LOCUS       NM_009528               3389 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 7B
            (Wnt7b), transcript variant 1, mRNA.
ACCESSION   NM_009528
VERSION     NM_009528.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Ide,H., Miike,K., Ohmori,T., Maruyama,K., Izumi,Y., Tanigawa,S. and
            Nishinakamura,R.
  TITLE     Mouse embryonic kidney transplantation identifies maturation
            defects in the medulla
  JOURNAL   Sci Rep 14 (1), 30293 (2024)
   PUBMED   39639083
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Xie,N., Landin Malt,A., Adylkhan,A., Rodeman,N., Moraes Borges,R.,
            Hwang,D., Liu,A., Smith,C., Hogan,A. and Lu,X.
  TITLE     Wnt7b acts in concert with Wnt5a to regulate tissue elongation and
            planar cell polarity via noncanonical Wnt signaling
  JOURNAL   Proc Natl Acad Sci U S A 121 (35), e2405217121 (2024)
   PUBMED   39172791
  REMARK    GeneRIF: Wnt7b acts in concert with Wnt5a to regulate tissue
            elongation and planar cell polarity via noncanonical Wnt signaling.
REFERENCE   3  (bases 1 to 3389)
  AUTHORS   Kimura,E., Mongan,M., Xiao,B., Christianto,A., Wang,J.,
            Carreira,V.S., Bolon,B., Zhang,X., Burns,K.A., Biesiada,J.,
            Medvedovic,M., Puga,A. and Xia,Y.
  TITLE     MAP3K1 regulates female reproductive tract development
  JOURNAL   Dis Model Mech 17 (3) (2024)
   PUBMED   38501211
REFERENCE   4  (bases 1 to 3389)
  AUTHORS   Wang,F., Chander,A., Yoon,Y., Welton,J.M., Wallingford,M.C.,
            Espejo-Serrano,C., Bustos,F., Findlay,G.M., Mager,J. and Bach,I.
  TITLE     Roles of the Rlim-Rex1 axis during X chromosome inactivation in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (52), e2313200120 (2023)
   PUBMED   38113263
REFERENCE   5  (bases 1 to 3389)
  AUTHORS   Cheng,T., Agwu,C., Shim,K., Wang,B., Jain,S. and Mahjoub,M.R.
  TITLE     Aberrant centrosome biogenesis disrupts nephron and collecting duct
            progenitor growth and fate resulting in fibrocystic kidney disease
  JOURNAL   Development 150 (24) (2023)
   PUBMED   37982452
REFERENCE   6  (bases 1 to 3389)
  AUTHORS   Conlon,R.A. and Rossant,J.
  TITLE     Exogenous retinoic acid rapidly induces anterior ectopic expression
            of murine Hox-2 genes in vivo
  JOURNAL   Development 116 (2), 357-368 (1992)
   PUBMED   1363087
REFERENCE   7  (bases 1 to 3389)
  AUTHORS   Brannan,C.I., Gilbert,D.J., Ceci,J.D., Matsuda,Y., Chapman,V.M.,
            Mercer,J.A., Eisen,H., Johnston,L.A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     An interspecific linkage map of mouse chromosome 15 positioned with
            respect to the centromere
  JOURNAL   Genomics 13 (4), 1075-1081 (1992)
   PUBMED   1354638
REFERENCE   8  (bases 1 to 3389)
  AUTHORS   McMahon,A.P., Joyner,A.L., Bradley,A. and McMahon,J.A.
  TITLE     The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from
            stepwise deletion of engrailed-expressing cells by 9.5 days
            postcoitum
  JOURNAL   Cell 69 (4), 581-595 (1992)
   PUBMED   1534034
REFERENCE   9  (bases 1 to 3389)
  AUTHORS   Gavin,B.J. and McMahon,A.P.
  TITLE     Differential regulation of the Wnt gene family during pregnancy and
            lactation suggests a role in postnatal development of the mammary
            gland
  JOURNAL   Mol Cell Biol 12 (5), 2418-2423 (1992)
   PUBMED   1373817
REFERENCE   10 (bases 1 to 3389)
  AUTHORS   Nusse,R., Brown,A., Papkoff,J., Scambler,P., Shackleford,G.,
            McMahon,A., Moon,R. and Varmus,H.
  TITLE     A new nomenclature for int-1 and related genes: the Wnt gene family
  JOURNAL   Cell 64 (2), 231 (1991)
   PUBMED   1846319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC058398.1, BC052018.1 and BQ032129.1.
