LOCUS       NM_009524               6286 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 5A
            (Wnt5a), transcript variant 1, mRNA.
ACCESSION   NM_009524
VERSION     NM_009524.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6286)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 6286)
  AUTHORS   Xie,N., Landin Malt,A., Adylkhan,A., Rodeman,N., Moraes Borges,R.,
            Hwang,D., Liu,A., Smith,C., Hogan,A. and Lu,X.
  TITLE     Wnt7b acts in concert with Wnt5a to regulate tissue elongation and
            planar cell polarity via noncanonical Wnt signaling
  JOURNAL   Proc Natl Acad Sci U S A 121 (35), e2405217121 (2024)
   PUBMED   39172791
  REMARK    GeneRIF: Wnt7b acts in concert with Wnt5a to regulate tissue
            elongation and planar cell polarity via noncanonical Wnt signaling.
REFERENCE   3  (bases 1 to 6286)
  AUTHORS   Paramore,S.V., Goodwin,K., Fowler,E.W., Devenport,D. and
            Nelson,C.M.
  TITLE     Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and
            widening independently of the planar cell polarity complex
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39225402
REFERENCE   4  (bases 1 to 6286)
  AUTHORS   Zhu,M., Gu,B., Thomas,E.C., Huang,Y., Kim,Y.K., Tao,H., Yung,T.M.,
            Chen,X., Zhang,K., Woolaver,E.K., Nevin,M.R., Huang,X.,
            Winklbauer,R., Rossant,J., Sun,Y. and Hopyan,S.
  TITLE     A fibronectin gradient remodels mixed-phase mesoderm
  JOURNAL   Sci Adv 10 (29), eadl6366 (2024)
   PUBMED   39028807
REFERENCE   5  (bases 1 to 6286)
  AUTHORS   Song,L., Li,Q., Xia,L., Sahay,A.E., Qiu,Q., Li,Y., Li,H.,
            Sasaki,K., Susztak,K., Wu,H. and Wan,L.
  TITLE     Single-cell multiomics reveals ENL mutation perturbs kidney
            developmental trajectory by rewiring gene regulatory landscape
  JOURNAL   Nat Commun 15 (1), 5937 (2024)
   PUBMED   39009564
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6286)
  AUTHORS   Burrus,L.W. and McMahon,A.P.
  TITLE     Biochemical analysis of murine Wnt proteins reveals both shared and
            distinct properties
  JOURNAL   Exp Cell Res 220 (2), 363-373 (1995)
   PUBMED   7556445
REFERENCE   7  (bases 1 to 6286)
  AUTHORS   McMahon,A.P., Joyner,A.L., Bradley,A. and McMahon,J.A.
  TITLE     The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from
            stepwise deletion of engrailed-expressing cells by 9.5 days
            postcoitum
  JOURNAL   Cell 69 (4), 581-595 (1992)
   PUBMED   1534034
REFERENCE   8  (bases 1 to 6286)
  AUTHORS   Gavin,B.J. and McMahon,A.P.
  TITLE     Differential regulation of the Wnt gene family during pregnancy and
            lactation suggests a role in postnatal development of the mammary
            gland
  JOURNAL   Mol Cell Biol 12 (5), 2418-2423 (1992)
   PUBMED   1373817
REFERENCE   9  (bases 1 to 6286)
  AUTHORS   Nusse,R., Brown,A., Papkoff,J., Scambler,P., Shackleford,G.,
            McMahon,A., Moon,R. and Varmus,H.
  TITLE     A new nomenclature for int-1 and related genes: the Wnt gene family
  JOURNAL   Cell 64 (2), 231 (1991)
   PUBMED   1846319
REFERENCE   10 (bases 1 to 6286)
  AUTHORS   Gavin,B.J., McMahon,J.A. and McMahon,A.P.
  TITLE     Expression of multiple novel Wnt-1/int-1-related genes during fetal
            and adult mouse development
  JOURNAL   Genes Dev 4 (12B), 2319-2332 (1990)
   PUBMED   2279700
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY721304.1, AK031512.1, AK031597.1, AK036824.1 and CT025649.7.
