LOCUS       NM_009527               3179 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 7A
            (Wnt7a), transcript variant 1, mRNA.
ACCESSION   NM_009527
VERSION     NM_009527.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3179)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   2  (bases 1 to 3179)
  AUTHORS   Kimura,E., Mongan,M., Xiao,B., Christianto,A., Wang,J.,
            Carreira,V.S., Bolon,B., Zhang,X., Burns,K.A., Biesiada,J.,
            Medvedovic,M., Puga,A. and Xia,Y.
  TITLE     MAP3K1 regulates female reproductive tract development
  JOURNAL   Dis Model Mech 17 (3) (2024)
   PUBMED   38501211
REFERENCE   3  (bases 1 to 3179)
  AUTHORS   Werren,E.A., LaForce,G.R., Srivastava,A., Perillo,D.R., Li,S.,
            Johnson,K., Baris,S., Berger,B., Regan,S.L., Pfennig,C.D., de
            Munnik,S., Pfundt,R., Hebbar,M., Jimenez-Heredia,R.,
            Karakoc-Aydiner,E., Ozen,A., Dmytrus,J., Krolo,A., Corning,K.,
            Prijoles,E.J., Louie,R.J., Lebel,R.R., Le,T.L., Amiel,J.,
            Gordon,C.T., Boztug,K., Girisha,K.M., Shukla,A., Bielas,S.L. and
            Schaffer,A.E.
  TITLE     TREX tetramer disruption alters RNA processing necessary for
            corticogenesis in THOC6 Intellectual Disability Syndrome
  JOURNAL   Nat Commun 15 (1), 1640 (2024)
   PUBMED   38388531
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3179)
  AUTHORS   Cheng,T., Agwu,C., Shim,K., Wang,B., Jain,S. and Mahjoub,M.R.
  TITLE     Aberrant centrosome biogenesis disrupts nephron and collecting duct
            progenitor growth and fate resulting in fibrocystic kidney disease
  JOURNAL   Development 150 (24) (2023)
   PUBMED   37982452
REFERENCE   5  (bases 1 to 3179)
  AUTHORS   Russell,N.X., Burra,K., Shah,R.M., Bottasso-Arias,N.,
            Mohanakrishnan,M., Snowball,J., Ediga,H.H., Madala,S.K. and
            Sinner,D.
  TITLE     Wnt signaling regulates ion channel expression to promote smooth
            muscle and cartilage formation in developing mouse trachea
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (6), L788-L802 (2023)
   PUBMED   37873566
REFERENCE   6  (bases 1 to 3179)
  AUTHORS   Gavin,B.J. and McMahon,A.P.
  TITLE     Differential regulation of the Wnt gene family during pregnancy and
            lactation suggests a role in postnatal development of the mammary
            gland
  JOURNAL   Mol Cell Biol 12 (5), 2418-2423 (1992)
   PUBMED   1373817
REFERENCE   7  (bases 1 to 3179)
  AUTHORS   Nusse,R., Brown,A., Papkoff,J., Scambler,P., Shackleford,G.,
            McMahon,A., Moon,R. and Varmus,H.
  TITLE     A new nomenclature for int-1 and related genes: the Wnt gene family
  JOURNAL   Cell 64 (2), 231 (1991)
   PUBMED   1846319
REFERENCE   8  (bases 1 to 3179)
  AUTHORS   Gavin,B.J., McMahon,J.A. and McMahon,A.P.
  TITLE     Expression of multiple novel Wnt-1/int-1-related genes during fetal
            and adult mouse development
  JOURNAL   Genes Dev 4 (12B), 2319-2332 (1990)
   PUBMED   2279700
REFERENCE   9  (bases 1 to 3179)
  AUTHORS   Lane,P.W. and Eicher,E.M.
  TITLE     Gene order in linkage group XVI of the house mouse
  JOURNAL   J Hered 70 (4), 239-244 (1979)
   PUBMED   489953
REFERENCE   10 (bases 1 to 3179)
  AUTHORS   Lane,P.W.
  TITLE     Two new mutations in linkage group XVI of the house mouse. Flaky
            tail and varitint-waddler-J
  JOURNAL   J Hered 63 (3), 135-140 (1972)
   PUBMED   4557539
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004683.1 and BC057586.1.
