LOCUS       NM_023653               2115 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 2
            (Wnt2), mRNA.
ACCESSION   NM_023653 XM_207981
VERSION     NM_023653.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2115)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2115)
  AUTHORS   Qiu,C., Martin,B.K., Welsh,I.C., Daza,R.M., Le,T.M., Huang,X.,
            Nichols,E.K., Taylor,M.L., Fulton,O., O'Day,D.R., Gomes,A.R.,
            Ilcisin,S., Srivatsan,S., Deng,X., Disteche,C.M., Noble,W.S.,
            Hamazaki,N., Moens,C.B., Kimelman,D., Cao,J., Schier,A.F.,
            Spielmann,M., Murray,S.A., Trapnell,C. and Shendure,J.
  TITLE     A single-cell time-lapse of mouse prenatal development from
            gastrula to birth
  JOURNAL   Nature 626 (8001), 1084-1093 (2024)
   PUBMED   38355799
REFERENCE   3  (bases 1 to 2115)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   4  (bases 1 to 2115)
  AUTHORS   Chen,S.Y. and Liu,F.C.
  TITLE     The Fgf9-Nolz1-Wnt2 axis regulates morphogenesis of the lung
  JOURNAL   Development 150 (16) (2023)
   PUBMED   37497597
REFERENCE   5  (bases 1 to 2115)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2115)
  AUTHORS   Nusse,R., Brown,A., Papkoff,J., Scambler,P., Shackleford,G.,
            McMahon,A., Moon,R. and Varmus,H.
  TITLE     A new nomenclature for int-1 and related genes: the Wnt gene family
  JOURNAL   Cell 64 (2), 231 (1991)
   PUBMED   1846319
REFERENCE   7  (bases 1 to 2115)
  AUTHORS   Gavin,B.J., McMahon,J.A. and McMahon,A.P.
  TITLE     Expression of multiple novel Wnt-1/int-1-related genes during fetal
            and adult mouse development
  JOURNAL   Genes Dev 4 (12B), 2319-2332 (1990)
   PUBMED   2279700
REFERENCE   8  (bases 1 to 2115)
  AUTHORS   McMahon,J.A. and McMahon,A.P.
  TITLE     Nucleotide sequence, chromosomal localization and developmental
            expression of the mouse int-1-related gene
  JOURNAL   Development 107 (3), 643-650 (1989)
   PUBMED   2693041
REFERENCE   9  (bases 1 to 2115)
  AUTHORS   Chan,A.M., Hilkens,J., Kroezen,V., Mitchell,P.J., Scambler,P.,
            Wainwright,B.J., Williamson,R. and Cooper,C.S.
  TITLE     Molecular cloning and localization to chromosome 6 of mouse INT1L1
            gene
  JOURNAL   Somat Cell Mol Genet 15 (6), 555-562 (1989)
   PUBMED   2531931
REFERENCE   10 (bases 1 to 2115)
  AUTHORS   Wainwright,B.J., Scambler,P.J., Stanier,P., Watson,E.K., Bell,G.,
            Wicking,C., Estivill,X., Courtney,M., Boue,A., Pedersen,P.S. et al.
  TITLE     Isolation of a human gene with protein sequence similarity to human
            and murine int-1 and the Drosophila segment polarity mutant
            wingless
  JOURNAL   EMBO J 7 (6), 1743-1748 (1988)
   PUBMED   2971536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068561.2, AK012093.1 and AK045120.1.
            
            On Jul 1, 2009 this sequence version replaced NM_023653.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045120.1, BC026373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC068561.2         176088-176172       c
            86-1809             AK012093.1         2-1725
            1810-2115           AK045120.1         1722-2027
FEATURES             Location/Qualifiers
     source          1..2115
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 8.08 cM"
     gene            1..2115
                     /gene="Wnt2"
                     /gene_synonym="2610510E18Rik; Int1l1; Irp; Mirp; Wnt-2;
                     Wnt2a"
                     /note="wingless-type MMTV integration site family, member
                     2"
                     /db_xref="GeneID:22413"
                     /db_xref="MGI:MGI:98954"
     exon            1..241
                     /gene="Wnt2"
                     /gene_synonym="2610510E18Rik; Int1l1; Irp; Mirp; Wnt-2;
                     Wnt2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1241
                     /gene="Wnt2"
                     /gene_synonym="2610510E18Rik; Int1l1; Irp; Mirp; Wnt-2;
                     Wnt2a"
                     /note="protein Wnt-2; INT-1-related protein;
                     wingless-related MMTV integration site 2"
                     /codon_start=1
                     /product="protein Wnt-2 precursor"
                     /protein_id="NP_076142.3"
                     /db_xref="CCDS:CCDS19928.1"
                     /db_xref="GeneID:22413"
                     /db_xref="MGI:MGI:98954"
                     /translation="MNVPLGGIWLWLPLLLTWLTPEVSSSWWYMRATGGSSRVMCDNV