            
            On Jan 19, 2018 this sequence version replaced NM_009524.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031512.1, AK031597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               BY721304.1         1-383
            384-1766            AK031512.1         94-1476
            1767-2718           AK031597.1         1740-2691
            2719-4013           AK036824.1         2097-3391
            4014-6286           CT025649.7         80967-83239         c
FEATURES             Location/Qualifiers
     source          1..6286
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 16.8 cM"
     gene            1..6286
                     /gene="Wnt5a"
                     /gene_synonym="8030457G12Rik; Wnt-5a"
                     /note="wingless-type MMTV integration site family, member
                     5A"
                     /db_xref="GeneID:22418"
                     /db_xref="MGI:MGI:98958"
     exon            1..642
                     /gene="Wnt5a"
                     /gene_synonym="8030457G12Rik; Wnt-5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             637..1779
                     /gene="Wnt5a"
                     /gene_synonym="8030457G12Rik; Wnt-5a"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein Wnt-5a; wingless-related MMTV
                     integration site 5A"
                     /codon_start=1
                     /product="protein Wnt-5a isoform 1 precursor"
                     /protein_id="NP_033550.2"
                     /db_xref="CCDS:CCDS26888.1"
                     /db_xref="GeneID:22418"
                     /db_xref="MGI:MGI:98958"
                     /translation="MKKPIGILSPGVALGTAGGAMSSKFFLMALATFFSFAQVVIEAN
                     SWWSLGMNNPVQMSEVYIIGAQPLCSQLAGLSQGQKKLCHLYQDHMQYIGEGAKTGIK
                     ECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELS
                     TCGCSRAARPKDLPRDWLWGGCGDNIDYGYRFAKEFVDARERERIHAKGSYESARILM
                     NLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAM
                     RLNSRGKLVQVNSRFNSPTTQDLVYIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDG
                     CELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK"
     exon            643..776
                     /gene="Wnt5a"
                     /gene_synonym="8030457G12Rik; Wnt-5a"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1027
                     /gene="Wnt5a"
                     /gene_synonym="8030457G12Rik; Wnt-5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1320
                     /gene="Wnt5a"
                     /gene_synonym="8030457G12Rik; Wnt-5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..6286
                     /gene="Wnt5a"
                     /gene_synonym="8030457G12Rik; Wnt-5a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4323..4328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt5a"
                     /gene_synonym="8030457G12Rik; Wnt-5a"
                     /note="hexamer: AATAAA"
     polyA_site      4349
                     /gene="Wnt5a"
                     /gene_synonym="8030457G12Rik; Wnt-5a"
ORIGIN      
        1 agtccctgga agcagacgtt tcggccacag acccagagag gaggagctga caatcaggag
       61 gcgtgagccg cctggagtct gcagaattcg tggtgtgaat gaactggggg catcttgggc
      121 acagggattg ccccccctcc ttccccgcct cgggccacag ttgagtagtg gggcattttt
      181 tttcaccttc ttgtgaagaa ttttttttat tatttgttgt aaagtctttt gcacaatcac
      241 gcccacattt ggggttggaa agccctaatt accgccgtcg ctgatggacg ttagagaggg
      301 agcgcctcgc cgcggaacag tcgcctgcgc gccctcgtcg gacccgcggc tcctgcactg
      361 tgtccccgct cggccctgcg cttgctgctc gcccgcgcgc gccggcgccc tctcggttcc