            
            On May 29, 2018 this sequence version replaced NM_009527.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049093.1, AK004683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3160              AK004683.1         18-3177
            3161-3179           BC057586.1         3171-3189
FEATURES             Location/Qualifiers
     source          1..3179
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 40.45 cM"
     gene            1..3179
                     /gene="Wnt7a"
                     /gene_synonym="px; tw; Wnt-7a"
                     /note="wingless-type MMTV integration site family, member
                     7A"
                     /db_xref="GeneID:22421"
                     /db_xref="MGI:MGI:98961"
     exon            1..315
                     /gene="Wnt7a"
                     /gene_synonym="px; tw; Wnt-7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1294
                     /gene="Wnt7a"
                     /gene_synonym="px; tw; Wnt-7a"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein Wnt-7a; postaxial hemimelia;
                     wingless-related MMTV integration site 7A"
                     /codon_start=1
                     /product="protein Wnt-7a isoform 1 precursor"
                     /protein_id="NP_033553.2"
                     /db_xref="CCDS:CCDS39568.1"
                     /db_xref="GeneID:22421"
                     /db_xref="MGI:MGI:98961"
                     /translation="MTRKARRCLGHLFLSLGIVYLRIGGFSSVVALGASIICNKIPGL
                     APRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSR
                     EAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGI
                     GFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTL
                     PQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPN
                     YCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYV
                     KCNTCSERTEMYTCK"
     exon            316..542
                     /gene="Wnt7a"
                     /gene_synonym="px; tw; Wnt-7a"
                     /inference="alignment:Splign:2.1.0"
     exon            543..814
                     /gene="Wnt7a"
                     /gene_synonym="px; tw; Wnt-7a"
                     /inference="alignment:Splign:2.1.0"
     exon            815..3162
                     /gene="Wnt7a"
                     /gene_synonym="px; tw; Wnt-7a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3126..3131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt7a"
                     /gene_synonym="px; tw; Wnt-7a"
                     /note="hexamer: AATAAA"
     polyA_site      3162
                     /gene="Wnt7a"
                     /gene_synonym="px; tw; Wnt-7a"
                     /note="major polyA site"
ORIGIN      
        1 aaacacttgc cgcgatcgct ggcgcgcagc ggcgcccctt gttgcgcttg ttctcccctc
       61 ctctggctcc gcggctcccg cgctctggga cagtctccag tgcctagcgc ggaccgacgc
      121 accgacggac cgcccaggga gcctcggccc gcgccccctg cgcaggctat gtggattgcc
      181 ccgccgggcc cggctggcgg gatcagcaca gcccggcccg tggcacccgc caccagcggg
      241 gactatgacc cggaaagcgc ggcgctgcct gggccacctc tttctcagcc tgggcatagt
      301 ctacctccgg atcggtggct tctcttcggt ggtagctctg ggtgcgagca tcatctgtaa
      361 caagatccca ggcctggctc ccagacagcg ggcaatctgc cagagccggc cggacgccat
      421 catcgtcata ggagaaggct cccaaatggg cctggacgag tgtcagtttc agttccgaaa
