LOCUS       NP_033552                364 aa            linear   ROD 25-FEB-2025
DEFINITION  protein Wnt-6 precursor [Mus musculus].
ACCESSION   NP_033552
VERSION     NP_033552.2
DBSOURCE    REFSEQ: accession NM_009526.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 364)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (residues 1 to 364)
  AUTHORS   Kostic,L., Leung,C., Ahmad Murad,K., Kancheva,S., Perna,S., Lee,B.
            and Barker,N.
  TITLE     Lgr5 marks stem/progenitor cells contributing to epithelial and
            muscle development in the mouse esophagus
  JOURNAL   Nat Commun 15 (1), 7145 (2024)
   PUBMED   39164270
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 364)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 364)
  AUTHORS   Zhang,B., Zhao,C., Shen,W., Li,W., Zheng,Y., Kong,X., Wang,J.,
            Wu,X., Zeng,T., Liu,Y. and Zhou,Y.
  TITLE     KDM2B regulates hippocampal morphogenesis by transcriptionally
            silencing Wnt signaling in neural progenitors
  JOURNAL   Nat Commun 14 (1), 6489 (2023)
   PUBMED   37838801
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 364)
  AUTHORS   Xie,X., Sun,L., Duan,Y., Lv,Z., Yao,X., Wang,C., Chen,X., Tian,S.,
            Yan,L., Shao,Y., Luo,H. and Liu,J.
  TITLE     SRSF2 in Sertoli cells is essential for testicular development and
            spermatogenesis in mice
  JOURNAL   FASEB J 37 (5), e22918 (2023)
   PUBMED   37039821
REFERENCE   6  (residues 1 to 364)
  AUTHORS   Burrus,L.W. and McMahon,A.P.
  TITLE     Biochemical analysis of murine Wnt proteins reveals both shared and
            distinct properties
  JOURNAL   Exp Cell Res 220 (2), 363-373 (1995)
   PUBMED   7556445
REFERENCE   7  (residues 1 to 364)
  AUTHORS   Smolich,B.D. and Papkoff,J.
  TITLE     Regulated expression of Wnt family members during neuroectodermal
            differentiation of P19 embryonal carcinoma cells: overexpression of
            Wnt-1 perturbs normal differentiation-specific properties
  JOURNAL   Dev Biol 166 (1), 300-310 (1994)
   PUBMED   7958454
REFERENCE   8  (residues 1 to 364)
  AUTHORS   Gavin,B.J. and McMahon,A.P.
  TITLE     Differential regulation of the Wnt gene family during pregnancy and
            lactation suggests a role in postnatal development of the mammary
            gland
  JOURNAL   Mol Cell Biol 12 (5), 2418-2423 (1992)
   PUBMED   1373817
REFERENCE   9  (residues 1 to 364)
  AUTHORS   Nusse,R., Brown,A., Papkoff,J., Scambler,P., Shackleford,G.,
            McMahon,A., Moon,R. and Varmus,H.
  TITLE     A new nomenclature for int-1 and related genes: the Wnt gene family
  JOURNAL   Cell 64 (2), 231 (1991)
   PUBMED   1846319
REFERENCE   10 (residues 1 to 364)
  AUTHORS   Gavin,B.J., McMahon,J.A. and McMahon,A.P.
  TITLE     Expression of multiple novel Wnt-1/int-1-related genes during fetal
            and adult mouse development
  JOURNAL   Genes Dev 4 (12B), 2319-2332 (1990)
   PUBMED   2279700
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133954.1, M89800.1 and AV303464.1.
            
            On Aug 28, 2003 this sequence version replaced NP_033552.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133954.1, BC048700.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.54 cM"
     Protein         1..364
                     /product="protein Wnt-6 precursor"
                     /note="protein Wnt-6; wingless-related MMTV integration
                     site 6"
                     /calculated_mol_wt=37249
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2425
     mat_peptide     24..364
                     /product="Protein Wnt-6. /id=PRO_0000041441"
                     /note="propagated from UniProtKB/Swiss-Prot (P22727.2)"
                     /calculated_mol_wt=37249
     Region          34..364
                     /region_name="Wnt_Wnt6"
                     /note="Wnt domain found in protein Wnt-6 and similar
                     proteins; cd19338"
                     /db_xref="CDD:381712"
     Site            85
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P22727.2)"
     Region          140..162
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P22727.2)"
     Site            order(222..223,226..228,236,343,345,347,349)
                     /site_type="other"
                     /note="Frizzled receptor binding site [polypeptide
                     binding]"
                     /db_xref="CDD:381712"
     Site            310
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P22727.2)"
     CDS             1..364
                     /gene="Wnt6"
                     /gene_synonym="Wnt-6"
                     /coded_by="NM_009526.3:255..1349"
                     /db_xref="CCDS:CCDS15056.1"
                     /db_xref="GeneID:22420"
                     /db_xref="MGI:MGI:98960"
ORIGIN      
        1 mlppvpsrlg llllllcpah vdglwwavgs plvmdptsic rkarrlagrq aelcqaepev
       61 vaelargarl gvrecqfqfr frrwncsshs kafgrvlqqd iretafvfai taagashavt
      121 qacsmgellq cgcqaprgra pprpsgllgt pgppgptgsp dasaawewgg cgddvdfgde
      181 ksrlfmdaqh krgrgdiral vqlhnneagr lavrshtrte ckchglsgsc alrtcwqklp
      241 pfrevgarll erfhgasrvm gtndgkallp avrtlkppgr adllyaadsp dfcapnrrtg
      301 spgtrgracn ssapdlsgcd llccgrghrq esvqleencl crfhwccvvq chrcrvrkel
      361 slcl
//
