LOCUS       NM_009521               3123 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 3
            (Wnt3), mRNA.
ACCESSION   NM_009521
VERSION     NM_009521.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3123)
  AUTHORS   Su,H., Zhi,D., Song,Y., Yang,Y., Wang,D., Li,X. and Cao,G.
  TITLE     Exploring the formation mechanism of short-tailed phenotypes in
            animals using mutant mice with the TBXT gene c.G334T developed by
            CRISPR/Cas9
  JOURNAL   Gene 910, 148310 (2024)
   PUBMED   38401832
REFERENCE   2  (bases 1 to 3123)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3123)
  AUTHORS   Zhang,B., Zhao,C., Shen,W., Li,W., Zheng,Y., Kong,X., Wang,J.,
            Wu,X., Zeng,T., Liu,Y. and Zhou,Y.
  TITLE     KDM2B regulates hippocampal morphogenesis by transcriptionally
            silencing Wnt signaling in neural progenitors
  JOURNAL   Nat Commun 14 (1), 6489 (2023)
   PUBMED   37838801
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3123)
  AUTHORS   Zhu,X., Senoo,M., Millar,S.E. and Ma,G.
  TITLE     Wnt/beta-catenin signaling controls mouse eyelid growth by
            mediating epithelial-mesenchymal interactions
  JOURNAL   Ocul Surf 29, 486-494 (2023)
   PUBMED   37453535
REFERENCE   5  (bases 1 to 3123)
  AUTHORS   Miyamoto,M., Kannan,S., Anderson,M.J., Liu,X., Suh,D., Htet,M.,
            Li,B., Kakani,T., Murphy,S., Tampakakis,E., Lewandoski,M.,
            Andersen,P., Uosaki,H. and Kwon,C.
  TITLE     Cardiac progenitors instruct second heart field fate through Wnts
  JOURNAL   Proc Natl Acad Sci U S A 120 (4), e2217687120 (2023)
   PUBMED   36649430
REFERENCE   6  (bases 1 to 3123)
  AUTHORS   Salinas,P.C. and Nusse,R.
  TITLE     Regional expression of the Wnt-3 gene in the developing mouse
            forebrain in relationship to diencephalic neuromeres
  JOURNAL   Mech Dev 39 (3), 151-160 (1992)
   PUBMED   1363370
REFERENCE   7  (bases 1 to 3123)
  AUTHORS   Moore,S.K., Appella,E., Villar,C.J. and Kozak,C.A.
  TITLE     Mapping of the mouse 86-kDa heat-shock protein expressed gene
            (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4,
            9, and 11
  JOURNAL   Genomics 10 (4), 1019-1029 (1991)
   PUBMED   1916807
REFERENCE   8  (bases 1 to 3123)
  AUTHORS   Roelink,H. and Nusse,R.
  TITLE     Expression of two members of the Wnt family during mouse
            development--restricted temporal and spatial patterns in the
            developing neural tube
  JOURNAL   Genes Dev 5 (3), 381-388 (1991)
   PUBMED   2001840
REFERENCE   9  (bases 1 to 3123)
  AUTHORS   Nusse,R., Brown,A., Papkoff,J., Scambler,P., Shackleford,G.,
            McMahon,A., Moon,R. and Varmus,H.
  TITLE     A new nomenclature for int-1 and related genes: the Wnt gene family
  JOURNAL   Cell 64 (2), 231 (1991)
   PUBMED   1846319
REFERENCE   10 (bases 1 to 3123)
  AUTHORS   Joseph,D.R., Adamson,M.C. and Kozak,C.A.
  TITLE     Genetic mapping of the gene for androgen-binding protein/sex
            hormone-binding globulin to mouse chromosome 11
  JOURNAL   Cytogenet Cell Genet 56 (2), 122-124 (1991)
   PUBMED   2013230
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596108.13.