      421 tgggcacatt tccacgctat accaactcct ctgcccgagt ccgggcgcca gtgctcgctt
      481 ccgctccggg tcgctgcgcc cacccgacgc gcccaggagg actccgcagc cctgctttgg
      541 attgtccccc aaggcttaac cccgacgctt cgcttgaatt cctcggccgc cttcgctcgg
      601 gtggcgactt cctctccgtg ccccctcccc ctcgccatga agaagcccat tggaatatta
      661 agcccgggag tggctttggg gaccgctgga ggtgccatgt cttccaagtt cttcctaatg
      721 gctttggcca cgtttttctc cttcgcccag gttgttatag aagctaattc ttggtggtct
      781 ctaggtatga ataaccctgt tcagatgtca gaagtatata tcataggtgc acagcctctc
      841 tgcagccaac tggcaggact ttctcaagga cagaagaaac tctgccactt gtatcaggac
      901 cacatgcagt acattggaga aggtgcgaag acaggcatca aggaatgcca gtaccagttc
      961 cggcatcgga gatggaactg cagcacagtg gacaatactt ctgtctttgg cagggtgatg
     1021 caaataggca gccgagagac ggccttcacg tacgcggtga gcgcagctgg ggtggtgaac
     1081 gccatgagcc gagcatgccg ggagggcgag ctgtctacct gtggctgcag ccgcgctgcg
     1141 cgccccaagg acctgcctcg ggactggttg tggggcggct gcggagacaa catcgactat
     1201 ggctaccgct tcgccaagga gttcgtggac gctagagaaa gggaacgaat ccacgctaag
     1261 ggttcctatg agagcgcacg catcctcatg aacttacaca acaatgaagc aggccgtagg
     1321 acagtataca acctggcaga tgtagcctgt aagtgtcatg gagtgtctgg ctcctgtagc
     1381 ctcaagacgt gctggctgca gctggcggac ttccggaagg tgggcgatgc cctcaaggag
     1441 aagtatgata gcgcggcggc catgaggctc aacagccggg gcaagctggt gcaggtcaac
     1501 agccgcttca actccccgac cacgcaggac ctggtctaca tcgaccccag tccggactac
     1561 tgtgtgcgca acgagagcac tggctcgctg ggcacgcagg gacgcctgtg caacaagacc
     1621 tcagagggga tggacggctg cgagctcatg tgctgtgggc gtggctatga ccagtttaag
     1681 acagtgcaga ccgaacgctg tcattgcaag tttcactggt gctgctatgt caaatgcaag
     1741 aagtgcacgg agattgtgga tcagttcgtg tgcaaatagt ggtgtgcctg cccttcaccc
     1801 agtcccactc ccaggaccca cttatttata gaaagtacag tgcttctggt tctttttatt
     1861 tctcccccaa gaattgcagc tggaaccatg tgttttgttt tgttttattt tgttttttct
     1921 tttctgttac catctaagaa ctctgtggtt tattattaat attataatta atatttggca
     1981 atagtggggg aaactaagaa aaatatttat tttgaggatc tttgcaaagt tagtacaaaa
     2041 tttctttctt ctgatgctac aggataaagg ggaaaaacta tgtattcgaa cttagctgtg
     2101 cagttggggg ttcacatcta gaaggtgtag gagccatttt cttctcaaac agagagtcct
     2161 ttgagatggg tggtatccag gtgaaggagg aggtacagac ccatgaataa cagttcctgt
     2221 gaccaaaatg aattgcaggt gctctggtac aaaagatctt aaatatagat atattaaata
     2281 tacatatatg ccaaaaatac agaatatgag acactcccta acccagaggt taccagcctg
     2341 gttttgtggg ttttttgttt tgttttgttt tttctttttt tgggttttgt ttgtttgttt
     2401 gtttgtttgt atttttggtg tgtgtgtgtg tgtatttcta gaatgatctt ttagaaggta
     2461 caagcaagaa tctcatatct tcagaagcag gcatatcatg tatgttactg tgtcccacct
     2521 acagatactc cattcatgaa tgggcctttt tctaacagtt catgaatatt ggggagccgg
     2581 tgggctgggg gagggaggtc cccagaaatt agaaaacttg aagtttccta cattgaggcc
     2641 ataatcttgt gttagcccag ctgattctta ataccagact tttagatcca taaaggaatt
     2701 tttgactaaa aaaaaaaaat cttgttttga aagccatctt attttcttaa aaatgaaaaa
     2761 ttacccatga atcccatttg caacccctca cccccacagg caacaagaaa gtcccatgta
     2821 gttgagcact gcgaacacct ctgtgaggag atgatggcag ccatcttcct gcatgatccc
     2881 atgccctttc tggactctct gctggccatg cttccgaatg gcagccctgg tggacactca
     2941 ctgctggtag ggcagaaaat gtacacgagg agccatgttc agaaccagcc acttaggggt
     3001 tgttctctga ggcttttctt tggaggtacg gtaacttgat gtgttttgat gatatctctt
     3061 ggcccaggga gtccacagag gtgttgcagc tgtttggttg ttatcctcct gcgtttagac
     3121 tttccatttg tgcttttcct attaccctgc aggtgtaccc taaaactgtt cctagtgtac
     3181 ttgaacagtt gcatttataa ggggggatgt ggtttaatgg tgcctgatat ctcagttttt
     3241 ttgtatataa catatatata aatatacata tataaatata gatataatta tatctcagtg
     3301 cagtctggga tttagaccta cagttttctc tgggcttgct ctctgcctgg agtatcgtcc
