LOCUS       NM_053116               1666 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 16
            (Wnt16), mRNA.
ACCESSION   NM_053116
VERSION     NM_053116.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1666)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1666)
  AUTHORS   Behrmann,A., Zhong,D., Li,L., Xie,S., Mead,M., Sabaeifard,P.,
            Goodarzi,M., Lemoff,A., Kozlitina,J. and Towler,D.A.
  TITLE     Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and
            Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice
  JOURNAL   Endocrinology 165 (2) (2023)
   PUBMED   38123514
  REMARK    GeneRIF: Wnt16 Promotes Vascular Smooth Muscle Contractile
            Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/-
            Mice.
REFERENCE   3  (bases 1 to 1666)
  AUTHORS   Wan,X., Zhao,S., Dai,Y., Zhang,J., Shen,Y., Gong,L. and Le,Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   4  (bases 1 to 1666)
  AUTHORS   Cai,S., Si,N., Wang,Y. and Yin,N.
  TITLE     Transcriptomic analysis of the upper lip and primary palate
            development in mice
  JOURNAL   Front Genet 13, 1039850 (2023)
   PUBMED   36685938
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1666)
  AUTHORS   Tornqvist,A.E., Nilsson,K.H., Li,L., Ohlsson,C. and
            Moverare-Skrtic,S.
  TITLE     Induced inactivation of Wnt16 in young adult mice has no impact on
            osteoarthritis development
  JOURNAL   PLoS One 17 (11), e0277495 (2022)
   PUBMED   36367882
  REMARK    GeneRIF: Induced inactivation of Wnt16 in young adult mice has no
            impact on osteoarthritis development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1666)
  AUTHORS   Chu,E.Y., Hens,J., Andl,T., Kairo,A., Yamaguchi,T.P., Brisken,C.,
            Glick,A., Wysolmerski,J.J. and Millar,S.E.
  TITLE     Canonical WNT signaling promotes mammary placode development and is
            essential for initiation of mammary gland morphogenesis
  JOURNAL   Development 131 (19), 4819-4829 (2004)
   PUBMED   15342465
REFERENCE   7  (bases 1 to 1666)
  AUTHORS   Heller,R.S., Dichmann,D.S., Jensen,J., Miller,C., Wong,G.,
            Madsen,O.D. and Serup,P.
  TITLE     Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in
            transgenic mice suggesting a role for Wnts in pancreas and foregut
            pattern formation
  JOURNAL   Dev Dyn 225 (3), 260-270 (2002)
   PUBMED   12412008
REFERENCE   8  (bases 1 to 1666)
  AUTHORS   Weidenfeld,J., Shu,W., Zhang,L., Millar,S.E. and Morrisey,E.E.
  TITLE     The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung
            epithelium
  JOURNAL   J Biol Chem 277 (23), 21061-21070 (2002)
   PUBMED   11914369
REFERENCE   9  (bases 1 to 1666)
  AUTHORS   Reddy,S., Andl,T., Bagasra,A., Lu,M.M., Epstein,D.J., Morrisey,E.E.
            and Millar,S.E.
  TITLE     Characterization of Wnt gene expression in developing and postnatal
            hair follicles and identification of Wnt5a as a target of Sonic
            hedgehog in hair follicle morphogenesis
  JOURNAL   Mech Dev 107 (1-2), 69-82 (2001)
   PUBMED   11520664
REFERENCE   10 (bases 1 to 1666)
  AUTHORS   McWhirter,J.R., Neuteboom,S.T., Wancewicz,E.V., Monia,B.P.,
            Downing,J.R. and Murre,C.
  TITLE     Oncogenic homeodomain transcription factor E2A-Pbx1 activates a
            novel WNT gene in pre-B acute lymphoblastoid leukemia
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11464-11469 (1999)
   PUBMED   10500199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053805.1, BC115925.1 and AK054110.1.
