LOCUS       NM_009526               2068 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 6
            (Wnt6), mRNA.
ACCESSION   NM_009526
VERSION     NM_009526.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2068)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2068)
  AUTHORS   Kostic,L., Leung,C., Ahmad Murad,K., Kancheva,S., Perna,S., Lee,B.
            and Barker,N.
  TITLE     Lgr5 marks stem/progenitor cells contributing to epithelial and
            muscle development in the mouse esophagus
  JOURNAL   Nat Commun 15 (1), 7145 (2024)
   PUBMED   39164270
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2068)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2068)
  AUTHORS   Zhang,B., Zhao,C., Shen,W., Li,W., Zheng,Y., Kong,X., Wang,J.,
            Wu,X., Zeng,T., Liu,Y. and Zhou,Y.
  TITLE     KDM2B regulates hippocampal morphogenesis by transcriptionally
            silencing Wnt signaling in neural progenitors
  JOURNAL   Nat Commun 14 (1), 6489 (2023)
   PUBMED   37838801
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2068)
  AUTHORS   Xie,X., Sun,L., Duan,Y., Lv,Z., Yao,X., Wang,C., Chen,X., Tian,S.,
            Yan,L., Shao,Y., Luo,H. and Liu,J.
  TITLE     SRSF2 in Sertoli cells is essential for testicular development and
            spermatogenesis in mice
  JOURNAL   FASEB J 37 (5), e22918 (2023)
   PUBMED   37039821
REFERENCE   6  (bases 1 to 2068)
  AUTHORS   Burrus,L.W. and McMahon,A.P.
  TITLE     Biochemical analysis of murine Wnt proteins reveals both shared and
            distinct properties
  JOURNAL   Exp Cell Res 220 (2), 363-373 (1995)
   PUBMED   7556445
REFERENCE   7  (bases 1 to 2068)
  AUTHORS   Smolich,B.D. and Papkoff,J.
  TITLE     Regulated expression of Wnt family members during neuroectodermal
            differentiation of P19 embryonal carcinoma cells: overexpression of
            Wnt-1 perturbs normal differentiation-specific properties
  JOURNAL   Dev Biol 166 (1), 300-310 (1994)
   PUBMED   7958454
REFERENCE   8  (bases 1 to 2068)
  AUTHORS   Gavin,B.J. and McMahon,A.P.
  TITLE     Differential regulation of the Wnt gene family during pregnancy and
            lactation suggests a role in postnatal development of the mammary
            gland
  JOURNAL   Mol Cell Biol 12 (5), 2418-2423 (1992)
   PUBMED   1373817
REFERENCE   9  (bases 1 to 2068)
  AUTHORS   Nusse,R., Brown,A., Papkoff,J., Scambler,P., Shackleford,G.,
            McMahon,A., Moon,R. and Varmus,H.
  TITLE     A new nomenclature for int-1 and related genes: the Wnt gene family
  JOURNAL   Cell 64 (2), 231 (1991)
   PUBMED   1846319
REFERENCE   10 (bases 1 to 2068)
  AUTHORS   Gavin,B.J., McMahon,J.A. and McMahon,A.P.
  TITLE     Expression of multiple novel Wnt-1/int-1-related genes during fetal
            and adult mouse development
  JOURNAL   Genes Dev 4 (12B), 2319-2332 (1990)
   PUBMED   2279700
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133954.1, M89800.1 and AV303464.1.
            
            On Dec 20, 2006 this sequence version replaced NM_009526.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133954.1, BC048700.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               AK133954.1         2-255
            255-296             M89800.1           1-42
            297-2057            AK133954.1         298-2058
            2058-2068           AV303464.1         281-291
FEATURES             Location/Qualifiers
     source          1..2068
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.54 cM"
     gene            1..2068
                     /gene="Wnt6"
                     /gene_synonym="Wnt-6"
                     /note="wingless-type MMTV integration site family, member
                     6"
                     /db_xref="GeneID:22420"
                     /db_xref="MGI:MGI:98960"
     exon            1..331
                     /gene="Wnt6"
                     /gene_synonym="Wnt-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1349
                     /gene="Wnt6"
                     /gene_synonym="Wnt-6"
                     /note="protein Wnt-6; wingless-related MMTV integration
                     site 6"
                     /codon_start=1
                     /product="protein Wnt-6 precursor"
                     /protein_id="NP_033552.2"
