LOCUS       NM_009520               3573 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 2B
            (Wnt2b), mRNA.
ACCESSION   NM_009520
VERSION     NM_009520.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3573)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 3573)
  AUTHORS   Takahashi,M., Isagawa,T., Sato,T., Takeda,N. and Kawakami,K.
  TITLE     Lineage tracing using Wnt2b-2A-CreERT2 knock-in mice reveals the
            contributions of Wnt2b-expressing cells to novel subpopulations of
            mesothelial/epicardial cell lineages during mouse development
  JOURNAL   Genes Cells 29 (10), 854-875 (2024)
   PUBMED   39109760
REFERENCE   3  (bases 1 to 3573)
  AUTHORS   Lan,L., Huang,C., Liu,D., Cheng,Y., Tang,R., Gu,J., Geng,L.,
            Cheng,Y. and Gong,S.
  TITLE     WNT2B activates macrophages via NF-kappaB signaling pathway in
            inflammatory bowel disease
  JOURNAL   FASEB J 38 (6), e23551 (2024)
   PUBMED   38489235
  REMARK    GeneRIF: WNT2B activates macrophages via NF-kappaB signaling
            pathway in inflammatory bowel disease.
REFERENCE   4  (bases 1 to 3573)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3573)
  AUTHORS   O'Connell,A.E., Raveenthiraraj,S., Oliveira,L.F.S., Adegboye,C.,
            Dasuri,V.S., Qi,W., Khetani,R.S., Singh,A., Sundaram,N., Lin,J.,
            Nandivada,P., Rincon-Cruz,L., Goldsmith,J.D., Thiagarajah,J.R.,
            Carlone,D.L., Turner,J.R., Agrawal,P.B., Helmrath,M. and
            Breault,D.T.
  TITLE     WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to
            Increased Inflammatory Cytokine Production
  JOURNAL   Cell Mol Gastroenterol Hepatol 18 (2), 101349 (2024)
   PUBMED   38697357
  REMARK    GeneRIF: WNT2B Deficiency Causes Enhanced Susceptibility to Colitis
            Due to Increased Inflammatory Cytokine Production.
REFERENCE   6  (bases 1 to 3573)
  AUTHORS   Uusitalo,M., Heikkila,M. and Vainio,S.
  TITLE     Molecular genetic studies of Wnt signaling in the mouse
  JOURNAL   Exp Cell Res 253 (2), 336-348 (1999)
   PUBMED   10585256
  REMARK    Review article
REFERENCE   7  (bases 1 to 3573)
  AUTHORS   Grove,E.A. and Tole,S.
  TITLE     Patterning events and specification signals in the developing
            hippocampus
  JOURNAL   Cereb Cortex 9 (6), 551-561 (1999)
   PUBMED   10498273
REFERENCE   8  (bases 1 to 3573)
  AUTHORS   Loureiro,J.J.
  TITLE     The Wnts
  JOURNAL   Curr Biol 9 (1), R4 (1999)
   PUBMED   9889131
REFERENCE   9  (bases 1 to 3573)
  AUTHORS   Grove,E.A., Tole,S., Limon,J., Yip,L. and Ragsdale,C.W.
  TITLE     The hem of the embryonic cerebral cortex is defined by the
            expression of multiple Wnt genes and is compromised in
            Gli3-deficient mice
  JOURNAL   Development 125 (12), 2315-2325 (1998)
   PUBMED   9584130
REFERENCE   10 (bases 1 to 3573)
  AUTHORS   Zakin,L.D., Mazan,S., Maury,M., Martin,N., Guenet,J.L. and
            Brulet,P.
  TITLE     Structure and expression of Wnt13, a novel mouse Wnt2 related gene
  JOURNAL   Mech Dev 73 (1), 107-116 (1998)
   PUBMED   9545553
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC166156.4.
