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1184
                     /gene="Wnt8b"
                     /note="protein Wnt-8b; wingless related MMTV integration
                     site 8b"
                     /codon_start=1
                     /product="protein Wnt-8b precursor"
                     /protein_id="NP_035850.3"
                     /db_xref="CCDS:CCDS50446.1"
                     /db_xref="GeneID:22423"
                     /db_xref="MGI:MGI:109485"
                     /translation="MFLMKPVCVLLVTCVLHRSHAWSVNNFLMTGPKAYLVYSSSVAA
                     GAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRN
                     CSLGDFDNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMN
                     LHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGAHLKEKYHAALKVD
                     LLQGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGR
                     ALGRWERRSCRRLCGDCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCSR
                     AERPPRGAAHKPGKNS"
     exon            197..230
                     /gene="Wnt8b"
                     /inference="alignment:Splign:2.1.0"
     exon            231..369
                     /gene="Wnt8b"
                     /inference="alignment:Splign:2.1.0"
     exon            370..495
                     /gene="Wnt8b"
                     /inference="alignment:Splign:2.1.0"
     exon            496..638
                     /gene="Wnt8b"
                     /inference="alignment:Splign:2.1.0"
     exon            639..3375
                     /gene="Wnt8b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttcatttc accacccctt aacactgttt gggatcgctt acacaccaag gtagccaccc
       61 ctctgcctcc gaggagaatg cttcccatct ctcaatgttt gagtcgctca ccctgccttt
      121 ctccgaagac catgtttctt atgaagcccg tgtgcgttct tctagtcact tgtgtccttc
      181 accgcagcca cgcctggtca gtgaacaatt ttctgatgac cggtccaaag gcttacctgg
      241 tctactccag cagcgtggcc gctggcgccc agagtggtat tgaagaatgt aaataccagt
      301 ttgcttggga ccgttggaat tgccccgaga gagctttaca gctgtccagc catggtggac
      361 ttcgaagcgc taaccgggag acagcatttg tgcacgccat cagctctgct ggggttatgt
      421 acaccctgac tagaaactgc agcctcggag actttgacaa ctgtggctgt gatgactccc
      481 gaaatggaca actggggggc caaggttggc tctggggagg ctgcagtgac aacgtgggct
      541 tcggagaggc aatttccaag cagtttgtgg atgccctcga gacaggacaa gatgcccggg
      601 cagccatgaa tctgcacaac aatgaggctg gccgcaaggc ggtcaagggc accatgaaac
      661 gcacgtgtaa gtgccacggt gtgtccggca gctgcaccac gcagacctgc tggttgcaac
      721 tgccagagtt ccgggaggta ggcgcgcact tgaaggagaa gtatcatgcg gcgctcaagg
      781 tggacctgct gcaaggcgcg ggcaacagcg cggcgggccg cggagccatc gccgacacct
      841 tccgctccat ctccacccgc gagctggtgc atctggagga ctccccagac tactgcctgg
      901 agaacaagac cctggggctg ctgggcaccg agggccgaga gtgtctgcgg cgcgggcgcg
      961 ccctgggtcg ctgggagcgc cgcagttgtc gccggctgtg cggggactgc gggctagcgg
     1021 tggaggagcg ccgcgccgag acagtgtcca gctgcaactg caagtttcac tggtgctgcg
     1081 cggtccgctg cgagcagtgc cgccggcggg tcaccaagta cttctgcagc cgcgcagagc
     1141 ggccgcccag aggcgctgcg cacaaaccgg gaaagaactc ctaagggtat ctatccctcc
     1201 cgcctccacc cctgttcgtc ctcggcttcc tttagagacc cccggaaata gaggaaccca
     1261 gaatggggga cctcgcactc cctagcccag agattctgac aggaggaggc tgcagtctct
     1321 accgagtgac actttgtagc tcactcgtag gtctcaaaac tgttataaaa ttctgcaagt
     1381 tgttcctgaa aagaggatga gaacaggcga gtctcctcac cccactttac ctacttcgga
     1441 ccccaatggt cgctcaatgc tggacctagc ttatcaggcc taggaagggc ccctctcaga
     1501 tattcagggt ccagggaaag acgtggccct tctcttgctc gccatagctt cacctccctc
     1561 ctgtgagcca gagcttctag gcctagactc cccgctgttg attattcaag aatctaacac
     1621 tttgtcttct catttcccta ctatttctgg aaagaaaaaa aaaacacaac caaatcaaaa
     1681 caacaaccaa acaaaaacat taagaaagaa aaagggaaga agcctttgaa taaggggtaa
     1741 gaggtaaccc cagagccaaa tgttactcct ctgtgacatc atgtcactgg caggcctcag
     1801 ctaagcagtg accttcctaa acaccaaaga tactccagtc acacccaagg ggtctcggag
     1861 tggtagaggt ctgtagtagg caggttggca atcattttct gattactttg tatcatagca
     1921 gcgtctaact ttgtctcctt ctccgcggga gctttgatct tctgagccaa gacaggcaaa
     1981 tcaaggtttt tggatctgtg cctcttaagg aagggcatag gaaggagaaa ccagacccta
     2041 atacctggtt ctcaaatagg cagggttcag aacatctgcc agatgcgttc tctgataagt
     2101 aaaccgtcac cggctccccc ccccccccac gctctgaaac tgttgctaag aggatgttca
     2161 gagccttaac ctatttaatt tattgcagtc tgaaatatgt cccttctccc aggtcctgac
     2221 ctcgctgatt gctgaggggg aagcacagca gaaacttacc ctctaagctc tctcctccct
     2281 cccactctgg cagggtacca tcttctccct gtagttgacg gcctaagtag ctagtttgat
     2341 ttgactgagg ttaatctgcc aaggattagt aaatcaccca cataaacctt ccgctcatgc
     2401 attcacttgg aagcccagag ctcgccgcgc cgcttctgag tttcttcctt gggcagtctg
     2461 gcagggtctt gtttatgaaa tgggtattgg gagaactgaa gagcaagctc agcccagacc
     2521 ttccccatag ctgttccttg ccctaggtta gacctgggtg tgggtatcca cagcactttt
     2581 gaagcagaga ctttcaaatt ctatactttc ttcctcttct gctgcaagta cagagctgag
     2641 ctcacaatgc caaagccaca gtgactacat cggaagagtg aaatgcccct gacattcggg
     2701 gacagtggcc tcgttaaacc tctgtgcatc ttctggtcct attgaaactt tgtgggaggc
     2761 agtttttctg gtattagcag gggacatact tcccttccct tttggggtct tttgctactt
     2821 cacttccagc tgtgagcaat tcttacctgt gccttctgag cctcctcagc tctccttttc
     2881 ctagtctttc agcagtgcgt gttaatccca ggtcttactg gacagttact tgataagtgt
     2941 acagaagaaa acccggcagt gcaactgaaa actctaaggg ttccacattg gaacgtgaag
     3001 ctgcattttt ccagggctct cagcagaacc gtggaagcat cgtgcttctg tgttcagaac
     3061 tttaaagtca gactccaaat gcctcctccg gcttgtcatt tcttccatag attagacttt
     3121 gtatcaccaa gtgggtatga gtgactccca gttcatccca gttctacaga gaacttcctg
     3181 cccatgcact acgccttcag cctttgttca cgctatacac actggagtgg agacagctaa
     3241 caacacacaa gcatccttca gttcacggct tcatgtccta cactaactca ctgagactct
     3301 gcagacaact ctagagctgc tgactgctga ctgggaagat tagacacctc tgaggtcagc
     3361 tagtcaaact ttaac
//
