LOCUS       NM_009523               3823 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 4
            (Wnt4), mRNA.
ACCESSION   NM_009523
VERSION     NM_009523.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3823)
  AUTHORS   Song,C., Sawall,J.K., Ji,X., Song,F., Liao,X., Peng,R., Ren,H.,
            Koyama,E., Pacifici,M. and Long,F.
  TITLE     Tgfbeta signaling stimulates glycolysis to promote the genesis of
            synovial joint interzone in developing mouse embryonic limbs
  JOURNAL   Sci Adv 11 (2), eadq4991 (2025)
   PUBMED   39772668
REFERENCE   2  (bases 1 to 3823)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   3  (bases 1 to 3823)
  AUTHORS   Song,L., Li,Q., Xia,L., Sahay,A.E., Qiu,Q., Li,Y., Li,H.,
            Sasaki,K., Susztak,K., Wu,H. and Wan,L.
  TITLE     Single-cell multiomics reveals ENL mutation perturbs kidney
            developmental trajectory by rewiring gene regulatory landscape
  JOURNAL   Nat Commun 15 (1), 5937 (2024)
   PUBMED   39009564
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3823)
  AUTHORS   Huang,B., Zeng,Z., Kim,S., Fausto,C.C., Koppitch,K., Li,H., Li,Z.,
            Chen,X., Guo,J., Zhang,C.C., Ma,T., Medina,P., Schreiber,M.E.,
            Xia,M.W., Vonk,A.C., Xiang,T., Patel,T., Li,Y., Parvez,R.K.,
            Der,B., Chen,J.H., Liu,Z., Thornton,M.E., Grubbs,B.H., Diao,Y.,
            Dou,Y., Gnedeva,K., Ying,Q., Pastor-Soler,N.M., Fei,T.,
            Hallows,K.R., Lindstrom,N.O., McMahon,A.P. and Li,Z.
  TITLE     Long-term expandable mouse and human-induced nephron progenitor
            cells enable kidney organoid maturation and modeling of plasticity
            and disease
  JOURNAL   Cell Stem Cell 31 (6), 921-939 (2024)
   PUBMED   38692273
REFERENCE   5  (bases 1 to 3823)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
  REMARK    GeneRIF: Calcium signaling induces partial EMT and renal fibrosis
            in a Wnt4[mCherry] knock-in mouse model.
REFERENCE   6  (bases 1 to 3823)
  AUTHORS   Luo,G., Hofmann,C., Bronckers,A.L., Sohocki,M., Bradley,A. and
            Karsenty,G.
  TITLE     BMP-7 is an inducer of nephrogenesis, and is also required for eye
            development and skeletal patterning
  JOURNAL   Genes Dev 9 (22), 2808-2820 (1995)
   PUBMED   7590255
REFERENCE   7  (bases 1 to 3823)
  AUTHORS   Dudley,A.T., Lyons,K.M. and Robertson,E.J.
  TITLE     A requirement for bone morphogenetic protein-7 during development
            of the mammalian kidney and eye
  JOURNAL   Genes Dev 9 (22), 2795-2807 (1995)
   PUBMED   7590254
REFERENCE   8  (bases 1 to 3823)
  AUTHORS   Gavin,B.J. and McMahon,A.P.
  TITLE     Differential regulation of the Wnt gene family during pregnancy and
            lactation suggests a role in postnatal development of the mammary
            gland
  JOURNAL   Mol Cell Biol 12 (5), 2418-2423 (1992)
   PUBMED   1373817
REFERENCE   9  (bases 1 to 3823)
  AUTHORS   Nusse,R., Brown,A., Papkoff,J., Scambler,P., Shackleford,G.,
            McMahon,A., Moon,R. and Varmus,H.
  TITLE     A new nomenclature for int-1 and related genes: the Wnt gene family
  JOURNAL   Cell 64 (2), 231 (1991)
   PUBMED   1846319
REFERENCE   10 (bases 1 to 3823)
  AUTHORS   Gavin,B.J., McMahon,J.A. and McMahon,A.P.
  TITLE     Expression of multiple novel Wnt-1/int-1-related genes during fetal
            and adult mouse development
  JOURNAL   Genes Dev 4 (12B), 2319-2332 (1990)
   PUBMED   2279700
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M89797.1 and AL645468.11.
