LOCUS       NM_001410505            2349 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 5B
            (Wnt5b), transcript variant 4, mRNA.
ACCESSION   NM_001410505 XM_006505924
VERSION     NM_001410505.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Luan,Y., Hu,J., Wang,Q., Wang,X., Li,W., Qu,R., Yang,C.,
            Rajendran,B.K., Zhou,H., Liu,P., Zhang,N., Shi,Y., Liu,Y., Tang,W.,
            Lu,J. and Wu,D.
  TITLE     Wnt5 controls splenic myelopoiesis and neutrophil functional
            ambivalency during DSS-induced colitis
  JOURNAL   Cell Rep 43 (3), 113934 (2024)
   PUBMED   38461416
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2349)
  AUTHORS   Zhang,B., Zhao,C., Shen,W., Li,W., Zheng,Y., Kong,X., Wang,J.,
            Wu,X., Zeng,T., Liu,Y. and Zhou,Y.
  TITLE     KDM2B regulates hippocampal morphogenesis by transcriptionally
            silencing Wnt signaling in neural progenitors
  JOURNAL   Nat Commun 14 (1), 6489 (2023)
   PUBMED   37838801
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2349)
  AUTHORS   Jena,S.K., Das,S., Chakraborty,S. and Ain,R.
  TITLE     Molecular determinants of epithelial mesenchymal transition in
            mouse placenta and trophoblast stem cell
  JOURNAL   Sci Rep 13 (1), 10978 (2023)
   PUBMED   37414855
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2349)
  AUTHORS   Burrus,L.W. and McMahon,A.P.
  TITLE     Biochemical analysis of murine Wnt proteins reveals both shared and
            distinct properties
  JOURNAL   Exp Cell Res 220 (2), 363-373 (1995)
   PUBMED   7556445
REFERENCE   7  (bases 1 to 2349)
  AUTHORS   Bradbury,J.M., Niemeyer,C.C., Dale,T.C. and Edwards,P.A.
  TITLE     Alterations of the growth characteristics of the fibroblast cell
            line C3H 10T1/2 by members of the Wnt gene family
  JOURNAL   Oncogene 9 (9), 2597-2603 (1994)
   PUBMED   8058323
REFERENCE   8  (bases 1 to 2349)
  AUTHORS   Gavin,B.J. and McMahon,A.P.
  TITLE     Differential regulation of the Wnt gene family during pregnancy and
            lactation suggests a role in postnatal development of the mammary
            gland
  JOURNAL   Mol Cell Biol 12 (5), 2418-2423 (1992)
   PUBMED   1373817
REFERENCE   9  (bases 1 to 2349)
  AUTHORS   Nusse,R., Brown,A., Papkoff,J., Scambler,P., Shackleford,G.,
            McMahon,A., Moon,R. and Varmus,H.
  TITLE     A new nomenclature for int-1 and related genes: the Wnt gene family
  JOURNAL   Cell 64 (2), 231 (1991)
   PUBMED   1846319
REFERENCE   10 (bases 1 to 2349)
  AUTHORS   Gavin,B.J., McMahon,J.A. and McMahon,A.P.
  TITLE     Expression of multiple novel Wnt-1/int-1-related genes during fetal
            and adult mouse development
  JOURNAL   Genes Dev 4 (12B), 2319-2332 (1990)
   PUBMED   2279700
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC128662.4 and AC126607.7.
            
            On Aug 9, 2022 this sequence version replaced XM_006505924.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784651.653837.1,
                                           SRR17784650.209479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AC128662.4         116757-117103
            348-484             AC126607.7         85822-85958         c
            485-732             AC126607.7         84021-84268         c
            733-1025            AC126607.7         77968-78260         c
            1026-2349           AC126607.7         70219-71542         c
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 56.86 cM"
     gene            1..2349
                     /gene="Wnt5b"
                     /gene_synonym="Wnt-5b"
                     /note="wingless-type MMTV integration site family, member
                     5B"
                     /db_xref="GeneID:22419"
                     /db_xref="MGI:MGI:98959"
     exon            1..347
                     /gene="Wnt5b"
                     /gene_synonym="Wnt-5b"
                     /inference="alignment:Splign:2.1.0"
     exon            348..484
                     /gene="Wnt5b"
                     /gene_synonym="Wnt-5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..1484
                     /gene="Wnt5b"
                     /gene_synonym="Wnt-5b"
                     /note="protein Wnt-5b; wingless-related MMTV integration
                     site 5B"
                     /codon_start=1
                     /product="protein Wnt-5b precursor"
                     /protein_id="NP_001397434.1"