                     /db_xref="CCDS:CCDS15056.1"
                     /db_xref="GeneID:22420"
                     /db_xref="MGI:MGI:98960"
                     /translation="MLPPVPSRLGLLLLLLCPAHVDGLWWAVGSPLVMDPTSICRKAR
                     RLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKAFGRVLQQDIR
                     ETAFVFAITAAGASHAVTQACSMGELLQCGCQAPRGRAPPRPSGLLGTPGPPGPTGSP
                     DASAAWEWGGCGDDVDFGDEKSRLFMDAQHKRGRGDIRALVQLHNNEAGRLAVRSHTR
                     TECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPAVRTLK
                     PPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQ
                     LEENCLCRFHWCCVVQCHRCRVRKELSLCL"
     exon            332..552
                     /gene="Wnt6"
                     /gene_synonym="Wnt-6"
                     /inference="alignment:Splign:2.1.0"
     exon            553..887
                     /gene="Wnt6"
                     /gene_synonym="Wnt-6"
                     /inference="alignment:Splign:2.1.0"
     exon            888..2068
                     /gene="Wnt6"
                     /gene_synonym="Wnt-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1600..1605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt6"
                     /gene_synonym="Wnt-6"
                     /note="hexamer: AATAAA"
     polyA_site      1630
                     /gene="Wnt6"
                     /gene_synonym="Wnt-6"
     regulatory      1676..1681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt6"
                     /gene_synonym="Wnt-6"
                     /note="hexamer: AATAAA"
     polyA_site      1697
                     /gene="Wnt6"
                     /gene_synonym="Wnt-6"
ORIGIN      
        1 gatttcttct ctccagcgag ctccgcagga gacacaggcg ctggctgctg ggtccgctct
       61 ccgcctccgc cgcgccctcc tcgcccggga tgggcccccc cgccgccacc gccgccggag
      121 ccctagtctc cgggccgccg cctcggtcgc cgcgtttgcc ctgaagcccg gtgcccgcgc
      181 gccccggctc accccgcagc ttcactcccc acccccagcc gcctccccgg ccagactgcg
      241 gtagagctct caggatgctg ccgccggtgc cctcccgcct cggactgctg ctgctgctct
      301 tgtgccccgc gcacgtcgat ggactgtggt gggccgtggg cagccccttg gtcatggatc
      361 ctaccagcat ctgcaggaag gccaggcggc tggcaggaag acaggccgag ctgtgccagg
      421 cggagccgga agtagtggca gagcttgccc gaggcgcaag actgggggtt cgagaatgtc
      481 agttccagtt ccgtttccga cgctggaact gctccagcca cagcaaggcc tttgggcgcg
      541 tcctgcagca ggacatccga gagacagctt tcgtgtttgc aatcaccgca gctggtgcca
      601 gccacgcggt cactcaagcc tgttccatgg gagagctcct acagtgtggt tgtcaggcac
      661 cccgcgggcg ggcaccgcct aggccctccg gccttctggg cactcctgga cctccaggac
      721 caactggctc tccagatgct agcgcagcct gggagtgggg aggctgcgga gacgatgtgg
      781 acttcgggga tgagaagtca agactcttta tggatgcgca gcacaagcgg ggccgtggag
      841 atatccgtgc attggtgcaa ctgcacaaca acgaggcggg caggctggcg gtgcggagtc
      901 acacgcgcac cgagtgtaag tgccatgggc tttcgggttc ctgcgctctg cgcacctgct
      961 ggcagaagct gcctccgttc cgcgaggtgg gcgcacggct gctggagcgc ttccacggcg
     1021 cctcgcgcgt catgggcacc aacgacggca aagctctgct gcctgcggtc cgcacactca
     1081 agcctcccgg acgagcggat ctcctctacg cagccgattc acccgacttc tgcgccccta
     1141 accggcgcac gggttcgccg ggcacgcgcg gacgcgcctg caacagcagt gccccggacc
     1201 tcagcggctg cgacctgttg tgctgcggtc gcgggcaccg ccaggagagc gtacagctcg
     1261 aggagaactg tctgtgccgc ttccactggt gctgcgtggt gcaatgccac cgctgccggg
     1321 tgcgcaagga actcagcctg tgcctctgac ccgtcgcctg cctcggaact gctggcagcc
     1381 acctctgggc catctacagg actattagat tccagcaggg ggcgctgtct gagtccagca
     1441 gctccctagg aaaagtacct atccaggcct tgggaaatta caggggccag ccaggaactt
     1501 ggggtttaca ccagcccacg aaagcccggg ggaacattcc cctgaaaggc cctttgctag
     1561 ttcctgcagg agatcactcc ccttggcccc ccagatggaa ataaaaaagc cagactctgc
     1621 cctctggaaa taatattcct cagaattact gggatggatg ggtgagttta gtatcaataa
     1681 agacatttaa atccacagtt tgagaggagg tagtcctaga gggccaggat atggaagaaa
     1741 gttggtcctg gtagagttag catttcagtc tgagtctatc attccacctg ttaccaaggc
     1801 atgacggagt gagggaggac ttatggaaag gcagaaaaga gggtgaggga gggctcctgg
     1861 aaacctttag cacaccttct gttctttctt ggctctcgag aacttgtggt cccatgttaa
     1921 aggaacacaa agaggccaga agcttctagt agtgggctta gttgtcaggc gtctgtgtga
     1981 acttttatgg cattctgtct ttctgtgact cctgatgaaa ttaacggtca tgagattaaa
     2041 agctcgtcat gaactgtaaa atgcaacg
//