            
            On Nov 17, 2006 this sequence version replaced NM_009520.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035653.1, AK043566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-413               AC166156.4         83262-83674
            414-634             AC166156.4         90127-90347
            635-912             AC166156.4         91779-92056
            913-1177            AC166156.4         93695-93959
            1178-3573           AC166156.4         97771-100166
FEATURES             Location/Qualifiers
     source          1..3573
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.88 cM"
     gene            1..3573
                     /gene="Wnt2b"
                     /gene_synonym="Wnt13"
                     /note="wingless-type MMTV integration site family, member
                     2B"
                     /db_xref="GeneID:22414"
                     /db_xref="MGI:MGI:1261834"
     exon            1..413
                     /gene="Wnt2b"
                     /gene_synonym="Wnt13"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1407
                     /gene="Wnt2b"
                     /gene_synonym="Wnt13"
                     /note="wnt-13; wingless related MMTV integration site 2b"
                     /codon_start=1
                     /product="protein Wnt-2b"
                     /protein_id="NP_033546.2"
                     /db_xref="CCDS:CCDS17706.1"
                     /db_xref="GeneID:22414"
                     /db_xref="MGI:MGI:1261834"
                     /translation="MLKLQGEDEAAQLAPRRARVPVPRPTAPDVSPSSARLGLACLLL
                     LLLLTLPARVDTSWWYIGALGARVICDNIPGLVSRQRQLCQRYPDIMRSVGEGAREWI
                     RECQHQFRHHRWNCTTLDRDHTVFGRAMLRSSREAAFVYAISSAGVVHAITRACSQGE
                     LSVCSCDPYTRGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLH
                     NNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRTGDYLRRRYDGAVQVTAT
                     QDGANFTAARQGYRHATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGTDGCE
                     IMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCKAPKKAEWLDQT"
     exon            414..634
                     /gene="Wnt2b"
                     /gene_synonym="Wnt13"
                     /inference="alignment:Splign:2.1.0"
     exon            635..912
                     /gene="Wnt2b"
                     /gene_synonym="Wnt13"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1177
                     /gene="Wnt2b"
                     /gene_synonym="Wnt13"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..3573
                     /gene="Wnt2b"
                     /gene_synonym="Wnt13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagccactg acaccgcacc cgaccgccca cacccggctc agcgctcgtc ggtctcctgg
       61 ccctgcacgc tcttgggaac cctgcgtctg gctcccgggc tccacgtgcc ttgaggtcct
      121 cggtcgccca tggtccccat ggccactctg tggggcgatc taggagacgc ctgaggaagc
      181 ccagacagtg cccgtccacg gccctgcggg cttcggggcg ggagtctgcg gggagctatg
      241 ctgaagctgc agggtgagga tgaagccgcg cagctcgccc ctcggcgtgc ccgcgtcccc
      301 gtgcccagac ccacggcccc cgacgtgtcc ccatcttccg cccgcctggg tcttgcctgc
      361 ctgctgctgc tgctactcct gactctgccg gcccgtgtag acacgtcctg gtggtacata
      421 ggggctctgg gagcccgagt gatctgtgac aacatccccg gtctggtgag ccggcagcgg
      481 cagttgtgtc aacgctaccc agacatcatg cgctcagtag gtgagggtgc ccgggaatgg
      541 atccgagagt gccagcacca gttccgtcac caccgctgga attgcaccac actggaccgg
      601 gaccacactg tctttggccg cgccatgctc agaagcagcc gggaggcagc gttcgtctat
      661 gctatctcgt cagcaggagt ggtccacgct atcactcggg cctgcagcca gggtgagctg