            
            On Aug 4, 2011 this sequence version replaced NM_009523.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M89797.1, BC103562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1101              M89797.1           1-1101
            1102-3823           AL645468.11        43291-46012
FEATURES             Location/Qualifiers
     source          1..3823
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 69.8 cM"
     gene            1..3823
                     /gene="Wnt4"
                     /gene_synonym="Wnt-4"
                     /note="wingless-type MMTV integration site family, member
                     4"
                     /db_xref="GeneID:22417"
                     /db_xref="MGI:MGI:98957"
     exon            1..122
                     /gene="Wnt4"
                     /gene_synonym="Wnt-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1101
                     /gene="Wnt4"
                     /gene_synonym="Wnt-4"
                     /note="protein Wnt-4; signal molecule; wingless-related
                     MMTV integration site 4"
                     /codon_start=1
                     /product="protein Wnt-4 precursor"
                     /protein_id="NP_033549.1"
                     /db_xref="CCDS:CCDS18815.1"
                     /db_xref="GeneID:22417"
                     /db_xref="MGI:MGI:98957"
                     /translation="MSPRSCLRSLRLLVFAVFSAAASNWLYLAKLSSVGSISEEETCE
                     KLKGLIQRQVQMCKRNLEVMDSVRRGAQLAIEECQYQFRNRRWNCSTLDSLPVFGKVV
                     TQGTREAAFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIA
                     YGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVK
                     TCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPS
                     PDFCEQDIRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFHTAQVELAERCGCRFHWCC
                     FVKCRQCQRLVEMHTCR"
     exon            123..358
                     /gene="Wnt4"
                     /gene_synonym="Wnt-4"
                     /inference="alignment:Splign:2.1.0"
     exon            359..490
                     /gene="Wnt4"
                     /gene_synonym="Wnt-4"
                     /inference="alignment:Splign:2.1.0"
     exon            491..633
                     /gene="Wnt4"
                     /gene_synonym="Wnt-4"
                     /inference="alignment:Splign:2.1.0"
     exon            634..3823
                     /gene="Wnt4"
                     /gene_synonym="Wnt-4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1183
                     /gene="Wnt4"
                     /gene_synonym="Wnt-4"
     polyA_site      1201
                     /gene="Wnt4"
                     /gene_synonym="Wnt-4"
                     /note="major polyA site"
     regulatory      3800..3805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt4"
                     /gene_synonym="Wnt-4"
                     /note="hexamer: GATAAA"
     polyA_site      3821
                     /gene="Wnt4"
                     /gene_synonym="Wnt-4"
                     /note="major polyA site"
ORIGIN      
        1 cgggagcctt gcggccgctg ccccgggctg ggcgcgcacg gcaccatgag cccccgttcg
       61 tgcctgcggt ccctgcgact cctcgtcttc gccgtgttct cggccgccgc gagcaattgg
      121 ctgtacctgg ccaagctgtc atcggtgggc agcatctccg aagaggagac gtgcgagaaa
      181 ctcaaaggcc tgatccagag gcaggtgcag atgtgcaaac ggaaccttga ggtgatggac
      241 tcagtgcgcc gtggtgccca gctggccatc gaggagtgcc aataccagtt ccggaaccgg
      301 cgctggaact gttccacact ggactccctc cctgtctttg ggaaggtggt gacacaaggg
      361 acccgggagg cggcctttgt atacgccatc tcttcagcag gtgtggcctt tgcagtgaca
      421 agggcatgca gcagtggaga actggagaag tgtggctgtg accggacagt gcacggggtc
      481 agcccacagg gcttccagtg gtcaggatgc tcggacaaca tcgcctatgg cgtagccttc
      541 tcacagtcct ttgtggacgt ccgggagagg agcaaggggg cctcctccag ccgggcactc
      601 atgaatcttc acaacaacga ggctggcagg aaggccatct tgacacacat gcgggtggag