            
            On Jul 25, 2009 this sequence version replaced NM_009528.2.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052018.1, M89802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-665               BC058398.1         1-665
            666-3369            BC052018.1         427-3130
            3370-3389           BQ032129.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 40.39 cM"
     gene            1..3389
                     /gene="Wnt7b"
                     /gene_synonym="Wnt-7b"
                     /note="wingless-type MMTV integration site family, member
                     7B"
                     /db_xref="GeneID:22422"
                     /db_xref="MGI:MGI:98962"
     exon            1..442
                     /gene="Wnt7b"
                     /gene_synonym="Wnt-7b"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..1421
                     /gene="Wnt7b"
                     /gene_synonym="Wnt-7b"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein Wnt-7b; wingless-related MMTV
                     integration site 7B"
                     /codon_start=1
                     /product="protein Wnt-7b isoform 1 precursor"
                     /protein_id="NP_033554.3"
                     /db_xref="CCDS:CCDS37171.1"
                     /db_xref="GeneID:22422"
                     /db_xref="MGI:MGI:98962"
                     /translation="MHRNFRKWIFYVFLCFGVLYVKLGALSSVVALGANIICNKIPGL
                     APRQRAICQSRPDAIIVIGEGAQMGIDECQHQFRFGRWNCSALGEKTVFGQELRVGSR
                     EAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADVRYGI
                     DFSRRFVDAREIKKNARRLMNLHNNEAGRKVLEDRMKLECKCHGVSGSCTTKTCWTTL
                     PKFREVGHLLKEKYNAAVQVEVVRASRLRQPTFLRIKQLRSYQKPMETDLVYIEKSPN
                     YCEEDAATGSVGTQGRLCNRTSPGADGCDTMCCGRGYNTHQYTKVWQCNCKFHWCCFV
                     KCNTCSERTEVFTCK"
     exon            443..669
                     /gene="Wnt7b"
                     /gene_synonym="Wnt-7b"
                     /inference="alignment:Splign:2.1.0"
     exon            670..941
                     /gene="Wnt7b"
                     /gene_synonym="Wnt-7b"
                     /inference="alignment:Splign:2.1.0"
     exon            942..3373
                     /gene="Wnt7b"
                     /gene_synonym="Wnt-7b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3348..3353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt7b"
                     /gene_synonym="Wnt-7b"
                     /note="hexamer: AATAAA"
     polyA_site      3369
                     /gene="Wnt7b"
                     /gene_synonym="Wnt-7b"
                     /note="major polyA site"
ORIGIN      
        1 gcggacacat tggccgcccc ggcgcaccgc gaggcgcgca cggccccagg cggctaagcc
       61 cagtggaggc agcgcccgcc cgctgctcct ggccccggcc tgcgctcgca gagtcccacg
      121 gtcactccgc tgggctccga ggtcgcggtt ccccgcccgg gtcactcccc cgggcgcacg
      181 cggcggctgc ggcgccctgg gctcaccatg gtggcaacgc gtgccgggtg cccacgcgtc
      241 gcccgcctcc cgagccgaag cgccggctga gcgtggtcct accgcagctc cctggctcct
      301 gcccggcccc tgcccacccg cgcgtcccct ccggccgcag ctgtctatgg cgcagccccc
      361 ctccctggat catgcacaga aactttcgaa agtggatctt ttacgtgttt ctctgctttg
      421 gcgtcctcta cgtgaagctc ggagcattgt catccgtggt ggccctggga gccaacatca
      481 tctgcaacaa gattcctggc ctggccccac ggcagcgtgc catctgccag agccgacccg
      541 atgccatcat tgtgatcggg gagggggcgc agatgggcat cgacgagtgc cagcaccagt