     3361 ttcattgcag tccaattggg atttcttttt ttccaaaaat tttgagtctt aacattgacc
     3421 tgtgacagga tcctaccacg aataccagga agcaagctaa gactcggagg aagctctcag
     3481 ggctcatgtc ctgaatgtat gttggttaga aagtagcctt tctgcttcct gcccatggcc
     3541 agttctccac cctctctttg gtgttctttg tggggagggc actgtggttt gtcgcagccc
     3601 tggacttcga gaggctccca gaacccagga tcaccagcct cctgtctgtt tgcttcactc
     3661 ctttcccagg gaggacttgg gactgtcctg tctgacagga cggatctgag ttcccgaagc
     3721 aaaccagctc accacataga tagctagttt aaacaatgtt ttaaaataag ggcacctctg
     3781 tttcaaaagt gacatctgct gtgttgtttt cgaggcctga tactcttaca aggtttgaaa
     3841 aaaaatgtgt gtatccattc atgggcttgg tagccttctg gtcacctcag tcctgtggct
     3901 cttaacttat tgcccaacaa tattcatttc ccctcagcta caatgaattg caagcaaaag
     3961 atgttgaaaa aaagcactaa tttagtttaa aatgtcactt tttggttttt attctacaaa
     4021 aaccatgaag ttctctctct ctctctctct ctctcttatt tgttaaatca gattatgttc
     4081 tttttttgtt tttgttttta gtgattcatg tttatgagca gagtggagtt taacaatcct
     4141 agctttaaaa aaaacctatt taatgtaaga tattctacgc atccttcaga tattttgtat
     4201 atcccctatg gcctttattc tgtactttta atgtacatat ttctgtcttg tgtgatttgt
     4261 atatttcact ggttaaaaaa aagaacattg aaaggcttat gccaatggaa gatagaatat
     4321 aaaataaaat gttacttgta tattggtaag aggtttcagt tgtccttcag ctaattcatg
     4381 tagagaaata tttttagttg aagccacaag agacagctta gggcagttat gtgttcaaat
     4441 aacagaagaa cagacttttt tttttttttt aaaccaaacc caaactgttg ggaaacctca
     4501 atagagctct atatgtattg gaacaaaagt ggaattctct tctcctatat atgttccttc
     4561 aaaaagagag agagaatcaa gcagatggct taaagctggt cacaggattg ctcacattct
     4621 tttggcatta tgcatgcgac ttaattgttt gagagtgtgt tgctattgta acatcccaga
     4681 gatgaatcaa aaaggctcac cctctcaccc aggagcagct tttcagctta tatacacatg
     4741 catgtacatg tgtgtgatat gcatgtgtgc atgcatgttt gtatttttgt gcttgccact
     4801 ataactattg cacctctcta ttcggtttga ctgaagaggg gtcttgtggg acatctctgt
     4861 gtcccagtct ttatgggaag aaagcaaggg tctgcagaga acaggaacta aagaatccct
     4921 gtgtgatgtg caattaatag aaggcctcct gctttctgga aatgtagacc agaatctggc
     4981 caggactgta gactgataca ttatctggtc ctttgccttt ttcttttccc tccctgcccc
     5041 tccccctctt gctttatgga taaccttgta acatattgaa acctttaaag gaaaccaaga
     5101 atgcattatt acacacacac acacacacac acacacacac acacacacac acacactaca
     5161 gtagaccaac atatagagtg tttaaaatag cttttctggg caaattcaaa caacttgtgg
     5221 ctctaggacg cacatctgtt tccgtttttc ttcagttgta tattgaccag tattctttat
     5281 tgctaaaaca tatactcggg gtagcaatgt cagcatcttt tcccttccca tcctggagag
     5341 cattcaagac cttcccagta caggaacatc aatgaagcat ttatatacag gcggtggcaa
     5401 gcagaaccac atccaaaatg gtcagtgtcg ggctctaggg caaggctatc ttgttccagt
     5461 cctgtttctt tgtgctcctg acctttgggg ctgccacttc ccaggacgac cactgcctgc
     5521 ccacactgtc cccccctccc cccgggggga ttttcccaat agccagttcc catgtgtctt
     5581 tttctgcaac ggtattcaag ccaatggaac cttcagatag ggcccaagag caggatgaca
     5641 caacctgtgg acaagagcta tattaacttg atcactagta tgagctaata ttaacatgat
     5701 cacccatgaa aggcgcctgc aagagctgtt tagtctgaaa tataggtaga gagcggggat
     5761 ggcaaggttg cttgtaactt ctggtacatg ttgaatgcac acacgcatgg aggcaagctc
     5821 taaatcactg cactgttact gtaaagcata ctttaaaaat atttattgtt ttgaaaagca
     5881 ttttctagtc ttccctctct tggtggagct gtaaacaaga tggcatgttg tgaaggttca
     5941 agatgatttt tttttaaatc gcagaaacat ttagacacct aagaactaaa acttataaaa
     6001 gggatctttg aatttgcctg ttaacatgga ttaatgttta cacttacagc tgatgattgg
     6061 acggtgtttt atgttaggga aatgccttgt taacgaactt catgaagcag atgtaattaa
     6121 aggttgatgt gagccaatct agaaggttga acagtgtttt caaagaacgg agagacttac
     6181 attttagacc aatctttata cattttgctg agctagaaag gagataaaga ttatttattt
     6241 ttgttcatat cttgtacttt tctattaaaa tcattttatg aaatcc
//