                     PGLVSRQRQLCHRHPDVMRAIGLGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLL
                     RSSRESAFVYAISSAGVVFAITRACSQGELKSCSCDPKKKGSAKDSKGTFDWGGCSDN
                     IDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLR
                     TCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANKRFKKPTKNDLVYFENSPD
                     YCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCECKFHWCCAV
                     RCQDCLEALDVHTCKAPKSADWATPT"
     exon            242..468
                     /gene="Wnt2"
                     /gene_synonym="2610510E18Rik; Int1l1; Irp; Mirp; Wnt-2;
                     Wnt2a"
                     /inference="alignment:Splign:2.1.0"
     exon            469..746
                     /gene="Wnt2"
                     /gene_synonym="2610510E18Rik; Int1l1; Irp; Mirp; Wnt-2;
                     Wnt2a"
                     /inference="alignment:Splign:2.1.0"
     exon            747..1011
                     /gene="Wnt2"
                     /gene_synonym="2610510E18Rik; Int1l1; Irp; Mirp; Wnt-2;
                     Wnt2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..2115
                     /gene="Wnt2"
                     /gene_synonym="2610510E18Rik; Int1l1; Irp; Mirp; Wnt-2;
                     Wnt2a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1790..1795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt2"
                     /gene_synonym="2610510E18Rik; Int1l1; Irp; Mirp; Wnt-2;
                     Wnt2a"
                     /note="hexamer: AATAAA"
     polyA_site      1810
                     /gene="Wnt2"
                     /gene_synonym="2610510E18Rik; Int1l1; Irp; Mirp; Wnt-2;
                     Wnt2a"
                     /note="major polyA site"
ORIGIN      
        1 agtctcacca ctagccgcag acgcgagcgg cgggggggcg ggggcgcaga ggcgccggca
       61 gccgtgacga ggcgctcccg gagctgagcg cttctgctcc gggcacgcat ggcgcccgca
      121 cacggagtct gacctgatgt agacgcaagg gggttaatat gaacgtccct ctcggtggaa
      181 tctggctctg gctccctctg ctcttgacct ggctcacccc tgaggtcagc tcttcatggt
      241 ggtacatgag agctacaggt ggctcctcca gggtgatgtg tgacaatgtg ccaggcctgg
      301 tgagccggca gcgtcagctg tgccaccgac acccagatgt gatgcgtgcc attggcctgg
      361 gtgtggctga gtggactgca gagtgccaac accagttccg ccagcatcgc tggaactgca
      421 acaccctgga cagagatcac agcctctttg gccgggtcct cctccgaagt agtcgggaat
      481 cggcctttgt ttacgccatc tcttcagctg gcgttgtatt tgccatcacc agggcctgta
      541 gccaaggaga attaaagtcc tgctcctgtg atccaaagaa gaaaggaagt gccaaggaca
      601 gcaaaggcac cttcgactgg ggtggctgca gtgacaatat tgactacggg atcaagtttg
      661 cccgtgcctt tgtagatgcc aaggagagga aaggcaagga tgccagagcc ctgatgaacc
      721 ttcacaacaa cagagctgga aggaaggctg taaagcgctt cttgaaacaa gaatgcaagt
      781 gtcatggtgt gagtggctcc tgtactctga ggacatgctg gctggccatg gctgacttca
      841 ggaaaacagg cgactatctc tggaggaagt acaatggggc catccaggta gtcatgaacc
      901 aggatggcac tggcttcact gtagccaata agaggtttaa gaagccaacg aaaaatgacc
      961 tcgtgtattt tgagaattct ccagactact gtatcaggga ccgagaggca ggctccctgg
     1021 gtacagcggg ccgtgtgtgc aacttgactt cccgaggcat ggacagctgc gaagttatgt
     1081 gttgtgggag aggctatgac acatcccacg tcacccggat gaccaagtgt gagtgtaaat
     1141 tccactggtg ctgtgccgtg cgctgtcagg actgcctgga ggccctggac gtgcacacat
     1201 gcaaggcccc caagagtgcc gactgggcga cgcctacatg acctcagcag aggtcatatt
     1261 cgccttttct tccctcaagg actccaatta catcttcaag gacactggac ctctgggttg
     1321 ttttcagggg ctctttctta aggcatgaag ccttcatctc aagagaaacc ccctttcccc
     1381 tctctggggg ccccaggact gggaaccacc tgctgcacat aagtacaccc tattctgtct
     1441 atcttgggca ttctgatgtc acctctcttc ctgctgattt ctttttggaa atggcatgac
     1501 aggctgttag aggaggaggg tcatagcccc ccaccactgt cacctagaca tttcctcttt
     1561 ggctgcgggg agaaacatca catagcgaag gaacttcctc tgtgttttcc cagattccaa
     1621 caacccagaa agtctgtgtt tccctggggc gcggggtagg gatggaaagc agaatgagct
     1681 gacaccaaaa tttcctcgga tttttttaaa aaaagagtaa gcaagggctt taactaagtg
     1741 atagctgttg atagcatcct tggtgacttt ctagagaaag atggcttcca ataaacatca
     1801 ggttaaaaca tgtatgtctt caaagaattt attggatatt tattggctat tggatataat
     1861 agggtgagaa tgtttgtcct ttcagactgt gttatttttg aactttcctg tcagccaaca
     1921 ccttagaaag tgattgctat tcctcactgt cccatcagtt taaggattct taagagatga
     1981 gacttctcag tgtgctctgg agagaatctg aaaggggaat ggatgatcta gcaatattat
     2041 ttaactactg ggtaaatatg gtttaaaaat aataataact ttgtgagtgg aatatcataa
     2101 atgtgcttgt atggc
//