      601 tccgattcgg ccgctggaac tgctccgccc tgggcgagaa gaccgtcttc gggcaagaac
      661 tccgagtagg gagtcgagag gctgccttca cctatgccat cacggcggcg ggcgtggcgc
      721 atgctgtcac cgctgcctgc agccagggca atctgagcaa ttgtggctgt gaccgggaga
      781 agcaaggcta ctacaaccag gcggaaggct ggaagtgggg gggctgctca gcggacgtcc
      841 gctacggcat cgacttttct cgtcgctttg tggatgcccg tgagatcaaa aagaacgcca
      901 ggcgcctcat gaaccttcac aacaatgagg cgggcagaaa ggttctggag gaccgcatga
      961 agctggaatg taagtgtcac ggtgtgtcag gctcctgtac caccaaaact tgctggacca
     1021 cgctacctaa gttccgcgag gtgggccacc tgctcaagga gaagtacaac gcagcggtgc
     1081 aggtggaggt ggtgcgagcc agccgcctgc gccagcccac cttcctgcgc atcaagcagc
     1141 tacgcagcta ccagaagcct atggagacgg acctggtgta catcgagaag tcgcccaact
     1201 actgcgagga ggacgcggcc acgggcagcg tgggcacgca gggccgtctg tgcaaccgca
     1261 cctcgccggg ggccgacggc tgtgacacca tgtgctgcgg ccgcggctac aacacgcacc
     1321 agtacaccaa ggtgtggcag tgtaactgca aattccactg gtgttgcttc gtcaagtgca
     1381 acacgtgcag cgagcgcacc gaggtcttca cctgcaagtg aggctcccgc gcaggcgcgc
     1441 tcggcccctg ccgaccctgc ggccctcgcc attattttgc acatccttct ttgcttctgg
     1501 agctgccagc tgcaggcaca ggagggtggg gatagaggtg gggagctcga gatactccag
     1561 gctccttcct actcgctctg tccccgccca gcatccaagg tcaacgcaat ggtggtctgg
     1621 tacccaatgg agacaaatcc ctttacttct ctttgggaaa gtgaaccaca aagggaccat
     1681 gagactctga gggtcacctc cctgcctgtg actggacaca gaaaggccac acccaccagt
     1741 cacactcaaa acggtttcct gggctgtttc ctgccggccc tgggcagtgt ggatggatgt
     1801 tgacaaaatt atttatgttt tcttagcatc agatgaggac tcagtactaa cgactgggta
     1861 gccagaccta accctatttg aggacaccct tccctcactc ctcccggccc ctccctgcag
     1921 ggtcctctgc tccttgcaga actcgaggat gtcagaattg gcacggaagc tggctggtgg
     1981 ggggactcct tatcagcacc ttgggagggg cttggtggcc ctacaaggcc tgagatggcc
     2041 gcagaggaca gccaatcttc cattccattt ggagactgtc atgcaaatca aatgtccctt
     2101 gtgtcaggct ccaggcatgc ctcgtcctct ccctggtcct tcaccctccc agcctgctgc
     2161 caacctccac ctccagttta caaattctct tctcctctgg agccaacctg acacccagga
     2221 ctgccccaca ggttcaggag aggtcaggga cagttgcccc acatgacaga tggacagagg
     2281 gcaatctgaa gatttactgg agaccccacg gctctgtgaa ataaatatac tgacacagcc
     2341 ccatccagcc caactctgga agttgccagg gtgatgggag gctgcacccc cttttcagta
     2401 ccttgggttt tgtccttctt ctgtgatcct gatgccagag aactgacatc cagaatttag
     2461 ggatgtattg gtcaggcccc ctgcctagtg tccactgata cctgcttcag ggtccttata
     2521 ttatgaggac atgggaccct caaacagggg tccgtgggaa gcttaatgtc ccatttcctc
     2581 aggcccttcc agatggggac agaagaactc aggcctgggc atatcccacc ctttcctcca
     2641 caacacatgg cagggtaaga aactgccagg gctgataata caactgccca cagcctaccc
     2701 cacactaagg tgtttcatag cagaagtcca tggaaatgtg gggtttggtg gccaccaagc
     2761 caggtggcct ggacattgac ctggggaagg tgacccttgt ttgcccttgc cttgcatcca
     2821 gctgtgtgtc cctatcatgt caggatgttc caagcctctg ggccactgga aatgtcccac
     2881 cctgatcctg gccccatctc ctcaccccaa gtcctgggat acccacgtcc gtcgcccagt
     2941 gtcccctgtg aggagcctgg ttaacttata ttgttatata gcgtcccctg tctgtcatgt
     3001 ctcttaagtt attgtgacct acactgggta ccggagggga tgggggatgg cttcagctgc
     3061 tgtcccccaa gccaggctcc tccttctgct tgaaacagac cctcgggggc ccctgatgcc
     3121 accgaggcaa ttcgcactgt ccctgggctg ccaggcacct gcgcctgcac tcggtcagcc
     3181 gcagaccttg ccttggggga gagaggtggt tagtggaccc aggcagggca ctggctgtcc
     3241 caatgctgtg tgctggggtg gaggtggccg ggcaccacat gtccttgaag tgccctactt
     3301 ctgatgggct gtgttcctgc ctcctctgga ggggagcact tagccccaat aaaagctgga
     3361 atcagaaaag caaaaaaaaa aaaaaaaaa
//
