LOCUS       NM_009522               2762 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 3A
            (Wnt3a), mRNA.
ACCESSION   NM_009522
VERSION     NM_009522.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2762)
  AUTHORS   Matsuoka,R., Kitajima,K., Nii,T., Zou,Z., Tanaka,K., Joo,K.,
            Ohkawa,Y., Ohga,S. and Meno,C.
  TITLE     Hyperglycaemia induces diet-dependent defects of the left-right
            axis by lowering intracellular pH
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167550 (2025)
   PUBMED   39442590
REFERENCE   2  (bases 1 to 2762)
  AUTHORS   Chehade,H., Gogoi,R., Adzibolosu,N.K., Galoforo,S., Fehmi,R.A.,
            Kheil,M., Fox,A., Kim,S., Rattan,R., Hou,Z., Morris,R.T.,
            Matherly,L.H., Mor,G. and Alvero,A.B.
  TITLE     BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian
            Cancer
  JOURNAL   Cancer Res Commun 4 (8), 2075-2088 (2024)
   PUBMED   39028933
  REMARK    GeneRIF: BRCA Status Dictates Wnt Responsiveness in Epithelial
            Ovarian Cancer.
REFERENCE   3  (bases 1 to 2762)
  AUTHORS   Su,H., Zhi,D., Song,Y., Yang,Y., Wang,D., Li,X. and Cao,G.
  TITLE     Exploring the formation mechanism of short-tailed phenotypes in
            animals using mutant mice with the TBXT gene c.G334T developed by
            CRISPR/Cas9
  JOURNAL   Gene 910, 148310 (2024)
   PUBMED   38401832
REFERENCE   4  (bases 1 to 2762)
  AUTHORS   Feng,X., Ye,Y., Zhang,J., Zhang,Y., Zhao,S., Mak,J.C.W., Otomo,N.,
            Zhao,Z., Niu,Y., Yonezawa,Y., Li,G., Lin,M., Li,X., Cheung,P.W.H.,
            Xu,K., Takeda,K., Wang,S., Xie,J., Kotani,T., Choi,V.N.T.,
            Song,Y.Q., Yang,Y., Luk,K.D.K., Lee,K.S., Li,Z., Li,P.S.,
            Leung,C.Y.H., Lin,X., Wang,X., Qiu,G., Watanabe,K., Wu,Z.,
            Posey,J.E., Ikegawa,S., Lupski,J.R., Cheung,J.P.Y., Zhang,T.J.,
            Gao,B. and Wu,N.
  CONSRTM   DISCO (Deciphering disorders Involving Scoliosis and COmorbidities)
            study group; Japanese Early Onset Scoliosis Research Group
  TITLE     Core planar cell polarity genes VANGL1 and VANGL2 in predisposition
            to congenital vertebral malformations
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2310283121 (2024)
   PUBMED   38669183
REFERENCE   5  (bases 1 to 2762)
  AUTHORS   Pappas,M.P., Kawakami,H., Corcoran,D., Chen,K.Q., Scott,E.P.,
            Wong,J., Gearhart,M.D., Nishinakamura,R., Nakagawa,Y. and
            Kawakami,Y.
  TITLE     Sall4 regulates posterior trunk mesoderm development by promoting
            mesodermal gene expression and repressing neural genes in the
            mesoderm
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38345319
REFERENCE   6  (bases 1 to 2762)
  AUTHORS   McMahon,A.P., Joyner,A.L., Bradley,A. and McMahon,J.A.
  TITLE     The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from
            stepwise deletion of engrailed-expressing cells by 9.5 days
            postcoitum
  JOURNAL   Cell 69 (4), 581-595 (1992)
   PUBMED   1534034
REFERENCE   7  (bases 1 to 2762)
  AUTHORS   Roelink,H. and Nusse,R.
  TITLE     Expression of two members of the Wnt family during mouse
            development--restricted temporal and spatial patterns in the
            developing neural tube
  JOURNAL   Genes Dev 5 (3), 381-388 (1991)
   PUBMED   2001840
REFERENCE   8  (bases 1 to 2762)
  AUTHORS   Henry,E.W. and Sidman,R.L.