      721 agcgtgtgca gctgtgaccc atatacccgc ggtcggcacc atgatcaacg aggggacttt
      781 gactggggtg gctgtagtga caacatccat tacggtgttc gctttgccaa ggcttttgtg
      841 gatgccaaag agaagaggct taaggatgcc cgggccctca tgaacttaca caacaaccgc
      901 tgtggtcgca cggctgttcg gagattcctg aagctggagt gcaagtgtca cggtgtgagt
      961 ggctcctgta ctctgcgcac ctgctggaga gcactctcag acttccgacg cacaggtgac
     1021 tacctgagga ggcgatatga tggggctgtg caggtgacgg ccacacagga tggggccaat
     1081 ttcacagcag cgcgccaggg ctatcgccac gccacccgga ctgatcttgt ctactttgac
     1141 aactcccctg actactgtgt cttggacaag gctgcaggtt ccctaggtac cgcaggccgc
     1201 gtctgcagca agacttctaa aggaacagat gggtgtgaaa tcatgtgttg tggccgaggg
     1261 tatgacacaa ctcgggtcac ccgcgtcacc cagtgtgagt gcaaattcca ctggtgctgt
     1321 gctgtgcggt gcaaggagtg cagaaacact gtggatgtcc acacatgcaa ggcccctaag
     1381 aaggcagagt ggctggacca gacctgaaca cacagaaacc tcattcttcc ctccacttca
     1441 agcctctgac tcaaaagcac aagacccttg catgcgcacc ttcctctacc ctcaatcctg
     1501 ggctgctatg gcttctgtca cggacctgga gagtgatccg gagggacccc aatgtcccgg
     1561 ccgcctggtt ccttagccct agggacgtgt tgatagggga tggatttagg aggctgagtg
     1621 actccctgat ggtccatctg gaggtttgaa gggagagtag gagaggtctg tcttcagagt
     1681 gatttgagtt gcactaagtc aaggctcatc ctcccctttg cttgcactga cttctgatcc
     1741 tctttgggta tgcaacagga agggaacctg gaggtagctt ccgtgtttga tgctactctg
     1801 cctgaggata ggacagagat aaaactgcct gtccctttgc tggagacagt acgggcagac
     1861 aatcttaggc catagtattc tgctgagacc ctgagatagc tagatgggtt agccacattg
     1921 aacaaggctc cacatcatgc ttctacgcag cttataaagt agtggtttgg tgaggaggaa
     1981 aatcacaatg ctctacagat acacattctc tgtgcctccc tttccaccta catcacacag
     2041 cagcagcctg ctcactggct gcctgttcag agtgaggcag cttgcagtgg gtcaaattct
     2101 taccaggcca ttagaggccc ggaacaggat tgtgagagaa tgacatagaa agcctggcta
     2161 ggccttggga cttcccccac atccactatt ccggagattc ggtaggaagg gaggtaactc
     2221 atgggaaggg tgagcgcacc tgatctcagg ggttccatga ggatcagtgt atactaggaa
     2281 ggcagagatc tcgcattttg ctagttcttg aggatcttca gctttgaagt aggaacaaaa
     2341 ggcagcagct atagagagag agctggtgct ggagccgagg tggcaaacat cctataaggc
     2401 ctttctcatt tacccagcaa atctttattt tgtgattcac caggtccaac tgttaactac
     2461 tgcacgttcc acgatcgact taaacaggga aggttctctc tgtgctactg accgttgcct
     2521 aacgagggta cacaggagtg gagccttcaa agagagcagg cacagtgaca tgggggttcc
     2581 aaaccttgat ggtctagttt tatgtgacct cgacaatggt catcttcttc cctattgata
     2641 aacagaaata gtatagaaat ccacagttag acttaggtct aatcccagct atttactctc
     2701 tattttttat tttcagcagg gtctttaaat tctcctctcc cattttctta tctgtaaagt
     2761 gagggtgaaa ctgagatcta actgtgcccc aaactctagc cgactgatag acgtcatcaa
     2821 cactctcact ggtcaagtac ttcctgcttc tctgggacct tctgatttag ggctgtctgg
     2881 gcagacaaca gactagattc aaaggctttc acaaggaatt ctggatatag ctcctctctc
     2941 tcttctcagg ttcctcttca tccaatcgta ctctcagatg tttgtggagc aacctctttc
     3001 tgcccaggca gcaggaggct ggggtggggt ggggtggggg ggcacagctc tggccacaga
     3061 ggcagattta tttggatgat aggactaata tttgtgtaac ctgctgagac ctgtgtggga
     3121 gagtttagta tggtttttct tttggtgagg ggatttgctc cggtttcaca tccattaaca
     3181 caaaacatga gctagtcagg gcccttgtgg tctgtggtga ggggatgact ggagaaacgg
     3241 gactgagtga gtcaggcgga gggaatgtct tcctcgcaga gtagagtcaa cgggataact
     3301 gatgagccag tggtggggtc acggaggggg gcggagggga agagggactt ctcttggaag
     3361 agaggagttt tggggcaggg gcgagaacat ccaagttacg gtatcagtga tggcattggc
     3421 cttcactggg gagccagcct gaggtaaatc tacttgtgct gtattctctt tgagtttggg
     3481 ttcttagctg tggcagacat ctgtgacatc tcatattact ccatgccttt gcctgggctc
     3541 caaattctag ctgataaaga tatacaacca ctt
//