      661 tgcaagtgtc acggggtgtc gggctcctgc gaggtaaaga cgtgctggcg tgctgtaccg
      721 cccttccgcc aggttggcca cgcgctaaag gagaagtttg acggtgccac ggaggtggag
      781 ccacgacgcg taggctcctc ccgggcgctg gtgcctcgga atgcacagtt caagccacat
      841 acagatgagg acctggtata cctggagcct agcccggact tctgtgagca ggacatccgc
      901 agtggcgtgc taggcacgag gggccgcacg tgcaacaaga catctaaagc cattgacggc
      961 tgcgagctac tgtgctgtgg ccgcggcttc cacacagcgc aagtggagct ggccgagcgc
     1021 tgtggctgca ggttccactg gtgctgcttc gtcaagtgcc ggcagtgcca gcggctcgtg
     1081 gagatgcaca cgtgccggtg accatgccgt ctgtgcccag gaccacctgc gtggcccagg
     1141 gaaggccaat aacttaaaca gtctcccacc acctacccca aaagatactg gttgtatttt
     1201 ttgttttggt ttggtttttg ggtcctcaag ttatttattg ccaaaaaaaa aaaaaaagaa
     1261 agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa
     1321 agaaagaaag aaagaaagaa agaaaaaaat aggcaggcaa cccccaaggg caccaaccag
     1381 ggcctccccg agcctgagcc tttgtgtgtg gctgcctctg accaaaggga ctttgtttat
     1441 gcctctggct gtccacattg accactgttg actactcagt cttgtcaagt gtccagtttt
     1501 ctacaggtag actaaaaaag taggtactaa ggagcggctg tagaccccac cgtccaggga
     1561 aacagatggc ccaatggcag ggatggcagg ttccatcttg gtggaattta tatcacctgc
     1621 aggaaaggag ctgacacctc tccaccacac atatacttgg ggaccgccag taactctggc
     1681 tctgagggtc cctagaaagg gaacggacag atatcaggtt aaaggctaag ggctctcggc
     1741 cctcatgcga gcagctagat tccaggcaag caaccgtgag ttaagacaag gatgcccagc
     1801 caggcgtggt ggtgcatgcc tttaatccca gcactcagga ggcagaggca ggtggatttc
     1861 tgagttcgag gccagcctgg tctacaaagt gagttccagg acagccagga ctatacagag
     1921 aaaccctgtc tcgaaaaacc aaaaaaaaaa aaaaaaaaaa aaaaaagaca aggatgtcca
     1981 cgtgaggcca gcccacctcc acctcaaact cctccatgag aggggaaacc tcccctattc
     2041 ccagactctc ctaggcaggg ttaggctgtc atcctggatt aggtcctagc ttgggcctgg
     2101 caagtcgcac acccgccccc tgttatgagt caccctcgca gttttgtcct ctgtgaagct
     2161 gagaatggaa atgttgcaga gacaggaaag ggctgtgcaa agagatccca ccctgtgata
     2221 tctccctcac ttaacaaaac ctagtgagca aacacaatgc cccatcagcc cctgtcctag
     2281 ggtatctccc tggatgatga catctgtcct gggaacaaac atggatgccc acccactctt
     2341 tgcagcaggt aatgatgcct gtcagcctca caagaccttg gcagaggcag agccgggctc
     2401 ctccctgggc ctgagcagtg ggctaggaac tctggctata actaaaggca cagggagaca
     2461 aggcagtagg agccagagac cacaggctgg gttggagccc acagggctgc aaagggctaa
     2521 gaggctgagt ggagaggggg acagctggag ggctgactaa ttaggtctca gaatccaagg
     2581 tacctccatc tccaggaccc tgggtcccca aggcctcgag tacagtaagg acaaaaggtt
     2641 ccccaaggga cataccatac ctggtgcctg gcccagaaca ccagccagac tgtcaagaac
     2701 ctaccaaatg ctctgtgaac aggacacaca aagaatcaac tgcctctcgg ctggatgacc
     2761 aagcctcaga ggaactttcc agcctgatgt ccaagtggct cccatgtcca ggactccagg
     2821 ttcgatgctt ccactctgag atccccttgg gaactctgca atcccaagct ctttgctatt
     2881 gggtggtgca aacgccaaat ccaggattct gaatacgggg cgcaggcctg cacaaactct
     2941 cctctgggcc tgtggtttgt gcctttctgg cgttggctcc ctgacgaaga gggtcaacac
     3001 ccttggcccc catccaagct ctctgctcat tgtccatctg aagaggcagc caaaaccaag
     3061 tgagatgctg gaaccacatt caaatgcaag gataatcttg ggcaggccgt ctctgatgtg
     3121 gatgaaagct gagctgacca agggtcccca cagctgcccg gctgggccca ctgatcctct
     3181 ggtagactta gttcagcacc agggaagatg tgaggacccc acacacacac acacatacac
     3241 agagccaggc ccaaactaag gaagcatggg gccacccctt cagagaatgc tgagccaagt
     3301 tccacatcca gtggggtcga gactgcttgt cattttgtgg acactatacc aagaaggcgg
     3361 gtccctagct cccctgtgct gatcctctca gagtcctgca ggctgtgact aggtgaatca
     3421 gaccacaggc tagaaccact gcccaggcca aagaaattca cagccatggt gggggacgtg
     3481 ggaggggggg ggggagcttc actggacttg tccagctcca aactgtctca aatataaaga
     3541 gctggcaaag gcgtgacgta gctcagcata tttgggtccc acaggaccca ggaagctgtc
     3601 cagaaggtcc acttcctacc tgaaccactc tctactgttg ttgtcacaag gcaaaagtgg
     3661 cattccttcc tccaaggcca gggctggaaa agccagctcc ggatgctgct actctaccgt
     3721 gctgccccac cccgtcctcc agtttttata tgaggctcct tggcattgtg acatccccac
     3781 ggcatagtct gagatgcacg ataaaaatgg ttatttctct atc
//