            
            On Mar 9, 2022 this sequence version replaced NM_009521.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132516.1, BC141274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AL596108.13        48215-48389
            176-417             AL596108.13        82191-82432
            418-683             AL596108.13        85369-85634
            684-1171            AL596108.13        86322-86809
            1172-3123           AL596108.13        90118-92069
FEATURES             Location/Qualifiers
     source          1..3123
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 67.5 cM"
     gene            1..3123
                     /gene="Wnt3"
                     /gene_synonym="Int-4; Wnt-3"
                     /note="wingless-type MMTV integration site family, member
                     3"
                     /db_xref="GeneID:22415"
                     /db_xref="MGI:MGI:98955"
     exon            1..175
                     /gene="Wnt3"
                     /gene_synonym="Int-4; Wnt-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1163
                     /gene="Wnt3"
                     /gene_synonym="Int-4; Wnt-3"
                     /note="proto-oncogene protein Wnt-3; proto-oncogene Wnt-3;
                     proto-oncogene Int-4; wingless-related MMTV integration
                     site 3"
                     /codon_start=1
                     /product="proto-oncogene Wnt-3 precursor"
                     /protein_id="NP_033547.1"
                     /db_xref="CCDS:CCDS25523.1"
                     /db_xref="GeneID:22415"
                     /db_xref="MGI:MGI:98955"
                     /translation="MEPHLLGLLLGLLLSGTRVLAGYPIWWSLALGQQYTSLASQPLL
                     CGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFG
                     PVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSE
                     DADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVK
                     TCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYALFKPPTERDLVY
                     YENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCVF
                     HWCCYVSCQECIRIYDVHTCK"
     exon            176..417
                     /gene="Wnt3"
                     /gene_synonym="Int-4; Wnt-3"
                     /inference="alignment:Splign:2.1.0"
     exon            418..683
                     /gene="Wnt3"
                     /gene_synonym="Int-4; Wnt-3"
                     /inference="alignment:Splign:2.1.0"
     exon            684..1171
                     /gene="Wnt3"
                     /gene_synonym="Int-4; Wnt-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..3123
                     /gene="Wnt3"
                     /gene_synonym="Int-4; Wnt-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1476..1481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt3"
                     /gene_synonym="Int-4; Wnt-3"
                     /note="hexamer: AATGAA"
     polyA_site      1500
                     /gene="Wnt3"
                     /gene_synonym="Int-4; Wnt-3"
     regulatory      3096..3101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt3"
                     /gene_synonym="Int-4; Wnt-3"
                     /note="hexamer: ATTAAA"
     polyA_site      3123
                     /gene="Wnt3"
                     /gene_synonym="Int-4; Wnt-3"
                     /note="major polyA site"
ORIGIN      
        1 atttccaacc tcaagtggac tttgttccaa ctattggggg cgtcgctccc cctcttcatg
       61 atcgccggca aacttcctcc tcggcgctgc ttctaatgga gccccacctg ctcgggctgc
      121 tactcggcct cctgctcagt ggcaccaggg tcctcgctgg ctacccaatt tggtggtccc
