LOCUS       NM_009519               2788 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 11
            (Wnt11), transcript variant 2, mRNA.
ACCESSION   NM_009519
VERSION     NM_009519.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2788)
  AUTHORS   Franks,N.E. and Allen,B.L.
  TITLE     Hedgehog-dependent and hedgehog-independent roles for growth arrest
            specific 1 in mammalian kidney morphogenesis
  JOURNAL   Development 151 (24) (2024)
   PUBMED   39629522
REFERENCE   2  (bases 1 to 2788)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   3  (bases 1 to 2788)
  AUTHORS   Polsani,N., Yung,T., Thomas,E., Phung-Rojas,M., Gupta,I.,
            Denker,J., Lau,K., Feng,X., Ibarra,B., Hopyan,S. and Atit,R.P.
  TITLE     Mesenchymal Wnts are required for morphogenetic movements of
            calvarial osteoblasts during apical expansion
  JOURNAL   Development 151 (12) (2024)
   PUBMED   38814743
REFERENCE   4  (bases 1 to 2788)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2788)
  AUTHORS   Cheng,T., Agwu,C., Shim,K., Wang,B., Jain,S. and Mahjoub,M.R.
  TITLE     Aberrant centrosome biogenesis disrupts nephron and collecting duct
            progenitor growth and fate resulting in fibrocystic kidney disease
  JOURNAL   Development 150 (24) (2023)
   PUBMED   37982452
REFERENCE   6  (bases 1 to 2788)
  AUTHORS   Malek,S.N., Yang,C.H., Earnshaw,W.C., Kozak,C.A. and Desiderio,S.
  TITLE     p150TSP, a conserved nuclear phosphoprotein that contains multiple
            tetratricopeptide repeats and binds specifically to SH2 domains
  JOURNAL   J Biol Chem 271 (12), 6952-6962 (1996)
   PUBMED   8636124
REFERENCE   7  (bases 1 to 2788)
  AUTHORS   Sullivan,S.L., Adamson,M.C., Ressler,K.J., Kozak,C.A. and Buck,L.B.
  TITLE     The chromosomal distribution of mouse odorant receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 884-888 (1996)
   PUBMED   8570653
REFERENCE   8  (bases 1 to 2788)
  AUTHORS   Brooker,D.R., Kozak,C.A. and Kleyman,T.R.
  TITLE     Epithelial sodium channel genes Scnn1b and Scnn1g are closely
            linked on distal mouse chromosome 7
  JOURNAL   Genomics 29 (3), 784-786 (1995)
   PUBMED   8575777
REFERENCE   9  (bases 1 to 2788)
  AUTHORS   Christiansen,J.H., Dennis,C.L., Wicking,C.A., Monkley,S.J.,
            Wilkinson,D.G. and Wainwright,B.J.
  TITLE     Murine Wnt-11 and Wnt-12 have temporally and spatially restricted
            expression patterns during embryonic development
  JOURNAL   Mech Dev 51 (2-3), 341-350 (1995)
   PUBMED   7547479
REFERENCE   10 (bases 1 to 2788)
  AUTHORS   Adamson,M.C., Dennis,C., Delaney,S., Christiansen,J., Monkley,S.,
            Kozak,C.A. and Wainwright,B.
  TITLE     Isolation and genetic mapping of two novel members of the murine
            Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and
            Wnt7a
  JOURNAL   Genomics 24 (1), 9-13 (1994)
   PUBMED   7896292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110039.13 and BC125484.1.
            
            On Jul 28, 2009 this sequence version replaced NM_009519.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X70800.1, AK031573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC110039.13        22685-22737         c
            54-1612             BC125484.1         1-1559
            1613-2788           AC110039.13        6835-8010           c
FEATURES             Location/Qualifiers
     source          1..2788
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.9 cM"
     gene            1..2788
                     /gene="Wnt11"
                     /note="wingless-type MMTV integration site family, member
                     11"
                     /db_xref="GeneID:22411"
                     /db_xref="MGI:MGI:101948"
     exon            1..346
                     /gene="Wnt11"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1328
                     /gene="Wnt11"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; protein Wnt-11; wingless-related MMTV
                     integration site 11"
                     /codon_start=1
                     /product="protein Wnt-11 isoform a precursor"
                     /protein_id="NP_033545.1"
                     /db_xref="CCDS:CCDS21475.1"
                     /db_xref="GeneID:22411"
                     /db_xref="MGI:MGI:101948"
                     /translation="MRARPQVCEALLFALALHTGVCYGIKWLALSKTPAALALNQTQH
                     CKQLEGLVSAQVQLCRSNLELMRTIVHAARGAMKACRRAFADMRWNCSSIELAPNYLL
                     DLERGTRESAFVYALSAATISHTIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADN
                     LSYGLLMGAKFSDAPMKVKKTGSQANKLMRLHNSEVGRQALRASLETKCKCHGVSGSC
                     SIRTCWKGLQELQDVAADLKTRYLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYL
                     QSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYH
                     WCCYVTCRRCERTVERYVCK"
     exon            347..582
                     /gene="Wnt11"
                     /inference="alignment:Splign:2.1.0"
     exon            583..860
                     /gene="Wnt11"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1153
                     /gene="Wnt11"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..2788
                     /gene="Wnt11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1770..1775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt11"
                     /note="hexamer: AATACA"
     polyA_site      1803
                     /gene="Wnt11"
                     /note="major polyA site"
     regulatory      1829..1834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt11"
                     /note="hexamer: AATATA"
     polyA_site      1856
                     /gene="Wnt11"
     regulatory      1868..1873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt11"
                     /note="hexamer: AATAAA"
     polyA_site      1890
                     /gene="Wnt11"
                     /note="major polyA site"
     regulatory      2766..2771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt11"
                     /note="hexamer: AATATA"
     polyA_site      2788
                     /gene="Wnt11"
ORIGIN      
        1 cctaatccga gcctgacgcc ggcgggtctc gggcggttcg gggagagagc ggactccttc
       61 ctcgctcagc ctccccggcc cgacccctcc tttgtaattt gaataaaacg cctcccagcc
      121 cgcgcgccgc cttaacccgc cgccctgttc tccgtgattg caggcggcgt gcgcgcagga
      181 acagcagcgg tggcctgcag gcggcggagt tcggtgcggc tcctgcaggg tgcgaccccc
      241 gggagcgccg ggcgcgcgcg acgatgaggg cgcggccgca ggtctgcgag gctctgctct
      301 ttgccttggc gctccacacc ggcgtgtgct atggcatcaa gtggctggca ctgtccaaga
      361 ctccggcagc cttggcactg aatcagacgc aacactgtaa acagctggag ggcctggtgt
      421 ctgcgcaggt gcagctctgc cgcagcaacc tggagctcat gcgcaccatc gtgcacgccg
      481 cccggggggc catgaaggcc tgccgtaggg ccttcgctga catgcgctgg aactgctcct
      541 ccatcgagct cgcccccaac tacctgcttg acctggagag aggtacacgg gagtcagcct
      601 tcgtgtatgc cctgtcggcc gccaccatca gtcacaccat cgcccgggcc tgcacctctg
      661 gcgacctgcc cggctgctcc tgcggccccg tcccaggtga gccacccggg cccgggaacc
      721 gctggggagg atgtgcggac aacctcagct acgggctcct catgggggcc aagttttccg
      781 atgctcctat gaaggtgaaa aaaacaggat cccaagccaa taaactgatg cgtctacaca
      841 acagtgaagt ggggagacag gctctacgtg cctccctgga aacgaagtgt aaatgccatg
      901 gggtgtctgg ctcctgctcc atccgcacct gttggaaggg gctgcaagag ctccaggacg
      961 tggctgctga cctcaagacc cgctacctgt cagccacgaa ggtggtacac cggcctatgg
     1021 gcacccgcaa acacttggtg cccaaggacc tggatatccg gcctgtgaag gactcagaac
     1081 ttgtgtatct acagagctcc cctgacttct gcatgaagaa tgagaaggtg ggatcccatg
     1141 ggacccaaga caggcagtgc aacaagactt ccaacggcag tgacagctgc gacctcatgt
     1201 gctgtgggcg cggctacaac ccctacacgg acagagtggt ggagcgatgt cactgcaagt
     1261 accactggtg ctgctacgtc acctgccgca ggtgtgagcg cacggtggag cgctacgtct
     1321 gcaagtgaga ccatatgccc cacccctgag gaggggtgct gctcctctga ggacccactc
     1381 aagggcctag agaccttggt ggacttccct gcagatgcca gatgccaggc gtgggaggcg
     1441 gcttgtgctg tgcctccact tggaagacac cacaccagga ggcctggtcg ccctgggaga
     1501 gccggggctt caaaggaaac tgataggatt aaaaataacc tggcagcctg gggcctgagt
     1561 gcccacatgt tgccttccag gctgctccaa gaagtcaggg cagggatggg taagactgtg
     1621 catttgacct ttcaaggcca gaaagaccgg ctttctggaa tgttctttgg gaccctgtgc
     1681 ccaccacatg gaaccactaa cttgggttgt aaatttttat tttccttccc ctctccgtgg
     1741 gatgtgggag ttacagaaat atttataaaa atacagcttt ttctttgggg tggctcactt
     1801 caatccctct ttatatatta tatatataaa tatatataat gattatatat tttaaacaag
     1861 tgtgtgaaat aaatgctgag caagccccaa tctgccccca aatctctgcc ctcctcaagt
     1921 gaccccagca gatcctgggc tggcaggagg actcttcagt ttccaggcaa ggcggcctcc
     1981 cattgatgtc ccagccccac ccggtcctcc gacctggtcc tggcccgttt ccctgtatgt
     2041 gatctgttgg tcaagggtga ggacagacgt cttgaaacat aaccctagtt ggcagtatct
     2101 ttattcctca gggacattct tacagcacag ccattggcca tggtttcaga cccattaagc
     2161 ttgctgcaag aaagctgaga ccttagggag gccgccctgg taggtttttg gtgggaccct
     2221 gaatggtggg cctggcccat actattgccc tgtctatgag gctgggcttg cactgtctaa
     2281 gcctggacgt tggggaaggc ccaggctcac agctcatgcc cgaacagggc ttgtggctac
     2341 tgatgtgcta agatacaggg accagcagga ccgattccct ctttcaagtg tggaaccagg
     2401 tgggccagga aaaactgttt gggtttggag ggtcggggga ggagggaagg cctgctgcag
     2461 gtggggttag ggagatgggg ggatctgatt tggacagggg tgtagactga ggtgcagggc
     2521 ggactcccat gtgggaatga gcagatgtta gggcctaggg ttctgaagta agccaggctg
     2581 cagagtcacc tttgtcaagc cagaaggacc tggcctgttt gtgatgtctg ccaataggct
     2641 ggaggccgaa agtaaaggac agagggacag cccaggagaa ggcaagagct gggggactcg
     2701 gccatccttc tctggcttta tctttcattc accattttaa agattttttt agcaatggaa
     2761 acaaaaatat acctaaaact gaaacttc
//
