LOCUS       NM_011718               2272 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 10B
            (Wnt10b), mRNA.
ACCESSION   NM_011718
VERSION     NM_011718.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2272)
  AUTHORS   Papagno,V., Sulic,A.M., Satta,J.P., Hoshiar,A.K., Kumar,V.,
            Jernvall,J. and Mikkola,M.L.
  TITLE     Wnt target gene Ascl4 is dispensable for skin appendage development
  JOURNAL   Int J Dev Biol (2024) In press
   PUBMED   38770834
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2272)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2272)
  AUTHORS   Liu,Y., Hu,G., Jia,Y., Qin,L., Xu,L., Chang,Y., Li,B. and Li,H.
  TITLE     Wnt10b knockdown regulates the relative balance of adipose
            tissue-resident T cells and inhibits white fat deposition
  JOURNAL   Mol Biol Rep 51 (1), 272 (2024)
   PUBMED   38302806
  REMARK    GeneRIF: Wnt10b knockdown regulates the relative balance of adipose
            tissue-resident T cells and inhibits white fat deposition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2272)
  AUTHORS   Huang,K., Cai,S., Fu,T., Zhu,Q., Liu,L., Yao,Z., Rao,P., Lan,X.,
            Li,Q. and Xiao,J.
  TITLE     Wnt10b regulates osteogenesis of adipose-derived stem cells through
            Wnt/beta-catenin signalling pathway in osteoporosis
  JOURNAL   Cell Prolif 57 (1), e13522 (2024)
   PUBMED   37340715
  REMARK    GeneRIF: Wnt10b regulates osteogenesis of adipose-derived stem
            cells through Wnt/beta-catenin signalling pathway in osteoporosis.
REFERENCE   5  (bases 1 to 2272)
  AUTHORS   Jia,Y., Liu,Y., Liu,S., Chang,Y., Xu,L. and Li,H.
  TITLE     Wnt10b knockdown promotes UCP1 expression in brown adipose tissue
            in mice
  JOURNAL   Genes Cells 28 (11), 764-775 (2023)
   PUBMED   37691290
  REMARK    GeneRIF: Wnt10b knockdown promotes UCP1 expression in brown adipose
            tissue in mice.
REFERENCE   6  (bases 1 to 2272)
  AUTHORS   Chin,H., Kwon,O.J., Jung,H.H., Kim,D.S. and Kozak,C.A.
  TITLE     Genetic mapping of the mouse genes encoding the voltage-sensitive
            calcium channel subunits
  JOURNAL   Genomics 28 (3), 592-595 (1995)
   PUBMED   7490102
REFERENCE   7  (bases 1 to 2272)
  AUTHORS   Christiansen,J.H., Dennis,C.L., Wicking,C.A., Monkley,S.J.,
            Wilkinson,D.G. and Wainwright,B.J.
  TITLE     Murine Wnt-11 and Wnt-12 have temporally and spatially restricted
            expression patterns during embryonic development
  JOURNAL   Mech Dev 51 (2-3), 341-350 (1995)
   PUBMED   7547479
REFERENCE   8  (bases 1 to 2272)
  AUTHORS   Lee,F.S., Lane,T.F., Kuo,A., Shackleford,G.M. and Leder,P.
  TITLE     Insertional mutagenesis identifies a member of the Wnt gene family
            as a candidate oncogene in the mammary epithelium of int-2/Fgf-3
            transgenic mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 2268-2272 (1995)
   PUBMED   7892260
REFERENCE   9  (bases 1 to 2272)
  AUTHORS   Adamson,M.C., Dennis,C., Delaney,S., Christiansen,J., Monkley,S.,
            Kozak,C.A. and Wainwright,B.
  TITLE     Isolation and genetic mapping of two novel members of the murine
            Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and
            Wnt7a
  JOURNAL   Genomics 24 (1), 9-13 (1994)
   PUBMED   7896292
REFERENCE   10 (bases 1 to 2272)
  AUTHORS   Moore,R., Dixon,M., Smith,R., Peters,G. and Dickson,C.
  TITLE     Complete nucleotide sequence of a milk-transmitted mouse mammary
            tumor virus: two frameshift suppression events are required for
            translation of gag and pol
  JOURNAL   J Virol 61 (2), 480-490 (1987)
   PUBMED   3027377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U30464.1, BC114969.1 and U61970.1.