  TITLE     Long lives for homozygous trembler mutant mice despite virtual
            absence of peripheral nerve myelin
  JOURNAL   Science 241 (4863), 344-346 (1988)
   PUBMED   3388045
REFERENCE   9  (bases 1 to 2762)
  AUTHORS   Lane,P.W., Ganser,A.L., Kerner,A.L. and White,W.F.
  TITLE     Spasmodic, a mutation on chromosome 11 in the mouse
  JOURNAL   J Hered 78 (6), 353-356 (1987)
   PUBMED   3429842
REFERENCE   10 (bases 1 to 2762)
  AUTHORS   Johnson,D.R.
  TITLE     The interfrontal bone and mutant genes in the mouse
  JOURNAL   J Anat 121 (Pt 3), 507-513 (1976)
   PUBMED   1018005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL713994.15.
            
            On Nov 18, 2022 this sequence version replaced NM_009522.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X56842.1, SRR10662772.1060964.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AL713994.15        63440-63616         c
            178-419             AL713994.15        48003-48244         c
            420-685             AL713994.15        29143-29408         c
            686-2762            AL713994.15        20896-22972         c
FEATURES             Location/Qualifiers
     source          1..2762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.17 cM"
     gene            1..2762
                     /gene="Wnt3a"
                     /gene_synonym="vt; Wnt-3a"
                     /note="wingless-type MMTV integration site family, member
                     3A"
                     /db_xref="GeneID:22416"
                     /db_xref="MGI:MGI:98956"
     exon            1..177
                     /gene="Wnt3a"
                     /gene_synonym="vt; Wnt-3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1165
                     /gene="Wnt3a"
                     /gene_synonym="vt; Wnt-3a"
                     /note="protein Wnt-3a; vestigial tail; wingless-related
                     MMTV integration site 3A"
                     /codon_start=1
                     /product="protein Wnt-3a precursor"
                     /protein_id="NP_033548.1"
                     /db_xref="CCDS:CCDS24766.1"
                     /db_xref="GeneID:22416"
                     /db_xref="MGI:MGI:98956"
                     /translation="MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCAS
                     IPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVL
                     DKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIE
                     FGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCW
                     WSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEA
                     SPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWC
                     CYVSCQECTRVYDVHTCK"
     exon            178..419
                     /gene="Wnt3a"
                     /gene_synonym="vt; Wnt-3a"
                     /inference="alignment:Splign:2.1.0"
     exon            420..685
                     /gene="Wnt3a"
                     /gene_synonym="vt; Wnt-3a"
                     /inference="alignment:Splign:2.1.0"
     exon            686..2762
                     /gene="Wnt3a"
                     /gene_synonym="vt; Wnt-3a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2739..2744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt3a"
                     /gene_synonym="vt; Wnt-3a"
                     /note="hexamer: AGTAAA"
     polyA_site      2762
                     /gene="Wnt3a"
                     /gene_synonym="vt; Wnt-3a"