            
            On Aug 8, 2009 this sequence version replaced NM_053116.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054110.1, BC115811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AK053805.1         2-41
            41-1474             BC115925.1         1-1434
            1475-1666           AK054110.1         1473-1664
FEATURES             Location/Qualifiers
     source          1..1666
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 9.22 cM"
     gene            1..1666
                     /gene="Wnt16"
                     /gene_synonym="E130309I19Rik"
                     /note="wingless-type MMTV integration site family, member
                     16"
                     /db_xref="GeneID:93735"
                     /db_xref="MGI:MGI:2136018"
     exon            1..375
                     /gene="Wnt16"
                     /gene_synonym="E130309I19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..1375
                     /gene="Wnt16"
                     /gene_synonym="E130309I19Rik"
                     /note="protein Wnt-16; wingless-related MMTV integration
                     site 16"
                     /codon_start=1
                     /product="protein Wnt-16 precursor"
                     /protein_id="NP_444346.3"
                     /db_xref="CCDS:CCDS19936.1"
                     /db_xref="GeneID:93735"
                     /db_xref="MGI:MGI:2136018"
                     /translation="MDRAALLALPSLCALWAAVLSLLPCGTQGNWMWLGIASFGVPEK
                     LGCADLPLNSRQKELCKRKPYLLPSIREGARLGIQECRSQFRHERWNCMVATTTSTQL
                     ATAPLFGYELSSGTKETAFIYAIMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSPSE
                     GWHWGGCSDDVQYGMWFSRKFLDLPIRNTTGKESRVLLAMNLHNNEAGRQAVAKLMSV
                     DCRCHGVSGSCAVKTCWKTMSSFEKIGHFLKDKYENSIQISDKTKRKMRRREKDQRQT
                     PILKDDLLYVHKSPNYCVENKKLGIPGTQGRECNRTSGGADGCNLLCCGRGYNTHVVR
                     HVERCECKFIWCCYVRCRRCESMTDVHTCK"
     exon            376..623
                     /gene="Wnt16"
                     /gene_synonym="E130309I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            624..910
                     /gene="Wnt16"
                     /gene_synonym="E130309I19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1666
                     /gene="Wnt16"
                     /gene_synonym="E130309I19Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcagcagaa gtttctcacc ttggaaagtg agggaagctc ccgcatctcc agctcatcct
       61 cacctctgcg ccagaggacc ttaggctact ttctccgcct tatcttgcct aggggactgc
      121 tgatagtctc tgtccttgct gccctgttta atgttacctt ccaggggaaa gagagcaagg
      181 aacaactggg tgctaagaaa ctgaccccag gccctgcggg cctctggaga gaggagacag
      241 aggaggagtg gctggggctg ggggtctcca tgcgtgggcc atggacagag cggcgctcct
      301 ggccctgccc agcttgtgtg cgctgtgggc agccgtgctg tcgctgctcc cctgcggaac
      361 ccagggcaac tggatgtggt tgggcatcgc ctctttcggg gtaccggaga agctgggctg
      421 cgccgacttg ccgctgaaca gccgccagaa ggagctgtgc aagaggaaac cgtacctgct
      481 gcctagcatc cgcgagggcg ccaggctggg cattcaggag tgcagaagcc agttccgaca
      541 cgagaggtgg aactgtatgg tcgccactac cacttccacc cagctcgcca cagcccccct
      601 ctttggctat gagctgagta gcggcaccaa ggagacagca ttcatttatg ccatcatggc
      661 agcgggcctg gtgcactctg tcaccaggtc atgcagtgca ggcaacatga ccgaatgttc
      721 ctgtgacacc accttgcaga atggtggctc accaagtgaa ggctggcact ggggaggatg
      781 ctcggatgat gtccagtacg gcatgtggtt cagcagaaag tttctagatc ttcccatcag
      841 aaacaccaca ggaaaagaaa gcagagtcct gctagccatg aatctacaca acaacgaagc
      901 ggggcggcag gctgtcgcca agttaatgtc tgtggactgc cgctgccacg gagtttccgg
      961 ctcctgtgct gtgaaaacct gctggaaaac tatgtcttct tttgaaaaga ttgggcattt
     1021 tttaaaggat aaatatgaaa acagcatcca gatctcagac aaaaccaaga ggaaaatgcg
     1081 caggagagaa aaagaccaga ggcagacccc cattctcaag gatgacttgc tgtacgttca
     1141 taagtctccc aactactgcg tggagaacaa gaaactgggg attcctggga cccagggcag
     1201 agagtgcaac cggacatcag gaggcgcaga tggctgtaac ctcctctgct gtggccgagg
     1261 ctacaacacc catgtagtca ggcacgtgga gaggtgtgag tgtaagttta tctggtgctg
     1321 ctacgtccgc tgcaggaggt gtgaaagtat gaccgatgtc cacacgtgta agtaacctct
     1381 ccgtccagcc tagcatgaga cgcctctgta gtaaccaagg tgtggtgttg gcatctggag
     1441 ggcgccccta ctgtgcactg atggggaagt cgctgcctgt aagagtgttc ccagacccct
     1501 gggctagtct acgatttctt tctttctggc aggcttcaaa tcacaagctg atccagagga
     1561 ttgcttggga ttctgaagtt gaaaaggttg gcagtcgcct ttggatgatt tgggaaatat
     1621 acattgatat acaggaaaca tcaaatctgt ttctgaagca atgtgg
//