            
            On Dec 12, 2009 this sequence version replaced NM_011718.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: U20658.1, U30464.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               U30464.1           1-293
            294-407             BC114969.1         270-383
            408-2217            U30464.1           406-2215
            2218-2272           U61970.1           2012-2066
FEATURES             Location/Qualifiers
     source          1..2272
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.65 cM"
     gene            1..2272
                     /gene="Wnt10b"
                     /gene_synonym="Wnt12"
                     /note="wingless-type MMTV integration site family, member
                     10B"
                     /db_xref="GeneID:22410"
                     /db_xref="MGI:MGI:108061"
     exon            1..293
                     /gene="Wnt10b"
                     /gene_synonym="Wnt12"
                     /inference="alignment:Splign:2.1.0"
     exon            294..407
                     /gene="Wnt10b"
                     /gene_synonym="Wnt12"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1503
                     /gene="Wnt10b"
                     /gene_synonym="Wnt12"
                     /note="protein Wnt-10b; wnt-12; wingless related MMTV
                     integration site 10b"
                     /codon_start=1
                     /product="protein Wnt-10b precursor"
                     /protein_id="NP_035848.1"
                     /db_xref="CCDS:CCDS27806.1"
                     /db_xref="GeneID:22410"
                     /db_xref="MGI:MGI:108061"
                     /translation="MLEEPRSRPPPLGLAGLLFLALFSRALSNEILGLKLPGEPPLTA
                     NTVCLTLSGLSKRQLGLCLRSPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGR
                     LPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAK
                     LLQLQALSRGKTFPISQPSPVPGSVPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSRE
                     APRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAIGAALR
                     ERLSRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTLGSPGTRGRAC
                     NKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK"
     exon            408..670
                     /gene="Wnt10b"
                     /gene_synonym="Wnt12"
                     /inference="alignment:Splign:2.1.0"
     exon            671..1044
                     /gene="Wnt10b"
                     /gene_synonym="Wnt12"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..2227
                     /gene="Wnt10b"
                     /gene_synonym="Wnt12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1722..1727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt10b"
                     /gene_synonym="Wnt12"
                     /note="hexamer: AATAGA"
     polyA_site      1742
                     /gene="Wnt10b"
                     /gene_synonym="Wnt12"
                     /note="major polyA site"
     regulatory      2201..2206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt10b"
                     /gene_synonym="Wnt12"
                     /note="hexamer: AATAAA"
     polyA_site      2227
                     /gene="Wnt10b"
                     /gene_synonym="Wnt12"
                     /note="major polyA site"
ORIGIN      
        1 ctcgagcaga accacccgtg agttaggtcg agcagagcca aagcccccgg tgcttcgtcg
       61 cgggttcgct cgctagctat ctggatcact ccctcccttt taccctccct tcctcccggc
      121 gggcggccgc ggcgacgccg gggaagcggc agagaggagt ggctgggcgc tgggagaatg
      181 ctgctccgcc gagggggctg aacccgacag tttccccacg gtttaagccc caagagccgg
      241 gcccgagtga ctcaaccgcg agccttgtgg atcctgcacc tgaaccgctg gaggcgctga
      301 ctgactcgcc caccggagcc tccgggcttc gacatgctgg aggagccccg gtctcggcct
      361 ccgcccttag gcctcgcggg tctcctgttc ttggctttgt tcagtcgggc tctaagcaat
      421 gagattctgg gccttaaact tcccggtgag ccgccgctga cggccaacac cgtgtgcttg
      481 accctgtccg gactgagtaa gcgacagctg gggctgtgcc tgcgcagccc cgacgtgacg
      541 gcgtcggcgc tccaggggct gcacatcgcc gttcacgagt gtcagcacca gctgcgcgac
      601 cagcgctgga actgctcggc actggagggc ggcggccggc tgccgcacca cagcgccatc
      661 ctcaagcgcg gtttccgtga gagtgctttc tccttctcca tgctggctgc tggggtcatg
      721 catgctgttg ccacagcctg cagcctgggc aagctggtga gctgcggctg cggatggaag
      781 ggtagtggtg agcaagaccg gcttagagcc aagctgctgc agcttcaggc actgtctcgg
      841 ggcaagactt tccccatctc ccagcccagc cctgttcctg gctcagtccc cagccccggc
      901 ccccaggaca cgtgggaatg gggtggctgt aaccacgaca tggacttcgg agagaagttc
      961 tctcgggatt tcttggattc cagggaggct ccccgggaca tccaggcgag aatgcggatc
     1021 cacaacaaca gggtgggacg ccaggtggta acggaaaacc tgaagcggaa gtgcaaatgc
     1081 catggaacgt caggcagctg ccaattcaag acctgttgga gggcagcgcc agagttccgg
     1141 gccatcgggg cagcactgag ggagcggctg agcagagcca tctttatcga tacccacaac
     1201 cgcaactctg gagcgttcca gccccgccta cgtccgcggc gcctctctgg agagctggtt
     1261 tactttgaga agtctcctga cttctgcgag cgagacccta ctctgggctc cccaggcacg
     1321 agaggccggg cttgcaacaa gaccagccgc ctcttggatg gctgtggcag cctgtgctgt
     1381 ggccgtgggc acaacgtgct ccggcagacg cgagtggagc gctgccactg tcgtttccac
     1441 tggtgctgtt atgtgctgtg tgatgagtgt aaagtcacag agtgggtcaa tgtgtgtaaa
     1501 tgaaggtgag cctcgcctag gcacgacgag gaggagaagc actgtgtgag ggctgctctc
     1561 tttcagccct ttgctcggat ttctgtctag ggtttatcgt ggctcccgga agctcagagc
     1621 atctgcctga gaacagctct gggggtgtag ggtcaggtga aatctgtaac gagcagcctt
     1681 ttgtggggga agtggcccca cactctgttc ttaaacactc gaatagacta agatgaaatg
     1741 cactgtactg ttagcgtctt ctctacctac agctccctcg ggctcaggtt cctacttcct
     1801 ttggataggg agtctatctt ttggccactc ctcttcctcg aaggataata gcaggcattg
     1861 tgtggagtca ataagacccg tatatatagc aagagaccac ctcttcctat ttgtggttct
     1921 caaactcctc cactacagcc cagaacctcc tcttatggga cctcgggtga caataatgag
     1981 aggttttcgg ttggaaaagg acagagggca gggaagcctc agacagctgt cttgtcaggc
     2041 tcttgggagg cttctccttc cgttcagttg ttgaaagggt ctctccaaag gaaaggtttt
     2101 agccataact cttggaggcc cttttccttc ttcagcagga agggtgggaa tggataattt
     2161 attttactga gatgtgttct tggttcctgt ttgaaactaa aataaattaa gttactgaac
     2221 tactggaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