                     /db_xref="GeneID:22419"
                     /db_xref="MGI:MGI:98959"
                     /translation="MPSLLLVVVAALLSSWAQLLTDANSWWSLALNPVQRPEMFIIGA
                     QPVCSQLPGLSPGQRKLCQLYQEHMSYIGEGAKTGIRECQHQFRQRRWNCSTVDNTSV
                     FGRVMQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRAARPKDLPRDWLWGG
                     CGDNVEYGYRFAKEFVDAREREKNFAKGSEEQGRALMNLQNNEAGRRAVYKMADVACK
                     CHGVSGSCSLKTCWLQLAEFRKVGDRLKEKYDSAAAMRITRQGKLELANSRFNQPTPE
                     DLVYVDPSPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDRFKSVQVERC
                     HCRFHWCCFVRCKKCTEVVDQYVCK"
     exon            485..732
                     /gene="Wnt5b"
                     /gene_synonym="Wnt-5b"
                     /inference="alignment:Splign:2.1.0"
     exon            733..1025
                     /gene="Wnt5b"
                     /gene_synonym="Wnt-5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..2349
                     /gene="Wnt5b"
                     /gene_synonym="Wnt-5b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2330..2335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt5b"
                     /gene_synonym="Wnt-5b"
                     /note="hexamer: ATTAAA"
     polyA_site      2349
                     /gene="Wnt5b"
                     /gene_synonym="Wnt-5b"
                     /note="major polyA site"
ORIGIN      
        1 cttttccggt tccttgggca gctcactgtg gtgttctgtg aggaaacaga ctaacagact
       61 ataggaaccg ccataaaagt gtttaaattc tgccctgagc taaggccaaa cactggcctc
      121 tagtgacctt tgcaggctac taacggtagg gtccttttat gtgcctcatg tttatccgga
      181 gactaactgg gccctaagtc ctgacagaag cctttcccgc tagaacaatc caggcatcag
      241 agtcccagtc tgagacctgc ctgtgtgggt ccggaccggg gtttgcagag tggaaatagc
      301 tcccgggtcg cttcgcagct ccggactcca aagggtgtca ccaaaaggga gctccgcttt
      361 ggaagatgtt ggtcccaggg cattgggatg ggttgaggcc ggccatgccc agcctgctgc
      421 tggtggtcgt ggcagctctg ctctccagct gggcacagct gctgactgac gccaactcct
      481 ggtggtcact agctctgaac ccagtgcaga gaccggagat gttcatcatt ggcgctcagc
      541 ccgtgtgcag ccaacttcct gggctttccc caggccagag aaagctgtgt cagttgtatc
      601 aggagcacat gtcctacatc ggggagggag ccaagacggg catcagagag tgccaacacc
      661 agtttcgaca gaggcgctgg aactgcagca ccgtggacaa cacatctgtc tttggcagag
      721 ttatgcagat aggtagccga gagactgcct tcacgtatgc agtgagcgcc gctggcgtgg
      781 tgaatgccat cagccgagcc tgcagagagg gtgagctgtc cacctgtggc tgcagccgtg
      841 ctgcgaggcc caaggacctg cctcgggact ggctgtgggg tggctgtgga gacaacgtgg
      901 agtacggcta ccgctttgcc aaggagtttg tggatgcccg agagcgtgag aagaactttg
      961 ccaagggatc ggaggagcag ggccgagctc tcatgaacct acagaacaac gaggctggcc
     1021 gccgggccgt gtataagatg gctgatgtcg cctgcaaatg tcacggagtc tccgggtcct
     1081 gcagcctcaa gacctgctgg ctccagctgg ccgagttccg caaggtgggg gaccgtttga
     1141 aggagaagta cgacagcgcc gcggccatgc gcatcacccg ccagggcaag ctggagctgg
     1201 ccaacagccg cttcaaccag cccaccccag aggacctggt ctacgtggac cccagtcctg
     1261 actactgcct gcgtaatgag accacaggct ccctgggcac ccagggtcgc ctctgcaaca
     1321 agacctcaga gggcatggac ggctgcgagc tcatgtgctg tggccgcggc tatgaccgct
     1381 tcaagagcgt tcaggtggaa cgctgccact gcaggttcca ctggtgttgc tttgtcagat
     1441 gcaaaaaatg caccgaggtt gtggaccagt atgtctgtaa gtgactgcac cacacgggcc
     1501 ttcaggccgc tcctctccgc ctcacaaaag tctatattat ataaatctat ctaaatatat
     1561 tttatatttg tacaaatgga tggatggatg gatgatagat aatcaagaga agaaagtgga
     1621 gaggaagagc ttaggagatg ctggccctct gtgaggactg gattttgctg gaaatccaca
     1681 accagtggga gagaaacggg cttttcccca ttttctggcc aggacttttg ggacatgggc
     1741 ttgagagtgt ctgtgcgcca tagcctccag gagacaggtg gggattagat gaaggaactg
     1801 gacttattcc acatctacag tcctgtgggg aagatgagtg tctgtgaccc tggccaggag
     1861 acccagaggc cctgtggaaa gacctgataa ccgggatggt agcctaggtc ttcctgaaaa
     1921 tggagccagc tttgggaagg ggctctgtac ttccttcttt tctcatctga gtacacactg
     1981 caggaaagtc ccctgcccca atatggggga gtggtctcaa gtcactccaa ccggtgaccg
     2041 taagagatct gggcctccct ggaccctggc tctgccttct gatgagaatg tcaccagctc
     2101 ctgcctcaag ctcttgtgcc aagagaaaga cggttctgtc acctgctaca gccaggaaga
     2161 cgtggagcaa acctgggatt tgactgggga ccaagtgcct gttgcacagg acaggaatct
     2221 gctgtcactc tgtcaaggga ggctttgaga atgacagggc atgctagcag gtcaggtcaa
     2281 ctgcctgtga gactgtcatc tctgcccaca tgtacagcgt ccctttgaca ttaaatatct
     2341 ttttactga
//