      181 tggccctggg ccagcagtac acatctctgg cctcccagcc tctgctctgc ggctccatcc
      241 caggcctggt ccccaagcaa ctgcgcttct gccgcaatta catcgagatc atgcccagcg
      301 tagcagaagg tgtgaagctg ggcatccagg agtgccagca tcagttccgg ggccgccggt
      361 ggaactgtac caccatagat gacagcctgg ccatctttgg gcctgtcttg gacaaagcca
      421 cccgtgaatc ggccttcgtg catgccatcg cctcggctgg tgtcgccttc gcagtcacac
      481 gctcctgcgc tgagggaacc tccaccatct gcggctgtga ctcacatcat aaggggccac
      541 ctggagaagg ctggaagtgg ggcggctgca gcgaggacgc cgacttcggg gtgctggtgt
      601 cccgggaatt tgcggatgcg cgggagaaca ggccagatgc ccgctcagct atgaacaagc
      661 acaacaatga agcaggccga acgaccatcc tggaccacat gcacctaaag tgtaaatgcc
      721 acgggttgtc cggcagctgc gaggtgaaga cctgctggtg ggcccagccc gacttccgtg
      781 ccattggcga cttcctcaag gacaagtacg acagtgcctc cgagatggtg gtggagaaac
      841 accgtgagtc ccgaggctgg gtggagaccc tgcgggctaa gtacgcgctc ttcaagccac
      901 ccaccgagag ggacctggtc tactacgaga actcccccaa cttttgtgag cccaacccag
      961 agacgggctc ctttggtacc agggaccgga cttgcaatgt cacctcccac ggcatcgatg
     1021 gctgcgatct gctgtgctgt ggccggggcc acaacacgag gacggagaaa cggaaggaga
     1081 aatgccattg cgtcttccac tggtgctgct atgtcagctg ccaagagtgt attcgcatct
     1141 acgatgtgca cacctgcaag tagtgagcca gggcactggg aaggggtaga ttgtgcggct
     1201 ggatccattc atcgaagtcc catgagaagc aggatctaga tccaggccag ccttcggcac
     1261 tggccagcaa ggagcatgga ctgttgccag ctgcatgtga taaacgacct ggacccagcc
     1321 ggcctcggac ggacgggcgg cttctttctc aactaacgtc tctccccctg ctctggatgg
     1381 tgtacggctt tacagagggg ctttctttat ggttttacca gggtctgctg gggacagact
     1441 cgaggcttac ctttgcacat gttaaagaaa ataaaaatga aaaaaaaaaa tctaccgcaa
     1501 cagaacaggc tgggctagtg tgagctcttg gcctggtggg aaggacaaga ccatggcgag
     1561 attctgtgtc caagctgcct ctactcgtga cattccaaga tgcctctgag gtgggaactg
     1621 tgaagtagga cagagccccg cagtcccctc ttgtccgtcg actcccattt aaattggaca
     1681 taccttgtcg ttctgagaaa agccatagat aggtgtagct gggatgtagt gatggggagg
     1741 cccctggcca acagtgggag caagatcttg agttttgaag acctcagagt tctgggcggc
     1801 ctgggaagcc atctgcagaa cagagttcct tgtgggctcc tgttttcgct agccctgttc
     1861 tgccctggag cgacagtcag atctccacgc ccctttctgt tgttctacag tgtccacctt
     1921 tactacgcgt tttttttttt ttttttcatg atgaccttgt aaataggtca gatgtggagg
     1981 caggtctctt ctggctccat ccaccacacc cagaaagaat gggctgctct gcccttctca
     2041 gccttgctaa ccagcagaca ccgaggagag cagcggggca ccttagagag caatctaaac
     2101 atggttggca ggtggggagg gtaaagagtc ccacttcctt tgtgttagaa ggcagactac
     2161 cctgcgtcct tttctcccat tggctgaagt aaccagaaag acaagagatc cttaacaagc
     2221 ccttcttccc acttgtaaaa gggatagcct atctcagttc ccaaggatct ggattagata
     2281 gatattcaaa agaggcaagc agcgaatgga ggcagctccc agctctgttc ccgacgcatg
     2341 atggtactgg ctgggtttag taaggtgggt ggggctgcac ggatcaatcc atcaactccg
     2401 tcttaaggag aatcagaaag aggagataaa atgggggaat ggggcagaac aaagaatttg
     2461 tcctttcccg cttctgtcta gggtctgcta atgctggctt gacgaggggt cagccacttc
     2521 tttcctgttg tgcagttggc ttgccaagca ggctccagta ggcccttgcc tgcactctct
     2581 accatgtgac catgagcact gctctaggga cacctcccat cccttcctag caccccaaat
     2641 gccccttccc atctctcctt ccagaagttg gaaatcaagt caactggata acgcttgtgt
     2701 gaggacactt gagcagaacg gatacaacaa tttacaagtc tcttcatatc tatgtattct
     2761 atattaaaag tgataaagtc atgtttccgg ggcgtattca agtagctgac aagtaattat
     2821 ttaataatag tacatgagcg cattgtaatt atcctcgcca tagtcaggta atagcatcca
     2881 atgggaggtc cctaccaacc tgctgtatcc aaagttttgt aaaaagttgt agaagttgtt
     2941 gatctttttg attttatatt caaaaagtct ctttttataa atattattta ttatacaatg
     3001 tatatacctt tgagttaact aagattatat attatataaa tatatatata tttggagaaa
     3061 atctatttca tcatgcagtt tttttctgtt aaatcattaa agagaaggta aacttcaaac
     3121 gga
//