      481 tggccgttgg aactgctcag cgctgggaga gcgtactgtc ttcgggaagg agctcaaagt
      541 ggggagtcgg gaggctgcct tcacctatgc gattatcgct gcgggcgtgg cccatgccat
      601 cactgctgcc tgcacccagg gcaacctgag cgactgtggc tgcgacaagg agaagcaagg
      661 ccagtaccac cgggacgagg gctggaagtg gggtggctgc tctgccgaca tccgctacgg
      721 catcggcttc gccaaggtct tcgtggatgc ccgggagatc aagcagaatg cccggacgct
      781 catgaactta cacaataacg aggcgggtcg gaagatcctg gaggagaaca tgaagctgga
      841 gtgtaagtgc catggtgtgt caggctcctg taccactaag acgtgctgga ccacactgcc
      901 acagttccga gagctaggct acgtgctcaa ggacaaatac aacgaggccg tccacgtgga
      961 gcctgtgcgt gccagtcgaa acaagcggcc cacctttctg aagatcaaga agcccctgtc
     1021 ctaccgcaag cccatggaca ctgacctggt gtatatcgag aagtcaccca attactgtga
     1081 agaggaccca gtgacaggca gcgtgggtac ccagggccga gcctgcaata agacagcccc
     1141 tcaggccagt ggctgtgacc tcatgtgctg tggccgtggc tacaacacac accagtacgc
     1201 ccgggtgtgg cagtgcaact gcaaattcca ctggtgctgc tacgtcaagt gtaacacgtg
     1261 cagcgagcgc acggagatgt atacgtgcaa gtgaatgcgg tcacaggtca gatcacaggc
     1321 aggatacagt ttccctgcag gccactgcct ggatgctcac agggaaagaa ccacagaagc
     1381 actgtccttg tcttttctgc tgagggggga ggggtattct gggtttcctg cagactcccg
     1441 tgggaagcat ctctcagagg cccgcccatt cttctccaca tggatgctgc tcagccaccc
     1501 tcccccagac accgcccgag cctctccagg gctggaacaa agttttctac ggcaggagct
     1561 ctggagcctc gggcctcgtc atagcaatat ttaacagttt attctgatat gagataatat
     1621 taatttattt aattaaagag aattcttcca cttcgtcggg atccgtcttc tgcaatcaaa
     1681 gtggactgct tgaggtcctg gtgggatgac ttgctaggac tgggagctga gaacagctgt
     1741 acataattat tctttatgca gatgtttcta ctagttgatt tcacaagtac ccttctgcag
     1801 cgctaggtgt taagtacaaa gagaagacgg tctttataca catatagata tatatatgca
     1861 tacacatttg taactttgtt ttgttttgtt tttgctgttt gctgctacct atccagactc
     1921 taagctggtc cagatctgga attgtttttc tccaggacgt gctcctatcc ttttgccctt
     1981 tacagttcaa acctctccgt tagaaaagtt ccattgggaa tggcgtgtgt gtgatgggga
     2041 cgaggatcac aaattcccag cagtttccat cctgaaacgt gaaccactgg ataagaggct
     2101 ttctaagaga ctatttttct atggatattt tatttatatg gagtctgcct gcggtgcccc
     2161 atggcccatg cctcttctta acactggtac tcactcaggg gcagaaggac aaggccaggt
     2221 gtgtgggcag gtcccccggg gaccctcaca cagctggagc ctggagttct atttgccaag
     2281 ggggccatag cagttaccag atgcctgggt tgggtatctt ctgtgttaaa caagagggaa
     2341 ccatcccctg gctttagcct gctaagctca gggcttggaa tggggtcact ggatggttat
     2401 cttgggagat gacctctgga tgagcctcag cggtgggtca gtcagtgtct cacacacttt
     2461 gagaagcatg ggacctggca ttcatcatca ggcagaggcc agctcaggga tgccgctatc
     2521 ccatcaggac agcccaggca ctgcctctag gtgaggtgta gtcctaagag aaggggtcaa
     2581 ggagggggaa ggaggaagcc aaggagtgtt ggccatcctc agtgaaagcg atgggagcgt
     2641 tctctcagca gcagagacac agctgtacct gtatctctcc aatgggaaac ccctccagaa
     2701 ggctggggat attttttatg tgtttccaca tgcatttcca cctgtgtgca tgtaagcaca
     2761 tgcgcacact cctgtgccag cactctgcgg cacctccagg gtgctcacgg gtacatgtgc
     2821 ttacatgtat ctctctgtgc ttgggagatc agaccatgtg catggagctg tatgcctgag
     2881 cacttgtggt ctcaggggtt atttccaggt atctgcattt gtgggtgggg tgcaaggtag
     2941 acagcaggga actgatttga ttgtgttgag ccacagtgag actgcaactc tgaactctgt
     3001 ctccacagct gctggtgaaa ctcagatgcc tgtgagacaa cagccctgag cctcatggcc
     3061 cacatgctgg gagcccctca gtgtctaggt catgtccagt cccccacctg ggttacatca
     3121 cgaccaataa acatggctgt atggctgatt tcttcccttg aaaaaaaaaa aaaaaaaaa
//