                     /note="major polyA site"
ORIGIN      
        1 acagagggcc cagcgccact gcagccgcgc cacctcccag ggccgggcca gcccaggcgt
       61 ccgcgctctc ggggtggact ccccccgctg cgcgctcaag ccggcgatgg ctcctctcgg
      121 atacctctta gtgctctgca gcctgaagca ggctctgggc agctacccga tctggtggtc
      181 cttggctgtg ggaccccagt actcctctct gagcactcag cccattctct gtgccagcat
      241 cccaggcctg gtaccgaagc agctgcgctt ctgcaggaac tacgtggaga tcatgcccag
      301 cgtggctgag ggtgtcaaag cgggcatcca ggagtgccag caccagttcc gaggccggcg
      361 ttggaactgc accaccgtca gcaacagcct ggccatcttt ggccctgttc tggacaaagc
      421 cacccgggag tcagcctttg tccatgccat cgcctccgct ggagtagctt tcgcagtgac
      481 acgctcctgt gcagagggat cagctgctat ctgtgggtgc agcagccgcc tccagggctc
      541 cccaggcgag ggctggaagt ggggcggctg tagtgaggac attgaatttg gaggaatggt
      601 ctctcgggag tttgccgatg ccagggagaa ccggccggat gcccgctctg ccatgaaccg
      661 tcacaacaat gaggctgggc gccaggccat cgccagtcac atgcacctca agtgcaaatg
      721 ccacgggcta tctggcagct gtgaagtgaa gacctgctgg tggtcgcagc cggacttccg
      781 caccatcggg gatttcctca aggacaagta tgacagtgcc tcggagatgg tggtagagaa
      841 acaccgagag tctcgtggct gggtggagac cctgaggcca cgttacacgt acttcaaggt
      901 gccgacagaa cgcgacctgg tctactacga ggcctcaccc aacttctgcg aacctaaccc
      961 cgaaaccggc tccttcggga cgcgtgaccg cacctgcaat gtgagctcgc atggcataga
     1021 tgggtgcgac ctgttgtgct gcgggcgcgg gcataacgcg cgcactgagc gacggaggga
     1081 gaaatgccac tgtgttttcc attggtgctg ctacgtcagc tgccaggagt gcacacgtgt
     1141 ctatgacgtg cacacctgca agtaggagag ctcctaacac gggagcaggg ttcattccga
     1201 ggggcaaggt tcctacctgg gggcggggtt cctacttgga ggggtctctt acttggggac
     1261 tcggttctta cttgagggcg gagatcctac ctgtgagggt ctcataccta aggacccggt
     1321 ttctgccttc agcctgggct cctatttggg atctgggttc ctttttaggg gagaagctcc
     1381 tgtctgggat acgggtttct gcccgagggt ggggctccac ttggggatgg aattccaatt
     1441 tgggccggaa gtcctacctc aatggcttgg actcctctct tgacccgaca gggctcaaat
     1501 ggagacaggt aagctactcc ctcaactagg tggggttcgt gcggatgggt gggaggggag
     1561 agattagggt ccctcctccc agaggcactg ctctatctag atacatgaga gggtgcttca
     1621 gggtgggccc tatttgggct tgaggatccc gtgggggcgg ggcttcaccc cgactgggtg
     1681 gaacttttgg agaccccctt ccactggggc aaggcttcac tgaagactca tgggatggag
     1741 ctccacggaa ggaggagttc ctgagcgagc ctgggctctg agcaggccat ccagctccca
     1801 tctggcccct ttccagtcct ggtgtaaggt tcaacctgca agcctcatct gcgcagagca
     1861 ggatctcctg gcagaatgag gcatggagaa gaactcaggg gtgataccaa gacctaacaa
     1921 accccgtgcc tgggtacctc ttttaaagct ctgcacccct tcttcaaggg ctttcctagt
     1981 ctccttggca gagctttcct gaggaagatt tgcagtcccc cagagttcaa gtgaacaccc
     2041 atagaacaga acagactcta tcctgagtag agagggttct ctaggaatct ctatggggac
     2101 tgctaggaag gatcctgggc atgacagcct cgtatgatag cctgcatccg ctctgacact
     2161 taatactcag atctcccggg aaacccagct catccggtcc gtgatgtcca tgccccaaat
     2221 gcctcagaga tgttgcctca ctttgagttg tatgaacttc ggagacatgg ggacacagtc
     2281 aagccgcaga gccagggttg tttcaggacc catctgattc cccagagcct gctgttgagg
     2341 caatggtcac cagatccgtt ggccaccacc ctgtcccgag cttctctagt gtctgtctgg
     2401 cctggaagtg aggtgctaca tacagcccat ctgccacaag agcttcctga ttggtaccac
     2461 tgtgaaccgt ccctcccccc tccagacagg ggaggggatg tggccataca ggagtgtgcc
     2521 tggagagcgc ggaaagagga agagaggctg cacacgcgtg gtgactgact gtcttctgcc
     2581 tggaactttg cgttcgcgct tgtaacttta ttttcaatgc tgctatatcc acccaccact
     2641 ggatttagac aaaagtgatt ttcttttttt ttttttcttt tctttctatg aaagaaatta
     2701 ttttagttta tagtatgttt gtttcaaata atggggaaag taaaaagaga gaaaaaaaat
     2761 aa
//
